University of California, San Francisco

Awards to the Institution

Program	Investigator	Award Title	Award Value
New Faculty Physician Scientist	Tippi MacKenzie	In Utero Embryonic Stem Cell Transplantation to Treat Congenital Anomalies	$2,661,742
Tools and Technologies III	Andrew Leavitt	Small molecule tools and scale-up technologies to expand human umbilical cord blood stem and progenitor cells for clinical and research use	$1,416,600
Conference	Susan Fisher	The Stem Cell Niche in Development and Disease	$5,000
Conference	Emmanuelle Passegue	CA-HSCI 1st Generation Stem Cell PI Meeting	$20,000
Conference II	David Rowitch	“Myelin Through the Ages: Evolution, Development, Degeneration and Disease” - 2018 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS)	$10,000
Alpha Stem Cell Clinics Network Expansion	Mark Walters	University of California, San Francisco (UCSF) CIRM Alpha Stem Cell Clinic	$5,707,388
New Cell Lines	Miguel Ramalho-Santos	Somatic cell age and memory in the generation of iPS cells	$1,307,201
Research Training Grant	Robert Blelloch	Scholars Research Training Program in Regenerative Medicine, Gene Therapy, and Stem Cell Research	$5,000,000
SEED Grant	Valerie Weaver	Force, Dimensionality and Stem Cell Fate	$529,762
Foundation - Discovery Stage Research Projects	Harold Chapman	Modulation of human alveolar stem cells to promote lung regeneration and avoid pulmonary fibrosis	$1,626,001
Comprehensive Grant	Randall Lee	Embryonic Stem Cell-Derived Therapies Targeting Cardiac Ischemic Disease	$2,424,353
Transplantation Immunology	Tippi MacKenzie	Maternal and Fetal Immune Responses to In Utero Hematopoietic Stem Cell Transplantation	$1,230,869
Early Translational III	Morton Cowan	Gene Correction of Autologous Hematopoietic Stem Cells in Artemis Deficient SCID	$3,862,367
Tissue Collection for Disease Modeling	Jacquelyn Maher	iPSC-derived Hepatocytes as Platforms for Research in Viral Hepatitis and Non-alcoholic Steatohepatitis	$791,680
SPARK	Katherine Nielsen	Developing High School Students' Research Practices and Regenerative Medicine Knowledge through a Summer Intern Program	$382,430
Conference	Regis Kelly	The Science of Staying Younger Longer	$6,500
Conference	Diana Laird	The 2014 Santa Cruz Developmental Biology Meeting	$3,000
Clinical Trial Stage Projects	Morton Cowan	Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells	$12,000,000
Therapeutic Translational Research Projects	Mark Walters	Curing Sickle cell Disease with CRISPR-Cas9 genome editing	$60,635
SEED Grant	Robert Blelloch	MicroRNA Regulation of Human Embryonic Stem Cell Self-Renewal and Differentiation	$605,886
Therapeutic Translational Research Projects	Hideho Okada	Development of novel synNotch CART cell therapy in patients with recurrent EGFRvIII+ glioblastoma	$4,556,536
SEED Grant	Linda Giudice	Human Embryonic Stem Cell Differentiation to Trophoblast: Basic Biology and Clinical Translation to Improve Human Fertility	$614,784
Foundation - Discovery Stage Research Projects	Robert Blelloch	Development of universal off-the-shelf iPSC derived dendritic cells for use as patient specific anti-tumor vaccine	$1,391,999
Comprehensive Grant	Harold Bernstein	Modeling Myocardial Therapy with Human Embryonic Stem Cells	$2,134,694
Tools and Technologies II	Daniel Lim	Development and preclinical testing of new devices for cell transplantation to the brain.	$1,795,891
Basic Biology IV	Barbara Panning	Investigation of the role of O-GlcNAcylation in SOX2 function during reprogramming	$1,260,037
