All CIRM Grants

Institution Researcher name Grant Type Grant Title Award Value
University of California, Irvine Robert Hunt Quest - Discovery Stage Research Projects Optimization of a human interneuron cell therapy for traumatic brain injury $250,000
University of California, Los Angeles Stanley Carmichael Quest - Discovery Stage Research Projects Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia. $250,000
University of California, San Diego Tariq Rana Quest - Discovery Stage Research Projects Development of COVID-19 Antiviral Therapy Using Human iPSC-Derived Lung Organoids $250,000
City of Hope, Beckman Research Institute Yanhong Shi Quest - Discovery Stage Research Projects Combating COVID-19 using human PSC-derived NK cells $249,998
Boston Children's Hospital David Williams Cure Sickle Cell Initiative Clinical Trial Stage Projects Phase 2 Study of Hematopoietic Stem Cell Gene Transfer Inducing Fetal Hemoglobin in Sickle Cell Disease $8,333,581
University of California, San Francisco Steven Deeks Clinical Trial Stage Projects Anti-HIV duoCAR-T cell therapy for HIV infection $8,970,732
Rocket Pharmaceuticals, Inc. Gayatri Rao Clinical Trial Stage Projects A Phase I Clinical Trial for a Lentiviral Gene Therapy Targeting the TCIRG1 Gene for Infantile Malignant Osteopetrosis (IMO) $3,728,485
University of California, Davis Diana Farmer Clinical Trial Stage Projects The CuRe Trial: Cellular Therapy for In Utero Myelomeningocele Repair $8,996,474
University of California, San Diego Dan Kaufman Quest - Discovery Stage Research Projects Human iPSC-derived chimeric antigen receptor-expressing macrophages for cancer treatment $222,200
University of California, Los Angeles Donald Kohn Quest - Discovery Stage Research Projects Hematopoietic Stem Cell Gene Therapy for X-linked Agammaglobulinemia $219,230
Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center Eiji Yoshihara Quest - Discovery Stage Research Projects Dual angiogenic and immunomodulating nanotechnology for subcutaneous stem cell derived islet transplantation for the treatment of diabetes $250,000
Vitabolus, Inc. Aline Betancourt Quest - Discovery Stage Research Projects The First Orally Delivered Cell Therapy for the Treatment of Inflammatory Bowel Disease $249,000
University of California, Irvine Mathew Blurton-Jones Quest - Discovery Stage Research Projects Transplantation of Pluripotent Stem Cell Derived Microglia for the Treatment of Adult-onset Leukoencephalopathy (HDLS/ALSP) $214,668
University of Southern California Justin Ichida Quest - Discovery Stage Research Projects Development of a SYF2 antisense oligonucleotide (ASO) treatment for ALS $222,300
University of California, San Diego Mark Tuszynski Progression Award - Discovery Stage Research Projects Simplification of Excipient Solution for Implanting Candidate Human H9-scNSC Cell Line for Spinal Cord Injury $180,000
Stanford University Helen Blau Progression Award - Discovery Stage Research Projects Stimulating endogenous muscle stem cells to counter muscle wasting $237,060
University of California, Berkeley Kevin Healy Progression Award - Discovery Stage Research Projects Safety “Clinical Trial” of the Cardiac Liability of COVID19 Polytherapy $224,500
University of California, Irvine Brian Cummings Progression Award - Discovery Stage Research Projects Human neural stem cell (hNSC) derived exosomes vs CSC14 hNSCs for the treatment of traumatic brain injury (TBI) $202,667
University of California, San Diego Karen Christman Discovery Research Projects Pro-healing biomaterial for treating lung inflammation associated with COVID-19 $221,758
University of California, Los Angeles Lili Yang Discovery Research Projects Battling COVID-19 Using Off-The-Shelf HSC-Engineered iNKT Cells $250,000
Neurona Therapeutics Cory Nicholas Progression Award - Discovery Stage Research Projects Global gene expression profiling of single inhibitory neurons derived from human stem cells $202,500
University of California, Irvine Daniela Bota Conference – The 2020 Grantee Meeting 2020 CIRM Grantee Meeting $157,862
Sanford Burnham Prebys Medical Discovery Institute Evan Snyder Discovery Research Projects Using hiPSC-derived lung organoids, a clinically-relevant system, to validate & winnow a list of approved drugs that inhibit SARS-CoV-2 cytopathy $228,229
University of California, San Diego Steve Dowdy Discovery Research Projects Development of Anti-COVID RNAi Therapeutics Using Human iPSC-Derived Alveolar Epithelial Cells $150,000
Celularity Inc Xiaokui Zhang Clinical Trial Stage Projects A phase I/II study of human placental hematopoietic stem cell derived natural killer cells (CYNK-001) for the treatment of adults with COVID-19 $750,000
University of Southern California PREET Chaudhary Discovery Research Projects Chimeric Antigen Receptor Targeting Spike Glycoprotein of SARS-cov2 $249,996
University of California, Los Angeles Song Li Discovery Research Projects Biomaterial vaccine to enhance the formation of SARS-CoV-2-specific T memory stem cells $149,916
University of California, Los Angeles Vaithilingaraja Arumugaswami Therapeutic Translational Research Projects COVID-19 Antiviral Therapy to Block Direct Cell Injury and Associated Tissue Damage $349,999
Stanford University Helen Blau Discovery Research Projects Application of PGE2/BPV, a muscle stem cell targeting therapeutic, to the treatment of COVID-19 associated diaphragm atrophy $149,996
Stanford University Albert Wong Discovery Research Projects Identifying HLA Class I Restricted Peptides That Induce CD8+ T Cells Against SARS-CoV-2 $249,999
City of Hope, Beckman Research Institute Jianhua Yu Discovery Research Projects Persistent Off-the-Shelf meACE2-CAR-IL-15 NK Cells Derived from CD34(+) Cord Blood Stem Cells to Prevent and Treat COVID-19 $150,000
University of California, Los Angeles Caroline Kuo Progression Award - Discovery Stage Research Projects Evaluation of Gene Therapy Approaches for Autosomal Recessive Hyper IgE Syndrome Due to Mutations in DOCK8 $234,000
Scripps Research Institute Stuart Lipton Discovery Research Projects Repurposing Aminoadamantane Nitrate Compounds to Inhibit SARS-CoV-2 Viral Activity and to Protect the Brain from Viral-Related Damage $150,000
University of Southern California Justin Ichida Discovery Research Projects Development of a novel PIKFYVE kinase inhibitor for the treatment of COVID-19 $150,000
University of California, San Francisco Michael Matthay Clinical Trial Stage Projects Mesenchymal Stromal Cells for ARDS (COVID positive and COVID negative) $701,049
ExCellThera Inc. Pierre Caudrelier Cure Sickle Cell Initiative Clinical Trial Stage Projects A Phase 1 Study of ECT-001 Expanded Cord Blood and Myeloablative Regimen with Reduced Toxicity in Patients with Severe Sickle Cell Disease. $2,000,000
University of California, Los Angeles Gay Crooks Discovery Research Projects Stem cell-based rapid identification of SARS-CoV-2 T cell epitopes and T cell receptors for therapeutic use $126,692
City of Hope, Beckman Research Institute John Zaia Clinical Trial Stage Projects Evaluation and Characterization of SARS-CoV-2 Antibody in Convalescent Volunteer Plasma Donors for Potential Therapeutic Use $999,999
University of California, Los Angeles Brigitte Gomperts Discovery Research Projects Identifying a lead compound for COVID19 using high throughput screening with lung stem cell organoids $149,998
Stanford University Hiromitsu Nakauchi Progression Award - Discovery Stage Research Projects Using metabolic pausing for maintaining stable and high-quality pluripotent stem cells $208,422
University of California, Davis Gerhard Bauer Conference - Manage The SPARK Annual Meeting The 2020 SPARK Annual Meeting $50,000
Stanford University Rosa Bacchetta Late Stage Preclinical Projects IND-enabling activities for a Phase 1 Study of Autologous CD4LVFOXP3 T Cells in Subjects with IPEX Syndrome $5,002,496
jCyte, Inc Henry Klassen Clinical Trial Stage Projects A Phase 2 Study of the Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa $6,608,592
Cedars-Sinai Medical Center Clive Svendsen Clinical Trial Stage Projects Clinical Study to Assess Safety and Efficacy of Subretinal Injection of Human Neural Progenitor Cells for Treatment of Retinitis Pigmentosa $10,444,063
University of California, Los Angeles Sophie Deng Clinical Trial Stage Projects Safety and Feasibility of Cultivated Autologous Limbal Stem Cells for Limbal Stem Cell Deficiency $10,301,486
Brain Neurotherapy Bio Krystof Bankiewicz Clinical Trial Stage Projects A Phase 1b Safety Study for MRI guided delivery of AAV2-GDNF for the treatment of Parkinson’s disease $5,510,462
University of California, Los Angeles Caroline Kuo Therapeutic Translational Research Projects Ex Vivo Gene Editing of Human Hematopoietic Stem Cells for the Treatment of X-Linked Hyper-IgM Syndrome $4,896,628
City of Hope, Beckman Research Institute Karen Aboody Therapeutic Translational Research Projects Neural Stem cell-mediated oncolytic immunotherapy for ovarian cancer $2,873,262
University of California, Los Angeles Yvonne Chen Therapeutic Translational Research Projects BCMA/CS1 Bispecific CAR-T Cell Therapy to Prevent Antigen Escape in Multiple Myeloma $3,176,805
