Organoid Modeling of Human Cortical Microcircuits

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Grant Award Details

Grant Number:
Disease Focus:
Human Stem Cell Use:
Award Value:

Progress Reports

Reporting Period:
Year 2

Grant Application Details

Application Title:

Organoid Modeling of Human Cortical Microcircuits

Public Abstract:
Research Objective

The proposed studies will develop three-dimensional cell culture methods for creating human brain neural circuits for disease research and drug discovery.


The proposed research will develop a new research platform for studying how neurons in the human brain function, how neurological disease subverts this activity, and how we might find new therapies.

Major Proposed Activities

  • Develop robust and reliable methods for creating three-dimensional organoid ("mini-brain" ) structures from human pluripotent stem cells.
  • Measure the ability of neurons within mini-brain structures to form functional connections with one another that resemble those seen in the human brain.
  • Determine how mini-brain neurons are organized at a larger network level to better model the normal and pathological activities of the human brain.
Statement of Benefit to California:
Neurological diseases are among the most debilitating medical conditions that affect millions of Californians each year, and many more worldwide. Few effective treatments for these diseases currently exist, in part because we know very little about the mechanisms underlying these conditions. Our proposed studies will develop an innovative cell culture platform to create a facsimile of human brain circuits that will enable us to better understand disease pathologies and discover new therapies.