|
Basic Biology V |
Christian Metallo |
Metabolic regulation of cardiac differentiation and maturation |
$1,124,834 |
|
Alpha Stem Cell Clinics |
Catriona Jamieson |
Alpha Stem Cell Clinic for the Development of Regenerative Therapies |
$8,679,137 |
|
Inception - Discovery Stage Research Projects |
Alysson Muotri |
Reverse transcriptase inhibitors as a novel therapeutic approach for neurological autoimmune disorders |
$210,060 |
|
Basic Biology I |
Karl Willert |
WNT signaling and the control of cell fate decisions in human pluripotent stem cells. |
$1,329,298 |
|
Conference |
Shu Chien |
The 14th UC Systemwide Bioengineering Symposium |
$5,000 |
|
New Cell Lines |
Steve Dowdy |
Protein transduction of transcription factors: a non-genetic approach to generate new pluripotent cell lines from human skin. |
$1,073,585 |
|
Therapeutic Translational Research Projects |
Catriona Jamieson |
A Splicing Modulator Targeting Cancer Stem Cells in Acute Myeloid Leukemia |
$2,511,767 |
|
New Faculty II |
Catriona Jamieson |
Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells |
$3,065,572 |
|
Quest - Discovery Stage Research Projects |
Jonathan Lin |
Small Molecule Proteostasis Regulators to Treat Photoreceptor Diseases |
$1,153,937 |
|
Tools and Technologies I |
Ying Liu |
Generation of disease models for neurodegenerative disorders in hESCs by gene targeting |
$709,829 |
|
Progression Award - Discovery Stage Research Projects |
John Brock |
Simplification of Excipient Solution for Implanting Candidate Human H9-scNSC Cell Line for Spinal Cord Injury |
$180,000 |
|
Basic Biology III |
David Cheresh |
Molecular basis of human ES cell neurovascular differentiation and co-patterning |
$1,359,996 |
|
Quest - Discovery Stage Research Projects |
Michael Karin |
Targeting pancreatic cancer stem cells with DDR1 antibodies. |
$1,425,600 |
|
Early Translational III |
Eugene Yeo |
Molecules to Correct Aberrant RNA Signature in Human Diseased Neurons |
$1,532,323 |
|
Foundation - Discovery Stage Research Projects |
Alon Goren |
Establishment of a novel approach to systematically study the dynamic organization of protein complexes in stem cells |
$1,515,601 |
|
Basic Biology IV |
Eugene Yeo |
Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration |
$1,260,360 |
|
Early Translational from Disease Team Conversion |
Lawrence Goldstein |
Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis |
$4,139,754 |
|
Basic Biology V |
Lawrence Goldstein |
Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes |
$1,050,300 |
|
Tools and Technologies III |
Shaochen Chen |
Development of 3D Bioprinting Techniques using Human Embryonic Stem Cells Derived Cardiomyocytes for Cardiac Tissue Engineering |
$1,368,264 |
|
Late Stage Preclinical Projects |
Stephanie Cherqui |
Ex vivo transduced autologous human CD34+ hematopoietic stem cells for treatment of cystinosis |
$5,273,189 |
|
Basic Biology I |
Eugene Yeo |
RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency |
$1,308,901 |
|
Conference |
Shu Chien |
10th Annual UC Systemwide Bioengineering Symposium |
$8,000 |
|
SEED Grant |
Sylvia Evans |
Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells |
$585,600 |
|
Therapeutic Translational Research Projects |
Dan Kaufman |
Human Embryonic Stem Cell-Derived Natural Killer Cells for Cancer Treatment |
$3,260,000 |
|
New Faculty II |
Mana Parast |
Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal |
$3,077,918 |
|
Clinical Trial Stage Projects |
Stephanie Cherqui |
Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. |
$11,999,944 |
|
Transplantation Immunology |
Martin Marsala |
Induction of immune tolerance after spinal grafting of human ES-derived neural precursors |
$1,387,800 |
|
Quest - Discovery Stage Research Projects |
Tannishtha Reya |
Targeting Critical Regulators of Cancer Stem Cells |
$1,148,264 |
|
Basic Biology III |
Deborah Spector |
Viral-host interactions affecting neural differentiation of human progenitors |
$1,372,660 |
|
Quest - Discovery Stage Research Projects |
Joseph Gleeson |
Novel antisense therapy to treat genetic forms of neurodevelopmental disease. |
$1,180,654 |
|
Early Translational III |
Eric Adler |
Identification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease |
$1,701,575 |
|
Basic Biology IV |
George Sen |
Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases. |
$1,080,000 |
|
Disease Team Therapy Development III |
Thomas Kipps |
Therapeutic Eradication of Cancer Stem Cells with UC-961 (Cirmtuzumab) |
$4,179,598 |
|
Research Leadership |
Eric Ahrens |
Molecular Imaging for Stem Cell Science and Clinical Application |
$5,680,474 |
|
Basic Biology V |
Dianne McKay |
Role of intracytoplasmic pattern recognition receptors in HSC engraftment |
$615,639 |
|
Tools and Technologies III |
Shyni Varghese |
Technologies to improve in vivo function of transplanted stem cells |
$1,373,683 |
|
Quest - Discovery Stage Research Projects |
Dan Kaufman |
Targeted off-the-shelf immunotherapy to treat refractory cancers |
$1,936,936 |
|
Basic Biology II |
Dong-Er Zhang |
RUNX1 in maintenance, expansion, and differentiation of therapeutic pluripotent stem cells |
$1,371,540 |
|
Therapeutic Translational Research Projects |
Karen Christman |
Injectable pro-regenerative scaffold for treating symptomatic peripheral artery disease |
$2,839,317 |
|
SEED Grant |
Binhai Zheng |
Genetic manipulation of human embryonic stem cells and its application in studying CNS development and repair |
$600,441 |
|
Inception - Discovery Stage Research Projects |
Gerald Morris |
Identification of antigenic neo-epitopes from in vitro reprogrammed human tissue precursors for regenerative therapy |
$193,500 |
|
Comprehensive Grant |
Yang Xu |
Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells |
$2,467,200 |
|
Therapeutic Translational Research Projects |
Mark Tuszynski |
Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI) |
$6,235,897 |
|
Transplantation Immunology |
Yang Xu |
Induction of immune tolerance to human embryonic stem cell-derived allografts |
$1,192,680 |
|
Quest - Discovery Stage Research Projects |
Dan Kaufman |
Human iPSC-derived chimeric antigen receptor expressing macrophages for improved cancer treatment. |
$1,256,332 |
|
Basic Biology III |
Kun Zhang |
Functional characterization of mutational load in nuclear reprogramming and differentiation |
$1,295,318 |
|
Quest - Discovery Stage Research Projects |
Alysson Muotri |
A treatment for Rett syndrome using glial-restricted neural progenitor cells |
$1,402,240 |
|
Early Translational III |
Lawrence Goldstein |
Identifying Drugs for Alzheimer's Disease with Human Neurons Made From Human IPS cells |
$1,774,420 |
|
Basic Biology IV |
David Traver |
DECIPHERING THE INSTRUCTIONS FOR VERTEBRATE HSC SPECIFICATION AND AMPLIFICATION. |
$1,363,698 |
|
Basic Biology V |
Cornelis Murre |
Epigenetic mechanisms that enforce pluripotency in embryonic stem cells |
$1,160,997 |
|
Disease Team Planning |
Lawrence Goldstein |
Human Stem Cell Approaches to Alzheimers Disease Therapies |
$55,000 |
|
Therapeutic Translational Research Projects |
Lawrence Goldstein |
Human Embryonic Stem Cell-Derived Neural Stem Cell Transplants in Amyotrophic Lateral Sclerosis |
$1,790,000 |
|
Quest - Discovery Stage Research Projects |
Alysson Muotri |
A treatment for Zika virus infection and neuroprotection efficacy |
$1,924,524 |
|
Basic Biology II |
Kun-Liang Guan |
The function of YAP in human embryonic stem cells |
$1,245,693 |
|
Conference II |
Robert Sah |
2016 Tissue Engineering and Regenerative Medicine International Society - Americas (TERMIS-AM) Conference in San Diego, CA on December 11-14, 2016 |
$40,000 |
|
SEED Grant |
Cornelis Murre |
Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells |
$473,952 |
|
Inception - Discovery Stage Research Projects |
Karl Wahlin |
An IPSC cell based model of macular degeneration for drug discovery. |
$232,200 |
|
Comprehensive Grant |
Lawrence Goldstein |
Using Human Embryonic Stem Cells to Understand and to Develop New Therapies for Alzheimer's Disease |
$1,859,414 |
|
Quest - Discovery Stage Research Projects |
Yuan Chen |
A Novel Approach to Eradicate Cancer Stem Cells |
$279,977 |
|
New Faculty I |
David Traver |
Genetic dissection of mesodermal commitment to the hematopoietic fates. |
$2,150,620 |
|
Quest - Discovery Stage Research Projects |
Ziwei Huang |
Development of a new therapeutic for directing target specific stem cell migration and treatment |
$1,129,512 |
|
Basic Biology III |
Anirvan Ghosh |
Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells |
$843,597 |
|
Foundation - Discovery Stage Research Projects |
Francesca Soncin |
Drivers of trophoblast stem/progenitor cell identity in human placenta |
$993,881 |
|
Early Translational III |
Yang Xu |
Human ES cell based therapy of heart failure without allogenic immune rejection |
$1,857,600 |
|