Neurona Therapeutics Cory Nicholas Therapeutic Translational Research Projects Development of a human stem cell-derived inhibitory neuron therapeutic for the treatment of chronic focal epilepsy $4,848,505
City of Hope, Beckman Research Institute Saul Priceman Clinical Trial Stage Projects A Phase I Study of Chimeric Antigen Receptor Engineered Stem/Memory T Cells for the Treatment of HER2-Positive Brain Metastases $9,015,149
University of Southern California Mark Humayun Therapeutic Translational Research Projects PRPE-SF, polarized hESC-derived RPE Soluble Factors, as a Therapy for Early Stage Dry Age-related Macular Degeneration $3,733,556
University of California, Irvine Brian Cummings Therapeutic Translational Research Projects An optimized human neural stem cell line (hNSC) for the treatment of traumatic brain injury (TBI) $4,804,737
University of California, San Diego Mark Tuszynski Therapeutic Translational Research Projects Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI) $6,235,897
Sanford Burnham Prebys Medical Discovery Institute Evan Snyder Therapeutic Translational Research Projects Human Neural Stem Cells (hNSCs) for neuroprotection in perinatal hypoxic-ischemic brain injury (HII)-Pre-IND-enabling Studies $4,963,684
University of California, Davis Mehrdad Abedi Conference - The 2020 Alpha Stem Cell Clinic Annual Symposium CIRM - Leading the New Era of Living Medicines $60,000
University of California, San Diego Stephanie Cherqui Clinical Trial Stage Projects Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. $11,999,944
University of California, San Francisco Peter Stock Clinical Trial Stage Projects Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM $11,083,012
Aspen Neuroscience Andres Bratt-Leal Progression Award - Discovery Stage Research Projects Autologous therapy for Parkinson's disease: single cell RNAseq for in depth characterization of transplanted cells $177,579
University of California, San Francisco Mark Walters Late Stage Preclinical Projects Curing Sickle cell Disease with CRISPR-Cas9 genome editing $2,242,805
University of California, Los Angeles Theodore Nowicki Clinical Trial Stage Projects Genetic Modification of Stem Cells and T cells to Activate the Immune System to Target Solid Tumors $4,693,839
Rocket Pharmaceuticals, Inc. Kinnari Patel Clinical Trial Stage Projects LADICell $6,567,085
Cal State Univ, San Marcos Bianca Mothe Conference - Manage The Bridges Annual Meeting 2020 and 2021 Bridges Annual Meeting $320,000
Ankasa Regenerative Therapeutics Ying Zhu Late Stage Preclinical Projects IND-enabling development of ART352-L, an endogenous stem cell reactivation therapy to enhance bone healing in the elderly $3,987,693
Stanford University Judith Shizuru Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $1,113,487
Jasper Therapeutics, Inc. Wendy Pang Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $2,313,398
University of California, Irvine Leslie Thompson Late Stage Preclinical Projects An hESC-derived hNSC Therapeutic for Huntington’s Disease $5,635,393
Stanford University Everett Meyer Clinical Trial Stage Projects Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients $11,955,585
Angiocrine Bioscience, Inc. Edward Kavalerchik Clinical Trial Stage Projects AB-205-001 Phase 1b Trial and Related Activities to Support Clinical Development of AB-205 $6,192,579
University of California, Davis Diana Farmer Late Stage Preclinical Projects Placental Mesenchymal Stem Cell Augmentation of Fetal Myelomeningocele Repair $5,619,643
Pathways to Stem Cell Science Victoria Fox Conference - Manage The SPARK Annual Meeting 2019 SPARK Annual Meeting $49,915
University of California, San Diego Jonathan Lin Quest - Discovery Stage Research Projects Small Molecule Proteostasis Regulators to Treat Photoreceptor Diseases $1,160,648
Children's Hospital of Los Angeles Tracy Grikscheit Quest - Discovery Stage Research Projects Universal Pluripotent Liver Failure Therapy (UPLiFT) $1,297,512
Scripps Research Institute Stuart Lipton Quest - Discovery Stage Research Projects Drug Development for Autism Spectrum Disorder Using Human Patient iPSCs $1,827,576
Stanford University Philip Beachy Quest - Discovery Stage Research Projects Pluripotent stem cell-derived bladder epithelial progenitors for definitive cell replacement therapy of bladder cancer $1,265,436
University of Southern California Neil Segil Quest - Discovery Stage Research Projects A screen for drugs to protect against chemotherapy-induced hearing loss, using sensory hair cells derived by direct lineage reprogramming from hiPSCs $741,574
Stanford University Alan Cheng Quest - Discovery Stage Research Projects Modulation of the Wnt pathway to restore inner ear function $1,394,870
City of Hope, Beckman Research Institute Xiuli Wang Late Stage Preclinical Projects CMV-specific T cells expressing anti-HIV CAR and CMV vaccine boost as immunotherapy for HIV/AIDS $3,812,797
University of California, San Francisco Karin Gaensler Therapeutic Translational Research Projects Developing engineered autologous leukemia vaccines to target residual leukemic stem cells $4,171,728
University of California, Los Angeles Steven Schwartz Therapeutic Translational Research Projects Clinical Translation of Autologous Regenerative Cell Therapy for Blindness $5,068,026
Stanford University Theodore Leng Therapeutic Translational Research Projects NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration $4,235,758
University of California, San Francisco Mark Walters Conference - The 2019 Alpha Stem Cell Clinic Annual Symposium 2019 Alpha Stem Cell Clinic Symposium - Mending Stem Cells: The Past, Present & Future Regenerative Medicine $60,000
Gladstone Institutes, J. David Li Gan Quest - Discovery Stage Research Projects Develop iPSC-derived microglia to treat progranulin-deficient Frontotemporal Dementia $1,547,157
Salk Institute for Biological Studies Ronald Evans Quest - Discovery Stage Research Projects Therapeutic immune tolerant human islet-like organoids (HILOs) for Type 1 Diabetes $1,637,209
Poseida Therapeutics, Inc. Devon Shedlock Late Stage Preclinical Projects Late-Stage Preclinical Study of CAR-T Memory Stem Cells Targeting PSMA (P-PSMA-101) for the Treatment of Castrate-Resistant Metastatic Prostate Cancer $3,992,090
University of California, San Francisco Hideho Okada Quest - Discovery Stage Research Projects Non-viral reprogramming of the endogenous TCRα locus to direct stem memory T cells against shared neoantigens in malignant gliomas $900,000
City of Hope, Beckman Research Institute Saul Priceman Quest - Discovery Stage Research Projects Chimeric Antigen Receptor-Engineered Stem/Memory T Cells for the Treatment of Recurrent Ovarian Cancer $1,381,104
Stanford University Katja Weinacht Quest - Discovery Stage Research Projects Regenerative Thymic Tissues as Curative Cell Therapy for Patients with 22q11 Deletion Syndrome $1,251,720
University of California, San Diego Eric Adler Quest - Discovery Stage Research Projects Genetically Modified Hematopoietic Stem Cells for the Treatment of Danon Disease $1,393,200
University of California, Los Angeles Lili Yang Quest - Discovery Stage Research Projects Preclinical Development of An HSC-Engineered Off-The-Shelf iNKT Cell Therapy for Cancer $1,404,000
University of California, San Francisco Krystof Bankiewicz Late Stage Preclinical Projects MRI Guided Delivery of Neural Progenitor Cells Secreting GDNF for the Treatment of Parkinson's disease $5,811,340
City of Hope, Beckman Research Institute John Zaia Late Stage Preclinical Projects Ex Vivo Gene Engineering of Blood Stem Cells for Enhanced Chemotherapy Efficacy in Glioblastoma Patients $3,684,259
University of California, Los Angeles Steven Dubinett Clinical Trial Stage Projects A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC $10,955,315
MAX BioPharma, Inc. Farhad Parhami Therapeutic Translational Research Projects Therapeutic development of Oxy200, an oxysterol with bone anabolic and anti-resorptive properties for intervention in osteoporosis $1,400,000
Stanford University Bertha Chen Therapeutic Translational Research Projects Autologous iPSC-derived smooth muscle cell therapy for treatment of urinary incontinence $5,977,155
University of California, Irvine Magdalene Seiler Therapeutic Translational Research Projects Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models $4,769,039
Children's Hospital of Oakland Research Institute Henry Erlich Diagnostic Translational Research Projects Development of a Noninvasive Prenatal Test for Beta-Hemoglobinopathies for Earlier Stem Cell Therapeutic Interventions $1,068,372
University of California, San Francisco Steven Mack Diagnostic Translational Research Projects Development of a Noninvasive Prenatal Test for Beta-Hemoglobinopathies for Earlier Stem Cell Therapeutic Interventions $653,234
Sangamo BioSciences, Inc. Bettina Cockroft Clinical Trial Stage Projects A Phase 1/2 Study to Assess the Safety, Tolerability, and Efficacy of ST-400 Autologous HSPC Transplant in Transfusion-dependent β-Thalassemia $8,000,000
University of California, San Francisco Morton Cowan Clinical Trial Stage Projects Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells $12,000,000

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