Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Osteonecrosis	Adult Stem Cell	Small molecule therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Amyotrophic Lateral Sclerosis, Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Cell imaging & tracking	UCSD	Research Insights
Spinal Cord Injury	Embryonic Stem Cell	Donor cell therapy	Lineage Cell	Clinical Trial, Phase 1 or Phase 1/2
HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Other	Embryonic Stem Cell	Cell imaging & tracking	UC Berkeley	Tool/Resources/Bottleneck
HIV-related Lymphoma, HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, X-linked Chronic Granulomatous Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Intestinal Disease, Neurological Disorders	iPS Cell	Donor cell therapy	CHLA	Pre-IND/IDE or Equivalent
Canavan Disease	iPS Cell	Gene-modified, personalized cell therapy	COH	Pre-IND/IDE or Equivalent
Leukemia, Acute Myeloid (AML), Multiple Myeloma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Pulmonary Hypertension, Vascular Disease	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Retinitis Pigmentosa	Other	Donor cell therapy	jCyte	Clinical Trial, Phase 2
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Vascular Disease	Adult Stem Cell	Biologic	UCSD	Pre-IND/IDE or Equivalent
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Gene-modified, donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	St. Jude	Clinical Trial, Phase 1 or Phase 1/2
Neurological Disorders, Zika virus	Adult Stem Cell, iPS Cell	Vaccine	UCLA	Development Candidate
Stroke	Embryonic Stem Cell	Donor cell therapy	Stanford	IND
Alpha Thalassemia Major	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Cancer	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSD	Pre-IND/IDE or Equivalent
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Personalized cell therapy	BrainStorm	Clinical Trial, Phase 3
Blood Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	Angiocrine	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Leukemia	Cancer Stem Cell	Antibody	UCSD	Clinical Trial, Phase 1 or Phase 1/2
Type 1 diabetes	Embryonic Stem Cell	Donor cell therapy	ViaCyte	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Arthritis, Osteoarthritis	Adult Stem Cell	Small molecule therapy	Calibr	Clinical Trial, Phase 1 or Phase 1/2
Blood Cancer, Bone Marrow Transplant and Viral Infection	Adult Stem Cell	Donor cell therapy	CHLA	Clinical Trial, Phase 1 or Phase 1/2
Multiple Myeloma	Adult Stem Cell	Gene-modified, personalized cell therapy	Poseida Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
Epidermolysis Bullosa	iPS Cell	Gene-modified, personalized cell therapy	Stanford	Pre-IND/IDE or Equivalent
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Small molecule therapy	UCSD	Pre-IND/IDE or Equivalent
Leukemia, Acute Myeloid (AML)	Embryonic Stem Cell	Donor cell therapy	UCSD	Pre-IND/IDE or Equivalent
Vascular Disease	iPS Cell	Personalized cell therapy	PAVIR	Proof of Concept, Research Insights
Hemophilia A	Adult Stem Cell	Gene modification	COH	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell	Gene-modified, donor cell therapy	UCSD	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell	Gene-modified, donor cell therapy	ViaCyte	Development Candidate
Muscular Dystrophy	Embryonic Stem Cell, iPS Cell	Personalized cell therapy	UCLA	Development Candidate
HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Development Candidate, Proof of Concept
Spinal Cord Injury	Adult Stem Cell	Donor cell therapy	UC Irvine	Development Candidate
Kidney Failure	Adult Stem Cell	Donor cell therapy	Medeor Therapeutics	Clinical Trial, Phase 3
Sickle Cell Disease	Adult Stem Cell	Donor cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Leukemia	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Beta Thalassemia	Adult Stem Cell	Gene-modified, personalized cell therapy	Sangamo	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	Orchard Therapeutics	Clinical Trial, Phase 2
Lung Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Bladder or Urinary Tract Disorder, Incontinence	iPS Cell	Personalized cell therapy	Stanford	Pre-IND/IDE or Equivalent
Retinitis Pigmentosa	Embryonic Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Beta Thalassemia, Sickle Cell Disease	Adult Stem Cell	Diagnostic Test	CHORI	Regulated Lab Test, Ready for Validation
Parkinson's Disease	Adult Stem Cell	Gene-modified, donor cell therapy	UCSF	IND

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering