All CIRM Grants

Institution Researcher name Grant Type Grant Title Award Value
Poseida Therapeutics, Inc. Devon Shedlock Late Stage Preclinical Projects Late-Stage Preclinical Study of CAR-T Memory Stem Cells Targeting PSMA (P-PSMA-101) for the Treatment of Castrate-Resistant Metastatic Prostate Cancer $3,992,090
University of California, San Francisco Hideho Okada Quest - Discovery Stage Research Projects Non-viral reprogramming of the endogenous TCRα locus to direct stem memory T cells against shared neoantigens in malignant gliomas $900,000
City of Hope, Beckman Research Institute Saul Priceman Quest - Discovery Stage Research Projects Chimeric Antigen Receptor-Engineered Stem/Memory T Cells for the Treatment of Recurrent Ovarian Cancer $1,381,104
Stanford University Vittorio Sebastiano Quest - Discovery Stage Research Projects Regenerative Thymic Tissues as Curative Cell Therapy for Patients with 22q11 Deletion Syndrome $865,282
University of California, San Diego Eric Adler Quest - Discovery Stage Research Projects Genetically Modified Hematopoietic Stem Cells for the Treatment of Danon Disease $1,393,200
University of California, Los Angeles Lili Yang Quest - Discovery Stage Research Projects Preclinical Development of An HSC-Engineered Off-The-Shelf iNKT Cell Therapy for Cancer $1,404,000
Gladstone Institutes, J. David Li Gan Quest - Discovery Stage Research Projects Develop iPSC-derived microglia to treat progranulin-deficient Frontotemporal Dementia $1,553,923
Salk Institute for Biological Studies Ronald Evans Quest - Discovery Stage Research Projects Therapeutic immune tolerant human islet-like organoids (HILOs) for Type 1 Diabetes $1,637,209
University of California, San Diego James Hagood Quest - Discovery Stage Research Projects Mesenchymal stem cell extracellular vesicles as therapy for pulmonary fibrosis $865,282
University of California, San Francisco Krystof Bankiewicz Late Stage Preclinical Projects MRI Guided Delivery of Neural Progenitor Cells Secreting GDNF for the Treatment of Parkinson's disease $5,811,340
City of Hope, Beckman Research Institute John Zaia Late Stage Preclinical Projects Ex Vivo Gene Engineering of Blood Stem Cells for Enhanced Chemotherapy Efficacy in Glioblastoma Patients $3,684,259
University of California, Los Angeles Steven Dubinett Clinical Trial Stage Projects A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC $11,815,315
MAX BioPharma, Inc. Farhad Parhami Therapeutic Translational Research Projects Therapeutic development of Oxy200, an oxysterol with bone anabolic and anti-resorptive properties for intervention in osteoporosis $1,689,855
Stanford University Bertha Chen Therapeutic Translational Research Projects Autologous iPSC-derived smooth muscle cell therapy for treatment of urinary incontinence $5,977,155
University of California, Irvine Magdalene Seiler Therapeutic Translational Research Projects Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models $4,769,039
Children's Hospital of Oakland Research Institute Cassandra Calloway Diagnostic Translational Research Projects Development of a Noninvasive Prenatal Test for Beta-Hemoglobinopathies for Earlier Stem Cell Therapeutic Interventions $1,721,606
University of California, San Francisco Morton Cowan Clinical Trial Stage Projects Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells $12,000,000
Stanford University Crystal Mackall Clinical Trial Stage Projects Phase 1 Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Adults with Recurrent or Refractory B Cell Malignancies $11,034,982
Sangamo BioSciences, Inc. Ed Conner Clinical Trial Stage Projects A Phase 1/2 Study to Assess the Safety, Tolerability, and Efficacy of ST-400 Autologous HSPC Transplant in Transfusion-dependent β-Thalassemia $8,000,000
Fate Therapeutics, Inc. Bob Valamehr Late Stage Preclinical Projects IND enabling development of FT516: A Natural Killer Cell Immunotherapy for Cancer Derived from a Human Inducible Pluripotent Stem Cell $4,000,000
City of Hope, Beckman Research Institute Joseph Rosenthal Clinical Trial Stage Projects Treatment of sickle cell disease by induction of mixed chimerism and immune tolerance using CD4+ T-depleted haploidentical blood stem cell transplant $5,742,180
Medeor Therapeutics, Inc. Steven Deitcher Clinical Trial Stage Projects Cellular Immunotherapy for Induction of Immune Tolerance in HLA Matched Living Donor Kidney Transplant Recipients $18,763,585
University of California, Irvine Leslie Thompson Conference II Stem Cells for Huntington’s Disease (HD) International (SC4HDI) Conference $36,133
