CIRM Training Program in Translational Regenerative Medicine
Grant Award Details
Grant Type:
Grant Number:
EDUC4-12751
Investigator(s):
Award Value:
$5,373,075
Status:
Active
Progress Reports
Reporting Period:
Year 1
Reporting Period:
Year 2
Reporting Period:
Year 3
Reporting Period:
Year 4
Grant Application Details
Application Title:
CIRM Training Program in Translational Regenerative Medicine
Public Abstract:
We propose a CIRM Scholars Training Program in stem cells and translational regenerative medicine for 4 PhD student, 8 postdoctoral (PhD) scientist and 8 clinical (MD) physician trainees. Training the next generation of scientists and clinicians is vital for the lasting success of stem cell research and the translation of lab discoveries into clinical therapies to repair and regenerate damaged and diseased tissues. Cedars-Sinai’s Regenerative Medicine Institute (RMI) is a world-renowned center for stem cell research and an ideal training environment. The proposed CIRM Scholars Training Program combines the unique strengths of faculty, scientists and clinicians with expertise in key areas of stem cell and regenerative medicine research to facilitate bench-to-bedside advances. Our stem cell and clinical biomanufacturing facilities provide cutting-edge resources to enhance the training environment. The Program offers formal training in: 1) the use of stem cells in regenerative medicine, 2) innovative techniques to study stem cells and model human diseases in the lab, and steps necessary before stem cell products can be manufactured for clinical use and evaluated in clinical trials, and 3) ethical, legal and social implications of stem cell research and regenerative medicine. The training experience is further enriched by partnerships with clinicians through the Cedars-Sinai Clinical Buddies Program, an annual RMI retreat to facilitate collaboration, and community outreach opportunities to educate and inform high school students, patients and other members of the broader community. Our proven track record of blending research excellence with experimental medicine and clinical practice demonstrates that we are uniquely positioned to offer such training.
Statement of Benefit to California:
This CIRM Scholar Training Program will benefit the state of California and its citizens by: 1) training scientists and clinicians, including those from underrepresented backgrounds, to perform stem cell research and develop novel regenerative medicine therapies, 2) preparing scientists and clinicians to be the next generation of leaders in the regenerative medicine field, 3) translating lab-based discoveries into therapeutic products that will benefit patients with a variety of diseases such as Alzheimer’s Disease, Parkinson’s Disease, ALS, cardiovascular disease, inflammatory bowel disease, organ dysfunction, osteoporosis and cancer, 4) providing outreach opportunities to educate high school students about stem cells and careers in regenerative medicine, and 5) sharing information about advances in regenerative medicine research and ethical and social issues related to stem cell research with patients and the general public to help them make healthcare decisions and more informed choices at the ballot box.
Publications
- bioRxiv (2023): 17 beta-estradiol impedes aortic root dilation and rupture in male Marfan mice. (PubMed: 37215011)
- Int J Mol Sci (2023): 17 beta-Estradiol Impedes Aortic Root Dilation and Rupture in Male Marfan Mice. (PubMed: 37686377)
- Sci Rep (2025): Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLE. (PubMed: 39828802)
- Nature (2023): Author Correction: Divergent transcriptional regulation of astrocyte reactivity across disorders. (PubMed: 36977770)
- Stem Cells Dev (2024): The Benefits of Stem Cell Biology and Tissue Engineering in Low-Earth Orbit. (PubMed: 38326760)
- J Extracell Vesicles (2022): Biodistribution of unmodified cardiosphere-derived cell extracellular vesicles using single RNA tracing. (PubMed: 35005847)
- Heart Lung Circ (2023): Biological Modification of Arrhythmogenic Substrates by Cell-Free Therapeutics. (PubMed: 37353457)
- Circ Res (2024): Biological Pacemakers: Present and Future. (PubMed: 38547251)
- Regen Med (2025): Biological tendon regeneration, are we almost there or is it still a stretch? (PubMed: 40799043)
- J Proteome Res (2023): BIRCH: An Automated Workflow for Evaluation, Correction, and Visualization of Batch Effect in Bottom-Up Mass Spectrometry-Based Proteomics Data. (PubMed: 36695565)
- Nature (2023): Blinded, randomized trial of sonographer versus AI cardiac function assessment. (PubMed: 37020027)
- Biomaterials (2021): Cardiosphere-derived cells, with and without a biological scaffold, stimulate myogenesis and recovery of muscle function in mice with volumetric muscle loss. (PubMed: 33951565)
- bioRxiv (2025): CDDO-Imidazole regulates RBC alloimmunization to the KEL antigen by activating Nrf2. (PubMed: 40235992)
