Tools and Technologies II

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RFA 10-02: CIRM Tools and Technologies Awards II

Tools and Technologies for Translational Bottlenecks

The CIRM Tools and Technology Awards II will support the inception, early stage development and evaluation for stem cell research applications of innovative tools and technologies that will overcome current roadblocks in translational stem cell research. CIRM encourages the submission of proposals that are focused on both the creation and design of novel tools and technologies and the optimization, improvement, standardization or scale up of an existing tool or technology for addressing a translational bottleneck. Proposals should be focused on tools and technologies directly applicable to the use of human cells.

Our collaborative funding partner, The Federal Ministry For Education and Research, Germany (BMBF) will participate in this RFA.

Please see the RFA for full details.

Application Process

Submission of an application for the CIRM Tools and Technologies Awards II RFA involves a two-step process. An eligible PI may submit one Preliminary Application (PreApp). PreApps will be evaluated by scientific specialists from outside California who are experts in specific areas of research described in the PreApp and by CIRM scientific staff, based on the scientific review criteria described in section VI of this RFA. Applicants whose projects are judged as most promising, competitive, and responsive to the RFA will be invited to submit a full Application. All other applicants will be deferred, with the opportunity to apply in response to a future RFA.

Preliminary Application Instructions and Forms

Each applicant must submit a Pre-Application using the PreApp Form for Tools and Technologies Awards II (see below). In addition to the PreApp form, all applicants must submit a Related Business Entities Disclosure Form. Each eligible applicant may submit only a single PreApp for this RFA.

You will need a fully functional copy of Adobe Acrobat version 8 or 9 (Standard or Professional) to complete, print, and save the PreApp and Related Business Entities Disclosure Forms. We recommend using Adobe Acrobat version 9 (or the latest version). Using Adobe Acrobat Reader will not permit you to save information that is entered in the form.

The completed PreApp form (less the Official signature) and the Related Business Entities Disclosure Form must be sent as interactive PDF documents (the original document format; documents must not be “flattened” or converted to another format) as email attachments to

In addition to the electronic submission of the completed PDF files, you must also submit a copy of the PreApp cover page showing the Authorized Organizational Official’s signature as either a hard copy (via express mail or courier service to Tools and Technologies II PreApp, CIRM, 210 King St., San Francisco, CA 94107), a fax copy (415-396-9142) or as a scanned PDF file to

All PreApp materials must be received by CIRM no later than 5:00 pm (PDT) on May 19, 2010. No exceptions will be made for late submissions. It is the PI’s responsibility to ensure that all required documents are received by the deadline.

Additionally, applicants whose proposals include a Collaborative Funding Partner PI must send an electronic copy of this PreApp by email to the designated BMBF point of contact listed in Appendix A.


Full Application Instructions and Forms

Full Applications will only be accepted from applicants who 1) submitted a PreApp and 2) are invited by CIRM to submit a Full Application. The PI (and Partner PI, if applicable) and research project proposed in the full application must be the same as described in the PreApp; otherwise, the full application is deemed ineligible. Full application forms will be available on the CIRM website in late July, 2010.

The Full Application consists of four parts: Part A: Application Information Form, Part B: Tools and Technologies Award Research Proposal, Part C: Biographical Sketches for Key Personnel, and Part D: Related Business Entities Disclosure Form.

You will need a fully functional copy of Adobe Acrobat version 8 or 9 (Standard or Professional) to complete, print, and save the application forms. We recommend using Adobe Acrobat version 9 (or the latest version). Using Adobe Acrobat Reader will not permit you to save information that is entered in the form.

All four parts of the full application for CIRM Tools and Technologies Awards II must be submitted together and received by CIRM no later than 5:00 pm (PDT) on August 26, 2010, in both electronic form and in hard copy (a signed original and five copies). It is the applicant’s responsibility to meet this deadline; no exceptions will be made.

