Stanford University

Awards to the Institution

Program	Investigator	Award Title	Award Value
Transplantation Immunology	Judith Shizuru	Purified allogeneic hematopoietic stem cells as a platform for tolerance induction	$1,233,275
Clinical Trial Stage Projects	Everett Meyer	Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients	$11,955,585
Basic Biology IV	Michelle Monje	Stem Cell Mechanisms Governing Discrete Waves of Gliogenesis in the Childhood Brain	$1,264,248
Disease Team Research I	Alfred Lane	iPS Cell-Based Treatment of Dominant Dystrophic Epidermolysis Bullosa	$11,039,208
Quest - Discovery Stage Research Projects	Roel Nusse	Preclinical development of human hepatocyte progenitor cells for cell therapy	$1,651,643
Inception - Discovery Stage Research Projects	Helen Blau	Prodrug innovation to target muscle stem cells and enhance muscle regeneration	$235,834
Basic Biology III	Aaron Hsueh	Correlated time-lapse imaging and single cell molecular analysis of human embryo development	$1,259,733
Major Facilities	John Hennessy	Stanford SIM1 Building	$43,578,000
SEED Grant	Joseph Wu	In Vivo Imaging of Human Embryonic Stem Cell Derivatives and Tumorigenicity	$623,634
Comprehensive Grant	Theo Palmer	Human oocyte development for genetic, pharmacological and reprogramming applications	$2,298,411
Clinical Trial Stage Projects	Crystal Mackall	Phase 1 Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Adults with Recurrent or Refractory B Cell Malignancies	$11,034,982
Basic Biology IV	Howard Chang	Long noncoding RNAs for pluripotency and cell fate commitment	$1,386,627
Basic Biology I	Julien Sage	The retinoblastoma (RB) gene family in cellular reprogramming	$1,357,085
Inception - Discovery Stage Research Projects	Phillip Yang	Activation of patient-specific endogenous myocardial repair through the exosomes generated from the hypoxic iPSC-derived cardiomyocytes (iCMs).	$234,619
Conference	Hank Greely	Stem Cell Policy: Understanding the Scientific and Legal Challenges Ahead	$5,838
Tools and Technologies II	Theo Palmer	Development of small molecule screens for autism using patient-derived iPS cells	$1,797,606
Disease Team Therapy Development III	Irving Weissman	Clinical Investigation of a Humanized Anti-CD47 Antibody in Targeting Cancer Stem Cells in Hematologic Malignancies and Solid Tumors	$6,505,568
SEED Grant	Krishna Shenoy	Technology for hESC-Derived Cardiomyocyte Differentiation and Optimization of Graft-Host Integration in Adult Myocardium	$572,891
Comprehensive Grant	Irving Weissman	Prospective isolation of hESC-derived hematopoietic and cardiomyocyte stem cells	$2,471,386
Inception - Discovery Stage Research Projects	Guillem Pratx	Novel metabolic labeling method for tracking stem cells to irradiated salivary glands using PET	$235,613
Training Grant I-1	Michael Longaker	Stanford CIRM Training Program	$3,035,282
Tools and Technologies III	Irving Weissman	Identification and isolation of transplantable human hematopoietic stem cells from pluripotent cell lines; two steps from primitive hematopoiesis to transplantable definitive cells, and non-toxic conditioning of hosts for hematopoeitic stem cell transp...	$1,271,952
Transplantation Immunology	Kenneth Weinberg	Engineered immune tolerance by Stem Cell-derived thymic regeneration	$1,271,729
Clinical Trial Stage Projects	Judith Shizuru	A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants	$3,715,031
Creativity Awards	Paul Utz	SIMR Program: Stem Cell & Developmental Biology Research Internships	$340,611
