Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Leukemia	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Beta Thalassemia	Adult Stem Cell	Gene-modified, personalized cell therapy	Sangamo	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	Orchard Therapeutics	Clinical Trial, Phase 2
Lung Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Bladder or Urinary Tract Disorder, Incontinence	iPS Cell	Personalized cell therapy	Stanford	Pre-IND/IDE or Equivalent
Retinitis Pigmentosa	Embryonic Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Beta Thalassemia, Sickle Cell Disease	Adult Stem Cell	Diagnostic Test	CHORI	Regulated Lab Test, Ready for Validation
Parkinson's Disease	Adult Stem Cell	Gene-modified, donor cell therapy	UCSF	IND
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	IND
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Ovarian Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Development Candidate, Proof of Concept
Thymic Disorder, 22q11 Deletion/DiGeorge	Embryonic Stem Cell, iPS Cell	Donor cell therapy	Stanford	Development Candidate, Proof of Concept
Heart Disease, Danon Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Development Candidate, Proof of Concept
Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	UCLA	Development Candidate, Proof of Concept
Dementia	iPS Cell	Donor cell therapy	Gladstone	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell	Gene-modified, donor cell therapy	Salk	Development Candidate, Proof of Concept
Vision Loss	iPS Cell	Small molecule therapy	UCSD	Development Candidate, Proof of Concept
Liver Disease	iPS Cell	Gene-modified, donor cell therapy	CHLA	Development Candidate, Proof of Concept
Autism	iPS Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Bladder or Urinary Tract Disorder, Solid Tumors	Embryonic Stem Cell	Donor cell therapy	Stanford	Development Candidate, Proof of Concept
Hearing Loss	iPS Cell	Model system development	USC	Proof of Concept, Tool/Resources/Bottleneck
Hearing Loss	Adult Stem Cell	Protein/peptide therapy	Stanford	Development Candidate, Proof of Concept
HIV/AIDS		Personalized cell therapy	COH	IND
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Age-related macular degeneration	iPS Cell	Personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Age-related macular degeneration	Adult Stem Cell	Donor cell therapy	Stanford	Pre-IND/IDE or Equivalent
Spina Bifida	Adult Stem Cell	Donor cell therapy	UC Davis	IND
Blood Cancer	Adult Stem Cell	Donor cell therapy	Angiocrine	Clinical Trial, Phase 1 or Phase 1/2
Huntington's Disease	Embryonic Stem Cell	Donor cell therapy	UC Irvine	IND
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Antibody	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Intervertebral disc degeneration	Adult Stem Cell	Personalized cell therapy	Ankasa	IND
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	IND
Sarcoma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Leukocyte Adhesion Deficiency	Adult Stem Cell	Gene-modified, personalized cell therapy	Rocket Pharmaceuticals, Inc.	Clinical Trial, Phase 1 or Phase 1/2
Parkinson's Disease	iPS Cell	Cell processing & handling	Aspen Neuroscience	Research Insights, Tool/Resources/Bottleneck
Type 1 diabetes	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Cystinosis, Kidney Failure	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer, Breast Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Age-related macular degeneration	Embryonic Stem Cell	Biologic	USC	Pre-IND/IDE or Equivalent
Traumatic Brain Injury	Embryonic Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Spinal Cord Injury	Embryonic Stem Cell	Donor cell therapy	UCSD	Pre-IND/IDE or Equivalent
Brain Injury, hypoxic, ischemic	Adult Stem Cell	Donor cell therapy	Sanford-Burnham	Pre-IND/IDE or Equivalent
IPEX Syndrome, Immune Disease	Vital Research Opportunity	Gene Therapy, cell free	Stanford	IND
Retinitis Pigmentosa		Donor cell therapy	jCyte	Clinical Trial, Phase 2
Retinitis Pigmentosa	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Corneal Damage	Adult Stem Cell	Personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Parkinson's Disease	Vital Research Opportunity	Gene Therapy, cell free	Brain Neurotherapy Bio	Clinical Trial, Phase 1 or Phase 1/2
Hyper IgM Syndrome, Immune Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
– Liver Disease
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering