University of California, San Diego

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Awards to the Institution

Program Investigator Award Title Award Value
Basic Biology V Miles Wilkinson New Regulators of Spermatogonial Stem Cells: RHOX Homeobox Transcription Factors $552,811
Inception - Discovery Stage Research Projects Tannishtha Reya Reprogramming human stem cells for blood cell generation $210,060
Tools and Technologies II Lawrence Goldstein Developing a method for rapid identification of high-quality disease specific hIPSC lines $1,692,334
Early Translational III Lawrence Goldstein Identifying Drugs for Alzheimer's Disease with Human Neurons Made From Human IPS cells $1,774,420
Tools and Technologies III Shyni Varghese Technologies to improve in vivo function of transplanted stem cells $1,373,683
SEED Grant Binhai Zheng Genetic manipulation of human embryonic stem cells and its application in studying CNS development and repair $600,441
Clinical Trial Stage Projects Stephanie Cherqui Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. $11,999,944
Early Translational IV Alysson Muotri A drug-screening platform for autism spectrum disorders using human astrocytes $1,656,456
Conference John Ravits Cell Therapy for amyotrophic Lateral Sclerosis (ALS) -Testing the Limits: What should we use as preclinical standards of clinical trials? $7,193
Tools and Technologies I Steve Dowdy TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells $720,000
Basic Biology III Farah Sheikh Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC $1,341,955
Disease Team Planning Dennis Carson CIRM Planning Grant in Leukemia $52,174
Early Translational II Catriona Jamieson Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy $3,103,041
Quest - Discovery Stage Research Projects Yang Xu Development of immune invisible beta cells as a cell therapy for type 1 diabetes through genetic modification of hESCs $1,960,560
Basic Biology IV George Sen Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases. $1,080,000
Late Stage Preclinical Projects Stephanie Cherqui Ex vivo transduced autologous human CD34+ hematopoietic stem cells for treatment of cystinosis $5,273,189
New Faculty II Mana Parast Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal $3,077,918
Basic Biology V Maike Sander Defining links between chromatin state and developmental competence $1,050,300
Therapeutic Translational Research Projects Ezra Cohen Development of ROR1 CAR-T cells to target cancer stem cells in advanced malignancies $5,795,584
Tools and Technologies II Karl Willert Homologous recombination in human pluripotent stem cells using adeno-associated virus. $1,659,043
Early Translational III Yang Xu Human ES cell based therapy of heart failure without allogenic immune rejection $1,857,600
Therapeutic Translational Research Projects Lawrence Goldstein Human Embryonic Stem Cell-Derived Neural Stem Cell Transplants in Amyotrophic Lateral Sclerosis $1,790,000
SEED Grant Cornelis Murre Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells $473,952
Early Translational from Disease Team Conversion Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $4,139,754
Conference Shu Chien The 14th UC Systemwide Bioengineering Symposium $5,000
Tools and Technologies I Ying Liu Generation of disease models for neurodegenerative disorders in hESCs by gene targeting $709,829
Basic Biology III Charles King Biological relevance of microRNAs in hESC differentiation to endocrine pancreas $1,313,649
Shared Labs Karl Willert Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells at UCSD $1,728,080
Early Translational II Alysson Muotri Developing a drug-screening system for Autism Spectrum Disorders using human neurons $1,376,198
Quest - Discovery Stage Research Projects Mark Tuszynski Neural Stem Cell Relays for Severe Spinal Cord Injury $1,905,173
Quest - Discovery Stage Research Projects Dan Kaufman Targeted off-the-shelf immunotherapy to treat refractory cancers $1,936,936
Comprehensive Grant Yang Xu Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells $2,467,200
Basic Biology V Wei Wang Systems-level discovery of the regulatory mechanisms directing differentiation of hESC $1,161,000
Clinical Trial Stage Projects Thomas Kipps A Phase 1b/2a Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab, and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in B-Cell Cancers $18,292,674
Basic Biology III Eugene Yeo Neural and general splicing factors control self-renewal, neural survival and differentiation $1,287,619
Early Translational III Mark Tuszynski Functional Neural Relay Formation by Human Neural Stem Cell Grafting in Spinal Cord Injury $4,600,447
Conference II John Ravits California ALS Research Summit 2016 $11,400
SEED Grant Anirvan Ghosh Generation of forebrain neurons from human embryonic stem cells $587,591
Disease Team Therapy Development III Thomas Kipps Therapeutic Eradication of Cancer Stem Cells with UC-961 (Cirmtuzumab) $4,179,598
Conference Shu Chien 10th Annual UC Systemwide Bioengineering Symposium $8,000
Transplantation Immunology Martin Marsala Induction of immune tolerance after spinal grafting of human ES-derived neural precursors $1,387,800
Research Training II Sylvia Evans Interdisciplinary Stem Cell Training Program at UCSD II $7,432,600
SEED Grant Catriona Jamieson Derivation and Characterization of Cancer Stem Cells from Human ES Cells $616,305
Disease Team Research I Dennis Carson Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) $19,999,826
Quest - Discovery Stage Research Projects Tannishtha Reya Targeting Cancer Stem Cells in Hematologic Malignancies $1,960,560
New Faculty Physician Scientist Mana Parast Human pluripotent stem cell-based therapeutics for preeclampsia $2,974,750
Quest - Discovery Stage Research Projects Alysson Muotri A treatment for Zika virus infection and neuroprotection efficacy $1,924,524
Comprehensive Grant Lawrence Goldstein Using Human Embryonic Stem Cells to Understand and to Develop New Therapies for Alzheimer's Disease $1,859,414
Basic Biology V Christian Metallo Metabolic regulation of cardiac differentiation and maturation $1,124,834
Basic Biology I Karl Willert WNT signaling and the control of cell fate decisions in human pluripotent stem cells. $1,329,298
Therapeutic Translational Research Projects Catriona Jamieson A Splicing Modulator Targeting Cancer Stem Cells in Acute Myeloid Leukemia $2,511,767
Basic Biology III David Cheresh Molecular basis of human ES cell neurovascular differentiation and co-patterning $1,359,996
Basic Biology IV Maike Sander Deciphering transcriptional control of pancreatic beta-cell maturation in vitro $1,258,560
Conference - The 2016 Alpha Stem Cell Clinic Annual Symposium Catriona Jamieson UCSD Division of Regenerative Medicine and CIRM Alpha Clinics Network Symposium $37,778
SEED Grant Shu Chien Combinatorial Platform for Optimizing Microenvironments to Control hESC Fate $577,148
Research Leadership Eric Ahrens Molecular Imaging for Stem Cell Science and Clinical Application $5,920,899
Therapeutic Translational Research Projects Karen Christman Injectable pro-regenerative scaffold for treating symptomatic peripheral artery disease $2,839,317
Transplantation Immunology Yang Xu Induction of immune tolerance to human embryonic stem cell-derived allografts $1,192,680
Training Grant I-1 Lawrence Goldstein Interdisciplinary Stem Cell Training Program at UCSD $3,459,396
Basic Biology III Binhai Zheng Generation and characterization of corticospinal neurons from human embryonic stem cells $1,355,063
Disease Team Research I Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $5,694,308
Quest - Discovery Stage Research Projects Eric Adler Genetically Modified Hematopoietic Stem Cells for the Treatment of Danon Disease $1,393,200
Tissue Collection for Disease Modeling Kang Zhang Generation of fibroblast cell lines in patients with common blinding eye diseases $1,034,425
Conference Joan Heller Brown International Society for Heart Research (ISHR) XX1 World Congress $10,000
Comprehensive Grant Martin Marsala Spinal ischemic paraplegia: modulation by human embryonic stem cell implant. $2,356,090
Basic Biology III Deborah Spector Viral-host interactions affecting neural differentiation of human progenitors $1,372,660
Basic Biology V Lawrence Goldstein Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes $1,050,300
Basic Biology I Eugene Yeo RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency $1,308,901
Therapeutic Translational Research Projects Dan Kaufman Human Embryonic Stem Cell-Derived Natural Killer Cells for Cancer Treatment $4,698,821
Basic Biology IV Miles Wilkinson Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State $1,360,450
Inception - Discovery Stage Research Projects Karl Wahlin Microenvironment based optimization of retinal induction using CRISPR-CAS9 reporter pluripotent stem cells as an expandable source of retinal progenitors and photoreceptors. $232,200
