DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we profile the DNA methylome, transcriptome, and global occupancy of histone modifications (H3K4me1, H3K4me3, H3K27me3, and…
Parkinson’s disease (PD) is a devastating movement disorder caused by the death of dopaminergic neurons (a type of neurons in the central nervous system) present in the midbrain. These neurons…
A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of…
Regenerative therapies require effective differentiation of stem cells to cell types that are functionally identical to those found in vivo. Many current differentiation protocols merely involve optimization of proteins added…
Embryonic stem cells have the potential to become any cell type in the adult organism, but coaxing them to a specific fate continues to be a challenge for researchers. While…
This manuscript identified metabolic consequences of stem cell cultivation procedures. As cells grow they must be split to be expanded. Some compounds used to passage or split cells cause stress…
Osteoarthritis (OA) is a common and burdensome condition affecting millions of people. Injuries to the joint's surface can increase the risk of OA. Current treatments for cartilage repair are only…
Embryonic stem (ES) cells have the unique ability to self-renew while maintaining a pluripotent state. They can readily be differentiated into all cell types upon exposure to the appropriate stimuli.…
