All CIRM Grants

Institution Researcher name Grant Type Grant Title Award Value
University of California, San Francisco Hideho Okada Therapeutic Translational Research Projects Development of novel synNotch CART cell therapy in patients with recurrent EGFRvIII+ glioblastoma $2,663,144
University of California, Los Angeles Lili Yang Therapeutic Translational Research Projects HSC-Engineered Off-The-Shelf CAR-iNKT Cell Therapy for Multiple Myeloma $5,949,651
University of California, Los Angeles Cristina Puig Saus Therapeutic Translational Research Projects CAR-Tnm cell therapy for melanoma targeting TYRP-1 $5,904,462
City of Hope, Beckman Research Institute Leo Wang Clinical Trial Stage Projects Phase I Study of IL13Rα2-Targeting CAR T Cells After Lymphodepletion for Children with Refractory or Recurrent Malignant Brain Tumors $8,401,309
Immune-Onc Therapeutics Joseph Woodard Clinical Trial Stage Projects Phase 1 Clinical Development of IO-202, A First-in-Class Antibody Targeting LILRB4, for the Treatment of AML with Monocytic Differentiation and CMML $6,000,000
University of California, Davis Diana Farmer Clinical Trial Stage Projects The CuRe Trial: Cellular Therapy for In Utero Myelomeningocele Repair $8,996,474
University of California, San Diego Dan Kaufman Quest - Discovery Stage Research Projects Human iPSC-derived chimeric antigen receptor-expressing macrophages for cancer treatment $222,200
University of California, Los Angeles Donald Kohn Quest - Discovery Stage Research Projects Hematopoietic Stem Cell Gene Therapy for X-linked Agammaglobulinemia $219,230
Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center Eiji Yoshihara Quest - Discovery Stage Research Projects Dual angiogenic and immunomodulating nanotechnology for subcutaneous stem cell derived islet transplantation for the treatment of diabetes $250,000
Vitabolus, Inc. Aline Betancourt Quest - Discovery Stage Research Projects The First Orally Delivered Cell Therapy for the Treatment of Inflammatory Bowel Disease $249,000
University of California, Irvine Mathew Blurton-Jones Quest - Discovery Stage Research Projects Transplantation of Pluripotent Stem Cell Derived Microglia for the Treatment of Adult-onset Leukoencephalopathy (HDLS/ALSP) $214,668
University of Southern California Justin Ichida Quest - Discovery Stage Research Projects Development of a SYF2 antisense oligonucleotide (ASO) treatment for ALS $222,300
University of California, Irvine Robert Hunt Quest - Discovery Stage Research Projects Optimization of a human interneuron cell therapy for traumatic brain injury $250,000
University of California, Los Angeles Stanley Carmichael Quest - Discovery Stage Research Projects Human-induced pluripotent stem cell-derived glial enriched progenitors to treat white matter stroke and vascular dementia. $250,000
University of California, San Diego Tariq Rana Quest - Discovery Stage Research Projects Development of COVID-19 Antiviral Therapy Using Human iPSC-Derived Lung Organoids $250,000
City of Hope, Beckman Research Institute Yanhong Shi Quest - Discovery Stage Research Projects Combating COVID-19 using human PSC-derived NK cells $249,998
Boston Children's Hospital David Williams Cure Sickle Cell Initiative Clinical Trial Stage Projects Phase 2 Study of Hematopoietic Stem Cell Gene Transfer Inducing Fetal Hemoglobin in Sickle Cell Disease $8,333,581
University of California, San Francisco Steven Deeks Clinical Trial Stage Projects Anti-HIV duoCAR-T cell therapy for HIV infection $8,970,732
Rocket Pharmaceuticals, Inc. Gayatri Rao Clinical Trial Stage Projects A Phase I Clinical Trial for a Lentiviral Gene Therapy Targeting the TCIRG1 Gene for Infantile Malignant Osteopetrosis (IMO) $3,728,485
University of California, San Diego Mark Tuszynski Progression Award - Discovery Stage Research Projects Simplification of Excipient Solution for Implanting Candidate Human H9-scNSC Cell Line for Spinal Cord Injury $180,000
Stanford University Helen Blau Progression Award - Discovery Stage Research Projects Stimulating endogenous muscle stem cells to counter muscle wasting $237,060
University of California, Berkeley Kevin Healy Progression Award - Discovery Stage Research Projects Safety “Clinical Trial” of the Cardiac Liability of COVID19 Polytherapy $224,500
University of California, Irvine Brian Cummings Progression Award - Discovery Stage Research Projects Human neural stem cell (hNSC) derived exosomes vs CSC14 hNSCs for the treatment of traumatic brain injury (TBI) $202,667
University of California, San Diego Karen Christman Discovery Research Projects Pro-healing biomaterial for treating lung inflammation associated with COVID-19 $221,758
University of California, Los Angeles Lili Yang Discovery Research Projects Battling COVID-19 Using Off-The-Shelf HSC-Engineered iNKT Cells $250,000
Neurona Therapeutics Cory Nicholas Progression Award - Discovery Stage Research Projects Global gene expression profiling of single inhibitory neurons derived from human stem cells $202,500
University of California, Irvine Daniela Bota Conference – The 2020 Grantee Meeting 2020 CIRM Grantee Meeting $176,762
Sanford Burnham Prebys Medical Discovery Institute Evan Snyder Discovery Research Projects Using hiPSC-derived lung organoids, a clinically-relevant system, to validate & winnow a list of approved drugs that inhibit SARS-CoV-2 cytopathy $228,229
University of California, San Diego Steve Dowdy Discovery Research Projects Development of Anti-COVID RNAi Therapeutics Using Human iPSC-Derived Alveolar Epithelial Cells $150,000
Celularity Inc Xiaokui Zhang Clinical Trial Stage Projects A phase I/II study of human placental hematopoietic stem cell derived natural killer cells (CYNK-001) for the treatment of adults with COVID-19 $750,000
University of Southern California PREET Chaudhary Discovery Research Projects Chimeric Antigen Receptor Targeting Spike Glycoprotein of SARS-cov2 $249,996
University of California, Los Angeles Song Li Discovery Research Projects Biomaterial vaccine to enhance the formation of SARS-CoV-2-specific T memory stem cells $149,916
University of California, Los Angeles Vaithilingaraja Arumugaswami Therapeutic Translational Research Projects COVID-19 Antiviral Therapy to Block Direct Cell Injury and Associated Tissue Damage $349,999
City of Hope, Beckman Research Institute Jianhua Yu Discovery Research Projects Persistent Off-the-Shelf meACE2-CAR-IL-15 NK Cells Derived from CD34(+) Cord Blood Stem Cells to Prevent and Treat COVID-19 $150,000
Stanford University Helen Blau Discovery Research Projects Application of PGE2/BPV, a muscle stem cell targeting therapeutic, to the treatment of COVID-19 associated diaphragm atrophy $149,996
Stanford University Albert Wong Discovery Research Projects Identifying HLA Class I Restricted Peptides That Induce CD8+ T Cells Against SARS-CoV-2 $249,999
University of California, Los Angeles Caroline Kuo Progression Award - Discovery Stage Research Projects Evaluation of Gene Therapy Approaches for Autosomal Recessive Hyper IgE Syndrome Due to Mutations in DOCK8 $234,000
Scripps Research Institute Stuart Lipton Discovery Research Projects Repurposing Aminoadamantane Nitrate Compounds to Inhibit SARS-CoV-2 Viral Activity and to Protect the Brain from Viral-Related Damage $150,000
University of Southern California Justin Ichida Discovery Research Projects Development of a novel PIKFYVE kinase inhibitor for the treatment of COVID-19 $150,000
University of California, San Francisco Michael Matthay Clinical Trial Stage Projects Mesenchymal Stromal Cells for ARDS (COVID positive and COVID negative) $701,049
ExCellThera Inc. Pierre Caudrelier Cure Sickle Cell Initiative Clinical Trial Stage Projects A Phase 1 Study of ECT-001 Expanded Cord Blood and Myeloablative Regimen with Reduced Toxicity in Patients with Severe Sickle Cell Disease. $2,000,000
University of California, Los Angeles Brigitte Gomperts Discovery Research Projects Identifying a lead compound for COVID19 using high throughput screening with lung stem cell organoids $149,998
University of California, Los Angeles Gay Crooks Discovery Research Projects Stem cell-based rapid identification of SARS-CoV-2 T cell epitopes and T cell receptors for therapeutic use $126,692
City of Hope, Beckman Research Institute John Zaia Clinical Trial Stage Projects Evaluation and Characterization of SARS-CoV-2 Antibody in Convalescent Volunteer Plasma Donors for Potential Therapeutic Use $999,999
Stanford University Hiromitsu Nakauchi Progression Award - Discovery Stage Research Projects Using metabolic pausing for maintaining stable and high-quality pluripotent stem cells $208,422
University of California, Davis Gerhard Bauer Conference - Manage The SPARK Annual Meeting The 2020 SPARK Annual Meeting $50,000
University of California, Los Angeles Yvonne Chen Therapeutic Translational Research Projects BCMA/CS1 Bispecific CAR-T Cell Therapy to Prevent Antigen Escape in Multiple Myeloma $3,176,805
Neurona Therapeutics Cory Nicholas Therapeutic Translational Research Projects Development of a human stem cell-derived inhibitory neuron therapeutic for the treatment of chronic focal epilepsy $4,848,505
Stanford University Rosa Bacchetta Late Stage Preclinical Projects IND-enabling activities for a Phase 1 Study of Autologous CD4LVFOXP3 T Cells in Subjects with IPEX Syndrome $5,002,496