Keystone Symposia on Molecular and Cellular Biology Thale Jarvis Conference II iPSCs: A Decade of Progress and Beyond $35,000
University of California, San Francisco David Rowitch Conference II “Myelin Through the Ages: Evolution, Development, Degeneration and Disease” - 2018 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) $10,000
International Society for Stem Cell Research Glori Rosenson Conference II ISSCR 2019 Nucleus Forum $24,000
International Society for Stem Cell Research Cathy Vijeh Conference II ISSCR 2019 $50,000
Stanford University Joseph Wu Conference II 2018 Stanford Drug Discovery and Stem Cell Technology Conference $15,000
University of California, Riverside Xiaoping Hu Conference II 19th Annual UC System-wide Bioengineering Symposium $15,000
University of California, Los Angeles John Adams Conference - The 2018 Alpha Stem Cell Clinic Annual Symposium Delivery of Stem Cell Therapeutics to Patients $60,000
University of California, San Diego Tannishtha Reya Quest - Discovery Stage Research Projects Targeting Cancer Stem Cells in Hematologic Malignancies $1,960,560
University of California, Los Angeles Scott Kitchen Quest - Discovery Stage Research Projects Engineering Lifelong Cellular Immunity to HIV $1,701,178
University of California, San Francisco Shuvo Roy Quest - Discovery Stage Research Projects Silicon Nanopore Membrane encapsulated enriched-Beta Clusters for Type 1 Diabetes treatment $1,113,000
University of California, Irvine Aileen Anderson Quest - Discovery Stage Research Projects Generation and in vitro profiling of neural stem cell lines to predict in vivo efficacy for chronic cervical spinal cord injury. $1,575,613
City of Hope, Beckman Research Institute Saswati Chatterjee Quest - Discovery Stage Research Projects Genome Editing of Sinusoidal Endothelial Stem Cells for Permanent Correction of Hemophilia A $2,182,193
Neurona Therapeutics Cory Nicholas Quest - Discovery Stage Research Projects Development of a Cellular Therapeutic for Treatment of Epilepsy $1,616,536
University of California, San Diego Yang Xu Quest - Discovery Stage Research Projects Development of immune invisible beta cells as a cell therapy for type 1 diabetes through genetic modification of hESCs $1,960,560
ViaCyte, Inc. Alan Agulnick Quest - Discovery Stage Research Projects Preclinical development of an immune evasive islet cell replacement therapy for type 1 diabetes $1,470,987
Stanford University Helen Blau Quest - Discovery Stage Research Projects Stimulating endogenous muscle stem cells to counter muscle atrophy $2,198,687
University of California, San Diego Mark Tuszynski Quest - Discovery Stage Research Projects Neural Stem Cell Relays for Severe Spinal Cord Injury $1,905,173
Stanford University Irving Weissman Quest - Discovery Stage Research Projects Towards hepatocyte cell replacement therapy: developing a renewable source of human hepatocytes from pluripotent stem cells $1,968,456
University of California, Los Angeles April Pyle Quest - Discovery Stage Research Projects Identification and Generation of Long Term Repopulating Human Muscle Stem Cells from Human Pluripotent Stem Cells $2,184,000
University of California, Los Angeles Stanley Carmichael Quest - Discovery Stage Research Projects iPS Glial Therapy for White Matter Stroke and Vascular Dementia $2,096,095
University of California, Davis Alice Tarantal Inception - Discovery Stage Research Projects Enhanced Branching Morphogenesis and Pluripotent Cell Lineage Differentiation for Pediatric Regenerative Therapies $235,800
Palo Alto Veterans Institute for Research Ngan Huang Inception - Discovery Stage Research Projects iPSC-Derived Smooth Muscle Progenitors for Treatment of Abdominal Aortic Aneurysm $172,621
Loma Linda University David Baylink Inception - Discovery Stage Research Projects Bone Marrow Targeting of Hematopoietic Stem Cells Engineered to Overexpress 25-OH-VD3 1-α-hydroxylase for Acute Myeloid Leukemia Therapy $178,967
Cedars-Sinai Medical Center Dmitriy Sheyn Inception - Discovery Stage Research Projects IVD rejuvenation using iPSC-derived notochordal cells $241,992
Zenobia Therapeutics Vicki Nienaber Inception - Discovery Stage Research Projects A new phenotypic screening platform that identifies biologically-relevant targets and lead compounds for the treatment of Parkinson’s disease $150,000
University of California, Los Angeles Alireza Moshaverinia Inception - Discovery Stage Research Projects Gingival mesenchymal stem cells as a novel treatment modality for periodontal tissue regeneration $194,483
Stanford University Anthony Oro Therapeutic Translational Research Projects DEBCT: Genetically Corrected, Induced Pluripotent Cell-Derived Epithelial Sheets for Definitive Treatment of Dystrophic Epidermolysis Bullosa $5,107,353
University of California, San Diego Karl Wahlin Inception - Discovery Stage Research Projects An IPSC cell based model of macular degeneration for drug discovery. $232,200
University of California, San Diego Catriona Jamieson Therapeutic Translational Research Projects A Splicing Modulator Targeting Cancer Stem Cells in Acute Myeloid Leukemia $2,511,767
University of California, San Diego Dan Kaufman Therapeutic Translational Research Projects Human Embryonic Stem Cell-Derived Natural Killer Cells for Cancer Treatment $4,698,821
University of California, San Francisco Semil Choksi Inception - Discovery Stage Research Projects Generation of human airway stem cells by direct transcriptional reprogramming for disease modeling and regeneration $238,408
Stanford University Guillem Pratx Inception - Discovery Stage Research Projects Novel metabolic labeling method for tracking stem cells to irradiated salivary glands using PET $235,613
University of California, Davis Alyssa Panitch Inception - Discovery Stage Research Projects Development of treatments to improve healing of ischemic wounds $235,800
University of California, San Diego Gerald Morris Inception - Discovery Stage Research Projects Identification of antigenic neo-epitopes from in vitro reprogrammed human tissue precursors for regenerative therapy $193,500
Stanford University Hiromitsu Nakauchi Inception - Discovery Stage Research Projects Optimizing self-renewal signaling kinetics to stabilize ex vivo hematopoietic stem cell expansion $210,906
Human BioMolecular Research Institute John Cashman Inception - Discovery Stage Research Projects Human Pancreatic Cancer Stem Cells: Developing a Novel Drug for Cancer Eradication $303,894
Loma Linda University Julia Unternaehrer-Hamm Inception - Discovery Stage Research Projects Targeting cancer stem cells with nanoparticle RNAi delivery to prevent recurrence and metastasis of ovarian cancer $172,870
California Institute for Biomedical Research Kristen Johnson Clinical Trial Stage Projects Evaluation of the Safety and Tolerability of KA34 in a Phase 1, Double-Blind, Dose Escalation Trial in Patients with Knee Osteoarthritis $8,447,523
Children's Hospital of Los Angeles Michael Pulsipher Clinical Trial Stage Projects Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation (ACES) $4,825,587
Poseida Therapeutics, Inc. Matthew Spear Clinical Trial Stage Projects Clinical Study of T stem cell memory (Tscm)-based CAR-T cells in Patients with Multiple Myeloma $19,813,407
University of California, Davis Gerhard Bauer Conference - Manage The SPARK Annual Meeting The 2018 SPARK Annual Meeting $48,305
Cal State Univ, San Marcos Bianca Mothe Conference - Manage The Bridges Annual Meeting 2018 and 2019 Bridges Annual Meeting $320,000
Alliance Forum Foundation George Hara Conference II 2017 World Alliance Forum in San Francisco (WAFSF) "Healthcare Game Changers" $5,000
RUNX1 Research Program Timothy Babich Conference II Living with and Curing RUNX1 FPD/AML Forum $9,500
Stanford University Matthew Porteus Late Stage Preclinical Projects Genome Editing of Autologous Hematopoietic Stem Cells to Treat Sickle Cell Disease $4,849,363
Nohla Therapeutics Inc Colleen Delaney Clinical Trial Stage Projects A Phase 2 Open-Label, Multi-Center, Randomized, Controlled, Optimal Dose-Finding Study of DCC-UCB in Adults Receiving High Dose Chemotherapy for AML $6,922,109
ViaCyte, Inc. Howard Foyt Clinical Trial Stage Projects Clinical trial of directly vascularized islet cell replacement therapy for high-risk type 1 diabetes $19,752,463
Humacyte, Inc. Jeffrey Lawson Clinical Trial Stage Projects A Phase 3 Study Comparing the Utility of Human Acellular Vessels to Arteriovenous Fistula in Subjects with End-Stage Renal Disease (California Sites) $14,082,865
Forty Seven Inc. Mark Chao Clinical Trial Stage Projects A Phase 1b Trial of Hu5F9-G4 Monotherapy or Hu5F9-G4 in Combination with Azacitidine in Patients with Acute Myeloid Leukemia $3,200,000
City of Hope, Beckman Research Institute Christine Brown Clinical Trial Stage Projects Phase I Study of Chimeric Antigen Receptor Engineered Central Memory T cells for the Treatment of Malignant Glioma $12,753,854
University of California, Davis Mehrdad Abedi Alpha Stem Cell Clinics Network Expansion Alpha Stem Cell Clinic for Northern and Central California $7,905,671
Children's Hospital of Oakland Research Institute Mark Walters Alpha Stem Cell Clinics Network Expansion University of California, San Francisco (UCSF) CIRM Alpha Stem Cell Clinic $7,999,999
