Disease Team Planning |
Stanley Carmichael |
Development of a Stem Cell Therapy to Promote Functional Recovery in Stroke |
$42,748 |
Early Translational II |
Leif Havton |
Repair of Conus Medullaris/Cauda Equina Injury using Human ES Cell-Derived Motor Neurons |
$75,628 |
Inception - Discovery Stage Research Projects |
Bennett Novitch |
Organoid Modeling of Human Cortical Microcircuits |
$208,916 |
Basic Biology II |
Douglas Black |
Programs of alternative splicing regulation by polypyrimidine tract binding protein |
$1,344,562 |
Conference |
Dana Jones |
7th CA/HSCI Junior PI Conference: Stem Cells 2.0 |
$2,500 |
Disease Team Research I |
Irvin Chen |
HPSC based therapy for HIV disease using RNAi to CCR5. |
$9,905,604 |
Conference II |
Song Li |
The 18th Annual UC System-Wide Bioengineering Symposium |
$25,000 |
SEED Grant |
William Lowry |
Modeling Human Embryonic Development with Human Embryonic Stem Cells |
$528,096 |
Quest - Discovery Stage Research Projects |
Lili Yang |
Preclinical Development of An HSC-Engineered Off-The-Shelf iNKT Cell Therapy for Cancer |
$1,404,000 |
Tools and Technologies I |
Hsian-Rong Tseng |
Microfluidic Platform for Screening Chemically Defined Conditions that Facilitate Clonal Expansion of Human Pluripotent Stem Cells |
$914,096 |
Progression Award - Discovery Stage Research Projects |
Caroline Kuo |
Evaluation of Gene Therapy Approaches for Autosomal Recessive Hyper IgE Syndrome Due to Mutations in DOCK8 |
$234,000 |
Tools and Technologies II |
Richard Gatti |
Use of hiPSCs to develop lead compounds for the treatment of genetic diseases |
$1,833,054 |
Research Training Grant |
William Lowry |
UCLA Training Program in Stem Cell Biology |
$5,000,000 |
Research Training II |
Kenneth Dorshkind |
UCLA CIRM Research Training Program II |
$7,790,488 |
Quest - Discovery Stage Research Projects |
Caroline Kuo |
Defining the Optimal Gene Therapy Approach of Human Hematopoietic Stem Cells for the Treatment of Dedicator of Cytokinesis 8 (DOCK8) Deficiency |
$1,386,232 |
New Faculty Physician Scientist |
Reza Ardehali |
Preclinical evaluation of human embryonic stem cell-derived cardiovascular progenitors in a large animal model |
$2,930,388 |
Quest - Discovery Stage Research Projects |
Gerald Lipshutz |
Gene Therapy for SLC6A8 Creatine Transporter Disorder |
$2,296,920 |
Disease Team Therapy Development III |
Donald Kohn |
Clinical Trial of Stem Cell Gene Therapy for Sickle Cell Disease |
$13,145,465 |
Therapeutic Translational Research Projects |
Scott Kitchen |
Hematopoietic Stem/Progenitor Cell-Based Chimeric Antigen Receptor Gene Therapy for HIV Infection |
$6,140,723 |
Shared Labs |
Scott Waugh |
CIRM Shared Research Laboratories |
$2,000,000 |
Tools and Technologies III |
Leif Havton |
Development of a Relevant Pre-Clinical Animal Model as a Tool to Evaluate Human Stem Cell-Derived Replacement Therapies for Motor Neuron Injuries and Degenerative Diseases |
$1,308,711 |
Inception - Discovery Stage Research Projects |
April Pyle |
Novel Platforms to Enhance In Vivo Delivery of Skeletal Muscle Progenitor Cells from Human Pluripotent Stem Cells |
$230,400 |
Basic Biology II |
Yong Kim |
Novel Mechanism in Self-Renewal/Differentiation of Human Embryonic Stem Cells |
$1,259,371 |
Conference |
Irvin Chen |
Stem Cells: A New Avenue of HIV Research and New Approaches to HIV Treatment |
$24,456 |
New Cell Lines |
Zack Jerome |
Generation of clinical grade human iPS cells |
$1,341,000 |
Inception - Discovery Stage Research Projects |
