New Faculty II

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I. PURPOSE 

The CIRM New Faculty Awards II will fund promising scientists in the critical early stages of their careers as independent investigators and faculty members establishing their own laboratories and programs. CIRM intends to provide salary and research support for up to five years, creating a stable environment for these new faculty members to build innovative and robust stem cell research programs in the state of California. 

The CIRM New Faculty Awards II are intended to achieve objectives not obtained through the CIRM New Faculty Awards I and are different from CIRM New Faculty Awards I in several respects, including (1) CIRM New Faculty Awards II focus particular attention on the need to recruit promising new physician-scientists into the field of stem cell research and (2) CIRM New Faculty Awards II include a mentoring requirement. 

Because the CIRM New Faculty Awards II RFA is a new request for applications, applicants who submitted an application in response to the CIRM New Faculty Awards I RFA should refrain from referring to their prior application, the scientific review of the application, or the score the application received. Any reference to review of applications submitted in response to RFA 07-02 may be grounds for disqualification. 

 

II. PROGRAM OBJECTIVES 

The use of stem cells in regenerative medicine is a promising area of research with the ultimate goal of developing novel diagnostics and therapies for disease. A cadre of well-trained scientists and physicians is needed to conduct the basic and clinical studies required to achieve this goal, but several obstacles hinder the entrance of new investigators into this rapidly advancing field. First, newly independent investigators face tremendous pressure to obtain results, publish scientific papers, and acquire grants quickly; therefore, they are reluctant to initiate innovative studies. Second, current levels of federal funding have made it difficult to obtain financial support, especially for investigators in the early stages of their careers. Particular challenges exist in areas that involve embryonic stem cell research where restrictions and uncertainty in federal funding have discouraged scientists from initiating projects. Finally, physician -scientists, who are critical to the translation of basic studies into clinical research, face the additional challenge of balancing research with clinical service.
The CIRM “New Faculty Awards II” program will encourage and foster the next generation of stem cell scientists in the state of California. Successful candidates for New Faculty Awards II will be Principal Investigators (PIs) who have completed their post- doctoral and/or residency training, and who are in the early phases of managing their own independent laboratories and research programs as faculty members at an applicant institution. Because effective stem cell -derived therapies may arise from unexpected sources, CIRM will support a broad range of research using the full spectrum of stem cell types and experimental approaches, including human embryonic stem cells, as well as adult and placental stem cells, umbilical cord cells, and vertebrate and invertebrate animal model systems. Note, however, that it is not the intention of this Request for Applications (RFA) to fund phased clinical trials. The CIRM New Faculty Awards II are intended to have a substantial impact on the career trajectory of successful candidates by offering the opportunity and necessary time to take full advantage of stem cells in their research. 

A strong institutional commitment to new faculty and to stem cell research plays an important role in making the field more attractive to scientists. CIRM wishes to encourage institutions to identify and invest in promising new basic and clinical investigators. Candidates for this award must have a commitment of independent space and position from their institution. The applicant institutions should have a proven track record in supporting the development of productive, independent investigators as faculty members in biomedical research. In addition, CIRM expects institutions committed to developing stem cell programs to make collaborative resources and technology platforms available to investigators in order to accelerate their research. This combination of independence, stable funding and a supportive research environment will give new faculty the greatest chance for success in developing stem cell therapies for patients.

 

III. AWARD INFORMATION 

Under this RFA, CIRM intends to commit up to $41 million to support two categories of faculty awards:

  1. New Faculty Awards II for Scientists – Each award will provide project costs of up to $300,000 per year for no more than five years.  

  1. New Faculty Awards II for Physician-Scientists – These awards are for PIs who have completed training in a medical residency program and will support individual project costs of up to $400,000 per year for no more than five years. Recipients of New Faculty Awards II for Physician-Scientists may qualify for a CIRM Medical School Loan Repayment Program

 

IV. ELIGIBILITY INFORMATION 

Applications will only be accepted from PIs who 1) have been officially nominated by their home institution and 2) have submitted a Letter of Intent (LOI) that was accepted by CIRM.

Institutional Eligibility 

This RFA is open to all academic and non-profit research institutions in the state of California. Non-profit means either: (1) a governmental entity of the state of California; or (2) a legal entity that is tax exempt under Internal Revenue Code section 501(c) and California Revenue and Taxation Code section 23701d. The number of applications that an institution may submit is limited by 1) the type of applicant institution and 2) the number of awards received previously under the New Faculty Awards I Program (RFA 07-02). Applicant institutions with a medical school accredited by the Liaison Committee on Medical Education (LCME) are eligible to submit up to five applications in response to this RFA, less the number of applications the ICOC approved for funding for that institution under the New Faculty Awards I Program (RFA 07 -02) . A single institution may submit a maximum of two applications (less any approved for funding under RFA 07-02) from applicants in the Scientist category with the remainder from the Physician -Scientist category. For example, an institution with an LCME-approved medical school that had a single application approved for funding under New Faculty Awards I could submit as many as four applications from physician- scientists under this award. Applicant institutions without an LCME-accredited medical school are eligible to submit a maximum of two applications (less any approved for funding under RFA 07-02); each of these applicants may belong to either the Scientist or Physician-Scientist category. These parameters are summarized in the following table:  

Institution
Total Nominations
Scientist
Physician-Scientist
 
 
Nominations
Nominations
With
5 less number
Up to 2 less number
Up to 5 less number (total)
Medical
approved for
of Scientists
approved for funding in New
School
funding in New
approved for
Faculty I (RFA 07-02) and
 
Faculty I (RFA 07-
funding in New
less number of Scientist
 
02)
Faculty I (RFA 07-
nominations submitted
 
 
02)
under this RFA
Without
2 less number
Up to 2 less number
Up to 2 less number (total)
Medical
approved for
(total) approved for
approved for funding in New
School
funding in New
funding in New
Faculty I (RFA 07-02) and
 
Faculty I (RFA 07-
Faculty I (RFA 07-
less number of Scientist
 
02)
02)
nominations submitted
 
 
 
under this RFA

 

Applicant institutions must certify the independent status of each nominated candidate. In addition, the applicant institution must certify that each candidate will devote a minimum of 33% effort to the research funded by this award. As a condition of funding, this minimum commitment cannot be reduced, with or without CIRM approval, notwithstanding any provision of the Grants Administration Policy for Academic and Non-profit Institutions.

A. Principal Investigator (PI) Eligibility 

Candidates for New Faculty Awards must have an M.D., Ph.D., or equivalent degree. Candidates for New Faculty Awards for Physician-Scientists must have completed training in a residency program. Individual PIs may be nominated for only one category of award and may submit only one application under this RFA. As of April 3, 2008, candidates must be within seven years of the start date of their first independent position. The candidate must be an independent investigator, which is defined as a faculty member with a multi-year commitment of support from the applicant institution. This commitment must include adequate laboratory space that is dedicated to and supervised by the PI, and start-up funding that includes financial support, equipment, and other resources. Candidates must hold full-time, faculty-level positions and must be paid employees in residence at the applicant institution at the time the application is submitted and throughout the life of the grant award. At academic institutions with tenure tracks, independent investigators must hold tenure-track positions. Notwithstanding any provision of the Grants Administration 

Policy for Academic and Non-profit Institutions, changes in PI are not allowed under this RFA. 

PIs for each category of award must devote a minimum of 33 percent effort exclusively to research proposed in their application. This minimum commitment cannot be reduced, with or without CIRM approval, notwithstanding any provision of the Grants Administration Policy. In addition to the minimum time commitment of 33 percent effort, physician-scientists may not expend more than 25 percent of their total effort on clinical duties other than those that are clearly related to their research program(s), and scientists are expected to expend not more than 25 percent of their total research effort on research unrelated to the stem cell field. 

 

V. REVIEW CRITERIA 

Applications will be evaluated in three areas: the Research Plan, the Principal Investigator, and the Institutional Commitment. 

     A. Research Plan 

The research plan will be evaluated primarily in two areas: the Significance and Innovation of the proposed research and the Design and Feasibility of the Research Plan.

      1. Significance and Innovation

    • The proposed research addresses an important issue in the stem cell

    • The proposed study,if sucessful,will significantly advance the field.

    • The proposed concept and approach are original and innovative

      2. Design and Feasibility of Research Plan

  • The proposed research is carefully designed to yield meaningful results.
  • Potential difficulties are identified, and alternative strategies are provided should initial approaches fail.
  • Preliminary data are compelling and supportive of the proposed concepts, hypotheses and approaches.
  • The PI and key personnel have the training and experience to conduct the proposed work.
  • The material resources are available, including key materials, animal models and equipment necessary for the proposed studies
  • The aims of the research can be achieved within the proposed timeframe.  
  1. Principal Investigator (PI)

The PI will be assessed on the basis of his/her Qualifications and Potential and on the Career Development and Mentoring Plans that will facilitate realization of the applicant’s potential.

      1. Qualifications and Potential

  •  The PI has a track record of past successes and accomplishments (e.g., publications, funding record, invited presentations).
  • The PI has high potential to become a leader in the stem cell field and make seminal contributions to its development.

      2. Career Development and Mentoring Plans

  •  The candidate has proposed an effective plan for developing a successful career in stem cell research.
  • Milestones in career development are realistic and achievable.

  • For physician-scientist candidates, clinical responsibilities and other duties are integrated into the plan.

  • Named mentors have appropriate qualifications and beneficial roles in the mentoring of the candidate.

  • The award will contribute significantly to enabling the PI to achieve his or her career goals.  

  1. Institutional Commitment

The institutional commitment will be evaluated based on the Commitment to the Investigator and the Institutional Track Record and Future Plans in supporting the development of newly independent faculty and stem cell research. 

     1. Commitment to the Investigator 

  • The institution has made a commitment to the candidate’s career, including laboratory space, salary and research support, and mentoring.

  • The institution provides significant support for the candidate’s research (e.g., necessary technology platforms, collaborative environment, and core facilities).  

  • The institution will continue to promote the scientific and leadership development of the candidate.

  • The institution will enhance the research environment by recruiting additional faculty and fellows whose research interests link with those of the candidate.

     2. Institutional Track Record and Future Plans 

  • The institution’s track record demonstrates its ability to promote the development of new biomedical research faculty.

  • The institution is committed to the continuing support of stem cell research programs and plans future expansion in this area.   

VI. APPLICATION PROCEDURE 

Applicant institutions and candidates must follow these instructions for submitting a Candidate Nomination Form, Letter of Intent, and Application for the CIRM New Faculty II Awards. Applications will only be accepted from PIs who 1) have been officially nominated on a Candidate Nomination Form (CNF) by their home institution and 2) have submitted a Letter of Intent (LOI) that was accepted by CIRM. 

A. Candidate Nomination Form (CNF) 

Applicant institutions must submit to CIRM a single Candidate Nomination Form (CNF) using the CNF template. The CNF must list the name, degree and employment title of each of the PI(s) the institution wishes to nominate for these awards. Additionally, the CNF must indicate the type of award (Scientist or Physician-Scientist) for which each PI is nominated. CIRM will accept only one CNF from each institution; this form must be signed by an institutional official (or his/her designate) authorized to nominate candidates on behalf of the entire institution. The signed original CNF (in hard copy) must be received by CIRM no later than 5:00pm (PST) on March 6, 2008. No exceptions will be made. 

Mail the signed original CNF to: 

New Faculty Awards II Candidate Nomination Form

California Institute for Regenerative Medicine

210 King Street

San Francisco, CA 94107 

B. Letter of Intent 

Candidates for either category of award must submit a letter of intent (LOI) using the LOI template. The letter should describe concisely the overall goals of the proposed research and technical approaches used to achieve these goals. Completed LOIs should be sent as an email attachment to NewFacultyAwardIILoi@cirm.ca.gov, and must be received by CIRM no later than 5:00PM (PST) on March 6, 2008. No exceptions will be made. Letters of intent are non-binding, but applications will not be accepted if an LOI has not been received by CIRM by the stated LOI deadline. 

C. Application Instructions 

Because the CIRM New Faculty Awards II RFA is a new request for applications, applicants who submitted an application in response to the CIRM New Faculty Awards I RFA should refrain from referring to their prior application, the scientific review of the application, or the score the application received. Any reference to review of applications submitted in response to RFA 07-02 may be grounds for disqualification. 

The application for CIRM New Faculty Awards II consists of four parts: 

Part A: Application Information Form. Part A includes: Abstract, Public Abstract, Statement of Benefit to California, Key Personnel, and Budget (section numbers 1, 2, 3, 4, and 5 below). 