New Faculty Physician Scientist |
Mana Parast |
Human pluripotent stem cell-based therapeutics for preeclampsia |
$2,974,750 |
|
Basic Biology V |
David Cheresh |
CD61-driven stemness program in epithelial cancer |
$1,161,000 |
|
Disease Team Planning |
Dennis Carson |
CIRM Planning Grant in Leukemia |
$52,174 |
|
Conference II |
John Ravits |
California ALS Research Summit 2016 |
$11,400 |
|
Conference |
Joan Heller Brown |
International Society for Heart Research (ISHR) XX1 World Congress |
$10,000 |
|
Early Translational II |
Catriona Jamieson |
Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy |
$3,103,041 |
|
Patent Assistance Fund Awards |
Rubén Flores |
Patent Assistance Fund Application - UCSD |
$38,162 |
|
SEED Grant |
Anirvan Ghosh |
Generation of forebrain neurons from human embryonic stem cells |
$587,591 |
|
Quest - Discovery Stage Research Projects |
Yang Xu |
Development of immune invisible beta cells as a cell therapy for type 1 diabetes through genetic modification of hESCs |
$1,924,791 |
|
Comprehensive Grant |
Martin Marsala |
Spinal ischemic paraplegia: modulation by human embryonic stem cell implant. |
$2,356,090 |
|
Discovery Research Projects |
Steve Dowdy |
Development of Anti-COVID RNAi Therapeutics Using Human iPSC-Derived Alveolar Epithelial Cells |
$150,000 |
|
Tools and Technologies II |
Shu Chien |
Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation |
$1,706,628 |
|
Research Training Grant |
Alysson Muotri |
Interdisciplinary Stem Cell Training Grant at UCSD III |
$4,992,446 |
|
Basic Biology III |
Farah Sheikh |
Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC |
$1,341,955 |
|
Foundation - Discovery Stage Research Projects |
Alexis Komor |
Development of a stem-cell based approach to interpret global effects of genetic variants contributing to neurodevelopmental disease risk |
$1,518,982 |
|
Early Translational III |
Mark Tuszynski |
Functional Neural Relay Formation by Human Neural Stem Cell Grafting in Spinal Cord Injury |
$4,600,447 |
|
Tissue Collection for Disease Modeling |
Kang Zhang |
Generation of fibroblast cell lines in patients with common blinding eye diseases |
$1,034,425 |
|
Basic Biology V |
Miles Wilkinson |
New Regulators of Spermatogonial Stem Cells: RHOX Homeobox Transcription Factors |
$552,811 |
|
Shared Labs |
Karl Willert |
Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells at UCSD |
$1,728,080 |
|
Conference - The 2016 Alpha Stem Cell Clinic Annual Symposium |
Catriona Jamieson |
UCSD Division of Regenerative Medicine and CIRM Alpha Clinics Network Symposium |
$37,778 |
|
Conference |
Lawrence Goldstein |
San Diego Stem Cell Science Education Symposium at UCSD |
$6,237 |
|
Early Translational II |
Alysson Muotri |
Developing a drug-screening system for Autism Spectrum Disorders using human neurons |
$1,376,198 |
|
Inception - Discovery Stage Research Projects |
Tannishtha Reya |
Reprogramming human stem cells for blood cell generation |
$210,060 |
|
SEED Grant |
Shu Chien |
Combinatorial Platform for Optimizing Microenvironments to Control hESC Fate |
$577,148 |
|
Quest - Discovery Stage Research Projects |
Mark Tuszynski |
Neural Stem Cell Relays for Severe Spinal Cord Injury |
$1,638,900 |
|
Early Translational I |
Yang Xu |
Developing induced pluripotent stem cells into human therapeutics and disease models |
$5,165,028 |
|
Discovery Research Projects |
Karen Christman |
Pro-healing biomaterial for treating lung inflammation associated with COVID-19 |
$221,758 |
|
Tools and Technologies II |
Lawrence Goldstein |
Developing a method for rapid identification of high-quality disease specific hIPSC lines |
$1,686,069 |
|
Late Stage Preclinical Projects |
Ezra Cohen |
Late Stage Pre-Clinical Development of a Cirmtuzumab Based CAR T-cell for the Treatment of ROR1+ Hematological Malignancies |
$4,130,260 |
|
Basic Biology III |
Charles King |
Biological relevance of microRNAs in hESC differentiation to endocrine pancreas |
$1,313,649 |
|
Foundation - Discovery Stage Research Projects |
Heidi Cook-Andersen |
Towards a trophectoderm stem-cell model representing human blastocysts of the highest implantation potential |
$1,584,000 |
|
Basic Biology IV |
Maike Sander |
Deciphering transcriptional control of pancreatic beta-cell maturation in vitro |
$1,258,560 |
|
Tissue Collection for Disease Modeling |
Joseph Gleeson |
CIRM Tissue Collection for Neurodevelopmental Disabilities |
$830,426 |
|
Basic Biology V |
Maike Sander |
Defining links between chromatin state and developmental competence |
$1,050,300 |
|
SEED Grant |
Catriona Jamieson |
Derivation and Characterization of Cancer Stem Cells from Human ES Cells |
$616,305 |
|
Inception - Discovery Stage Research Projects |
Karl Wahlin |
Microenvironment based optimization of retinal induction using CRISPR-CAS9 reporter pluripotent stem cells as an expandable source of retinal progenitors and photoreceptors. |
$232,200 |
|
Conference |
Dong-Er Zhang |
International RUNX Workshop |
$24,000 |
|
Disease Team Research I |
Dennis Carson |
Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) |
$19,999,826 |
|
Therapeutic Translational Research Projects |
Ezra Cohen |
Development of ROR1 CAR-T cells to target cancer stem cells in advanced malignancies |
$5,795,584 |
|
New Faculty II |
Shyni Varghese |
A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment |
$2,300,569 |
|
Quest - Discovery Stage Research Projects |
Tannishtha Reya |
Targeting Cancer Stem Cells in Hematologic Malignancies |
$1,960,560 |
|
Shared Labs |
Karl Willert |
Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells at UCSD |
$1,737,133 |
|
Quest - Discovery Stage Research Projects |
Dan Kaufman |
Human iPSC-derived chimeric antigen receptor-expressing macrophages for cancer treatment |
$222,200 |
|
Tools and Technologies II |
Karl Willert |
Homologous recombination in human pluripotent stem cells using adeno-associated virus. |
$1,659,043 |
|
SPARK |
James Murphy |
Summer Program To Accelerate Regenerative Medicine Knowledge (SPARK) |
$503,846 |
|
Research Training II |
Sylvia Evans |
Interdisciplinary Stem Cell Training Program at UCSD II |
$7,432,600 |
|
Alpha Stem Cell Clinics Network Expansion |
Catriona Jamieson |
UC San Diego Health CIRM Alpha Stem Cell Clinic |
$8,000,000 |
|
Basic Biology IV |
Miles Wilkinson |
Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State |
$1,360,450 |
|
Tissue Collection for Disease Modeling |
James Brewer |
Collection of skin biopsies to prepare fibroblasts from patients with Alzheimer's disease and cognitively healthy elderly controls |
$643,693 |
|
Basic Biology V |
Wei Wang |
Systems-level discovery of the regulatory mechanisms directing differentiation of hESC |
$1,161,000 |
|
Basic Biology III |
Binhai Zheng |
Generation and characterization of corticospinal neurons from human embryonic stem cells |
$1,355,063 |
|
Inception - Discovery Stage Research Projects |
Dionicio Siegel |
New Methods for the Chemical Expansion of Hematopoietic Stem and Progenitor Cells |
$232,200 |
|
Conference |
John Ravits |
Cell Therapy for amyotrophic Lateral Sclerosis (ALS) -Testing the Limits: What should we use as preclinical standards of clinical trials? |
$7,193 |
|
Disease Team Research I |
Lawrence Goldstein |
Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis |
$5,694,308 |
|
Clinical Trial Stage Projects |
Thomas Kipps |
A Phase 1b/2a Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab, and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in B-Cell Cancers |
$18,292,674 |
|
New Faculty II |
Benjamin Yu |
Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins |
$3,017,978 |
|
Quest - Discovery Stage Research Projects |
Eric Adler |
Genetically Modified Hematopoietic Stem Cells for the Treatment of Danon Disease |
$1,393,200 |
|
Tools and Technologies I |
Steve Dowdy |
TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells |
$720,000 |
|
Quest - Discovery Stage Research Projects |
Tariq Rana |
Development of COVID-19 Antiviral Therapy Using Human iPSC-Derived Lung Organoids |
$250,000 |
|
Basic Biology III |
Eugene Yeo |
Neural and general splicing factors control self-renewal, neural survival and differentiation |
$1,287,619 |
|
Quest - Discovery Stage Research Projects |
Eugene Yeo |
RNA-directed therapy for Huntington's disease |
$1,253,110 |
|
Training Grant I-1 |
Lawrence Goldstein |
Interdisciplinary Stem Cell Training Program at UCSD |
$3,459,396 |
|
Therapeutic Translational Research Projects |
Stephanie Cherqui |
CRISPR/Cas9-mediated gene editing of Hematopoietic stem and progenitor cells for Friedreich’s ataxia |
$4,846,579 |
|
Basic Biology IV |
Ananda Goldrath |
Mechanisms to protect hESC-derived cells from allogenic immune rejection |
$1,160,997 |
|
Early Translational IV |
Alysson Muotri |
A drug-screening platform for autism spectrum disorders using human astrocytes |
$1,656,456 |
