Brinzolamide microsponge-loaded in situ gel for sustained ocular delivery: design, characterization and in vivo evaluation.

To make glaucoma eye drops last longer before being washed away by tears, scientists developed a two-part delivery system that packs the drug into microscopic, time-release “microsponges” and suspends them in a special liquid that instantly turns into a thick gel upon touching the eye. This combination holds the medication on the eye’s surface for a much longer period, allowing for a steady, sustained release of the drug. When tested, this new formula was completely painless, caused no irritation, and was significantly more effective at lowering dangerous eye pressure than standard treatments, offering a highly promising and efficient new approach to managing glaucoma.