- Front Bioeng Biotechnol (2024): Collagen scaffold-seeded iTenocytes accelerate the healing and functional recovery of Achilles tendon defects in a rat model. (PubMed: 39713100)
- Ann Clin Transl Neurol (2025): Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome. (PubMed: 40317698)
- Nat Commun (2021): Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses. (PubMed: 34764253)
- PLoS One (2021): Delayed repolarization and ventricular tachycardia in patients with heart failure and preserved ejection fraction. (PubMed: 34255806)
- J Mol Cell Cardiol Plus (2023): Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction. (PubMed: 37273847)
- Am J Hematol (2022): Diminished durability of chimeric antigen receptor T-cell efficacy with severe or prolonged postinfusion cytopenias. (PubMed: 35358346)
- J Orthop Res (2023): Directing iPSC differentiation into iTenocytes using combined scleraxis overexpression and cyclic loading. (PubMed: 36203346)
- J Mol Cell Cardiol Plus (2024): Distinct phenotypes induced by acute hypoxia and TGF-beta1 in human adult cardiac fibroblasts. (PubMed: 39329164)
- bioRxiv (2024): Distributed Collaboration for Data, Analysis Pipelines, and Results in Single-Cell Omics. (PubMed: 39131282)
- Nature (2022): Divergent transcriptional regulation of astrocyte reactivity across disorders. (PubMed: 35614216)
- Front Cell Dev Biol (2021): Engineered Fibroblast Extracellular Vesicles Attenuate Pulmonary Inflammation and Fibrosis in Bleomycin-Induced Lung Injury. (PubMed: 34660588)
- Methods Mol Biol (2021): Engineering Shape-Controlled Microtissues on Compliant Hydrogels with Tunable Rigidity and Extracellular Matrix Ligands. (PubMed: 33340354)
- Eur Heart J (2025): Enhanced Parkin-mediated mitophagy mitigates adverse left ventricular remodelling after myocardial infarction: role of PR-364. (PubMed: 39601359)
- J Orthop Res (2024): Exercise improves load bearing bone structural properties in female secreted protein acidic and rich in cysteine (SPARC) null mice but not in males. (PubMed: 39105654)
- Prog Cardiovasc Dis (2021): Exercising immune cells: The immunomodulatory role of exercise on atrial fibrillation. (PubMed: 34274371)
- Mol Ther Nucleic Acids (2021): Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice. (PubMed: 34094713)
- Cells (2025): Exosomes as Future Therapeutic Tools and Targets for Corneal Diseases. (PubMed: 40643480)
- Front Cell Dev Biol (2021): Extracellular Vesicles Secreted by TDO2-Augmented Fibroblasts Regulate Pro-inflammatory Response in Macrophages. (PubMed: 34751245)
- Int J Cancer (2021): Filgrastim associations with CAR T-cell therapy. (PubMed: 33091961)
- J Physiol (2021): Fine-tuning SERCA activity to treat distinct heart failure syndromes. (PubMed: 34387381)
- J Proteome Res (2023): High-Field Asymmetric Waveform Ion Mobility Spectrometry: Practical Alternative for Cardiac Proteome Sample Processing. (PubMed: 37040897)
- Anal Chem (2023): High-Throughput Single-Cell Proteomic Analysis of Organ-Derived Heterogeneous Cell Populations by Nanoflow Dual-Trap Single-Column Liquid Chromatography. (PubMed: 37289937)
- Mol Ther Methods Clin Dev (2023): The hunt for novel AAV capsids with improved cardiac tropism. (PubMed: 37886605)
- Int J Mol Sci (2024): Identification of Disease-Relevant, Sex-Based Proteomic Differences in iPSC-Derived Vascular Smooth Muscle Cells. (PubMed: 39796045)
- Trends Cell Biol (2023): Implementing standardized diversity, equity, and inclusion approaches within scientific communities. (PubMed: 37730511)
- Cancer Res (2024): Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis. (PubMed: 38231476)
- Arterioscler Thromb Vasc Biol (2024): Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease. (PubMed: 38385289)
- Sci Transl Med (2023): Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats. (PubMed: 38055799)
- Basic Res Cardiol (2025): Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice. (PubMed: 39739013)
- J Orthop Res (2023): iPSC-derived tenocytes seeded on microgrooved 3D printed scaffolds for Achilles tendon regeneration. (PubMed: 36961351)
- Sci Rep (2022): iPSC-neural crest derived cells embedded in 3D printable bio-ink promote cranial bone defect repair. (PubMed: 36333414)
- J Histochem Cytochem (2024): Laminin Beta 2 Is Localized at the Sites of Blood-Brain Barrier and Its Disruption Is Associated With Increased Vascular Permeability, Histochemical, and Transcriptomic Study. (PubMed: 39340425)
- Stem Cell Reports (2025): Long-term preservation of muscle function and structure by repeated administration of cardiosphere-derived cells in mdx mice. (PubMed: 40118057)
- JACC Basic Transl Sci (2024): Macrophages Contribute to Cardiac Fibrosis and Diastolic Dysfunction in Systemic Sclerosis. (PubMed: 39822601)
- Circulation (2022): Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction. (PubMed: 34905696)
- Nat Commun (2024): Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas. (PubMed: 38509063)
- J Neuroinflammation (2024): Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging. (PubMed: 38840206)
