Publications by CIRM grantees

The following list of publications describe research carried out with CIRM funding. Click on the publication title for a brief summary of the research and for more information about the CIRM grants that contributed to the research.

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Year Journal
In Utero Treatment of Myelomeningocele with Placental Mesenchymal Stromal Cells - Selection of an Optimal Cell Line in Preparation for Clinical Trials. 2019 J Pediatr Surg
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. 2019 Nature
Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution. 2019 Cell
Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas. 2019 Sci Rep
Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. 2019 Cell Res
Circulating tumor cells exhibit metastatic tropism and reveal brain metastasis drivers. 2019 Cancer Discov
An Improved Two-Step Protocol for Trophoblast Differentiation of Human Pluripotent Stem Cells. 2019 Curr Protoc Stem Cell Biol
Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro. 2019 Invest Ophthalmol Vis Sci
Diagnostic criteria for limbal stem cell deficiency before surgical intervention-A systematic literature review and analysis. 2019 Surv Ophthalmol
Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA. 2019 Stem Cells Transl Med
Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro. 2019 Sci Rep
Human induced pluripotent stem cell line with genetically encoded fluorescent voltage indicator generated via CRISPR for action potential assessment post-cardiogenesis. 2019 Stem Cells
Classification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading. 2019 Cornea
The application of human amniotic membrane in the surgical management of limbal stem cell deficiency. 2019 Ocul Surf
Comparison of endothelial keratoplasty techniques in patients with prior glaucoma surgery - a case-matched study. 2019 Am J Ophthalmol
Chronic myelogenous leukemia stem cells require cell-autonomous pleiotrophin signaling. 2019 J Clin Invest
PTPsigma inhibitors promote hematopoietic stem cell regeneration. 2019 Nat Commun
Phenotypic Variation Between Stromal Cells Differentially Impacts Engineered Cardiac Tissue Function. 2019 Tissue Eng Part A
Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. 2019 J Gen Physiol
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. 2019 Neuron
Fiber-based platform for synchronous imaging of endogenous and exogenous fluorescence of biological tissue. 2019 Opt Lett
Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development. 2019 Cell Stem Cell
Transposable Elements, Inflammation, and Neurological Disease. 2019 Front Neurol
Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders. 2019 Physiology (Bethesda)
Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice. 2019 Blood
Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice. 2019 Blood
Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. 2019 Nat Commun
Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes. 2019 ACS Nano
Paramagnetic Fluorinated Nanoemulsions for in vivo F-19 MRI. 2019 Mol Imaging Biol
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-beta in iPSC-Derived Alzheimer's Disease Neurons. 2019 Cell Stem Cell
Brain organoids as a model system for human neurodevelopment and disease. 2019 Semin Cell Dev Biol
Effect of inoculum density on human-induced pluripotent stem cell expansion in 3D bioreactors. 2019 Cell Prolif
Online measurement of oxygen enables continuous noninvasive evaluation of human-induced pluripotent stem cell (hiPSC) culture in a perfused 3D hollow-fiber bioreactor. 2019 J Tissue Eng Regen Med
Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells. 2019 EBioMedicine
Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts. 2019 Toxicol Sci
CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. 2019 Science
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. 2019 Nature
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation. 2019 Elife
Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele. 2019 Fetal Diagn Ther
Cardiac fibrosis: potential therapeutic targets. 2019 Transl Res
Harnessing the versatility of PLGA nanoparticles for targeted Cre-mediated recombination. 2019 Nanomedicine
Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer. 2019 Mol Ther Oncolytics
Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. 2019 Nat Commun
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. 2019 Sci Rep
Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination. 2019 Cell Stem Cell
Single-cell genomics identifies cell type-specific molecular changes in autism. 2019 Science
Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1. 2019 N Engl J Med
T cell antigen discovery via trogocytosis. 2019 Nat Methods
Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. 2019 Am J Cancer Res
LRRK2 modifies alpha-syn pathology and spread in mouse models and human neurons. 2019 Acta Neuropathol

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