Alireza Moshaverinia |
Gingival mesenchymal stem cells as a novel treatment modality for periodontal tissue regeneration |
$194,483 |
New Faculty II |
Antoni Ribas |
Stem Cells for Immune System Regeneration to Fight Cancer |
$3,072,000 |
Therapeutic Translational Research Projects |
Steven Schwartz |
Clinical Translation of Autologous Regenerative Cell Therapy for Blindness |
$5,068,026 |
Tools and Technologies I |
Michael Phelps |
Novel Tools and Technologies for Translational PET Imaging of Cell-based Therapies |
$914,039 |
Discovery Research Projects |
Song Li |
Biomaterial vaccine to enhance the formation of SARS-CoV-2-specific T memory stem cells |
$149,916 |
Tools and Technologies II |
Martin Martin |
Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders |
$1,783,250 |
Therapeutic Translational Research Projects |
Irene Llorente |
Clinical Translation of Allogenic Regenerative Cell Therapy for White Matter Stroke and Vascular Dementia |
$775,689 |
Disease Team Therapy Planning I |
Antoni Ribas |
Genetic Re-programming of Stem Cells to Fight Cancer |
$97,785 |
Quest - Discovery Stage Research Projects |
Dinesh Rao |
Novel methods to eliminate cancer stem cells |
$1,384,347 |
Tissue Collection for Disease Modeling |
Brigitte Gomperts |
Using human induced pluripotent stem cells to improve our understanding of Idiopathic Pulmonary Fibrosis |
$811,231 |
Quest - Discovery Stage Research Projects |
Richard Pietras |
Reversal of dysregulated myelopoiesis in breast cancers and cancer stem cells to boost antitumor immunotherapy |
$2,327,680 |
Disease Team Therapy Development III |
Dennis Slamon |
A Phase I dose escalation and expansion clinical trial of the novel first-in-class Polo-like Kinase 4 (PLK4) inhibitor, CFI-400945 in patients with advanced solid tumors |
$5,683,693 |
Therapeutic Translational Research Projects |
Sophie Deng |
Extracellular Vesicle-Based Therapy for Corneal Scars |
$5,779,276 |
Therapeutic Translational Research Projects |
Anthony Aldave |
AAV Gene Therapy for Treating Congenital Hereditary Endothelial Dystrophy associated with Biallelic SLC4A11 Mutations |
$4,338,166 |
Early Translational II |
Sophie Deng |
Regeneration of Functional Human Corneal Epithelial Progenitor Cells |
$697,507 |
Clinical Trial Stage Projects |
Donald Kohn |
A Phase I/II, Non Randomized, Multicenter, Open-Label Study of G1XCGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease |
$7,083,364 |
Inception - Discovery Stage Research Projects |
Owen Witte |
Identification of stem cell surface markers as potential therapeutic targets for advanced prostate cancer |
$209,160 |
Basic Biology II |
Benhur Lee |
The EphrinB2/EphB4 axis in regulating hESC pluripotency and differentiation |
$1,371,936 |
Conference |
Tatiana Segura |
2013 Materials Research Society (MRS) Spring Meeting Symposium
"Design of Cell Instructive Materials" |
$4,000 |
New Cell Lines |
Amander Clark |
Generation of Pluripotent Cell Lines from Human Embryos |
$1,167,416 |
Quest - Discovery Stage Research Projects |
April Pyle |
Identification and Generation of Long Term Repopulating Human Muscle Stem Cells from Human Pluripotent Stem Cells |
$2,148,519 |
New Faculty II |
Brigitte Gomperts |
Stem Cells in Lung Cancer |
$2,381,572 |
Clinical Trial Stage Projects |
Theodore Nowicki |
Genetic Modification of Stem Cells and T cells to Activate the Immune System to Target Solid Tumors |
$4,230,000 |
Transplantation Immunology |
Gay Crooks |