Part B: New Faculty Awards II Research Proposal. Part B includes: Rationale and Significance, Specific Aims, Research Design and Methods, Preliminary Results and Feasibility, References, Laboratory/Clinical Facilities including major equipment, and Career Development and Mentoring Plans (section numbers 6, 7, 8, 9, 10, 11, 12, and 13 below). 

Part C: Biographical Sketches for Key Personnel and Named Mentors.

Part D: Institutional Letter of Commitment (No template provided). Part D includes: Institutional Commitment (section number 14 below).

 The application for New Faculty Awards II includes the following sections: 

  1. Abstract (up to 3000 characters in Part A)  

State the goals of the proposal; summarize the overall plans of the proposed research and how they will meet the stated objectives of the proposal. Describe the rationale for these studies and techniques employed to pursue these goals. Explain the likelihood of this proposal being funded by the federal government.  

  1. Public Abstract (up to 3000 characters in Part A)  

Briefly describe in lay language the proposed research and how it will, directly or indirectly, contribute to the development of diagnostics, tools or therapies. This Public Abstract will become public information; therefore, do  not include proprietary or confidential information or information that could identify the candidate and applicant institution. 

  1. Statement of Benefit to California (up to 3000 characters in Part A)  

Describe in a few sentences how the proposed research will benefit the state of California and its citizens. This Statement of Benefit will become public information; therefore, do not include proprietary or confidential information or information that could identify the candidate and applicant institution.  

  1. Key Personnel (included in Part A)  

List all key personnel and their roles on the project. Key personnel are defined as individuals who contribute to the scientific development or execution of the project in a substantive, measurable way, whether or not they receive salaries or compensation under the grant. Key personnel may include any technical staff, trainees, co-investigators (collaborators), or consultants who meet this definition. A minimum of one percent effort is required for each key person. For each key scientific person listed (except for technical staff and students), provide a 2 page biographical sketch using the template provided (include in Part C). The biosketch should highlight prior research experience and/or special skills related to the proposed research. Include relevant publications.  

Provide all budget information requested in the budget section of the application form. All allowable costs for research grants are detailed in the CIRM Grants Administration Policy (GAP). Under this RFA, allowable costs include the following:

  1. Budget (included in Part A)

    • Salaries for Key Personnel

      Salary support for Key Personnel may include support for the Principal Investigator, Co-Investigators, Research Associates, and technical support staff (all of whom must be resident and work in California) based on percent of full time effort commensurate with the established salary structure of the applicant institution. The total salary requested by the PI must be based on a full-time, 12-month staff appointment. Because CIRM considers pre-doctoral, post-doctoral and clinical fellows as trainees and not as employees, institutions may request stipend, health insurance and allowable tuition and fees as costs for trainees. Administrative support salaries are expected to be covered by the Indirect Costs for the grant.

    • Supplies

      Supplies, including specialized reagents and animal costs may be purchased with grant funds. Minor equipment purchases (< $5,000 per item) are considered Supplies and may be included as direct costs in the budget.

    • Travel

      Recipients (PIs) of CIRM New Faculty Awards II are required to attend an annual CIRM-organized meeting in California and should include in the budget the travel costs for this meeting. Travel costs associated with collaborations necessary to the grant are allowable. Details of allowable travel costs can be found in the CIRM GAP.

    • Equipment

      Major equipment (> $5,000 per item) necessary for conducting the proposed research at the applicant institution should be itemized. Equipment costs should not be included as allowable direct costs in indirect cost calculations.

    • Indirect Costs

      Indirect costs will be limited to 20 percent of allowable direct research funding costs awarded by CIRM (i.e., project costs and facilities costs), exclusive of the costs of equipment, tuition and fees, and subcontract amounts in excess of $25,000.

  1. Rationale and Significance (up to 1 page in Part B) 

Summarize the context and background of the present application and the specific rationale for the work proposed. Evaluate existing knowledge and specifically identify the gaps that the project is intended to fill. State how the proposed research meets CIRM’s goals of funding innovative, perhaps scientifically risky and untested research. If the aims of the application are achieved, state how this information will contribute to the development of diagnostics and/or therapies based on stem cell research.  

  1. Specific Aims (up to 1 page in Part B)  

Explain the long-term objectives and the goal of the specific research proposed, e.g., to test a stated hypothesis, create a novel design, solve a specific problem, challenge an existing paradigm or practice, develop a new therapy, address a critical barrier to progress in the field, or develop new technology. Identify and enumerate each specific aim of the proposal in a concise and step-wise fashion, and describe how each aim will lead to the broad goal of this research.  

  1. Research Design and Methods (up to 5 pages in Part B)  

Describe concisely, but in sufficient detail to permit evaluation of the merit of the research, the experimental design, methods and techniques to be employed to achieve the goals specified in the proposal. Identify the new or risky aspects of the research, anticipated pitfalls, and plans to overcome or circumvent difficulties that may arise. Describe the methods of analysis of results, including criteria for success of the proposed studies. If collaboration is integral to the success of the project, describe how this will be achieved. Provide a realistic timetable for completing each proposed specific aim of the project; where appropriate provide specific milestones for evaluating the achievement of each specific aim.

  1. Preliminary Results and Feasibility (up to 2 pages in Part B)  

Provide preliminary data to support the concepts, hypotheses and/or approaches proposed in the application. Provide any information that will help to establish the experience and competence of the investigator to pursue the proposed project.  

  1. References (up to 3 pages in Part B)  

List all references used in the body of the proposal.  

  1. Laboratory/Clinical Facilities including major equipment (up to 1 page in Part B)

Provide a short description of the facilities and environment in which the work will be done, and the major equipment and resources available for conducting the proposed research. Discuss ways in which the proposed studies will benefit from unique features of the scientific environment or employ useful collaborative arrangements where applicable.  

  1. Career Development and Plan (up to 2 pages in Part B)  

Describe the PI’s plan for developing a successful career in stem cell research. State the key goals that will define success, the milestones that must be reached, and potential obstacles to overcome. How will this award help the PI achieve these goals? Describe the metrics to be used in monitoring progress against the plan. The career development plan must justify the need for a five-year period of sustained research funding, and must be tailored to the individual needs of the candidate.  

  1. Mentoring Plan (up to 1 page in Part B)  

Provide the name of one or more individuals who will serve as mentors to the PI during the duration of the project. Describe the nature and frequency of mentorship activities. Describe the processes for receiving formal evaluations and feedback from mentors. For each named mentor provide a 2 page biographical sketch using the Named Mentor Biosketch template provided (include in Part C).  

  1. Institutional Commitment (up to 2 pages in Part D)

The applicant institution must provide a letter of support, signed by a senior organizational official who has the authority, or who has been delegated the authority, to commit the applicant institution to support the candidate, documenting in specific terms the nature of the institutioncurrent and future commitment to the candidate’s development into a productive, independent investigator during the period of the award. This statement must indicate the institution’s support for the candidate’s proposed level of effort related to this award, commitment to release time if necessary, and the availability of appropriate facilities, collaborative resources and administrative support during the award period. A discussion of the institution’s track record and future plans for developing new biomedical research faculty, and the commitment to on-going development of stem cell programs should also be included.

 

VII. SUBMITTING AN APPLICATION 

Applications will only be accepted from PIs who 1) have been officially nominated on a Candidate Nomination Form (CNF) from their home institution and 2) have submitted a Letter of Intent (LOI) that was accepted by CIRM. 

The application for CIRM New Faculty Awards consists of four parts:

Part A: Application Information Form

Part B: New Faculty Awards II Research Proposal

Part C: Biographical Sketches for Key Personnel and Mentors

Part D: Institutional Letter of Commitment (no template provided)

All four parts of the application for CIRM New Faculty Awards II must be submitted together and received by CIRM no later than 5:00PM (PDT) on April 3, 2008. This is the applicant’s responsibility and no exceptions will be made. Candidates must use the appropriate CIRM templates to complete Parts A, B and C. These templates will be available on the CIRM website by February 13, 2008. Send electronic copies of all four parts of the application as attachments in a single email to NewFacultyAwardII@cirm. ca.gov. In addition to the electronic submittal, candidates must submit an original copy of the application signed by both the PI and the institution’s AOO, plus 5 copies (preferably double-sided) of the application to:

New Faculty Awards II Application 

California Institute for Regenerative Medicine

210 King Street

San Francisco, CA 94107

The original application plus the five copies must be received by CIRM no later than 5:00PM (PDT) on April 3, 2008. This is the applicant’s responsibility and no exceptions will be made. 

