UCLA gene therapy offers children with LAD-I new hope
Diagnosed with LAD-I at age eight after years of hospitalizations, Marley Gaskins’ immune system is restored after participating in a CIRM-funded clinical trial.
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CIRM-funded clinical trial gives siblings a second chance at life
The Langenhop children, all diagnosed with LAD-I, now have healthy immune systems after participating in a CIRM-funded clinical trial at UCLA.
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Accelerating Cures for Californians—and Beyond
The California Institute for Regenerative Medicine (CIRM) is a state agency created by California voters to accelerate stem cell and gene therapies for people with unmet medical needs. Since 2004, Californians have entrusted CIRM with $8.5 billion to accelerate promising discoveries through clinical trials, train a regenerative medicine workforce, strengthen the state’s biotechnology economy, and expand access to transformative treatments.
Driving Innovation
Accelerating world class science
CIRM is a catalyst for discovery, supporting cutting-edge cell and gene therapies to advance the field of medicine. Through our research and development programs, CIRM continues to accelerate the translation of groundbreaking discoveries into therapies that have the potential to make a real impact on the lives of Californians and patients worldwide.
Building On Discoveries
CIRM supports the full spectrum of research, from early discovery research to clinical trials, while building infrastructure to advance innovation and providing education programs to train the next generation of scientists.
Discovery
Supports innovative early-stage research projects
Preclinical
Advances research for pre-clinical studies or broad end use
Clinical
Supports clinical stage projects
Education
Provides opportunities to diverse, next-generation scientists
Infrastructure
Addresses infrastructure challenges in regenerative medicine
Fueling Growth
Making an impact across California and the world
CIRM drives new possibilities in science and promotes economic growth by creating jobs, funding infrastructure, and growing a diverse workforce to drive progress in the regenerative medicine field.
Investments in CIRM-funded research by biotech, pharma and industry partners
Interns, fellows, and trainees supported through educational and training programs
Full-time equivalent
jobs created
Photo Credit: UC Regents
Impacting Communities
Bringing Therapies to Californians
CIRM is committed to making groundbreaking cell and gene therapy treatments accessible to people who need them.
Funding Progress
To date, CIRM has funded and supported more than 100 cell and gene therapy clinical trials, each aiming to find treatments for diseases and conditions that affect people across California and worldwide.
CIRM-Funded Clinical Trials
Inspiring The Future
Calling the next generation of scientists
CIRM is passionate about catalyzing growth in regenerative medicine while championing inclusivity. Our education and training programs provide internships and opportunities to inspire scientists and trainees at various levels.
Stories from The Stem Cellar
CIRM’s official blog
“An awesome responsibility”: A conversation with CIRM board member Kim Barrett
It’s not every day that you get to contribute to something that could help save a life, but when Kim Barrett joined the board of the California Institute for Regenerative Medicine (CIRM), that’s exactly what happened.
Winner of Beast Games becomes champion for his son’s rare disease
You can do a lot with $10 million. Yet, when Jeffrey Randall Allen won the largest prize in game show history on Amazon Prime Video’s Beast Games there was only one thing he wanted to spend his $10 million on—research that might help find a cure for his son’s rare disease.
Tackling Sickle Cell Disease from within
Evie Junior was born with sickle cell disease, a life-threatening condition that affects around 100,000 Americans, most of them Black and Latino. People with sickle cell disease have blood cells that are shaped like a hook (or sickle) rather than smooth and round, which can create clogs, causing intense pain, organ damage, and stroke.