Engineering Thymic Regeneration to Induce Tolerance |
$1,235,445 |
Therapeutic Translational Research Projects |
Vaithilingaraja Arumugaswami |
COVID-19 Antiviral Therapy to Block Direct Cell Injury and Associated Tissue Damage |
$349,999 |
Basic Biology III |
Gay Crooks |
Forming the Hematopoietic Niche from Human Pluripotent Stem Cells |
$1,252,857 |
Therapeutic Translational Research Projects |
Arjun Deb |
Targeting stromal progenitors to prevent the development of heart failure |
$4,841,428 |
Disease Team Therapy Planning I |
Stanley Nelson |
Combination therapy to Enhance Antisense Mediated Exon Skipping for Duchenne Muscular Dystrophy |
$68,947 |
Quest - Discovery Stage Research Projects |
Xian-Jie Yang |
Developing gene therapy for dominant optic atrophy using human pluripotent stem cell-derived retinal organoid disease models |
$1,345,691 |
Early Translational IV |
Robert Reiter |
Clinical Development of an N-cadherin Antibody to Target Cancer Stem Cells |
$4,075,668 |
Quest - Discovery Stage Research Projects |
Song Li |
Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy |
$2,267,714 |
Basic Biology V |
Lili Yang |
Differentiation of Human Hematopoietic Stem Cells into iNKT Cells |
$614,400 |
SEED Grant |
Hanna Mikkola |
Improving microenvironments to promote hematopoietic stem cell development from human embryonic stem cells |
$550,241 |
Research Leadership |
John Chute |
Niche-Focused Research: Discovery & Development of Hematopoietic Regenerative Factors |
$4,645,297 |
Conference - Lung Regenerative Medicine Workshop |
Brigitte Gomperts |
Stem Cells for Lung Diseases - Overcoming Barriers to Find New Therapies |
$44,548 |
Early Translational II |
Noriyuki Kasahara |
Stem cell-based carriers for RCR vector delivery to glioblastoma |
$3,340,625 |
Conference |
Martina Wiedau-Pazos |
California ALS Summit 2011 |
$13,300 |
SEED Grant |
Irvin Chen |
Genetic modification of the human genome to resist HIV-1 infection and/or disease progression |
$616,800 |
Quest - Discovery Stage Research Projects |
Stanley Carmichael |
iPS Glial Therapy for White Matter Stroke and Vascular Dementia |
$2,086,130 |
Comprehensive Grant |
Gay Crooks |
Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC) |
$1,653,416 |
Clinical Trial Stage Projects |
Sophie Deng |
Safety and Feasibility of Cultivated Autologous Limbal Stem Cells for Limbal Stem Cell Deficiency |
$10,301,486 |
New Faculty I |
Dana Jones |
Characterization of mechanisms regulating de-differentiation and the re-acquisition of stem cell identity |
$382,773 |
Discovery Research Projects |
Lili Yang |
Battling COVID-19 Using Off-The-Shelf HSC-Engineered iNKT Cells |
$250,000 |
Basic Biology III |
Yi Sun |
Studying neurotransmission of normal and diseased human ES cell-derived neurons in vivo |
$1,382,400 |
Quest - Discovery Stage Research Projects |
Song Li |
iPSC Extracellular Vesicles for Diabetes Therapy |
$1,354,928 |
Training Grant I-1 |
Owen Witte |
CIRM Type I Comprehensive Training Program |
$3,660,398 |
Quest - Discovery Stage Research Projects |
Lili Yang |
Combating Ovarian Cancer Using Stem Cell-Engineered Off-The-Shelf CAR-iNKT Cells |
$1,404,000 |
Early Translational IV |
Zack Jerome |
Stem Cell Programming With Chimeric Antigen Receptors to Eradicate HIV Infection |
$4,925,166 |
Foundation - Discovery Stage Research Projects |
Gay Crooks |
Engineering pluripotent stem cells for universally available, off-the-shelf T cell therapies |
$1,352,753 |
Basic Biology V |
Denis Evseenko |