 

VIII. SCHEDULE OF RECEIPT AND ANTICIPATED REVIEW

  

 
Receipt of Candidate Nomination Forms and Letters
5:00PM (PST) on March 6, 2008
 
of Intent:
 
 
 
Receipt of Applications:
 
5:00PM (PDT) on April 3, 2008
 
Review of Applications by Grants Working Group
June/July, 2008
 
(GWG):
 
 
 
Review and Approval by ICOC:
Summer, 2008
 
Earliest Funding of Awards:
 
Fall, 2008

 

IX. REVIEW AND AWARD PROCESS 

CIRM New Faculty Awards II applications will be reviewed by the CIRM Scientific and Medical Research Funding Working Group (the Grants Working Group, or GWG). The GWG consists of fifteen basic and clinical scientists from institutions outside California, seven patient advocates who are members of the Independent Citizen’s Oversight Committee (ICOC), and the Chair of the ICOC. The membership of the GWG can be viewed on the GWG page. The ICOC was established by the California Stem Cell Research and Cures Act (Proposition 71) to oversee CIRM and makes all final funding decisions. The composition of the ICOC can be viewed on the governing board page.

Fifteen scientists on the GWG will review the applications and rate them according to scientific and technical merit. For New Faculty Awards II applications, particular emphasis will be placed on the innovation and design of the research plan, the qualifications, career development and mentoring plans of the Principal Investigator, and the commitment and track record of the applicant institution. 

The full membership of the GWG will then review the entire portfolio of applications, taking into consideration the following criteria: 

o Appropriate balance between innovation and feasibility. 

o Where relevant, the appropriate balance between fundamental research, therapy development and clinical application. 

o Where relevant, the appropriate balance and range of diseases addressed. 

o Other considerations from the perspective of patient advocates. 

The GWG’s final recommendations for funding will then be forwarded to the ICOC, which will make all final funding decisions. 

 

X. CONTACTS: 

For information about this RFA:

Michael P. Yaffe, Ph.D.

Scientific Officer

California Institute for Regenerative Medicine

210 King Street

San Francisco, CA 94107

Email: myaffe@cirm .ca.gov

Tel: 415-396-9238

Fax: 415-396-9141

For information about the review process:

Gilberto R Sambrano, Ph.D.
Senior Officer to the Grants Working Group

California Institute for Regenerative Medicine

210 King Street

San Francisco, CA 94107

Email: gsambrano@cirm.ca.gov

Phone: (415) 396-9103

FAX: (415) 396-9141

 

For information about electronic forms:

Ed Dorrington
Director of Grants Management Systems

California Institute for Regenerative Medicine

210 King Street 

San Francisco, CA 94107

Email: edorrington@cirm.ca.gov

Phone: (415) 396-9108

FAX: (415) 396-9141

 

For programmatic information:

Patricia Olson, Ph.D.

Director of Scientific Activities

California Institute for Regenerative Medicine

210 King Street

San Francisco, CA 94107

Email: polson@cirm.ca.gov

Phone: (415) 396-9116

FAX: (415) 396-9141

 

XI. OTHER REQUIREMENTS 

A. CIRM Grants Administration Policy: 

CIRM’s Grants Administration Policy (GAP) for Academic and Non-profit Institutions serves as the standard terms and conditions of grant awards issued by CIRM except as noted herein. All research conducted under this award must comply with the stated policy, which can be found on the CIRM website regulations page. Funding from year to year will depend on scientific progress achieved. 

B. Evaluation of the Program: 

In fulfilling our commitment to the State of California, CIRM may request information essential to an assessment of the effectiveness of this program. Accordingly, recipients are hereby notified that they may be contacted after the completion of this award for periodic updates on various aspects of their employment history, publications, support from research grants or contracts, honors and awards, professional activities, and other information helpful in evaluating the impact of the program. CIRM also retains the right to audit all expenditures of CIRM funds. 

C. Human Stem Cell Research Regulations: 

CIRM has adopted medical and ethical standards for human stem cell research. All research conducted under this award will be expected to comply with these standards.

While these regulations prohibit donors of gametes, embryos, somatic cells or human tissue from receiving valuable consideration for their donation, they do allow for reimbursement for permissible expenses as determined by an IRB. 

