Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Implantation of engineered adipocytes suppresses tumor progression in cancer models. 2025 Nat Biotechnol
In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells. 2025 bioRxiv
Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells. 2025 Aging Cell
Integrated Longitudinal Transcriptomic and Proteomic Analysis of the Murine Lung Response to Influenza A Virus. 2025 Am J Respir Cell Mol Biol
Integrated single-nuclei and spatial transcriptomic profiling of human sacrococcygeal teratomas reveals heterogeneity in cellular composition and X-chromosome inactivation. 2025 bioRxiv
Integrated workflow for analysis of immune enriched spatial proteomic data with IMmuneCite. 2025 Sci Rep
Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses. 2025 Gut Microbes
Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy. 2025 Sci Transl Med
Intravenous and intracranial GD2-CAR T cells for H3K27M(+) diffuse midline gliomas. 2025 Nature
Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice. 2025 Basic Res Cardiol
KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS. 2025 bioRxiv
Large language model agents can use tools to perform clinical calculations. 2025 NPJ Digit Med
Lentiviral vectors for hematopoietic stem cell gene therapy restore alpha-globin expression in alpha-thalassemia red blood cells. 2025 Cell Rep Med
LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK. 2025 Mol Metab
Limbal epithelial cells detected in stage III limbal stem cell deficiency by multimodal anterior segment imaging. 2025 Am J Ophthalmol
Lineage-resolved atlas of the developing human cortex. 2025 Nature
Long noncoding RNA BCYRN1 promotes cardioprotection by enhancing human and murine regulatory T cell dynamics. 2025 J Clin Invest
Long-term preservation of muscle function and structure by repeated administration of cardiosphere-derived cells in mdx mice. 2025 Stem Cell Reports
Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency. 2025 N Engl J Med
Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction. 2025 bioRxiv
Measurement and clinical interpretation of CRISPR off-targets. 2025 Nat Genet
MeCP2 regulates telencephalic development in human cerebral organoids. 2025 Cell Rep
Menthol, a consumer product additive, adversely affects human embryonic stem cells via activation of TRPM8 and TRPA1 channels. 2025 Stem Cells Transl Med
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1. 2025 Nature
Microgliopathy as a primary mediator of neuronal death in models of Friedreich’s Ataxia. 2025 Nat Commun
Micropatterning Photoconductive Peptide Assemblies on Stiff and Soft Biomaterial Substrates. 2025 ACS Appl Mater Interfaces
Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury. 2025 Brain Behav Immun
MitoScribe single-cell molecular recorder logs graded signaling dynamics into mitochondrial DNA. 2025 bioRxiv
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. 2025 Stem Cell Reports
Molecular Signatures in Cortical Development. 2025 Annu Rev Neurosci
Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology. 2025 bioRxiv
MYOD represses gene expression from non-E-box motifs. 2025 Genes Dev
Neuroendocrinology and the Genetics of Obesity. 2025 Endocrinology
Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics. 2025 Nat Commun
On the Feasibility of SERS-Based Monitoring of Drug Loading Efficiency in Exosomes for Targeted Delivery. 2025 Biosensors (Basel)
Opposing roles of p38alpha-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. 2025 Cell Rep
Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells. 2025 Med
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells. 2025 Nat Commun
Paracrine effect of human stem cell-derived progenitor cells on remodeling of the vagina. 2025 NPJ Regen Med
Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers. 2025 bioRxiv
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling. 2025 bioRxiv
Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1. 2025 Stem Cell Reports
Process of radical resection for advanced buccal cancer and the ‘sandwich’ technique for craniomaxillofacial defect repair using an anterolateral thigh chimeric myocutaneous flap. 2025 J Craniomaxillofac Surg
Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids. 2025 RSC Adv
Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects. 2025 J Hematol Oncol
Proteome-wide profiling of S-nitrosylated proteins using the SNOTRAP probe and mass spectrometry-based detection. 2025 Nat Protoc
Protocol for deep-learning-driven cell type label transfer in single-cell RNA sequencing data. 2025 STAR Protoc
Protocol for the isolation and characterization of mouse alveolar bone marrow hematopoietic stem cells. 2025 STAR Protoc
Protocol for vibratome sectioning, immunofluorescence, and S-phase labeling of inner ear organoids. 2025 STAR Protoc
Protocol to study ductal progenitor-like cells from the adult human pancreas using 3D suspension and methylcellulose-based culture systems. 2025 STAR Protoc