Research Objective

This project will interrogate interactions, distribution, and function of high-confidence neuropsychiatric disorder risk proteins, and identify convergent pathobiology of patient genetic variants.

Impact

Datasets and stem cell resources in this project will establish a molecularly-informed genotype to phenotype discovery platform for defining druggable pathways in neuropsychiatric disorders. Californians have voted to support stem cell research towards treatments for brain disorders by earmarking over 25% of the funds for brain and CNS projects. Neuropsychiatric disorders represent major fraction of CNS disorders, and are characterized by phenotypic heterogeneity, and complex etiologies. This project will create data and resources to provide biologically informed estimate of disease risk and identify molecular pathways that can serve as molecular targets for drug development.