New Faculty II Shyni Varghese A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment $2,300,569
Basic Biology V Cornelis Murre Epigenetic mechanisms that enforce pluripotency in embryonic stem cells $1,160,997
Conference II Robert Sah 2016 Tissue Engineering and Regenerative Medicine International Society - Americas (TERMIS-AM) Conference in San Diego, CA on December 11-14, 2016 $40,000
New Faculty I David Traver Genetic dissection of mesodermal commitment to the hematopoietic fates. $2,150,620
Early Translational III Eugene Yeo Molecules to Correct Aberrant RNA Signature in Human Diseased Neurons $1,532,323
Alpha Stem Cell Clinics Catriona Jamieson Alpha Stem Cell Clinic for the Development of Regenerative Therapies $7,999,137
New Cell Lines Steve Dowdy Protein transduction of transcription factors: a non-genetic approach to generate new pluripotent cell lines from human skin. $1,073,585
Quest - Discovery Stage Research Projects James Hagood Mesenchymal stem cell extracellular vesicles as therapy for pulmonary fibrosis $0
Tissue Collection for Disease Modeling Joseph Gleeson CIRM Tissue Collection for Neurodevelopmental Disabilities $830,426
Conference Lawrence Goldstein San Diego Stem Cell Science Education Symposium at UCSD $6,237
Early Translational I Yang Xu Developing induced pluripotent stem cells into human therapeutics and disease models $5,165,028
Basic Biology III Kun Zhang Functional characterization of mutational load in nuclear reprogramming and differentiation $1,295,318
Basic Biology V Dianne McKay Role of intracytoplasmic pattern recognition receptors in HSC engraftment $615,639
Basic Biology II Dong-Er Zhang RUNX1 in maintenance, expansion, and differentiation of therapeutic pluripotent stem cells $1,371,540
Inception - Discovery Stage Research Projects Gerald Morris Identification of antigenic neo-epitopes from in vitro reprogrammed human tissue precursors for regenerative therapy $193,500
Basic Biology IV Ananda Goldrath Mechanisms to protect hESC-derived cells from allogenic immune rejection $1,160,997
Inception - Discovery Stage Research Projects Dionicio Siegel New Methods for the Chemical Expansion of Hematopoietic Stem and Progenitor Cells $232,200
New Faculty II Benjamin Yu Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $3,017,978
Basic Biology V David Cheresh CD61-driven stemness program in epithelial cancer $1,161,000
Patent Assistance Fund Awards Rubén Flores Patent Assistance Fund Application - UCSD $38,162
Tools and Technologies II Shu Chien Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation $1,706,628
Early Translational III Eric Adler Identification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease $1,701,575
Tools and Technologies III Shaochen Chen Development of 3D Bioprinting Techniques using Human Embryonic Stem Cells Derived Cardiomyocytes for Cardiac Tissue Engineering $1,368,264
SEED Grant Sylvia Evans Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells $585,600
Quest - Discovery Stage Research Projects Jonathan Lin Small Molecule Proteostasis Regulators to Treat Photoreceptor Diseases $1,160,648
Tissue Collection for Disease Modeling James Brewer Collection of skin biopsies to prepare fibroblasts from patients with Alzheimer's disease and cognitively healthy elderly controls $643,693
Conference Dong-Er Zhang International RUNX Workshop $24,000
Shared Labs Karl Willert Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells at UCSD $1,737,133
Basic Biology III Anirvan Ghosh Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells $843,597
Disease Team Planning Lawrence Goldstein Human Stem Cell Approaches to Alzheimers Disease Therapies $55,000
Basic Biology II Kun-Liang Guan The function of YAP in human embryonic stem cells $1,245,693
Inception - Discovery Stage Research Projects Karl Wahlin An IPSC cell based model of macular degeneration for drug discovery. $232,200
Basic Biology IV Eugene Yeo Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration $1,260,360
Inception - Discovery Stage Research Projects Alysson Muotri Reverse transcriptase inhibitors as a novel therapeutic approach for neurological autoimmune disorders $210,060
New Faculty II Catriona Jamieson Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells $3,065,572
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