Promoting survival and countering hypertrophy of pluripotent stem cell (PSC)-derived chondrocytes |
$411,330 |
Alpha Stem Cell Clinics |
John Adams |
UCLA-UCI Alpha Stem Cell Clinic (ASCC) Consortium |
$8,680,000 |
Therapeutic Translational Research Projects |
Lili Yang |
Stem Cell-Based iNKT Cell Therapy for Cancer |
$6,956,775 |
Basic Biology I |
Robb Maclellan |
Human Cardiovascular Progenitors, their Niches and Control of Self-renewal and Cell Fate |
$917,667 |
Quest - Discovery Stage Research Projects |
April Pyle |
CRISPR/Cas9 nanoparticle enabled therapy for Duchenne Muscular Dystrophy in muscle stem cells |
$2,150,400 |
Early Translational II |
Sophie Deng |
Regeneration of Functional Human Corneal Epithelial Progenitor Cells |
$1,524,947 |
Patent Assistance Fund Awards |
Adele Rennie |
Patent Assistance Fund - UCLA |
$84,973 |
SEED Grant |
Siavash Kurdistani |
Cellular epigenetic diversity as a blueprint for defining the identity and functional potential of human embryonic stem cells |
$549,698 |
Quest - Discovery Stage Research Projects |
Scott Kitchen |
Engineering Lifelong Cellular Immunity to HIV |
$1,701,178 |
Comprehensive Grant |
Zack Jerome |
Human Embryonic Stem Cell Therapeutic Strategies to Target HIV Disease |
$2,401,903 |
Therapeutic Translational Research Projects |
Caroline Kuo |
Ex Vivo Gene Editing of Human Hematopoietic Stem Cells for the Treatment of X-Linked Hyper-IgM Syndrome |
$4,896,628 |
New Faculty I |
Siavash Kurdistani |
Epigenetics in cancer stem cell initiation and clinical outcome prediction |
$3,063,450 |
Quest - Discovery Stage Research Projects |
Donald Kohn |
Hematopoietic Stem Cell Gene Therapy for X-linked Agammaglobulinemia |
$219,230 |
Basic Biology III |
Ali Nsair |
Characterization and Engineering of the Cardiac Stem Cell Niche |
$1,127,741 |
Clinical Trial Stage Projects |
Donald Kohn |
Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects |
$5,827,000 |
Disease Team Therapy Development - Research |
Antoni Ribas |
Genetic Re-programming of Stem Cells to Fight Cancer |
$14,144,221 |
COMPASS Training Grant |
Tracy Johnson |
COMPASS: Accelerating Stem Cell Research by Educating and Empowering New Stem Cell Researchers |
$2,910,000 |
Early Translational IV |
Donald Kohn |
Beta-Globin Gene Correction of Sickle Cell Disease in Hematopoietic Stem Cells |
$1,651,884 |
Foundation - Discovery Stage Research Projects |
Brigitte Gomperts |
Overcoming barriers for airway stem cell gene therapy for Cystic Fibrosis |
$1,472,858 |
Basic Biology V |
Bennett Novitch |
In vitro modeling of human motor neuron disease |
$1,147,114 |
Tools and Technologies III |
Hanna Mikkola |
A suite of engineered human pluripotent stem cell lines to facilitate the generation of hematopoietic stem cells |
$1,382,400 |
Conference II |
Donald Kohn |
Primary Immune Deficiency Treatment Consortium (PIDTC) Annual Scientific Workshop |
$29,807 |
Basic Biology I |
Luisa Iruela-Arispe |
Molecular Characterization and Functional Exploration of Hemogenic Endothelium |
$1,371,477 |
Clinical Trial Stage Projects |
Donald Kohn |
Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects |
$10,156,925 |
Early Translational II |
Bruno Peault |
Harnessing native fat-residing stem cells for bone regeneration |
$5,359,076 |
Quest - Discovery Stage Research Projects |
Caroline Kuo |
Targeted Gene Editing in the Treatment of X-Linked Hyper-IgM Syndrome |
$1,512,333 |
SEED Grant |
Noriyuki Kasahara |
Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues |
$399,239 |
Conference - The 2018 Alpha Stem Cell Clinic Annual Symposium |
John Adams |
Delivery of Stem Cell Therapeutics to Patients |
$60,000 |
Comprehensive Grant |
Guoping Fan |
Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair |
$2,412,995 |
Therapeutic Translational Research Projects |
Yvonne Chen |
BCMA/CS1 Bispecific CAR-T Cell Therapy to Prevent Antigen Escape in Multiple Myeloma |
$3,176,805 |
New Faculty I |
Hanna Mikkola |
Mechanisms of Hematopoietic stem cell Specification and Self-Renewal |
$2,286,900 |
Quest - Discovery Stage Research Projects |
Stanley Carmichael |
Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia. |
$250,000 |
Basic Biology III |
Kathrin Plath |
Discovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells |
$1,364,598 |
Late Stage Preclinical Projects |
Antoni Ribas |
Skin regeneration and wound healing with a topical BRAF inhibitor |
$5,005,126 |
Basic Biology IV |
Kathrin Plath |
Understanding the status of the X chromosomes in human ESCs and preimplantation embryos |
$1,382,400 |
Foundation - Discovery Stage Research Projects |
Melissa Spencer |
Engineering AAV capsids for transduction of neural and muscle stem cells |
$999,999 |
Early Translational IV |
Gerald Lipshutz |
Gene therapy-corrected autologous hepatocyte-like cells from induced pluripotent stem cells for the treatment of pediatric single enzyme disorders |
$1,801,629 |
Foundation - Discovery Stage Research Projects |
Kathrin Plath |
Characterization and applications of human blastoids for understanding early human embryogenesis |
$1,402,137 |
Basic Biology V |
Samantha Butler |
Assessing the mechanism by which the Bone Morphogenetic Proteins direct stem cell fate |
$515,730 |
Tools and Technologies III |
James Dunn |
Skin-derived precursor cells for the treatment of enteric neuromuscular dysfunction |
$1,044,423 |
Inception - Discovery Stage Research Projects |
Stanley Carmichael |
iPS-Interneuron Transplantation for Neural Repair after Stroke |
$229,396 |
Basic Biology I |
Bennett Novitch |
Molecular Characterization of hESC and hIPSC-Derived Spinal Motor Neurons |
$1,228,278 |
Quest - Discovery Stage Research Projects |
John Chute |
Protein tyrosine phosphatase - sigma inhibitors for hematopoietic regeneration |
$2,115,735 |
Disease Team Research I |
Dennis Slamon |
Therapeutic Opportunities To Target Tumor Initiating Cells in Solid Tumors |
$19,979,660 |
Quest - Discovery Stage Research Projects |
Gay Crooks |
Platform Technology for Pluripotent Stem Cell-Derived T cell Immunotherapy |
$965,636 |
SEED Grant |
Zoran Galic |
Genetic Enhancement of the Immune Response to Melanoma via hESC-derived T cells |
$616,800 |
Therapeutic Translational Research Projects |
Peter Butler |
Personalized Cell Therapy for Diabetes |
$1,494,896 |
Early Translational I |
Gabriel Travis |
Development of a Stem Cell-based Transplantation Strategy for Treating Age-related Macular Degeneration |
$5,487,136 |
Discovery Research Projects |
Brigitte Gomperts |
Identifying a lead compound for COVID19 using high throughput screening with lung stem cell organoids |
$149,998 |
New Faculty I |
Kathrin Plath |
In vitro reprogramming of mouse and human somatic cells to an embryonic state |
$2,229,427 |
Therapeutic Translational Research Projects |
Lili Yang |
HSC-Engineered Off-The-Shelf CAR-iNKT Cell Therapy for Multiple Myeloma |
$5,281,199 |
Basic Biology III |
William Lowry |
Molecular determinants of accurate differentiation from human pluripotent stem cells |
$677,115 |
Therapeutic Translational Research Projects |
Donald Kohn |
Autologous MPO Knock-Out Hematopoietic Stem and Progenitor Cells for Pulmonary Arterial Hypertension |
$4,751,297 |
Basic Biology IV |
Owen Witte |
Trop2 dependent and independent mechanisms of self-renewal in human cancer stem cells |
$1,254,960 |
Alpha Stem Cell Clinics Network Expansion |
Noah Federman |
Expansion of the Alpha Stem Cell and Gene Therapy Clinic at UCLA |
$8,000,000 |
Early Translational from Disease Team Conversion |
Stanley Nelson |
Combination therapy to Enhance Antisense Mediated Exon Skipping for Duchenne Muscular Dystrophy |
$1,823,545 |
Foundation - Discovery Stage Research Projects |
William Lowry |
Defining the source of dysfunction in monogenic Intellectual Disability Syndrome neurons |
$1,500,337 |
Major Facilities |
Gene Block |
UCLA CIRM Institute |
$19,854,900 |
Tools and Technologies III |
Carla Koehler |
A small molecule tool for reducing the malignant potential in reprogramming human iPSCs and ESCs |
$1,283,900 |
Inception - Discovery Stage Research Projects |
Arjun Deb |
Targeting progenitors in scar tissue to reduce chronic scar burden |
$230,400 |
Basic Biology I |
Michael Teitell |
Mitochondrial Metabolism in hESC and hiPSC Differentiation, Reprogramming, and Cancer |
$1,323,029 |
Late Stage Preclinical Projects |
Sophie Deng |
Regeneration of a Normal Corneal Surface by Limbal Stem Cell Therapy |
$4,244,211 |
Disease Team Research I |
Donald Kohn |
Stem Cell Gene Therapy for Sickle Cell Disease |
$8,833,695 |
Quest - Discovery Stage Research Projects |
Vaithilingaraja Arumugaswami |
Immunization strategies to prevent Zika viral congenital eye and brain disease |
$2,128,867 |
SEED Grant |
Michael Teitell |
Role of Mitochondria in Self-Renewal Versus Differentiation of Human Embryonic Stem Cells |
$543,274 |
Clinical Trial Stage Projects |
Steven Dubinett |
A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC |
$10,955,315 |
Shared Labs |
Owen Witte |
CIRM Shared Research Laboratories |
$1,751,297 |
Discovery Research Projects |
Gay Crooks |
Stem cell-based rapid identification of SARS-CoV-2 T cell epitopes and T cell receptors for therapeutic use |
$126,692 |
Tools and Technologies II |
Stanley Carmichael |
Development of a Hydrogel Matrix for Stem Cell Growth and Neural Repair after Stroke |
$1,825,613 |
Therapeutic Translational Research Projects |
Cristina Puig Saus |
CAR-Tnm cell therapy for melanoma targeting TYRP-1 |
$5,904,462 |
Basic Biology III |
Shuo Lin |
Etsrp/ER71 mediated stem cell differentiation into vascular lineage |
$1,378,781 |
Quest - Discovery Stage Research Projects |
Donald Kohn |
Hematopoietic Stem Cell Gene Therapy for Alpha Thalassemia |
$1,177,739 |
New Faculty Physician Scientist |
Ali Nsair |
Human Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells for Cardiac Cell Therapy. |
$2,316,894 |
Quest - Discovery Stage Research Projects |
Frank Pajonk |
Development of novel small molecules against cancer stem cells in solid cancers |
$2,340,000 |
Early Translational from Disease Team Conversion |
Irvin Chen |
Development of a humanized mouse model for testing anti-HIV HSPC gene therapy strategies in HIV-1 infected mice. |
$1,505,000 |
Late Stage Preclinical Projects |
Steven Schwartz |
Clinical Translation of Autologous Regenerative Pluripotent Stem Cell Therapy for Blindness |
$6,000,000 |
Disease Team Planning |
Irvin Chen |
Stem Cell Therapy for AIDS- Disease Team Planning |
$51,490 |