Disease Team Research I	Gary Steinberg	Embryonic-Derived Neural Stem Cells for Treatment of Motor Sequelae following Sub-cortical Stroke	$17,244,851
Quest - Discovery Stage Research Projects	Matthew Porteus	Genome Editing to Correct Cystic Fibrosis Mutations in Airway Stem Cells	$1,968,456
Quest - Discovery Stage Research Projects	Mark Mercola	Multipotent Cardiovascular Progenitor Regeneration of the Myocardium after MI	$1,809,234
Basic Biology III	Joanna Wysocka	Enhancer-mediated gene regulation during early human embryonic development	$1,420,618
Disease Team Planning	Robert Robbins	{REDACTED} Cardiovascular Regenerative Team	$25,119
SEED Grant	Joanna Wysocka	Role of Chromatin Modifiers in Regulating Human Embryonic Stem Cell Pluripotency	$629,952
Early Translational I	Jill Helms	Enhancing healing via Wnt-protein mediated activation of endogenous stem cells	$6,464,126
Therapeutic Translational Research Projects	Bertha Chen	Autologous iPSC-derived smooth muscle cell therapy for treatment of urinary incontinence	$5,977,155
Basic Biology IV	Gerald Crabtree	Mechanism and Utility of Direct Neuronal Conversion with a MicroRNA-Chromatin Switch	$1,392,150
Basic Biology I	Helen Blau	Molecular Mechanisms of Reprogramming towards Pluripotency	$1,408,332
Inception - Discovery Stage Research Projects	Bertha Chen	Autologous iPSC-based therapy for radiation induced bladder injury	$235,836
Conference	Joseph Wu	Cardiovascular Tissue Engineering Symposium	$25,000
Tools and Technologies II	Sarah Heilshorn	Preparation and Delivery of Clinically Relevant Numbers of Stem Cells Using 3D Hydrogels	$600,695
Research Leadership	Hiromitsu Nakauchi	Generation of functional cells and organs from iPSCs	$5,427,512
SEED Grant	Calvin Kuo	Differentiation of Human Embryonic Stem Cells to Intestinal Fates	$554,176
Comprehensive Grant	Stefan Heller	Generation of inner ear sensory cells from human ES cells toward a cure for deafness	$2,330,371
Inception - Discovery Stage Research Projects	Hiromitsu Nakauchi	Optimizing self-renewal signaling kinetics to stabilize ex vivo hematopoietic stem cell expansion	$210,906
Early Translational III	Joseph Wu	Heart Repair with Human Tissue Engineered Myocardium	$4,396,738
Tools and Technologies III	Joseph Wu	Macaca mulatta as advanced model for predictive preclinical testing of engineered cardiac autografts and allografts	$1,689,744
New Faculty I	Anne Brunet	Molecular mechanisms involved in adult neural stem cell maintenance	$2,348,435
New Faculty Physician Scientist	Alan Cheng	Enhancing hair cell regeneration in mouse and human inner ear	$3,088,525
Disease Team Research I	Irving Weissman	Development of Therapeutic Antibodies Targeting Human Acute Myeloid Leukemia Stem Cells	$18,759,276
Conference	Julien Sage	3rd International RB conference	$10,000
Conference II	Samuel Strober	Third International Workshop on Clinical Tolerance	$29,500
Basic Biology III	Sean Wu	Elucidating Molecular Basis of Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells	$1,260,537
Shared Labs	Theo Palmer	The Stanford University Center for Human Embryonic Stem Cell Research and Education	$2,439,590
SEED Grant	Phillip Yang	In Vivo Molecular Magnetic Resonance Imaging of Human Embryonic Stem Cells in Murine Model of Myocardial Infarction	$629,952
Shared Labs	Vittorio Sebastiano	The Stanford University Center for Human Embryonic Stem Cell Research and Education	$3,434,600
Quest - Discovery Stage Research Projects	Vittorio Sebastiano	Regenerative Thymic Tissues as Curative Cell Therapy for Patients with 22q11 Deletion Syndrome	$1,251,720