jCyte, Inc Henry Klassen Clinical Trial Stage Projects A Phase 2 Study of the Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa $6,608,592
Cedars-Sinai Medical Center Clive Svendsen Clinical Trial Stage Projects Clinical Study to Assess Safety and Efficacy of Subretinal Injection of Human Neural Progenitor Cells for Treatment of Retinitis Pigmentosa $10,444,063
University of California, Los Angeles Sophie Deng Clinical Trial Stage Projects Safety and Feasibility of Cultivated Autologous Limbal Stem Cells for Limbal Stem Cell Deficiency $10,301,486
Brain Neurotherapy Bio Krystof Bankiewicz Clinical Trial Stage Projects A Phase 1b Safety Study for MRI guided delivery of AAV2-GDNF for the treatment of Parkinson’s disease $5,510,462
University of California, Los Angeles Caroline Kuo Therapeutic Translational Research Projects Ex Vivo Gene Editing of Human Hematopoietic Stem Cells for the Treatment of X-Linked Hyper-IgM Syndrome $4,896,628
City of Hope, Beckman Research Institute Karen Aboody Therapeutic Translational Research Projects Neural Stem cell-mediated oncolytic immunotherapy for ovarian cancer $2,873,262
City of Hope, Beckman Research Institute Saul Priceman Clinical Trial Stage Projects A Phase I Study of Chimeric Antigen Receptor Engineered Stem/Memory T Cells for the Treatment of HER2-Positive Brain Metastases $9,015,149
University of Southern California Mark Humayun Therapeutic Translational Research Projects PRPE-SF, polarized hESC-derived RPE Soluble Factors, as a Therapy for Early Stage Dry Age-related Macular Degeneration $3,733,556
University of California, Irvine Brian Cummings Therapeutic Translational Research Projects An optimized human neural stem cell line (hNSC) for the treatment of traumatic brain injury (TBI) $4,804,737
University of California, San Diego Mark Tuszynski Therapeutic Translational Research Projects Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI) $6,235,897
Sanford Burnham Prebys Medical Discovery Institute Evan Snyder Therapeutic Translational Research Projects Human Neural Stem Cells (hNSCs) for neuroprotection in perinatal hypoxic-ischemic brain injury (HII)-Pre-IND-enabling Studies $4,963,684
University of California, Davis Mehrdad Abedi Conference - The 2020 Alpha Stem Cell Clinic Annual Symposium CIRM - Leading the New Era of Living Medicines $60,000
University of California, San Diego Stephanie Cherqui Clinical Trial Stage Projects Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. $11,999,944
University of California, San Francisco Peter Stock Clinical Trial Stage Projects Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM $11,083,012
Aspen Neuroscience Andres Bratt-Leal Progression Award - Discovery Stage Research Projects Autologous therapy for Parkinson's disease: single cell RNAseq for in depth characterization of transplanted cells $177,579
University of California, San Francisco Mark Walters Late Stage Preclinical Projects Curing Sickle cell Disease with CRISPR-Cas9 genome editing $2,242,805
University of California, Los Angeles Theodore Nowicki Clinical Trial Stage Projects Genetic Modification of Stem Cells and T cells to Activate the Immune System to Target Solid Tumors $4,693,839
Rocket Pharmaceuticals, Inc. Kinnari Patel Clinical Trial Stage Projects LADICell $6,567,085
Cal State Univ, San Marcos Bianca Mothe Conference - Manage The Bridges Annual Meeting 2020 and 2021 Bridges Annual Meeting $320,000
Ankasa Regenerative Therapeutics Ying Zhu Late Stage Preclinical Projects IND-enabling development of ART352-L, an endogenous stem cell reactivation therapy to enhance bone healing in the elderly $3,987,693
Stanford University Judith Shizuru Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $1,113,487
Jasper Therapeutics, Inc. Wendy Pang Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $2,313,398
University of California, Irvine Leslie Thompson Late Stage Preclinical Projects An hESC-derived hNSC Therapeutic for Huntington’s Disease $5,635,393
Stanford University Everett Meyer Clinical Trial Stage Projects Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients $11,955,585
Angiocrine Bioscience, Inc. Edward Kavalerchik Clinical Trial Stage Projects AB-205-001 Phase 1b Trial and Related Activities to Support Clinical Development of AB-205 $6,192,579
University of California, Davis Diana Farmer Late Stage Preclinical Projects Placental Mesenchymal Stem Cell Augmentation of Fetal Myelomeningocele Repair $5,619,643
Pathways to Stem Cell Science Victoria Fox Conference - Manage The SPARK Annual Meeting 2019 SPARK Annual Meeting $49,915
