Publications by CIRM grantees

The following list of publications describe research carried out with CIRM funding. Click on the publication title for a brief summary of the research and for more information about the CIRM grants that contributed to the research.

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Year Journal
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-beta in iPSC-Derived Alzheimer's Disease Neurons. 2019 Cell Stem Cell
Brain organoids as a model system for human neurodevelopment and disease. 2019 Semin Cell Dev Biol
Effect of inoculum density on human-induced pluripotent stem cell expansion in 3D bioreactors. 2019 Cell Prolif
Online measurement of oxygen enables continuous noninvasive evaluation of human-induced pluripotent stem cell (hiPSC) culture in a perfused 3D hollow-fiber bioreactor. 2019 J Tissue Eng Regen Med
Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells. 2019 EBioMedicine
Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts. 2019 Toxicol Sci
CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. 2019 Science
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. 2019 Nature
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation. 2019 Elife
Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele. 2019 Fetal Diagn Ther
Cardiac fibrosis: potential therapeutic targets. 2019 Transl Res
Harnessing the versatility of PLGA nanoparticles for targeted Cre-mediated recombination. 2019 Nanomedicine
Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer. 2019 Mol Ther Oncolytics
Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. 2019 Nat Commun
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. 2019 Sci Rep
Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination. 2019 Cell Stem Cell
Single-cell genomics identifies cell type-specific molecular changes in autism. 2019 Science
Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1. 2019 N Engl J Med
T cell antigen discovery via trogocytosis. 2019 Nat Methods
Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. 2019 Am J Cancer Res
LRRK2 modifies alpha-syn pathology and spread in mouse models and human neurons. 2019 Acta Neuropathol
The role of cellular interactions in the induction of hepatocyte polarity and functional maturation in stem cell-derived hepatic cells. 2019 Differentiation
Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. 2019 Cancers (Basel)
Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. 2019 PLoS One
CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFbeta and BMP through SMAD signaling. 2019 Osteoarthritis Cartilage
Video-based kinetic analysis of calcification in live osteogenic human embryonic stem cell cultures reveals the developmentally toxic effect of Snus tobacco extract. 2019 Toxicol Appl Pharmacol
Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. 2019 Nat Biotechnol
TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. 2019 Cell Stem Cell
Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. 2019 Cell Rep
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. 2019 Elife
Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes. 2019 FASEB J
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors. 2019 Nat Methods
Development of innate immune cells from human pluripotent stem cells. 2019 Exp Hematol
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells. 2019 Semin Immunopathol
Cardiac and skeletal muscle effects in the randomized HOPE-Duchenne trial. 2019 Neurology
Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells. 2019 Methods Mol Biol
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment. 2019 Cell
Atoh1(+) secretory progenitors possess renewal capacity independent of Lgr5(+) cells during colonic regeneration. 2019 EMBO J
The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism. 2018 Mol Autism
Endothelin receptor emerges as a potential target of Hoxa9-mediated leukemogenesis. 2018 Leuk Res
Imaging dynamic and selective low-complexity domain interactions that control gene transcription. 2018 Science
A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes. 2018 Elife
RNA polymerase II clustering through carboxy-terminal domain phase separation. 2018 Nat Struct Mol Biol
Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos. 2018 Elife
Inflammatory Cytokine TNFalpha Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. 2018 Cell
Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC. 2018 Fluids Barriers CNS
Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy. 2018 Stem Cells Int
KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development. 2018 Nat Commun
Programmed cell removal by calreticulin in tissue homeostasis and cancer. 2018 Nat Commun
Autologous Induced Pluripotent Stem Cell-Derived Neurons to Treat Parkinson's Disease. 2018 Stem Cells Dev

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