Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling. 2026 Dev Cell
Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy. 2026 J Clin Invest
Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model. 2026 Mol Ther
Single-Cell Analysis Reveals Peripheral Helper T Cells in Rheumatoid Arthritis-Related Interstitial Lung Disease. 2026 Arthritis Rheumatol
Single-Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm. 2026 Mol Cell Proteomics
Single-cell transcriptomics-informed induced pluripotent stem cells differentiation to tenogenic lineage. 2026 Elife
Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors. 2026 Signal Transduct Target Ther
Substituted cysteine accessibility method (SCAM) in membrane transporters studies: Learn from lactose permease. 2026 Biochimie
Surviving the Nucleus Pulposus Desert: Next-Generation Strategies for Intervertebral Disc Cell Therapy. 2026 JOR Spine
Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis. 2026 bioRxiv
Targeting peptide homes to spinal cord injury in a rat model. 2026 J Trauma Acute Care Surg
Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice. 2026 Mol Neurodegener
Virus-like particles based on plant viruses and bacteriophages: emerging strategies for the delivery of nucleic acid therapeutics. 2026 Chem Sci
Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease. 2026 Cell
Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy. 2026 Front Immunol
[(18)F]FDG-PET and [(18)F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation. 2025 Sci Rep
A Comparison of in vivo Tumor-Homing Abilities of Placental-Derived and Bone Marrow-Derived Mesenchymal Stromal Cells in High-Risk Neuroblastoma. 2025 J Pediatr Surg
A human-specific regulatory mechanism revealed in a pre-implantation model. 2025 Nature
A Living Organoid Biobank of Crohn’s Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes. 2025 medRxiv
A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity. 2025 Bioact Mater
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders. 2025 Cell Stem Cell
A Rare Hematopoietic Stem Cell-Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging. 2025 Aging Cell
A simple approach of nuclei isolation for single nucleus multiome sequencing. 2025 J Mol Cell Cardiol
A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues. 2025 Nat Immunol
A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity. 2025 Haematologica
Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence. 2025 Nat Commun
Aberrant S-nitrosylation in the TCA cycle contributes to mitochondrial dysfunction, energy compromise, and synapse loss in neurodegenerative diseases. 2025 Neurotherapeutics
Accelerated 3D qCEST of the Spine in a Porcine Model Using MR Multitasking at 3T. 2025 NMR Biomed
Accelerated Tempo of Cortical Neurogenesis in Down Syndrome. 2025 bioRxiv
Acholinebio-ionicliquid-functionalized gelatin methacryloyl hydrogel for chronic wound healing 2025 European Polymer Journal
Active telomere elongation by a subclass of cancer-associated POT1 mutations. 2025 Genes Dev
Adipose tissue ageing: implications for metabolic health and lifespan. 2025 Nat Rev Endocrinol
ADMET-AI Enables Interpretable Predictions of Drug-Induced Cardiotoxicity. 2025 Circulation
Advances in carbon nanomaterials and their polymeric composites in neural tissue engineering. 2025 Adv Drug Deliv Rev
Affinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies. 2025 J Immunother Cancer
Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies. 2025 Nat Commun
Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLE. 2025 Sci Rep
An infusible extracellular matrix biomaterial improves survival in a model of severe systemic inflammation. 2025 NPJ Regen Med
An SSTR2-somatostatin chemotactic axis drives T cell progenitor homing to the intestines. 2025 Nat Immunol
Anatomical and molecular insights into avian inner ear sensory hair cell regeneration. 2025 Dev Biol
Androgenetic alopecia. 2025 Nat Rev Dis Primers
Astroglia’s role in synchronized spontaneous neuronal activity: from physiology to pathology. 2025 Front Cell Neurosci
Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury. 2025 Sci Transl Med
Axial nephron fate switching demonstrates a plastic system tunable on demand. 2025 Nat Commun
Bilateral carotid-jugular arteriovenous graft implantation in an ovine model is safe and durable for facilitation of arteriovenous graft innovation. 2025 Animal Model Exp Med
Biological tendon regeneration, are we almost there or is it still a stretch? 2025 Regen Med
CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentation. 2025 Nat Commun
CDDO-Imidazole regulates RBC alloimmunization to the KEL antigen by activating Nrf2. 2025 bioRxiv
Challenging Reward Structures and Organizational Cultures that Propagate Stem Cell Hyperbole. 2025 Stem Cell Rev Rep
Characterizing and controlling CRISPR repair outcomes in nondividing human cells. 2025 Nat Commun