Basic Biology IV

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RFA 11-03: CIRM Basic Biology Awards IV

The CIRM Basic Biology Awards IV will fund research grants to investigate basic mechanisms underlying stem cell biology, cellular plasticity, and cellular differentiation. These awards will also fund the use of in vitro, human stem cell based models for exploring disease mechanisms and other medically relevant processes. Studies supported by these awards will form the foundation for future translational and clinical advances, enabling the realization of the full potential of human stem cells and reprogrammed cells for therapies and as tools for biomedical innovation.

This RFA includes participation by members of CIRM’s Collaborative Funding Partner (CFP) Program. Appendices A-D describe additional requirements and procedures for applicants whose proposals include a request for funding from a CFP.

Please see the full RFA for details.
RFA 11-03: CIRM Basic Biology Awards IV [pdf]

Appendix A: German Federal Ministry for Education and Research (BMBF) 
Appendix B: Institute for Stem Cell Biology and Regenerative Medicine, India (inSTEM)
Appendix C: Ministry of Science and Technology of the People’s Republic of China (MOST) Amended 12.09.11
Appendix D: National Research Agency of France (ANR)

Application Process

Submission of an application for the CIRM Basic Biology IV RFA involves a two-step process. An eligible PI may submit one Preliminary Application (PreApp). PreApps will be evaluated by scientific specialists from outside California who are experts in specific areas of research described in the PreApp and by CIRM scientific staff, based on the scientific review criteria described in section IX of this RFA. Applicants whose projects are judged as most promising, competitive, and responsive to the RFA will be invited to submit a full application. All other applicants will be deferred, with the opportunity to apply in response to a future RFA.

Preliminary Application (PreApp) Instructions

PreApps must be submitted online via the CIRM Grants Management Portal at

Each PI may submit only a single PreApp for this RFA.

The deadline for submission is 5:00 pm (PST) on January 10, 2012. No exceptions to this deadline will be made.

To submit a Preliminary Application:

  1. Go to the Grants Management Portal ( and log in with your existing CIRM Username and Password. If you do not have a Username, Click on the “New User” link and follow the instructions to create a CIRM Username and password.
  2. After logging in, your home page will display a list of open RFAs. Click on the “Apply for this grant” link corresponding to the Basic Biology Awards IV RFA.
  3. Complete each section by clicking on the appropriate link and following the posted instructions. Proposal and signature page templates can be found in the “Upload Required Documents” section.
  4. The “Done with Preliminary Application” button becomes enabled when all sections are complete and all required documents have been uploaded. Once “Done with Preliminary Application” has been selected, you will no longer be able to make changes to your PreApp.
  5. To ensure the process is complete, go back to your home page and check the list under “Your Preliminary Applications“. The status for Basic Biology IV should be “Submitted“.

Full Application Process

Full Applications will only be accepted from applicants who 1) submitted a PreApp and 2) are invited by CIRM to submit a full application.

The application for the CIRM Basic Biology IV RFA consists of four parts:

Part A: Application Information Form (Web-based form)
Part B: Proposal (MS Word template)
Part C: Biographical Sketches and Letters of Support (MS Word template)
Part D: Related Business Entities Disclosure Form (Adobe PDF template)

All four parts of the full Application for CIRM Basic Biology IV must be submitted together and received by CIRM no later than 5:00 pm (PDT) on April 25, 2012, in both electronic form and in hard copy (a signed original and five copies). It is the applicant’s responsibility to meet this deadline; no exceptions will be made.

You will need a fully functional copy of Adobe Acrobat version 8 or 9 (Standard or Professional) to complete, print, and save Part D of the full Application. We recommend using Adobe Acrobat version 8.1 (or the latest version). Using Adobe Acrobat Reader will not permit you to save information that is entered in the form.

Schedule of CIRM deadlines and reviews Date
Pre-Applications due 5:00 pm (PST), January 10, 2012
Invitations for full Applications sent out by CIRM March 23, 2012
Full Applications due 5:00 pm (PDT), April 25, 2012
Review of full Applications by Grants Working Group (GWG)  June, 2012
Review and Approval by ICOC September, 2012
Earliest Funding of Awards November, 2012

No exceptions will be made to the indicated deadlines.


