Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Microfluidic capillary transit velocity as a functional measure for sickle cell disease and in vitro-derived red blood cells. 2026 Lab Chip
Neural stem cell delivery of oncolytic CRAd-S-pk7 immunotherapy for stage 3 ovarian cancer: Dose-regimen studies. 2026 Mol Ther Oncol
Neuroepithelial regulation across development, regeneration, aging, and sex. 2026 Semin Cell Dev Biol
Oligonucleotide Synthesis Errors Are a Source of Untoward Variation in HDR-Mediated Gene Editing. 2026 Genes (Basel)
On the interpretation of astrocytic calcium signalling with graphene oxide electrodes. 2026 Nat Nanotechnol
Oxidative stress-regulatory role of miR-10b-5p in the diabetic human cornea revealed through integrated multi-omics analysis. 2026 Diabetologia
Patterning human kidney organoids with synthetic Wnt-secreting organizers. 2026 Science
Precision therapeutics for early onset epilepsy: Allele-selective antisense oligonucleotides for SCN2A-related epilepsy. 2026 Mol Ther Nucleic Acids
Probing neuropsychiatric disorders through in vivo CRISPR screening. 2026 Curr Opin Genet Dev
Protocol for inducing dorsal spinal sensory interneurons from mouse embryonic stem cell-derived neuromesodermal progenitors. 2026 STAR Protoc
Pyridoxine supplementation amelioratesSGPL1 R222Q variant sphingosine phosphate lyase insufficiency syndrome in mice. 2026 J Clin Invest
Pyridoxine supplementation confers protection against SGPL1 (R222Q) variant sphingosine phosphate lyase insufficiency syndrome. 2026 bioRxiv
RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization. 2026 J Leukoc Biol
Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling. 2026 Dev Cell
Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy. 2026 J Clin Invest
Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model. 2026 Mol Ther
Signal triangulation coordinates cell fate decisions in the developing jaw. 2026 bioRxiv
Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis. 2026 bioRxiv
Single-Cell Analysis Reveals Peripheral Helper T Cells in Rheumatoid Arthritis-Related Interstitial Lung Disease. 2026 Arthritis Rheumatol
Single-Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm. 2026 Mol Cell Proteomics
Single-cell transcriptomics-informed induced pluripotent stem cells differentiation to tenogenic lineage. 2026 Elife
Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors. 2026 Signal Transduct Target Ther
Substituted cysteine accessibility method (SCAM) in membrane transporters studies: Learn from lactose permease. 2026 Biochimie
Surviving the Nucleus Pulposus Desert: Next-Generation Strategies for Intervertebral Disc Cell Therapy. 2026 JOR Spine
Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis. 2026 bioRxiv
Targeting peptide homes to spinal cord injury in a rat model. 2026 J Trauma Acute Care Surg
Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice. 2026 Mol Neurodegener
Virus-like particles based on plant viruses and bacteriophages: emerging strategies for the delivery of nucleic acid therapeutics. 2026 Chem Sci
Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease. 2026 Cell
Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy. 2026 Front Immunol
[(18)F]FDG-PET and [(18)F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation. 2025 Sci Rep
A Comparison of in vivo Tumor-Homing Abilities of Placental-Derived and Bone Marrow-Derived Mesenchymal Stromal Cells in High-Risk Neuroblastoma. 2025 J Pediatr Surg
A human-specific regulatory mechanism revealed in a pre-implantation model. 2025 Nature
A Living Organoid Biobank of Crohn’s Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes. 2025 medRxiv
A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity. 2025 Bioact Mater
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders. 2025 Cell Stem Cell
A Rare Hematopoietic Stem Cell-Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging. 2025 Aging Cell
A simple approach of nuclei isolation for single nucleus multiome sequencing. 2025 J Mol Cell Cardiol
A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues. 2025 Nat Immunol
A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity. 2025 Haematologica
Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence. 2025 Nat Commun
Aberrant S-nitrosylation in the TCA cycle contributes to mitochondrial dysfunction, energy compromise, and synapse loss in neurodegenerative diseases. 2025 Neurotherapeutics
Accelerated 3D qCEST of the Spine in a Porcine Model Using MR Multitasking at 3T. 2025 NMR Biomed
Accelerated Tempo of Cortical Neurogenesis in Down Syndrome. 2025 bioRxiv
Acholinebio-ionicliquid-functionalized gelatin methacryloyl hydrogel for chronic wound healing 2025 European Polymer Journal
Active telomere elongation by a subclass of cancer-associated POT1 mutations. 2025 Genes Dev
Adipose tissue ageing: implications for metabolic health and lifespan. 2025 Nat Rev Endocrinol
ADMET-AI Enables Interpretable Predictions of Drug-Induced Cardiotoxicity. 2025 Circulation
Advances in carbon nanomaterials and their polymeric composites in neural tissue engineering. 2025 Adv Drug Deliv Rev
Affinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies. 2025 J Immunother Cancer