Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Myelin organoids for the study of Alzheimer’s disease. 2023 Front Neurosci
Neonatal Cardiovascular-Progenitor-Cell-Derived Extracellular Vesicles Activate YAP1 in Adult Cardiac Progenitor Cells. 2023 Int J Mol Sci
Neurons require glucose uptake and glycolysis in vivo. 2023 Cell Rep
Ocular Surface Regeneration by Limbal Stem Cells Therapies: State of the Art, Challenges, and Perspectives. 2023 Stem Cells Transl Med
OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis. 2023 Proc Natl Acad Sci U S A
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism. 2023 Cell Metab
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. 2023 Nature
Patient-derived SLC6A1 variant S295L results in an epileptic phenotype similar to haploinsufficient mice. 2023 Epilepsia
Personalized antisense oligonucleotides ‘for free, for life’ – the n-Lorem Foundation. 2023 Nat Med
Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2. 2023 bioRxiv
Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition. 2023 bioRxiv
Preferential FGF18/FGFR activity in pseudoglandular versus canalicular stage human lung fibroblasts. 2023 Front Cell Dev Biol
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis. 2023 Nat Genet
Present and Future Modeling of Human Psychiatric Connectopathies With Brain Organoids. 2023 Biol Psychiatry
Presentation of Human Neural Stem Cell Antigens Drives Regulatory T Cell Induction. 2023 J Immunol
Profiling of repetitive RNA sequences in the blood plasma of patients with cancer. 2023 Nat Biomed Eng
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design. 2023 iScience
Programmable Bio-Ionic Liquid Functionalized Hydrogels for in Situ 3D Bioprinting of Electronics at the Tissue Interface 2023 Materials Today Advances
Protein-encapsulated doxorubicin reduces cardiotoxicity in hiPSC-cardiomyocytes and cardiac spheroids while maintaining anticancer efficacy. 2023 Stem Cell Reports
Protocol for the isolation of mouse muscle stem cells using fluorescence-activated cell sorting. 2023 STAR Protoc
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice. 2023 Cell Mol Gastroenterol Hepatol
PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection. 2023 JCI Insight
Purification and functional characterization of novel human skeletal stem cell lineages. 2023 Nat Protoc
Pushing the boundaries of brain organoids to study Alzheimer’s disease. 2023 Trends Mol Med
Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells. 2023 Nat Cell Biol
Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors. 2023 Hum Mol Genet
RNA editing: Expanding the potential of RNA therapeutics. 2023 Mol Ther
RNA Modifications in Cancer Stem Cell Biology. 2023 Cancer Treat Res
RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. 2023 Blood
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. 2023 Nat Commun
Signalling by senescent melanocytes hyperactivates hair growth. 2023 Nature
Simultaneous multi-site editing of individual genomes using retron arrays. 2023 bioRxiv
Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes. 2023 Nat Cardiovasc Res
Single mRNA detection of Wnt signaling pathway in the human limbus. 2023 Exp Eye Res
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance. 2023 Sci Adv
Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. 2023 iScience
SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs. 2023 Development
Sonogenetic control of multiplexed genome regulation and base editing. 2023 Nat Commun
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus. 2023 Nat Biomed Eng
Stem Cell-Based Organoid Models of Neurodevelopmental Disorders. 2023 Biol Psychiatry
Stereochemical Control of Splice Modulation in FD-895 Analogues. 2023 J Med Chem
Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells. 2023 Cell Rep
Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. 2023 Elife
Sustained postconfluent culture of human mammary epithelial cells enriches for luminal and c-Kit+ subtypes. 2023 Breast Cancer Res
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. 2023 bioRxiv
T-allo10 Infusion after αβ depleted-HSCT in Children and Young Adults with Hematologic Malignancies: Improved Immune Reconstitution in the Absence of Severe GvHD 2023 Transplantation and Cellular Therapy
Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation. 2023 Anal Chem
Targeting the ADPKD methylome using nanoparticle-mediated combination therapy. 2023 APL Bioeng
Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets. 2023 Neurobiol Dis
The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain. 2023 Cell Rep