Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Cartilage defect	Embryonic Stem Cell	Donor cell therapy	USC	IND
Blood Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	IND
Muscular Dystrophy	Embryonic Stem Cell	Protein/peptide therapy	Juvena Therapeutics Inc	Pre-IND/IDE or Equivalent
Stroke	iPS Cell	Donor cell therapy	UCLA	Pre-IND/IDE or Equivalent
Heart Disease	Adult Stem Cell	Antibody	UCLA	Pre-IND/IDE or Equivalent
IPEX Syndrome	Adult Stem Cell	Gene-modified, personalized cell therapy	ImmunoVec	Pre-IND/IDE or Equivalent
Brain Cancer	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Heart Disease	iPS Cell	Protein/peptide therapy	Regencor, Inc.	Pre-IND/IDE or Equivalent
Metabolic Disorders	Somatic Cell	Gene-modified, personalized cell therapy	Immusoft Corporation	Pre-IND/IDE or Equivalent
Duchenne Muscular Dystrophy	Somatic Cell	Gene Therapy, cell free	MyoGene Bio LLC	Pre-IND/IDE or Equivalent
B cell cancers	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Spinal Cord Injury	Adult Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Heart Disease	iPS Cell	Model system development	Organos Inc.	Tool/Resources/Bottleneck
Heart failure	Adult Stem Cell	Nucleic acid based therapy	Cedars-Sinai	Development Candidate, Proof of Concept
Neurological Disorders	iPS Cell	Gene Therapy, cell free	Navega Therapeutics	Development Candidate, Proof of Concept
Spinal Cord Injury	iPS Cell	Donor cell therapy	Stanford	Development Candidate, Proof of Concept
Multiple Myeloma	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Multiple Sclerosis	Adult Stem Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Kidney Disease	Somatic Cell	Gene Therapy, cell free	UCSF	Development Candidate, Proof of Concept
Neurological Disorders, Sanfilippo Syndrome/MPS III	iPS Cell	Gene-modified, personalized cell therapy	UC Irvine	Development Candidate, Proof of Concept
Huntington's Disease	iPS Cell	Gene Therapy, cell free	UCSD	Development Candidate, Proof of Concept
Cartilage defect	Adult Stem Cell	Biologic	The Stone Research Foundation for Sports Medicine and Arthritis	Development Candidate, Proof of Concept
Cartilage defect, Osteoarthritis	Embryonic Stem Cell	Donor cell therapy	Scripps Health	Development Candidate, Proof of Concept
Type 1 diabetes	iPS Cell	Biologic	UCLA	Development Candidate, Proof of Concept
Muscle Injury	Adult Stem Cell	Personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Skeletal/Smooth Muscle disorders	Embryonic Stem Cell, iPS Cell	Exosomes based therapy	Stanford	Development Candidate, Proof of Concept
Sarcoma	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell	Gene-modified, donor cell therapy	Salk	Development Candidate, Proof of Concept
Breast Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	Cytonus Therapeutics, Inc.	Development Candidate, Proof of Concept
Other	Adult Stem Cell	Protein/peptide therapy	Intact Therapeutics, Inc.	Development Candidate, Proof of Concept
Immune Disease, Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 2
IPEX Syndrome	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Wounds, ulcers		Small molecule therapy	UCLA	IND
Solid Tumors	Adult Stem Cell	Personalized cell therapy	BioEclipse Therapeutics INC.	Clinical Trial, Phase 1 or Phase 1/2
Retinitis Pigmentosa	Somatic Cell	Gene Therapy, cell free	Ray Therapeutics, INC	Pre-IND/IDE or Equivalent
Hypertension, pulmonary arterial	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Prostate Cancer		Gene-modified, personalized cell therapy	USC	Pre-IND/IDE or Equivalent
Kidney Failure	Adult Stem Cell	Device	UC Davis	Pre-IND/IDE or Equivalent
Muscle Injury	Adult Stem Cell	Personalized cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Epilepsy	Embryonic Stem Cell	Donor cell therapy	Neurona Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
			Tenaya Therapeutics, Inc.
			Stanford
			UCLA
Blood Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Development Candidate, Proof of Concept
			UC Davis
			Scripps
Intestinal Disease	iPS Cell	Exploring disease mechanisms	Cedars-Sinai	Proof of Concept, Tool/Resources/Bottleneck
			UCSD
			UCLA
Alzheimer's Disease, Parkinson's Disease	iPS Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
–– Hypertension, pulmonary arterial
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
– Sanfilippo Syndrome/MPS III
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscle Injury
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
– Wounds, ulcers
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering