Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI)
Grant Award Details
Grant Type:
Grant Number:
CLIN1-15450
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$6,000,000
Status:
Active
Grant Application Details
Application Title:
Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI)
Public Abstract:
Therapeutic Candidate or Device
Human embryonic stem cell-derived neural stem cells.
Indication
Spinal cord injury
Therapeutic Mechanism
The proposed neural stem cell therapy will be transplanted into a spinal cord injury site, providing cell replacement and a new neuronal relay across the injury site in an effort to promote significant functional improvement.
Unmet Medical Need
There are more than half a million Americans living with spinal cord injury (SCI). There are currently no approved therapies for promoting recovery in movement, sensation, bowel, bladder or sexual function.
Project Objective
IND submission
Major Proposed Activities
Human embryonic stem cell-derived neural stem cells.
Indication
Spinal cord injury
Therapeutic Mechanism
The proposed neural stem cell therapy will be transplanted into a spinal cord injury site, providing cell replacement and a new neuronal relay across the injury site in an effort to promote significant functional improvement.
Unmet Medical Need
There are more than half a million Americans living with spinal cord injury (SCI). There are currently no approved therapies for promoting recovery in movement, sensation, bowel, bladder or sexual function.
Project Objective
IND submission
Major Proposed Activities
- Generate clinical grade human embryonic stem cell-derived neural stem cells and qualify release assays.
- Conduct GLP in vivo studies in rats.
- Conduct GLP in vivo studies in non-human primates.
Statement of Benefit to California:
The incidence of SCI in California is ~44 cases per million people. This proposal offers hope that an effective therapy could be offered to people affected by SCI. The development of this program will also establish a new avenue for job development through an effort to make this therapy available to all Californians and Americans.