- Cell Rep Med (2022): MicroRNA-dependent suppression of biological pacemaker activity induced by TBX18. (PubMed: 36543116)
- J Mol Cell Cardiol (2021): Mitochondrial architecture in cardiac myocytes depends on cell shape and matrix rigidity. (PubMed: 33038389)
- Nat Protoc (2022): Molecular profiling of enteric nervous system cell lineages. (PubMed: 35676375)
- Nature (2024): MYCT1 controls environmental sensing in human haematopoietic stem cells. (PubMed: 38839950)
- Sci Adv (2022): A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient. (PubMed: 36475790)
- bioRxiv (2024): The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity. (PubMed: 39314333)
- Eur Heart J (2024): Non-coding RNA yREX3 from human extracellular vesicles exerts macrophage-mediated cardioprotection via a novel gene-methylating mechanism. (PubMed: 38865332)
- Proteomics Clin Appl (2024): A novel micropeptide, Slitharin, exerts cardioprotective effects in myocardial infarction. (PubMed: 38444254)
- Ann Biomed Eng (2021): Optical Clearing of Skeletal Muscle Bundles Engineered in 3-D Printed Templates. (PubMed: 32748107)
- bioRxiv (2024): Oral bioavailability of a noncoding RNA drug, TY1, that acts on macrophages. (PubMed: 38746093)
- Diabetologia (2026): Oxidative stress-regulatory role of miR-10b-5p in the diabetic human cornea revealed through integrated multi-omics analysis. (PubMed: 41115935)
- Radiol Case Rep (2024): Paraneoplastic NMDA encephalitis, a case report and an extensive review of available literature. (PubMed: 38288050)
- Pediatr Pulmonol (2024): A personalized medicine approach to optimize care for a pediatric cystic fibrosis patient with atypical clinical symptoms. (PubMed: 37818777)
- J Craniomaxillofac Surg (2025): Process of radical resection for advanced buccal cancer and the ‘sandwich’ technique for craniomaxillofacial defect repair using an anterolateral thigh chimeric myocutaneous flap. (PubMed: 40461340)
- Physiol Rev (2024): Proteomics of the heart. (PubMed: 38300522)
- Physiol Genomics (2023): Proteomics of novel induced pluripotent stem cell-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line. (PubMed: 37306406)
- Curr Protoc (2024): Recording and Interpretation of Active Calcium Transients in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (PubMed: 39446337)
- J Am Soc Nephrol (2021): Renal Inflammation Induces Salt Sensitivity in Male db/db Mice through Dysregulation of ENaC. (PubMed: 33731332)
- Bioengineering (Basel) (2023): Retention of Human iPSC-Derived or Primary Cells Following Xenotransplantation into Rat Immune-Privileged Sites. (PubMed: 37760151)
- Acta Neuropathol (2023): Retinal pathological features and proteome signatures of Alzheimer’s disease. (PubMed: 36773106)
- Arq Bras Cardiol (2024): The Role of Atrial Fibrosis for Atrial Fibrillation: Not Always Essential? (PubMed: 38198354)
- Mol Metab (2021): Sensory neurons expressing calcitonin gene-related peptide alpha regulate adaptive thermogenesis and diet-induced obesity. (PubMed: 33412345)
- Nat Commun (2023): A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus. (PubMed: 37582805)
- iScience (2022): Single-cell atlas unveils cellular heterogeneity and novel markers in human neonatal and adult intervertebral discs. (PubMed: 35754733)
- Mol Cell Proteomics (2025): Single-Cell Proteomics Reveals Specific Cellular Subtypes in Cardiomyocytes Derived From Human iPSCs and Adult Hearts. (PubMed: 39855627)
- bioRxiv (2024): Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage. (PubMed: 37090543)
- Nanomedicine (2021): Small molecule inhibitors and culture conditions enhance therapeutic cell and EV potency via activation of beta-catenin and suppression of THY1. (PubMed: 33321216)
- Korean Circ J (2022): Sudden Death and Ventricular Arrhythmias in Heart Failure With Preserved Ejection Fraction. (PubMed: 35388994)
- PLoS One (2022): Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy. (PubMed: 35316276)
- JACC Clin Electrophysiol (2023): Systemic Delivery of Extracellular Vesicles Attenuates Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction. (PubMed: 36858679)
- Biology (Basel) (2023): Targeting Endothelial HIF2alpha/ARNT Expression for Ischemic Heart Disease Therapy. (PubMed: 37508425)
- J Extracell Biol (2023): TDO2-augmented fibroblasts secrete EVs enriched in immunomodulatory Y-derived small RNA. (PubMed: 38938522)
- Curr Protoc (2023): Tetracycline-Inducible and Reversible Stable Gene Expression in Human iPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain. (PubMed: 37283517)
- Int J Cardiol (2023): The tour-de-force for reducing cardiovascular disease risk in diabetic patients. (PubMed: 37061096)
- Aging (Albany NY) (2022): Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs. (PubMed: 36585921)
- Nat Commun (2025): Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction. (PubMed: 39885127)
- Front Oncol (2024): In vitro and in vivo modeling systems of supratentorial ependymomas. (PubMed: 38469231)
- iScience (2023): WIP1 is a novel specific target for growth hormone action. (PubMed: 37876819)