Basic Biology V	Mark Anderson	Generation of a functional thymus to induce immune tolerance to stem cell derivatives	$1,191,000
Inception - Discovery Stage Research Projects	Andrew Brack	Examining the efficacy of GDF11 antibody as a rejuvenator of aged human muscle stem cell capacity and muscle repair .	$180,000
Conference	Jeffrey Rosenfeld	California ALS Research Summit 2014	$8,563
Patent Assistance Fund Awards	Karin Immergluck	Patent Assistance Fund Proposal - UCSF	$87,257
Late Stage Preclinical Projects	Krystof Bankiewicz	MRI Guided Delivery of Neural Progenitor Cells Secreting GDNF for the Treatment of Parkinson's disease	$5,811,340
Basic Biology II	John Rubenstein	MGE Enhancers to Select for Interneuron Precursors Produced from Human ES Cells	$1,387,800
Clinical Trial Stage Projects	Michael Matthay	Mesenchymal Stromal Cells for ARDS (COVID positive and COVID negative)	$701,049
SEED Grant	Su Guo	Identifying small molecules that stimulate the differentiation of hESCs into dopamine-producing neurons	$542,619
Therapeutic Translational Research Projects	Arun Wiita	CD72 nanoCARs for the treatment of refractory pediatric B-cell acute lymphoblastic leukemia	$3,330,801
New Faculty II	Robert Blelloch	Mechanisms of small RNA regulation in early embryonic development	$2,790,695
Alpha Stem Cell Clinics Network Expansion	Mark Walters	University of California, San Francisco (UCSF) Alpha Stem Cell Clinic (ASCC)	$7,994,347
Comprehensive Grant	Samuel Pleasure	Human stem cell derived oligodendrocytes for treatment of stroke and MS	$2,459,235
Basic Biology III	Jason Pomerantz	Phenotypic Analysis of Human ES Cell-Derived Muscle Stem Cells	$1,381,296
Basic Biology IV	Miguel Ramalho-Santos	Genetic dissection of human cellular reprogramming to pluripotency	$1,184,883
Basic Biology V	Valerie Weaver	Biophysical Determinants of Early Embryonic Stem Cell Fate Specification	$1,186,500
Inception - Discovery Stage Research Projects	Holger Willenbring	Generation of bile duct-competent transplantable human liver organoids	$206,460
Conference	Tippi MacKenzie	In Utero Hematopoietic Stem Cell Transplantation and Maternal-Fetal Tolerance	$17,526
Inception - Discovery Stage Research Projects	Sonja Schrepfer	Hypo-immunogenic cardiac patches for myocardial regeneration	$235,818
Quest - Discovery Stage Research Projects	Hideho Okada	Non-viral reprogramming of the endogenous TCRα locus to direct stem memory T cells against shared neoantigens in malignant gliomas	$900,000
Early Translational II	Arturo Alvarez-Buylla	Inhibitory Nerve Cell Precursors: Dosing, Safety and Efficacy	$1,564,016
Clinical Trial Stage Projects	Steven Deeks	Anti-HIV duoCAR-T cell therapy for HIV infection	$8,970,732
SEED Grant	Holger Willenbring	Induction of pluripotency in fibroblasts by fusion with enucleated human embryonic stem cell syncytia	$329,245
SPARK	Katherine Nielsen	Stem Cell Summer Research Experiences	$508,750
New Faculty II	Holger Willenbring	Molecular dissection of adult liver regeneration to guide the generation of hepatocytes from pluripotent stem cells	$2,832,008
Late Stage Preclinical Projects	Karin Gaensler	Development of TriLeukeVax, an Engineered Autologous Leukemia Vaccine for Stimulating Cytolytic Immune Responses to Residual Leukemic Stem Cells	$6,000,000
Comprehensive Grant	Arnold Kriegstein	Derivation of Inhibitory Nerve Cells from Human Embryonic Stem Cells	$2,410,874
Basic Biology III	John Murnane	Genomic instability during culturing of human embryonic stem cells	$1,070,919
Basic Biology IV	Jeremy Reiter	Modeling disease in human embryonic stem cells using new genetic tools	$1,387,800
Major Facilities	A. Washington	UCSF CIRM Building	$34,862,400
Late Stage Preclinical Projects	Jennifer Puck	Ex Vivo Transduction of the Human Artemis (DCLRE1C) cDNA by Lentiviral Vector AProArt into CD34+ Hematopoietic Cells for Artemis (ART)-Deficient Severe Combined Immunodeficiency (SCID)	$4,268,865
Conference	Jason Rock	Tri-Institutional Stem Cell Retreat	$3,500
Quest - Discovery Stage Research Projects	Holger Willenbring	Preclinical development of AAV vector-mediated in vivo hepatic reprogramming of myofibroblasts as a therapy for liver fibrosis	$1,638,389
Therapeutic Translational Research Projects	Karin Gaensler	Developing engineered autologous leukemia vaccines to target residual leukemic stem cells	$4,171,728
Early Translational II	Markus Muschen	Dual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication	$2,756,536
Diagnostic Translational Research Projects	Steven Mack	Development of a Noninvasive Prenatal Test for Beta-Hemoglobinopathies for Earlier Stem Cell Therapeutic Interventions	$633,014
SEED Grant	Didier Stainier	Endodermal differentiation of human ES cells	$611,027
Quest - Discovery Stage Research Projects	Julia Carnevale	Generating deeper and more durable BCMA CAR T cell responses in Multiple Myeloma through non-viral knockin/knockout multiplexed genome engineering	$1,463,368
New Faculty II	Jeremy Reiter	High throughput modeling of human neurodegenerative diseases in embryonic stem cells	$2,259,092
Comprehensive Grant	Susan Fisher	Constructing a fate map of the human embryo	$2,430,487
Research Training II	Susan Fisher	Training Program in Stem Cell Research at UCSF	$7,814,027
Creativity Awards	Katherine Nielsen	UCSF SEP High School Intern Program	$168,947
Disease Team Planning	Jeffrey Bluestone	A CIRM Disease Team for the Treatment and Cure of Diabetes	$55,000
Quest - Discovery Stage Research Projects	Tejal Desai	Thin Film Encapsulation Devices for Human Stem Cell derived Insulin Producing Cells	$1,092,063
Conference	Brian Black	Weinstein Cardiovascular Development Conference	$35,000
Clinical Trial Stage Projects	Tippi MacKenzie	In Utero Hematopoietic Stem Cell Transplantation For The Treatment Of Fetuses With Alpha Thalassemia Major	$10,906,978
Conference - The 2019 Alpha Stem Cell Clinic Annual Symposium	Mark Walters	2019 Alpha Stem Cell Clinic Symposium - Mending Stem Cells: The Past, Present & Future Regenerative Medicine	$60,000
Disease Team Research I	Mitchel Berger	Stem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)	$6,214,914
Therapeutic Translational Research Projects	Hideho Okada	Development of novel synNotch CART cell therapy in patients with recurrent EGFRvIII+ glioblastoma	$525,000
SEED Grant	Heike Daldrup-Link	Labeling of human embryonic stem cells with iron oxide nanoparticles and fluorescent dyes for a non-invasive cell depiction with MR imaging and optical imaging	$240,214
Quest - Discovery Stage Research Projects	Julie Saba	Providing a cure for sphingosine phosphate lyase insufficiency syndrome (SPLIS) through adeno-associated viral mediated SGPL1 gene therapy	$1,463,400
New Faculty II	Ophir Klein	Laying the groundwork for building a tooth: analysis of dental epithelial stem cells	$3,075,251
Shared Labs	Linda Giudice	The University of California San Francisco Shared Research and Teaching Laboratory: a Non-Federal Human Embryonic Stem Cell Resource for the Bay Area Community	$3,289,649
Training Grant I-1	Susan Fisher	Training Grant I	$2,868,145
New Faculty Physician Scientist	Ophir Klein	Stem cell therapy for inflammatory bowel disease	$3,019,013
