Dr. Wu and his team at Stanford University will use hESCs to generate cardiomyocytes (CM), a type of cell that makes up the heart muscle. The newly created hESC-CMs will then be administered to patients at the site of the […]
Osteoarthritis (OA) is a common and burdensome condition affecting millions of people. Injuries to the joint’s surface can increase the risk of OA. Current treatments for cartilage repair are only moderately effective and often result in the replacement of damaged […]
Research Objective The expected outcome of these studies is a cellular therapeutic for Type I Diabetes: engineered human islets for transplant into patients, surpassing the function of beta cells or progenitors alone. Impact The proposed studies would address key bottlenecks […]
Research Objective The proposed studies will determine the optimal approaches to differentiate and transplant stem cell-derived corneal endothelial cells. Impact These data will provide foundational proof-of-concept data that will allow the rapid advance of a cell therapy towards clinical application. […]
Translational Candidate H9 (WA09) embryonic stem cell-derived neural stem cells with a spinal cord identity (H9-NSCsc) Area of Impact Severe spinal cord injury Mechanism of Action Our candidate therapy for SCI uses human neural stem cells in a gel-like matrix […]
Retinal degenerative (RD) diseases that target photoreceptors and/or the adjacent retinal pigment epithelium (RPE) affect millions of people. For those suffering from currently incurable RD diseases such as age-related macular degeneration and retinitis pigmentosa, stem cell-based therapy is being pursued […]
Translational Candidate Human embryonic stem cell (hESC)-derived natural killer (NK) cells to target relapsed/refractory Acute Myelogenous Leukemia (AML) Area of Impact hESC-derived NK cells provide a novel and potent approach to treat relapsed or refractory AML that is resistant to […]
Translational Candidate Spinal cord injections of human embryonic stem cell (hESC)-derived allogeneic neural stem cells (heNSCs) for treatment of ALS Area of Impact Treatment of Amyotrophic Lateral Sclerosis (ALS) Mechanism of Action Although the exact molecular mechanism of action is […]
Stem cell-based cardiac tissue generation has become a powerful tool to enhance our understanding of heart development and test novel therapeutics for cardiovascular diseases. However, the transitional stages from pluripotent cells to committed cardiomyocytes has not yet been fully characterized. […]
Therapeutic Candidate or Device The therapeutic candidate is human embryonic stem cell-derived cardiomyocytes (hESC-CMs) as a new therapy for chronic ischemic cardiomyopathy patients Indication hESC-CMs will be indicated for treatment of heart failure (HF) and for preventing progression to HF […]
