Injectable PLGA Microscaffolds with Laser-Induced Enhanced Microporosity for Nucleus Pulposus Cell Delivery.

Lower back pain is often caused by the breakdown of the cushions between our spinal bones, known as spinal discs. While injecting healthy cells into these damaged discs could help heal them, the cells usually die off quickly or float away because the inside of a spinal disc is such a harsh, cramped environment. To solve this, scientists used advanced lasers to sculpt tiny, porous plastic “microscaffolds” that act like protective, microscopic texturized cradles for the new cells. These micro-cradles give the cells a safe surface to cling to and grow on, yet they are still small enough to be injected directly into the spine through a tiny needle without crushing the cells inside. By keeping the healing cells alive, healthy, and locked in place exactly where they are needed, this new technique could finally provide a minimally invasive way to actually repair damaged discs rather than just masking the pain