New Faculty Physician Scientist	Jason Pomerantz	Characterization of Human Skeletal Muscle Stem Cells for Clinical Application	$2,959,014
Disease Team Planning	Jeffrey Lotz	A CIRM Disease Team for the Repair of Traumatically Injured and Arthritic Cartilage	$33,172
Quest - Discovery Stage Research Projects	Julie Sneddon	Designing a cellular niche for transplantation of human embryonic stem cell-derived beta cells	$2,006,076
Conference	Arnold Kriegstein	UCSF Frontiers of Neural Stem Cells Symposium	$35,000
Inception - Discovery Stage Research Projects	Semil Choksi	Generation of human airway stem cells by direct transcriptional reprogramming for disease modeling and regeneration	$238,408
Late Stage Preclinical Projects	Mark Walters	Curing Sickle cell Disease with CRISPR-Cas9 genome editing	$2,242,805
New Cell Lines	Susan Fisher	Optimization of Human Embryonic Stem Cell Derivation Techniques and Production/Distribution of GMP-Grade Lines	$1,383,419
Quest - Discovery Stage Research Projects	Marisa Medina	iPSCs as a screening tool to predict risk of nonalcoholic fatty liver disease	$813,000
SEED Grant	Miguel Ramalho-Santos	Transcriptional Regulation of Human Embryonic Stem Cells	$595,755
Quest - Discovery Stage Research Projects	Brian Feeley	Matrix Assisted Cell Transplantation of Promyogenic Fibroadipogenic Progenitor (FAP) Stem Cells	$1,179,478
New Faculty II	Emmanuelle Passegue	Mechanisms Underlying the Responses of Normal and Cancer Stem Cells to Environmental and Therapeutic Insults	$2,124,488
Transplantation Immunology	Mark Anderson	Stem cell differentiation to thymic epithelium for inducing tolerance to stem cells	$1,314,089
Early Translational III	Arnold Kriegstein	Human ES cell-derived MGE inhibitory interneuron transplantation for spinal cord injury	$1,623,251
New Faculty Physician Scientist	Ann Zovein	Human endothelial reprogramming for hematopoietic stem cell therapy.	$2,197,683
Shared Labs	Linda Giudice	The University of California San Francisco Shared Research and Teaching Laboratory: a Non-Federal Human Embryonic Stem Cell Resource for the Bay Area Community	$2,144,758
Conference	Peter Stock	IPITA 2013 - 14th World Congress of the International Pancreas and Islet transplant Association	$10,000
Conference	Ophir Klein	Stem Cells Craniofacial Development and Disease	$4,500
Quest - Discovery Stage Research Projects	Shuvo Roy	Silicon Nanopore Membrane encapsulated enriched-Beta Clusters for Type 1 Diabetes treatment	$1,113,000
Clinical Trial Stage Projects	Peter Stock	Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM	$11,083,012
New Cell Lines	Long-cheng Li	Induction of pluripotent stem cells by small RNA-guided transcriptional activation	$1,368,461
Cure Sickle Cell Initiative Clinical Trial Stage Projects	Mark Walters	Transplantation of CRISPR-CAS9 Corrected Hematopoietic Stem Cells (CRISPR_SCD001) in Patients with Severe Sickle Cell Disease	$8,389,407
SEED Grant	Thea Tlsty	Role of the tumor suppressor gene, p16INK4a, in regulating stem cell phenotypes in embryonic stem cells and human epithelial cells.	$614,784
Conference II	Rong Wang	22nd International Vascular Biology Meeting	$50,000
Comprehensive Grant	Andrew Leavitt	Understanding hESC-based Hematopoiesis for Therapeutic Benefit	$2,460,822
Transplantation Immunology	Jeffrey Bluestone	Stem cell tolerance through the use of engineered antigen-specific regulatory T cells	$1,152,768
Early Translational III	Holger Willenbring	Generation of safe and therapeutically effective human induced hepatocyte-like cells	$1,544,170
			Total: $252,684,215.00