Send electronic copies of all parts of the application as attachments in a single email to In addition to the electronic submission, candidates must submit an original copy of the application (consisting of Parts A-D) signed by both the applicant and the institution’s Authorized Organizational Official (AOO), plus 5 copies of the full application (preferably double-sided) to:

Tools and Technologies Awards II Application
California Institute for Regenerative Medicine
210 King Street
San Francisco, CA 94107

Schedule of Deadlines and Reviews
Pre-Applications Due 5:00pm (PDT), May 19, 2010
Invitations for Full Applications Sent Out by CIRM July 23, 2010
Full Applications Due  5:00pm (PDT), August 26, 2010
Review of Full Applications by Grants Working Group (GWG)  November, 2010
Review and Approval by ICOC January, 2011
Earliest Funding of Awards Spring, 2011

No exceptions will be made to the indicated deadlines.

ICOC Approval:
January 27, 2011
Total Awards:
Award Value:


Institution Investigator Grant Title Award Value
University of California, San Diego Karl H. Willert Homologous recombination in human pluripotent stem cells using adeno-associated virus. $1,659,043
Stanford University Dr. Marius Wernig MD, PhD Cellular tools to study brain diseases affecting synaptic transmission $1,664,382
Stanford University Dr. Irving L Weissman MD Antibody tools to deplete or isolate teratogenic, cardiac, and blood stem cells from hESCs $1,463,814
TriFoil Imaging, Inc. Dr. Joann Zhang Tri-resolution Visualization System for Stem Cells and Tissue Regeneration Monitoring $1,456,989
Cedars-Sinai Medical Center Professor Clive Niels Svendsen Use of iPS cells (iPSCs) to develop novels tools for the treatment of spinal muscular atrophy. $1,933,022
University of California, Berkeley Dr. David V. Schaffer Engineering Defined and Scaleable Systems for Dopaminergic Neuron Differentiation of hPSCs $1,340,816
Stanford University Dr. Brian K. Rutt Development of Single Cell MRI Technology using Genetically-Encoded Iron-Based Reporters $1,833,348
Parkinson’s Institute Dr. Birgitt Schuele Editing of Parkinson’s disease mutation in patient-derived iPSCs by zinc-finger nucleases $1,327,983
University of California, San Francisco Dr Daniel A. Lim MD, PHD Development and preclinical testing of new devices for cell transplantation to the brain. $1,795,891
GMR Epigenetics Dr. Jifan Hu Robust generation of induced pluripotent stem cells by a potent set of engineered factors $1,356,052
Stanford University Dr. Sarah C Heilshorn Preparation and Delivery of Clinically Relevant Numbers of Stem Cells Using 3D Hydrogels $600,695
University of California, San Diego Dr. Lawrence S. B. Goldstein Developing a method for rapid identification of high-quality disease specific hIPSC lines $1,686,069
University of California, Los Angeles Dr. Richard A. Gatti Use of hiPSCs to develop lead compounds for the treatment of genetic diseases $1,833,054
Stanford University Dr. Theo D. Palmer PhD Development of small molecule screens for autism using patient-derived iPS cells $1,797,606
University of California, Berkeley Dr. Steven M. Conolly Magnetic Particle Imaging: A Novel Ultra-sensitive Imaging Scanner for Tracking Stem Cells In Vivo $1,311,596
University of California, San Diego Shu Chien Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation $1,706,628
University of California, Los Angeles Dr. Thomas Carmichael M.D., Ph.D. Development of a Hydrogel Matrix for Stem Cell Growth and Neural Repair after Stroke $1,825,613
Stanford University Dr. Michele Calos Site-specific integration of Lmx1a, FoxA2, & Otx2 to optimize dopaminergic differentiation $1,592,897
Fluidigm Corporation Dr. Marc A Unger Development and Application of Versatile, Automated, Microfluidic Cell Culture System $1,939,236
University of California, Los Angeles Dr. Martin Gabriel Martin Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders $1,783,250