Basic Biology IV	Roel Nusse	Asymmetric stem cell division oriented by a local self-renewing signal	$1,039,058
Basic Biology II	Steven Artandi	Self-renewal and senescence in iPS cells derived from patients with a stem cell disease	$931,285
Inception - Discovery Stage Research Projects	Philip Beachy	Curing bladder cancer by replacing corrupted urothelium with differentiated hES cells	$210,906
Clinical Trial Stage Projects	Samuel Strober	Induction of Tolerance to Combined Kidney and Hematopoietic Progenitor Cell Transplants from HLA Haplotype Matched Living Donors	$6,653,266
Tools and Technologies II	Brian Rutt	Development of Single Cell MRI Technology using Genetically-Encoded Iron-Based Reporters	$1,833,348
Basic Biology V	Xinnan Wang	Misregulated Mitophagy in Parkinsonian Neurodegeneration	$1,174,943
SEED Grant	John Cooke	EC regeneration in cerebrovascular ischemia: role of NO	$476,995
Comprehensive Grant	Roel Nusse	Guiding the developmental program of human embryonic stem cells by isolated Wnt factors	$1,710,462
Quest - Discovery Stage Research Projects	Helen Blau	Stimulating endogenous muscle stem cells to counter muscle atrophy	$2,198,687
Early Translational III	Helen Blau	Local Delivery of Rejuvenated Old Muscle Stem Cells to Increase Strength in Aged Patients	$1,825,920
Preclinical Development Awards	Matthew Porteus	Pre-clinical development of gene correction therapy of hematopoietic stem cells for SCID-X1	$874,877
Conference	Thomas Rando	Third Annual Symposium on Regenerative Rehabilitation	$20,000
New Faculty I	Howard Chang	Noncoding RNAs in Cell Fate Determination	$2,985,894
New Faculty Physician Scientist	Michelle Monje	White matter neuroregeneration after chemotherapy: stem cell therapy for “chemobrain”	$2,800,536
New Cell Lines	Julie Baker	Derivation of hESC Lines with Disease Lesions	$1,404,725
Late Stage Preclinical Projects	Gary Steinberg	Intraparenchymal NR1 Stem Cell Therapy for Chronic Subcortical Ischemic Stroke	$5,300,000
Research Training II	Theo Palmer	Stanford CIRM Training Program	$7,017,629
Genomics Centers of Excellence Awards (R)	Michael Snyder	Center of Excellence for Stem Cell Genomics - Stanford	$22,796,609
SEED Grant	Susan McConnell	Optimization of guidance response in human embryonic stem cell derived midbrain dopaminergic neurons in development and disease	$607,363
Tools and Technologies I	Helen Blau	Regulation of Stem Cell Fate in Bioengineered Arrays of Hydrogel Microwells	$949,608
Quest - Discovery Stage Research Projects	Philip Beachy	Pluripotent stem cell-derived bladder epithelial progenitors for definitive cell replacement therapy of bladder cancer	$1,265,436
Basic Biology IV	Anne Brunet	Energy metabolism and aging pathways in human stem cell reprogramming and differentiation	$1,414,044
Basic Biology II	Garry Nolan	Kinase signaling analysis of iPS cell reprogramming and differentiation	$1,343,100
Inception - Discovery Stage Research Projects	Jeffrey Goldberg	Embryonic Stem Cells for Corneal Endothelial Degeneration	$235,836
Tool Translational Research Projects	Joseph Wu	A Novel, Robust and Comprehensive Predictive Tool Using Human Disease-Specific Induced Pluripotent Stem Cells for Preclinical Drug Screening	$1,000,000
Tools and Technologies II	Irving Weissman	Antibody tools to deplete or isolate teratogenic, cardiac, and blood stem cells from hESCs	$1,463,814
Basic Biology V	Helen Blau	Mass Cytometry to Delineate the Human Muscle Stem Cell Hierarchy and Dysfunction in Aging	$1,175,357
