Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI)

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Grant Award Details

Grant Number:
CLIN1-15450
Investigator(s):
Human Stem Cell Use:
Award Value:
$6,000,000
Status:
Pre-Active

Grant Application Details

Application Title:

Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI)

Public Abstract:
Therapeutic Candidate or Device

Human embryonic stem cell-derived neural stem cells.

Indication

Spinal cord injury

Therapeutic Mechanism

The proposed neural stem cell therapy will be transplanted into a spinal cord injury site, providing cell replacement and a new neuronal relay across the injury site in an effort to promote significant functional improvement.

Unmet Medical Need

There are more than half a million Americans living with spinal cord injury (SCI). There are currently no approved therapies for promoting recovery in movement, sensation, bowel, bladder or sexual function.

Project Objective

IND submission

Major Proposed Activities

  • Generate clinical grade human embryonic stem cell-derived neural stem cells and qualify release assays.
  • Conduct GLP in vivo studies in rats.
  • Conduct GLP in vivo studies in non-human primates.
Statement of Benefit to California:
The incidence of SCI in California is ~44 cases per million people. This proposal offers hope that an effective therapy could be offered to people affected by SCI. The development of this program will also establish a new avenue for job development through an effort to make this therapy available to all Californians and Americans.