Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Immune Disease, Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Antibody	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Melanoma, Skin cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Osteonecrosis	Adult Stem Cell	Small molecule therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Heart Disease	Embryonic Stem Cell	Donor cell therapy	Stanford	IND
Intestinal Disease	Adult Stem Cell	Personalized cell therapy	CHLA	Development Candidate, Proof of Concept
Blood Disorders	Embryonic Stem Cell	Donor cell therapy	UCSF	Research Insights
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Age-related macular degeneration	Embryonic Stem Cell	Donor cell therapy	USC	Clinical Trial, Phase 1 or Phase 1/2
Respiratory Disorders	iPS Cell	Exploring stem cell mechanisms	Cedars-Sinai	Research Insights
Blood Disorders	iPS Cell	Model system development	Stanford	Research Insights, Tool/Resources/Bottleneck
Amyotrophic Lateral Sclerosis, Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Cell imaging & tracking	UCSD	Research Insights
Spinal Cord Injury	Embryonic Stem Cell	Donor cell therapy	Asterias	Clinical Trial, Phase 1 or Phase 1/2
HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Other	Embryonic Stem Cell	Cell imaging & tracking	UC Berkeley	Tool/Resources/Bottleneck
Heart Disease, Neurological Disorders	Embryonic Stem Cell, iPS Cell	Tissue engineering	Gladstone	Proof of Concept, Research Insights
Liver Disease	iPS Cell	Cell processing & handling	USC	Tool/Resources/Bottleneck
Blood Disorders	Embryonic Stem Cell	Specific Cell Type Derivation	UCLA	Tool/Resources/Bottleneck
Skeletal/Smooth Muscle disorders	Embryonic Stem Cell, iPS Cell	Tissue engineering	UCSD	Tool/Resources/Bottleneck
Bone or Cartilage Disease	Adult Stem Cell	Tissue engineering	Stanford	Proof of Concept, Research Insights
Blood Disorders	Adult Stem Cell	Cell processing & handling	UCSF	Tool/Resources/Bottleneck
Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Spinal Muscular Atrophy	Embryonic Stem Cell	Model system development	UCLA	Tool/Resources/Bottleneck
HIV-related Lymphoma, HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, X-linked Chronic Granulomatous Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders	Adult Stem Cell	Exploring stem cell mechanisms	UCLA	Development Candidate, Proof of Concept, Research Insights
Intestinal Disease, Neurological Disorders	iPS Cell	Donor cell therapy	CHLA	Pre-IND/IDE or Equivalent
Metabolic Disorders, Neurological Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	UC Davis	Pre-IND/IDE or Equivalent
Brain Cancer	Cancer Stem Cell	Vaccine	Stanford	Pre-IND/IDE or Equivalent
Canavan Disease	iPS Cell	Gene-modified, personalized cell therapy	COH	Pre-IND/IDE or Equivalent
Multiple Myeloma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Vision Loss	iPS Cell	Cell processing & handling	UCSD	Tool/Resources/Bottleneck
Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Donor cell therapy	UC Berkeley	Proof of Concept
Autism	Adult Stem Cell	Gene-modified, donor cell therapy	UC Davis	Development Candidate, Proof of Concept
Cystinosis	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	IND
Heart disease associated with Duchenne muscular dystrophy	Adult Stem Cell	Donor cell therapy	Capricor	Clinical Trial, Phase 2
Kidney Failure	Adult Stem Cell	Biologic	Humacyte	Clinical Trial, Phase 3
Bone or Cartilage Disease	Embryonic Stem Cell	Donor cell therapy	USC	Pre-IND/IDE or Equivalent
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	CHORI	Pre-IND/IDE or Equivalent
Pulmonary Hypertension, Vascular Disease	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Colon Cancer	Cancer Stem Cell	Antibody	Forty Seven	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders, Immune Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Development Candidate
Type 1 diabetes	Embryonic Stem Cell	Device	UCSF	Proof of Concept
Liver Disease	Adult Stem Cell	Donor cell therapy	Stanford	Development Candidate
Huntington's Disease	Embryonic Stem Cell	Gene-modified, donor cell therapy	UC Irvine	Development Candidate, Proof of Concept
Heart Disease	Directly Reprogrammed Cell	Gene modification	Gladstone	Proof of Concept
Blood Cancer, Ovarian Cancer	Embryonic Stem Cell, iPS Cell	Donor cell therapy	UCSD	Development Candidate
Blood Disorders, Blood Cancer	Adult Stem Cell	Small molecule therapy	UCLA	Development Candidate
Diabetes	Embryonic Stem Cell	Donor cell therapy	UCSF	Development Candidate, Proof of Concept
Cystic Fibrosis	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Development Candidate
Neurological Disorders, Zika virus	iPS Cell	Small molecule therapy	UCSD	Development Candidate
Corneal Damage	Adult Stem Cell	Personalized cell therapy	UCLA	IND

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
– Liver Disease
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering