Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
A facilitatory role of astrocytes in axonal regeneration after acute and chronic spinal cord injury. 2024 Exp Neurol
A fibroblast-dependent TGF-beta1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis. 2024 J Clin Invest
A framework for N-of-1 trials of individualized gene-targeted therapies for genetic diseases. 2024 Nat Commun
A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS. 2024 Nature
A maternal brain hormone that builds bone. 2024 Nature
A novel high-titer, bifunctional lentiviral vector for autologous hematopoietic stem cell gene therapy of sickle cell disease. 2024 Mol Ther Methods Clin Dev
A Panoramic View of Cell Population Dynamics in Mammalian Aging. 2024 bioRxiv
A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa. 2024 Nat Commun
A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response. 2024 Proc Natl Acad Sci U S A
Acid-degradable lipid nanoparticles enhance the delivery of mRNA. 2024 Nat Nanotechnol
Activation of ductal progenitor-like cells from adult human pancreas requires extracellular matrix protein signaling. 2024 iScience
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells. 2024 Cell Mol Immunol
AMPK Drives both Glycolytic and Oxidative Metabolism in Murine and Human T Cells During Graft-versus-host Disease. 2024 Blood Adv
An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis. 2024 Cell
An Endothelial Cell Is Not Simply an Endothelial Cell. 2024 Stem Cells Dev
An experimental census of retrons for DNA production and genome editing. 2024 bioRxiv
An improved method for generating human spinal cord neural stem cells. 2024 Exp Neurol
Ancestral Diversity of Skin Reaches Single-Cell Resolution. 2024 J Invest Dermatol
Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal Leukoencephalopathy. 2024 bioRxiv
Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder. 2024 Nat Med
Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment. 2024 Nat Commun
Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic beta-cells. 2024 iScience
CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes. 2024 Nat Commun
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions. 2024 Nat Neurosci
Charting and probing the activity of ADARs in human development and cell-fate specification. 2024 Nat Commun
Chitosan-Polyethylene Glycol Inspired Polyelectrolyte Complex Hydrogel Templates Favoring NEO-Tissue Formation for Cardiac Tissue Engineering. 2024 Gels
Circadian Clock in Muscle Disease Etiology and Therapeutic Potential for Duchenne Muscular Dystrophy. 2024 Int J Mol Sci
Collagen scaffold-seeded iTenocytes accelerate the healing and functional recovery of Achilles tendon defects in a rat model. 2024 Front Bioeng Biotechnol
Comparing fabrication techniques for engineered cardiac tissue. 2024 J Biomed Mater Res A
Conductive Microgel Annealed Scaffolds Enhance Myogenic Potential of Myoblastic Cells. 2024 Adv Healthc Mater
Conserved and divergent features of trophoblast stem cells. 2024 J Mol Endocrinol
Continuous multiplexed phage genome editing using recombitrons. 2024 Nat Biotechnol
CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity. 2024 Cell Stem Cell
Custom-engineered hydrogels for delivery of human iPSC-derived neurons into the injured cervical spinal cord. 2024 Biomaterials
Decellularized Extracellular Matrix Improves Mesenchymal Stromal Cell Spheroid Response to Chondrogenic Stimuli. 2024 Tissue Eng Part A
Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma. 2024 Sci Adv
Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease. 2024 Sci Rep
Development of neuronal timescales in human cortical organoids and rat hippocampus dissociated cultures. 2024 J Neurophysiol
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity. 2024 Diabetologia
Directed Differentiation of Neurons from Human iPSCs for Modeling Neurological Disorders. 2024 Methods Mol Biol
Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation. 2024 Elife
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme. 2024 Cell
Does vaping increase the likelihood of SARS-CoV-2 infection? Paradoxically yes and no. 2024 Am J Physiol Lung Cell Mol Physiol
Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin. 2024 Sci Adv
Effects of amyloid-beta-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype. 2024 Acta Biomater
Electroacupuncture may protect pulmonary dysplasia in offspring with perinatal nicotine exposure by altering maternal gut microbiota and metabolites. 2024 Front Microbiol
Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds. 2024 Adv Mater
Engineering allorejection-resistant CAR-NKT cells from hematopoietic stem cells for off-the-shelf cancer immunotherapy. 2024 Mol Ther
Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. 2024 Nat Commun
EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin Inhibitory Synapse Development. 2024 J Neurosci