SEED Grant	Aaron Hsueh	Patient-specific cells with nuclear transfer	$629,653
Comprehensive Grant	Julie Baker	Functional Genomic Analysis of Chemically Defined Human Embryonic Stem Cells	$2,518,303
Quest - Discovery Stage Research Projects	Irving Weissman	Towards hepatocyte cell replacement therapy: developing a renewable source of human hepatocytes from pluripotent stem cells	$1,968,456
Early Translational III	Bertha Chen	Autologous iPSC Therapy for Urinary Incontinence	$4,715,738
SPARK	Paul Utz	Stem Cell and Regenerative Medicine- Summer Research Internship	$392,975
Conference	Fan Yang	2014 Materials Research Society (MRS) Spring Meeting: Symposium Y: Biomaterials for Biomolecule Delivery and Understanding Cell-Niche Interactions	$10,000
New Faculty I	Karl Deisseroth	Bioengineering technology for fast optical control of differentiation and function in stem cells and stem cell progeny	$2,424,209
Tissue Collection for Disease Modeling	Joachim Hallmayer	Induced pluripotent stem cells from children with autism spectrum disorders	$530,265
New Cell Lines	Michele Calos	Safe, efficient creation of human induced pluripotent stem cells without the use of retroviruses	$1,406,875
Disease Team Planning	Thomas Rando	Stem Cell Therapy for Muscular Dystrophy	$0
Disease Team Therapy Planning I	Judith Shizuru	A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants	$90,147
Tools and Technologies III	Anthony Oro	A Chromatin Context Tool for Predicting iPS Lineage Predisposition and Tissue Graftability	$1,391,125
SEED Grant	Mark Kay	Novel vectors for gene transfer into human ES cells	$574,737
Transplantation Immunology	Christopher Contag	Engineering Embryonic Stem Cell Allografts for Operational Tolerance	$1,411,338
Quest - Discovery Stage Research Projects	Alan Cheng	Modulation of the Wnt pathway to restore inner ear function	$1,394,870
Basic Biology IV	Michael Cleary	Prostaglandin pathway regulation of self-renwal in hematopoietic and leukemia stem cells	$1,244,455
Basic Biology II	Aaron Hsueh	Maturation of Human Oocytes for SCNT and Embryonic Stem Cell Derivation	$1,309,018
Quest - Discovery Stage Research Projects	Hiromitsu Nakauchi	Novel Rejuvenated T Cell Immunotherapy for Lung Cancer	$1,968,456
Conference II	Joseph Wu	2017 Stanford Drug Discovery and Stem Cell Technology Conference	$2,359
Tools and Technologies II	Marius Wernig	Cellular tools to study brain diseases affecting synaptic transmission	$1,664,382
Basic Biology V	Marius Wernig	Mechanisms of human induced neuronal cell reprogramming	$1,178,370
SEED Grant	Thomas Wandless	Reprogramming Differentiated Human Cells to a Pluripotent State	$380,005
Comprehensive Grant	Theo Palmer	Immunology of neural stem cell fate and function	$2,396,000
Conference II	Joseph Wu	2018 Stanford Drug Discovery and Stem Cell Technology Conference	$15,000
Disease Team Therapy Development - Research	Judith Shizuru	A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants	$19,068,382
Therapeutic Translational Research Projects	Albert Wong	2nd Generation Vaccine for the Treatment of Glioblastoma	$2,929,889
Conference	Joseph Wu	Cardiovascular Regenerative Medicine Symposium	$9,000
New Faculty I	Joanna Wysocka	Trithorax and Polycomb methyltransferase complexes in cell fate determination.	$2,373,903
Tissue Collection for Disease Modeling	Joseph Wu	Tissue Collection for Accelerating iPSC Research in Cardiovascular Diseases	$1,291,832