Angiocrine Bioscience, Inc. Paul Finnegan Clinical Trial Stage Projects AB-110-001 Phase 1b Trial and Related Activities to Support Clinical Development of AB-110 $5,000,000
University of California, San Diego Thomas Kipps Clinical Trial Stage Projects A Phase 1b/2a Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab, and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in B-Cell Cancers $18,292,674
International Alliance for Biological Standardization Anthony Lubiniecki Conference - Manage a Symposium on Pluripotent Stem Cell Manufacturing Basis of Standardization for Cell Therapies $100,000
University of California, San Diego Ezra Cohen Therapeutic Translational Research Projects Development of ROR1 CAR-T cells to target cancer stem cells in advanced malignancies $5,795,584
BrainStorm Cell Therapeutics Ralph Kern Clinical Trial Stage Projects A Phase 3, Randomized, Placebo-controlled Multicenter Study to Evaluate Efficacy & Safety of Repeated Administrations of NurOwn® in Patients with ALS $15,912,390
JDRF International Esther Latres Conference II JDRF Encapsulation Consortium Fall 2017 Meeting $42,425
City of Hope, Beckman Research Institute Yuan Chen Quest - Discovery Stage Research Projects A Novel Approach to Eradicate Cancer Stem Cells $1,839,484
Stanford University Mark Mercola Quest - Discovery Stage Research Projects Multipotent Cardiovascular Progenitor Regeneration of the Myocardium after MI $1,809,234
University of California, Davis Deborah Lieu Quest - Discovery Stage Research Projects Microenvironment for hiPSC-derived pacemaking cardiomyocytes $2,042,728
University of California, Los Angeles Caroline Kuo Quest - Discovery Stage Research Projects Targeted Gene Editing in the Treatment of X-Linked Hyper-IgM Syndrome $1,512,333
X-Therma Inc. Xiaoxi Wei Quest - Discovery Stage Research Projects Non-Toxic, Highly-Effective Bioinspired Cryoprotectants for On-Demand Stem Cell Therapies $887,883
University of California, Los Angeles Gay Crooks Quest - Discovery Stage Research Projects Platform Technology for Pluripotent Stem Cell-Derived T cell Immunotherapy $965,636
Rumi Scientific CA Ali Brivanlou Quest - Discovery Stage Research Projects Discovery of therapeutics for Huntington’s Disease $1,399,800
University of California, Los Angeles Vaithilingaraja Arumugaswami Quest - Discovery Stage Research Projects Immunization strategies to prevent Zika viral congenital eye and brain disease $2,128,867
University of California, Irvine Brian Cummings Quest - Discovery Stage Research Projects Identification and characterization of the optimal human neural stem cell line (hNSC) for the treatment of traumatic brain injury (TBI) 2.0. $1,671,213
City of Hope, Beckman Research Institute Markus Müschen Quest - Discovery Stage Research Projects Lgr5-mediated self-renewal in B cell selection and leukemia-initiation $2,186,520
Stanford University Gary Steinberg Late Stage Preclinical Projects Intraparenchymal NR1 Stem Cell Therapy for Chronic Subcortical Ischemic Stroke $5,300,000
Scaled Biolabs Inc. Justin Cooper-White Quest - Discovery Stage Research Projects A tool for rapid development of clinical-grade protocols for dopaminergic neuronal differentiation of Parkinson’s Disease patient-derived iPSCs $657,528
Cellerant Therapeutics, Inc. Jagath Junutula Late Stage Preclinical Projects Development of CLT030-ADC, a Leukemic Stem Cell Targeting Antibody-Drug-Conjugate, for Treatment of Acute Myeloid Leukemia $6,863,755
University of California, San Francisco Holger Willenbring Quest - Discovery Stage Research Projects Preclinical development of AAV vector-mediated in vivo hepatic reprogramming of myofibroblasts as a therapy for liver fibrosis $1,638,389
SanBio, Inc. Damien Bates Clinical Trial Stage Projects A Double-Blind, Controlled Ph 2b Study of the Safety and Efficacy of Modified Stem Cells in Patients with Chronic Motor Deficit from Ischemic Stroke $19,998,580
University of California, Berkeley Kevin Healy Quest - Discovery Stage Research Projects Human Cardiac Chip for Assessment of Proarrhythmic Risk $899,595
University of California, San Francisco Tippi MacKenzie Clinical Trial Stage Projects In Utero Hematopoietic Stem Cell Transplantation For The Treatment Of Fetuses With Alpha Thalassemia Major $10,906,978
University of Southern California Biju Thomas Inception - Discovery Stage Research Projects A Novel Tissue Engineering Technique to Repair Degenerated Retina $215,133
University of California, San Francisco Sonja Schrepfer Inception - Discovery Stage Research Projects Hypo-immunogenic cardiac patches for myocardial regeneration $238,500

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