For information about this RFA or the review process:

Gilberto R. Sambrano, Ph.D.
Senior Review Officer
California Institute for Regenerative Medicine
Phone: (415) 396-9103

ICOC Approval:
September 6, 2012
Total Awards:
Award Value:


Institution Investigator Grant Title Award Value
University of California, San Diego George Sen Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases. $1,080,000
Gladstone Institutes, J. David Dr. Benoit Bruneau Epigenetic regulation of human cardiac differentiation $1,568,148
Stanford University Dr. Gerald R. Crabtree Mechanism and Utility of Direct Neuronal Conversion with a MicroRNA-Chromatin Switch $1,392,150
Stanford University Dr. Roel Nusse Asymmetric stem cell division oriented by a local self-renewing signal $1,038,600
Buck Institute for Age Research Deepak A Lamba 3D Modeling of Retina using Polymer Scaffolds for Understanding Disease Pathogenesis $1,212,553
University of California, San Francisco Dr. Jeremy Reiter Modeling disease in human embryonic stem cells using new genetic tools $1,387,800
University of California, San Francisco Barbara Panning Investigation of the role of O-GlcNAcylation in SOX2 function during reprogramming $1,260,037
University of California, Davis Dr. Deborah K Lieu Induction of Pluripotent Stem Cell-Derived Pacemaking Cells $1,333,689
Stanford University Dr. Howard Y. Chang Long noncoding RNAs for pluripotency and cell fate commitment $1,386,627
University of California, San Diego Miles F Wilkinson Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State $1,360,450
Sanford Burnham Prebys Medical Discovery Institute Dr. Huei-sheng Vincent Chen Studying Arrhythmogenic Right Ventricular Dysplasia with patient-specific iPS cells $1,579,250
University of California, San Diego Ananda Goldrath Mechanisms to protect hESC-derived cells from allogenic immune rejection $1,160,997
City of Hope, Beckman Research Institute Dr. Yanhong Shi Ph.D. Modeling Alexander disease using patient-specific induced pluripotent stem cells $1,366,656
Cedars-Sinai Medical Center Eduardo Marbán Mechanism of heart regeneration by cardiosphere-derived cells $1,367,604
University of California, San Diego Maike Sander Deciphering transcriptional control of pancreatic beta-cell maturation in vitro $1,258,560
University of California, Los Angeles Dr. Owen N Witte M.D. Trop2 dependent and independent mechanisms of self-renewal in human cancer stem cells $1,254,960
Stanford University Ben A Barres Phenotyping Human Astrocytes in Health and Disease $0
University of California, Berkeley Dr. Robert Tjian Transcriptional regulation of pluripotency in human embryonic stem cells $1,220,968
University of California, Los Angeles Dr. Kathrin Plath Dr. Understanding the status of the X chromosomes in human ESCs and preimplantation embryos $1,382,400
Gladstone Institutes, J. David Dr. Steve M. Finkbeiner Common molecular mechanisms in neurodegenerative diseases using patient based iPSC neurons $1,395,184
Stanford University Alexander Robert Dunn Role of mechanical signaling in stem cell self-renewal and differentiation $1,062,998
Stanford University Dr. Anne Brunet Energy metabolism and aging pathways in human stem cell reprogramming and differentiation $1,414,044
University of California, San Francisco Dr. Miguel Ramalho-Santos Genetic dissection of human cellular reprogramming to pluripotency $1,184,883
Gladstone Institutes, J. David Sheng Ding PhD A new paradigm of lineage-specific reprogramming $1,568,395
Stanford University Michael Cleary Prostaglandin pathway regulation of self-renwal in hematopoietic and leukemia stem cells $1,244,455
Stanford University Michelle Monje Stem Cell Mechanisms Governing Discrete Waves of Gliogenesis in the Childhood Brain $1,264,248
University of California, San Diego Gene Wei-Ming Yeo Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration $1,260,360