“Permissible Expenses” means necessary and reasonable costs directly incurred as a result of donation participation in research activities and may include costs such as those associated with travel, housing, child care, medical care, health insurance and actual lost wages. For research activities proposing to obtain gametes, embryos, somatic cell or human tissue from human subjects, CIRM requires the candidate to submit, at the time of application, their reimbursement policy describing how they intend to calculate permissible expenses. 

D. Use of Human Fetal Tissue:

Adult stem cells are derived from various differentiated tissues, including human fetal tissue. When using human fetal tissue in research, CIRM grantees shall abide by any regulations developed by the CIRM Scientific and Medical Accountability Standards Working Group and ratified by the ICOC (see Title 17, California Code of Regulations, sections 100085 et seq.).

E. Intellectual Property Policy for Non-profit Organizations: 

CIRM has adopted policies that govern intellectual property resulting from CIRM-funded research that also govern this award.

 


ICOC Approval:
August 13, 2008
Total Awards:
24
Award Value:
$57,684,225

Awards

Institution Investigator Grant Title Award Value
Benjamin D. Yu Dr. Benjamin D. Yu Medical School Loan Repayment Program $28,388
Gladstone Institutes, J. David Dr. Yadong Huang Defining the Isoform-Specific Effects of Apolipoprotein E on the Development of iPS Cells into Functional Neurons in Vitro and in Vivo $2,757,303
University of California, San Francisco Dr. Emmanuelle Passegue Mechanisms Underlying the Responses of Normal and Cancer Stem Cells to Environmental and Therapeutic Insults $2,124,488
University of California, San Francisco Dr. Ophir Klein MD, PhD Laying the groundwork for building a tooth: analysis of dental epithelial stem cells $3,075,251
University of California, Merced Dr. Kara E McCloskey Building Cardiac Tissue from Stem Cells and Natural Matrices $1,656,083
University of California, Irvine Dr Edwin S Monuki Mechanisms in Choroid Plexus Epithelial Development $2,793,395
University of California, Berkeley Dr. Lin He The roles of non-coding RNAs in the self-renewal and differentiation of pluripotent stem cells $1,406,823
University of California, San Francisco Dr. Robert Blelloch Dr. Mechanisms of small RNA regulation in early embryonic development $2,790,695
University of California, Los Angeles Dr. Antoni Ribas MD/PhD Stem Cells for Immune System Regeneration to Fight Cancer $3,072,000
San Diego State University Foundation Dr. Ricardo M. Zayas The molecular basis underlying adult neurogenesis during regeneration and tissue renewal $1,712,225
University of Southern California Dr. Qilong Ying Mechanisms Underlying the Diverse Functions of STAT3 in Embryonic Stem Cell Fate Regulation $2,261,174
University of California, San Diego Dr. Benjamin D. Yu Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $3,017,978
University of California, San Diego Dr. Shyni Varghese A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment $2,300,569
University of California, San Francisco Dr. Holger F Willenbring Molecular dissection of adult liver regeneration to guide the generation of hepatocytes from pluripotent stem cells $2,832,008
Children’s Hospital of Los Angeles Dr. Tracy Cannon Grikscheit M.D. Mechanism of Tissue Engineered Small Intestine Formation $3,211,122
University of California, San Diego Dr. Mana M Parast Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal $3,077,918
University of Southern California Dr. Gage Crump Skeletogenic Neural Crest Cells in Embryonic Development and Adult Regeneration of the Jaw $2,247,403
University of California, San Diego Catriona Jamieson Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells $3,065,572
Stanford University Dr. Ching-Pin Chang VEGF signaling in adventitial stem cells in vascular physiology and disease $3,005,695
Ludwig Institute for Cancer Research Dr. Bing Ren Mechanisms of chromatin dynamics at enhancers during ES cell differentiation $1,726,564
University of California, Los Angeles Dr. Brigitte N Gomperts Stem Cells in Lung Cancer $2,381,572
University of California, Davis Dr. Paul S. Knoepfler Molecular mechanisms governing hESC and iPS cell self-renewal and pluripotency $2,157,255
University of California, San Francisco Dr. Jeremy Reiter High throughput modeling of human neurodegenerative diseases in embryonic stem cells $2,259,092
Gladstone Institutes, J. David Dr. Benoit Bruneau Induction of cardiogenesis in pluripotent cells via chromatin remodeling factors $2,723,653
Total:
$57,684,225.33