University of California, San Francisco Karin Gaensler Therapeutic Translational Research Projects Developing engineered autologous leukemia vaccines to target residual leukemic stem cells $4,171,728
University of California, Los Angeles Steven Schwartz Therapeutic Translational Research Projects Clinical Translation of Autologous Regenerative Cell Therapy for Blindness $5,068,026
Stanford University Theodore Leng Therapeutic Translational Research Projects NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration $4,235,758
University of California, San Diego Jonathan Lin Quest - Discovery Stage Research Projects Small Molecule Proteostasis Regulators to Treat Photoreceptor Diseases $1,160,648
Children's Hospital of Los Angeles Tracy Grikscheit Quest - Discovery Stage Research Projects Universal Pluripotent Liver Failure Therapy (UPLiFT) $1,297,512
Scripps Research Institute Stuart Lipton Quest - Discovery Stage Research Projects Drug Development for Autism Spectrum Disorder Using Human Patient iPSCs $1,827,576
Stanford University Philip Beachy Quest - Discovery Stage Research Projects Pluripotent stem cell-derived bladder epithelial progenitors for definitive cell replacement therapy of bladder cancer $1,265,436
University of Southern California Neil Segil Quest - Discovery Stage Research Projects A screen for drugs to protect against chemotherapy-induced hearing loss, using sensory hair cells derived by direct lineage reprogramming from hiPSCs $741,574
Stanford University Alan Cheng Quest - Discovery Stage Research Projects Modulation of the Wnt pathway to restore inner ear function $1,394,870
City of Hope, Beckman Research Institute Xiuli Wang Late Stage Preclinical Projects CMV-specific T cells expressing anti-HIV CAR and CMV vaccine boost as immunotherapy for HIV/AIDS $3,812,797
University of California, San Francisco Mark Walters Conference - The 2019 Alpha Stem Cell Clinic Annual Symposium 2019 Alpha Stem Cell Clinic Symposium - Mending Stem Cells: The Past, Present & Future Regenerative Medicine $60,000
Poseida Therapeutics, Inc. Devon Shedlock Late Stage Preclinical Projects Late-Stage Preclinical Study of CAR-T Memory Stem Cells Targeting PSMA (P-PSMA-101) for the Treatment of Castrate-Resistant Metastatic Prostate Cancer $3,992,090
University of California, San Francisco Hideho Okada Quest - Discovery Stage Research Projects Non-viral reprogramming of the endogenous TCRα locus to direct stem memory T cells against shared neoantigens in malignant gliomas $900,000
City of Hope, Beckman Research Institute Saul Priceman Quest - Discovery Stage Research Projects Chimeric Antigen Receptor-Engineered Stem/Memory T Cells for the Treatment of Recurrent Ovarian Cancer $1,351,174
Stanford University Katja Weinacht Quest - Discovery Stage Research Projects Regenerative Thymic Tissues as Curative Cell Therapy for Patients with 22q11 Deletion Syndrome $1,251,720
University of California, San Diego Eric Adler Quest - Discovery Stage Research Projects Genetically Modified Hematopoietic Stem Cells for the Treatment of Danon Disease $1,393,200
University of California, Los Angeles Lili Yang Quest - Discovery Stage Research Projects Preclinical Development of An HSC-Engineered Off-The-Shelf iNKT Cell Therapy for Cancer $1,404,000
Gladstone Institutes, J. David Li Gan Quest - Discovery Stage Research Projects Develop iPSC-derived microglia to treat progranulin-deficient Frontotemporal Dementia $1,547,157
Salk Institute for Biological Studies Ronald Evans Quest - Discovery Stage Research Projects Therapeutic immune tolerant human islet-like organoids (HILOs) for Type 1 Diabetes $1,637,209
City of Hope, Beckman Research Institute John Zaia Late Stage Preclinical Projects Ex Vivo Gene Engineering of Blood Stem Cells for Enhanced Chemotherapy Efficacy in Glioblastoma Patients $3,684,259
University of California, San Francisco Krystof Bankiewicz Late Stage Preclinical Projects MRI Guided Delivery of Neural Progenitor Cells Secreting GDNF for the Treatment of Parkinson's disease $5,811,340
University of California, Los Angeles Steven Dubinett Clinical Trial Stage Projects A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC $10,955,315
MAX BioPharma, Inc. Farhad Parhami Therapeutic Translational Research Projects Therapeutic development of Oxy200, an oxysterol with bone anabolic and anti-resorptive properties for intervention in osteoporosis $1,400,000
Stanford University Bertha Chen Therapeutic Translational Research Projects Autologous iPSC-derived smooth muscle cell therapy for treatment of urinary incontinence $5,977,155

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