Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK. 2025 Mol Metab
Limbal epithelial cells detected in stage III limbal stem cell deficiency by multimodal anterior segment imaging. 2025 Am J Ophthalmol
Lineage tracing of both quiescent G0 and active Hoxb5+ LT-HSCs that actively contribute to homeostatic mouse hematopoiesis. 2025 Proc Natl Acad Sci U S A
Lineage-resolved atlas of the developing human cortex. 2025 Nature
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment. 2025 Aging Cell
Long noncoding RNA BCYRN1 promotes cardioprotection by enhancing human and murine regulatory T cell dynamics. 2025 J Clin Invest
Long-term preservation of muscle function and structure by repeated administration of cardiosphere-derived cells in mdx mice. 2025 Stem Cell Reports
Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency. 2025 N Engl J Med
Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction. 2025 bioRxiv
Measurement and clinical interpretation of CRISPR off-targets. 2025 Nat Genet
MeCP2 regulates telencephalic development in human cerebral organoids. 2025 Cell Rep
Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis. 2025 Neuro Oncol
Menthol, a consumer product additive, adversely affects human embryonic stem cells via activation of TRPM8 and TRPA1 channels. 2025 Stem Cells Transl Med
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1. 2025 Nature
Microgliopathy as a primary mediator of neuronal death in models of Friedreich’s Ataxia. 2025 Nat Commun
Micropatterning Photoconductive Peptide Assemblies on Stiff and Soft Biomaterial Substrates. 2025 ACS Appl Mater Interfaces
Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury. 2025 Brain Behav Immun
MitoScribe single-cell molecular recorder logs graded signaling dynamics into mitochondrial DNA. 2025 bioRxiv
Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells. 2025 Stem Cell Reports
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. 2025 Stem Cell Reports
Molecular Signatures in Cortical Development. 2025 Annu Rev Neurosci
Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology. 2025 bioRxiv
Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis. 2025 Nat Commun
Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures. 2025 bioRxiv
MYOD represses gene expression from non-E-box motifs. 2025 Genes Dev
Neonatally-derived multipotent Islet-1+ Mesp1+FOXA2+ stem cell clones restore cardiac function in sheep. 2025 Front Cardiovasc Med
Neuroendocrinology and the Genetics of Obesity. 2025 Endocrinology
Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics. 2025 Nat Commun
Nuclear receptor 4A1 is critical for neutrophil-dependent pulmonary immunity to Klebsiella pneumoniae infection. 2025 Front Immunol
On the Feasibility of SERS-Based Monitoring of Drug Loading Efficiency in Exosomes for Targeted Delivery. 2025 Biosensors (Basel)
Opposing roles of p38alpha-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. 2025 Cell Rep
Oral Bioavailability of a Noncoding RNA Drug, TY1, That Acts on Macrophages. 2025 J Extracell Biol
Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells. 2025 Med
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells. 2025 Nat Commun
p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2(+) breast cancer that limits trastuzumab deruxtecan efficacy. 2025 Nat Cancer
Paracrine effect of human stem cell-derived progenitor cells on remodeling of the vagina. 2025 NPJ Regen Med
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells. 2025 Nat Protoc
Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers. 2025 bioRxiv
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling. 2025 bioRxiv
Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading. 2025 Nucleic Acids Res
Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models. 2025 Sci Transl Med
Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1. 2025 Stem Cell Reports
Process of radical resection for advanced buccal cancer and the ‘sandwich’ technique for craniomaxillofacial defect repair using an anterolateral thigh chimeric myocutaneous flap. 2025 J Craniomaxillofac Surg
Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids. 2025 RSC Adv
Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects. 2025 J Hematol Oncol
Proteome-wide profiling of S-nitrosylated proteins using the SNOTRAP probe and mass spectrometry-based detection. 2025 Nat Protoc
Protocol for deep-learning-driven cell type label transfer in single-cell RNA sequencing data. 2025 STAR Protoc
Protocol for live-cell calcium imaging of human lung microvascular endothelial vessel-on-a-chip model. 2025 STAR Protoc
Protocol for the isolation and characterization of mouse alveolar bone marrow hematopoietic stem cells. 2025 STAR Protoc
Protocol for vibratome sectioning, immunofluorescence, and S-phase labeling of inner ear organoids. 2025 STAR Protoc