New Cell Lines	Michael Longaker	Derivation and analysis of pluripotent stem cell lines with inherited TGF-b mediated disorders from donated IVF embryos and reprogrammed adult skin fibroblasts	$1,406,636
SEED Grant	Julien Sage	Functions of RB family proteins in human embryonic stem cells	$498,609
Late Stage Preclinical Projects	Matthew Porteus	Genome Editing of Autologous Hematopoietic Stem Cells to Treat Sickle Cell Disease	$4,849,363
Disease Team Therapy Planning I	Albert Wong	Recombinant Bispecific Antibody Targeting Cancer Stem Cells for the Therapy of Glioblastoma	$109,750
Tools and Technologies III	Fan Yang	Injectable Macroporous Matrices to Enhance Stem Cell Engraftment and Survival	$1,438,200
Transplantation Immunology	Robert Negrin	Regulatory T cell induced tolerance to ESC transplantation	$1,382,658
Therapeutic Translational Research Projects	Theodore Leng	NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration	$4,235,758
Basic Biology IV	Alexander Dunn	Role of mechanical signaling in stem cell self-renewal and differentiation	$1,062,998
Early Translational II	Michele Calos	Stem Cell Therapy for Duchenne Muscular Dystrophy	$2,267,261
Quest - Discovery Stage Research Projects	Rosa Bacchetta	GENE EDITING FOR FOXP3 IN HUMAN HSC	$984,228
Patent Assistance Fund Awards	Katharine Ku	Funding for Patent Applications for CIRM-funded Inventions out of Stanford University	$3,525
Basic Biology III	Michael Clarke	USP16 controls stem cell number: implications for Down Syndrome	$1,263,826
Basic Biology V	Gary Steinberg	Paracrine and synaptic mechanisms underlying neural stem cell-mediated stroke recovery	$1,178,370
SEED Grant	Kenneth Weinberg	Embryonic stem cell-derived thymic epithelial cells	$628,793
Comprehensive Grant	Christopher Zarins	Engineering a Cardiovascular Tissue Graft from Human Embryonic Stem Cells	$2,454,490
Tools and Technologies III	James Dunn	Skin-derived precursor cells for the treatment of enteric neuromuscular dysfunction	$773,327
Disease Team Therapy Development - Research	Joseph Wu	Human Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure	$19,060,330
Basic Biology I	Susan McConnell	Identification and characterization of human ES-derived DA neuronal subtypes	$1,404,853
Conference II	Joseph Wu	Drug Discovery & Stem Cell Models for Cardiovascular Disease Conference	$7,500
Conference	Thomas Rando	Keystone Symposia, 'The Life of a Stem Cell: From Birth to Death'	$50,000
Tools and Technologies II	Michele Calos	Site-specific integration of Lmx1a, FoxA2, & Otx2 to optimize dopaminergic differentiation	$1,592,897
Early Translational IV	Michele Calos	Engineered iPSC for therapy of limb girdle muscular dystrophy type 2B	$1,876,253
New Cell Lines	Theo Palmer	Derivation and comparative analysis of human pluripotent ESCs, iPSCs and SSCs: Convergence to an embryonic phenotype	$1,409,243
New Faculty II	Ching-Pin Chang	VEGF signaling in adventitial stem cells in vascular physiology and disease	$3,005,695
Therapeutic Translational Research Projects	Anthony Oro	DEBCT: Genetically Corrected, Induced Pluripotent Cell-Derived Epithelial Sheets for Definitive Treatment of Dystrophic Epidermolysis Bullosa	$5,107,353
Disease Team Therapy Planning I	Robert Robbins	Human Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure	$73,030
Tools and Technologies III	Sarah Heilshorn	Injectable Hydrogels for the Delivery, Maturation, and Engraftment of Clinically Relevant Numbers of Human Induced Pluripotent Stem Cell-Derived Neural Progenitors to the Central Nervous System	$1,347,767
			Total: $382,911,650.00