Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Osteonecrosis	Adult Stem Cell	Small molecule therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders	iPS Cell	Model system development	Stanford	Research Insights, Tool/Resources/Bottleneck
Amyotrophic Lateral Sclerosis, Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Cell imaging & tracking	UCSD	Research Insights
Spinal Cord Injury	Embryonic Stem Cell	Donor cell therapy	Lineage Cell	Clinical Trial, Phase 1 or Phase 1/2
HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Other	Embryonic Stem Cell	Cell imaging & tracking	UC Berkeley	Tool/Resources/Bottleneck
Heart Disease, Neurological Disorders	Embryonic Stem Cell, iPS Cell	Tissue engineering	Gladstone	Proof of Concept, Research Insights
HIV-related Lymphoma, HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, X-linked Chronic Granulomatous Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders, Leukemia	Adult Stem Cell	Exploring stem cell mechanisms	UCLA	Development Candidate, Proof of Concept, Research Insights
Intestinal Disease, Neurological Disorders	iPS Cell	Donor cell therapy	CHLA	Pre-IND/IDE or Equivalent
Canavan Disease	iPS Cell	Gene-modified, personalized cell therapy	COH	Pre-IND/IDE or Equivalent
Multiple Myeloma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Kidney Failure	Adult Stem Cell	Biologic	Humacyte	Clinical Trial, Phase 3
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	CHORI	Pre-IND/IDE or Equivalent
Pulmonary Hypertension, Vascular Disease	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Colon Cancer	Cancer Stem Cell	Antibody	Forty Seven	Clinical Trial, Phase 1 or Phase 1/2
Liver Disease	Adult Stem Cell	Donor cell therapy	Stanford	Development Candidate
Corneal Damage	Adult Stem Cell	Personalized cell therapy	UCLA	IND
Retinitis Pigmentosa	Other	Donor cell therapy	jCyte	Clinical Trial, Phase 2
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Vascular Disease	Adult Stem Cell	Biologic	UCSD	Pre-IND/IDE or Equivalent
Type 1 diabetes	Adult Stem Cell	Personalized cell therapy	Caladrius Biosciences	Clinical Trial, Phase 2
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Gene-modified, donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	St. Jude	Clinical Trial, Phase 1 or Phase 1/2
Skeletal/Smooth Muscle disorders	Adult Stem Cell	Protein/peptide therapy	Stanford	Research Insights
B cell cancers, Leukemia	Cancer Stem Cell	Antibody	COH	Development Candidate, Proof of Concept
Liver Disease	Directly Reprogrammed Cell	Gene modification	UCSF	Development Candidate
Heart Disease	iPS Cell	Model system development	UC Berkeley	Proof of Concept
Heart Disease	iPS Cell	Donor cell therapy	Stanford	Development Candidate, Proof of Concept
Heart Disease	iPS Cell	Personalized cell therapy	UC Davis	Proof of Concept
Hyper IgM Syndrome	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Development Candidate, Proof of Concept
Other	Embryonic Stem Cell, iPS Cell	Cell processing & handling	X-Therma	Proof of Concept, Tool/Resources/Bottleneck
Neurological Disorders, Zika virus	Adult Stem Cell, iPS Cell	Vaccine	UCLA	Development Candidate
Stroke	Embryonic Stem Cell	Donor cell therapy	Stanford	IND
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Antibody	Cellerant Therapeutics	IND
Stroke	Adult Stem Cell	Gene-modified, donor cell therapy	SanBio, Inc.	Clinical Trial, Phase 2
Alpha Thalassemia Major	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Cancer	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSD	Pre-IND/IDE or Equivalent
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Personalized cell therapy	BrainStorm	Clinical Trial, Phase 3
Blood Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	Angiocrine	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Leukemia	Cancer Stem Cell	Antibody	UCSD	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	IND
Type 1 diabetes	Embryonic Stem Cell	Donor cell therapy	ViaCyte	Clinical Trial, Phase 1 or Phase 1/2
Kidney Failure	Adult Stem Cell	Biologic	Humacyte	Clinical Trial, Phase 3
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Antibody	Forty Seven	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Arthritis, Osteoarthritis	Adult Stem Cell	Small molecule therapy	Calibr	Clinical Trial, Phase 1 or Phase 1/2
Blood Cancer, Bone Marrow Transplant and Viral Infection	Adult Stem Cell	Donor cell therapy	CHLA	Clinical Trial, Phase 1 or Phase 1/2

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
– Liver Disease
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering