Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Autism	iPS Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Hearing Loss	iPS Cell	Model system development	USC	Proof of Concept, Tool/Resources/Bottleneck
Hearing Loss	Adult Stem Cell	Protein/peptide therapy	Stanford	Development Candidate, Proof of Concept
HIV/AIDS		Personalized cell therapy	COH	IND
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Age-related macular degeneration	iPS Cell	Personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Age-related macular degeneration	Adult Stem Cell	Donor cell therapy	Stanford	Pre-IND/IDE or Equivalent
Blood Cancer	Adult Stem Cell	Donor cell therapy	Angiocrine	Clinical Trial, Phase 1 or Phase 1/2
Huntington's Disease	Embryonic Stem Cell	Donor cell therapy	UC Irvine	IND
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	IND
Sarcoma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Leukocyte Adhesion Deficiency	Adult Stem Cell	Gene-modified, personalized cell therapy	Rocket Pharmaceuticals, Inc.	Clinical Trial, Phase 1 or Phase 1/2
Parkinson's Disease	iPS Cell	Cell processing & handling	Aspen Neuroscience	Research Insights, Tool/Resources/Bottleneck
Type 1 diabetes	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Cystinosis, Kidney Failure	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer, Breast Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Age-related macular degeneration	Embryonic Stem Cell	Biologic	USC	Pre-IND/IDE or Equivalent
Traumatic Brain Injury	Embryonic Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Spinal Cord Injury	Embryonic Stem Cell	Donor cell therapy	UCSD	Pre-IND/IDE or Equivalent
Brain Injury, hypoxic, ischemic	Adult Stem Cell	Donor cell therapy	Sanford-Burnham	Pre-IND/IDE or Equivalent
IPEX Syndrome, Immune Disease	Vital Research Opportunity	Gene Therapy, cell free	Stanford	IND
Retinitis Pigmentosa		Therapeutic Approach	jCyte	Clinical Trial, Phase 2
Retinitis Pigmentosa	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Corneal Damage	Adult Stem Cell	Personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Parkinson's Disease	Vital Research Opportunity	Gene Therapy, cell free	Brain Neurotherapy Bio	Clinical Trial, Phase 1 or Phase 1/2
Hyper IgM Syndrome, Immune Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Ovarian Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Pre-IND/IDE or Equivalent
Multiple Myeloma	Adult Stem Cell	Personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Epilepsy	Embryonic Stem Cell	Donor cell therapy	Neurona Therapeutics	Pre-IND/IDE or Equivalent
Colon Cancer	Cancer Stem Cell	Small molecule therapy	UCSD	Development Candidate, Proof of Concept
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
	Embryonic Stem Cell	Cell processing & handling	Stanford	Research Insights
COVID-19, Respiratory Disorders	iPS Cell	Small molecule therapy	UCLA	Development Candidate, Proof of Concept
COVID-19, Respiratory Disorders	Adult Stem Cell	Model system development	UCLA	Development Candidate, Proof of Concept, Tool/Resources/Bottleneck
COVID-19, Respiratory Disorders	Vital Research Opportunity	Convalescent Plasma	COH	Clinical Trial, Phase 1 or Phase 1/2
COVID-19	iPS Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
COVID-19	iPS Cell	Small molecule therapy	USC	Development Candidate, Proof of Concept
COVID-19	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 2
Sickle Cell Disease	Adult Stem Cell	Donor cell therapy	ExCellThera Inc.	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders, Immune Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Proof of Concept
COVID-19	Adult Stem Cell	Small molecule therapy	Stanford	Development Candidate, Proof of Concept
COVID-19	Adult Stem Cell	Vaccine	Stanford	Development Candidate, Proof of Concept
COVID-19	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Development Candidate, Proof of Concept
COVID-19	Adult Stem Cell	Vaccine	UCLA	Development Candidate, Proof of Concept
COVID-19	Adult Stem Cell	Small molecule therapy	UCLA	Pre-IND/IDE or Equivalent
COVID-19, Respiratory Disorders	Adult Stem Cell	Donor cell therapy	Celularity Inc	Clinical Trial, Phase 1 or Phase 1/2
COVID-19, Respiratory Disorders	iPS Cell	Gene-modified, donor cell therapy	USC	Development Candidate, Proof of Concept
COVID-19, Respiratory Disorders	iPS Cell	Small molecule therapy	Sanford-Burnham	Development Candidate, Proof of Concept
COVID-19	iPS Cell	Cell delivery or targeting	UCSD	Tool/Resources/Bottleneck

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering