Funding Opportunities for Infrastructure Projects

Objective

The mission of California Institute for Regenerative Medicine (CIRM) is to accelerate world class science to deliver transformative regenerative medicine treatments in an equitable manner to a diverse California and world. In December 2021, CIRM released its Strategic Plan for 2022-2027. The Strategic Plan describes CIRM’s Infrastructure Programs which are designed to address the challenges that currently hinder progress in the regenerative medicine field.

INFR 4: Alpha Clinics Network Expansion Award

The Alpha Clinics Network Expansion Award aims to expand existing capacities for delivering stem cell, gene therapies and other advanced treatment to patients. The Alpha Clinics Network is designed to serve as a competency hub for regenerative medicine training, clinical research, and the delivery of approved treatments. 

Please see the RFA for full details:

Watch a video recording of our Alpha Clinics Network Concept Plan from April 2022. The slide deck is available here.

An FAQ, which will be periodically updated in response to ongoing questions received by CIRM, and tips on the application WYSIWYG editor are available. 

Applications for the Alpha Clinics Network Expansion are closed. 


INFR 5: California Cell and Gene Therapy Manufacturing Network, Phase One Awards

The California Cell and Gene Therapy Manufacturing Network aims to establish a statewide manufacturing network comprising academic process development and GMP manufacturing facilities as well as industry manufacturing partners that will: (1) accelerate and de-risk pathways to commercialization for cell and gene therapies (2) advance industry standards and incorporate quality-by-design in cell and gene therapy manufacturing, and (3) build a diverse, highly skilled manufacturing workforce in California.

CIRM will issue two phases of awards governed by two separate requests for applications (RFAs). This RFA describes the first phase of awards that will fund California academic GMP facilities to make initial progress toward the three network goals (described above) at their individual facilities.

Please see the RFA for full details:

Watch a video recording of our INFR5 Phase 1 RFA webinar from November 17, 2022. The slide deck is available here. A frequently asked questions (FAQ) list is also provided for reference.

Applications for the California Cell and Gene Therapy Manufacturing Network, Phase I awards are closed.


INFR 6: Shared Resources Laboratories for Stem Cell-Based Modeling 

The Shared Resources Laboratories (SRL) for Stem Cell-Based Modeling program intends to accelerate regenerative medicine research by establishing a network of core facilities that 1) broaden access to stem cell-based models across CA, 2) advance standards and reproducibility of stem cell-based models, 3) increase access to educational opportunities in stem cell-based techniques, and 4) develop sustainable stem cell core infrastructure. 

The program intends to fund two different types of SRL that will be solicited through two separate requests for applications (RFAs): 1) Establishing (E)-SRLs to provide local access to stem cell-based models, training, specialized equipment, and educational opportunities in geographic areas/locations where access to models is limited; and 2) Enhancing / Expanding (E/E)-SRLs to enable leading experts in stem cell-based modeling to share their models and expertise locally and broadly across California.  

Please see the concept, approved by the ICOC on October 27, 2022 and amended on December 15,2022 for some details: 

The RFAs and applications are still under development and the application due date has not yet been established but is currently estimated Q3 2023. Please visit this web page for updates, and subscribe to receive information about CIRM Funding Opportunities


To Submit an Application:

  1. Go to the Grants Management Portal (https://grants.cirm.ca.gov) and log in with your existing CIRM Username and Password. If you do not have a Username, Click on the "New User" link and follow the instructions to create a CIRM Username and password.
  2. After logging in, Click on the Menu tab. Select the tab labeled "Open Programs". Under the section labeled "RFAs and Programs Open for Applications", click on the applicable link to "Start an INFR Application".
  3. Complete each section of the Application by clicking on the appropriate link and following the posted instructions. Proposal templates can be located and submitted under the "Uploads" section.
  4. To submit your Application, click on the "Done with Application" button. The "Done with Application" button will be enabled when all of the mandatory sections have been completed. Please note that once this has been selected, you will no longer be able to make changes to your Application.
  5. To confirm submission of your Application, select the tab labeled "Your Applications" and check the table under the section labeled "Your Submitted Applications". You will see your Application number and project title listed once the submission process has been completed.

For more information on the programs and buildings we've funded, check out our Program and Building Infrastructure Page.