Embryonic Stem Cells for Corneal Endothelial Degeneration

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Grant Award Details

Grant Number:

Disease Focus:
Human Stem Cell Use:
Award Value:

Progress Reports

Reporting Period:
Year 1

Grant Application Details

Application Title:

Embryonic Stem Cells for Corneal Endothelial Degeneration

Public Abstract:
Research Objective

The proposed studies will determine the optimal approaches to differentiate and transplant stem cell-derived corneal endothelial cells.


These data will provide foundational proof-of-concept data that will allow the rapid advance of a cell therapy towards clinical application.

Major Proposed Activities

  • Determine optimal conditions to generate human corneal endothelial cells from human stem cells, assaying both cellular and functional markers.
  • Test efficacy in a rabbit model that closely mimics human injury or degeneration, examining disease-relevant functional assays.
Statement of Benefit to California:
1. Employing California's citizens in the research funded through CIRM and thereafter as this project advances. 2. Developing a first-in-class treatment for California's citizens with corneal diseases affecting their vision.