Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer. 2024 Cell Stem Cell
Human cerebellar organoids with functional Purkinje cells. 2024 Cell Stem Cell
Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques. 2024 bioRxiv
Implantation of autologous induced pluripotent stem cell-derived islets provides long-term insulin independence in a patient with type 1 diabetes. 2024 Am J Transplant
Implementation of Well-Being for Cardiothoracic Surgeons. 2024 Thorac Surg Clin
Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet. 2024 bioRxiv
Increased mitochondrial mutation heteroplasmy induces aging phenotypes in pluripotent stem cells and their differentiated progeny. 2024 Aging Cell
Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications. 2024 Signal Transduct Target Ther
Inhibition of Pyruvate Oxidation Diminishes Melanoma Progression. 2024 J Invest Dermatol
Integrated Single-Cell Analysis Reveals Spatially and Temporally Dynamic Heterogeneity in Fibroblast States during Wound Healing. 2024 J Invest Dermatol
Integration of Functional Polymers and Biosensors to Enhance Wound Healing. 2024 Adv Healthc Mater
Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses. 2024 bioRxiv
Isolation of Mouse Pancreatic Endothelial Cells. 2024 J Vis Exp
Label-free metabolic optical biomarkers track stem cell fate transition in real time. 2024 Sci Adv
Lentiviral vectors for precise expression to treat X-linked lymphoproliferative disease. 2024 Mol Ther Methods Clin Dev
Locoregional delivery of IL-13Ralpha2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial. 2024 Nat Med
Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility. 2024 Elife
Mechanistic Understanding of Enhancing Bioactivity via Bio-Ionic Liquids Functionalization of Biomaterials 2024 Applied Materials Today
Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism. 2024 Neuron
Microglia protect against age-associated brain pathologies. 2024 Neuron
Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability. 2024 bioRxiv
Molecular profiling of human blastocysts reveals primitive endoderm defects among embryos of decreased implantation potential. 2024 Cell Rep
Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells. 2024 Lab Chip
Nanofiber-microwell cell culture system for spatially patterned differentiation of pluripotent stem cells in 3D. 2024 Mater Today Bio
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling. 2024 Cell Rep
Neutrophil Granulopoiesis Optimized Through Ex Vivo Expansion of Hematopoietic Progenitors in Engineered 3D Gelatin Methacrylate Hydrogels. 2024 Adv Healthc Mater
Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance. 2024 bioRxiv
Non-canonical Wnt pathway expression in the developing mouse and human retina. 2024 Exp Eye Res
Non-invasive prenatal testing of beta-hemoglobinopathies using next generation sequencing, in-silico sequence size selection, and haplotyping. 2024 Croat Med J
Ocular Mucous Membrane Pemphigoid Demonstrates a Distinct Autoantibody Profile from Those of Other Autoimmune Blistering Diseases: A Preliminary Study. 2024 Antibodies (Basel)
Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy. 2024 Sci Adv
Overexpression of AMPKgamma2 increases AMPK signaling to augment human T cell metabolism and function. 2024 J Biol Chem
Pathway to independence: perspectives on the future. 2024 Development
Perinatal nicotine vaping exposure induces pro-myofibroblastic phenotype in rat bone marrow-derived mesenchymal stem cells. 2024 Reprod Toxicol
Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet. 2024 Sci Rep
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation. 2024 Nat Neurosci
Precision proteoform design for 4R tau isoform selective templated aggregation. 2024 Proc Natl Acad Sci U S A
Profiling human brain vascular cells using single-cell transcriptomics and organoids. 2024 Nat Protoc
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain. 2024 Nat Neurosci
Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. 2024 Cell
Recent developments in translational imaging of in vivo gene therapy outcomes. 2024 Mol Ther
Regulation of nuclear transcription by mitochondrial RNA in endothelial cells. 2024 Elife
Respiratory exposure to agricultural dust extract promotes increased intestinal Tnfalpha expression, gut barrier dysfunction, and endotoxemia in mice. 2024 Am J Physiol Gastrointest Liver Physiol
Response to Arbache et al., “Comment on ‘Vulvar lichen sclerosus and vitiligo: Overlap and clinical features'”. 2024 J Am Acad Dermatol
Resuscitative Thoracotomy for Traumatic Cardiac Arrest: Potential Impact of Resource Constraint on Outcomes and Blood Product Utilization. 2024 J Surg Res
Risk Factors for Major Pregnancy Complications in Female Cardiothoracic Surgeons. 2024 Ann Surg
Robust genome and cell engineering via in vitro and in situ circularized RNAs. 2024 Nat Biomed Eng
Role of long noncoding RNAs in diabetes-associated peripheral arterial disease. 2024 Cardiovasc Diabetol
Safeguarding genomic integrity in beta-cells: implications for beta-cell differentiation, growth, and dysfunction. 2024 Biochem Soc Trans
Scaling Insulin-Producing Cells by Multiple Strategies. 2024 Endocrinol Metab (Seoul)