Orthogonal IL2 Receptor Transduced Regulatory T Cells for Clinical Application
Grant Award Details
Grant Type:
Grant Number:
DISC2-14935
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$1,920,652
Status:
Active
Grant Application Details
Application Title:
Orthogonal IL2 Receptor Transduced Regulatory T Cells for Clinical Application
Public Abstract:
Research Objective
Genetically modified cells that help control immune reactions
Impact
Improved treatment for patients undergoing transplantation
Major Proposed Activities
Genetically modified cells that help control immune reactions
Impact
Improved treatment for patients undergoing transplantation
Major Proposed Activities
- To identify the optimal source of regulatory T cells for introduction of the novel IL2 receptor
- To test the impact of a novel IL2 protein on activating the regulatory T cells
- To determine the optimal dose and schedule of the novel IL2 protein to expand the regulatory T cells in preclinical models
- To test whether the optimal cell product has enhanced function in controlling disease.
Statement of Benefit to California:
Many Californians suffer from diseases where transplantation of blood forming stem cells or solid organs are required. Despite success many challenges persist that can be addressed by developing a better strategy to control tissue rejection. This project is successful will set the stage for clinical testing that could aid many patients in California and worldwide.