Alpha Clinics Trials

The Alpha Clinics Network is pursuing its goal to accelerate the development and delivery of stem cell treatments to patients through high quality clinical trials.

Browse the list of ongoing trials at Alpha Clinic locations in the table below. You can sort trials based on different fields by clicking on the appropriate column header. Trials are automatically listed by status of trial enrollment and Alpha Clinic location.

Alpha Clinic Trials

Alpha Clinic	Alpha Clinic Contact	Trial Sponsor	Disease Indication	Clinical Trial Name	Status of Enrollment	Learn More
UCI	UCI Stem Cell Clinic (949) 824-3990 stemcell@uci.edu	Longeveron	Aging frailty	Phase IIb Trial to Evaluate Longeveron Mesenchymal Stem Cells to Treat Aging Frailty	Active, not recruiting
UC Davis	Jane McCluskey 916-703-9302 jmccluskey@ucdavis.edu	Pluristem Ltd.	Muscle Injury - hip fracture	Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study, Designed to Determine the Efficacy, Safety, and Tolerability of Intramuscular Administration of Allogeneic PLX-PAD Cells for the Treatment of Muscle Injury Following Arthroplasty	Recruiting
City of Hope	Karen Reckamp, MD 626-218-9200 kreckamp@coh.org	Glaxo Smith Kline (GSK)	Cancer - Lung	Pilot Immunotherapy Study With Autologous T-cells Specific for New York Esophageal Antigen-1 (NY-ESO-1)/ Cancer-testis Antigen-2 (LAGE-1a)-Positive Advanced Non-small Cell Lung Cancer (NSCLC) Either Alone or in Combination With Pembrolizumab	No longer active
UCSF & UCSD & CIRM	Jane McCluskey 916-703-9302 jmccluskey@ucdavis.edu	CIRM	ARDS/COVID	Prospective, Randomized, Multi-center Phase 2 Clinical Trial of Allogeneic Bone Marrow-derived Human Mesenchymal Stromal Cells (hMSCs) for the Treatment of Acute Respiratory Distress Syndrome (ARDS)	No longer active	Prospective, Randomized, Multi-center Phase 2 Clinical Trial of Allogeneic Bone Marrow-derived Human Mesenchymal Stromal Cells (
City of Hope	Tanya Dorff, MD 626-218-9200 tdorff@coh.org	City of Hope	Cancer - Prostate	PSCA-CAR T Cells in Treating Patients With Metastatic Castration Resistant Prostate Cancer	Recruiting
UCI	UCI Stem Cell Clinic (949) 824-3990 stemcell@uci.edu	jCyte	Eye - Retinitis Pigmentosa (RP)	Safety of a Single, Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Retinitis Pigmentosa	No longer active
City of Hope	Joseph Rosenthal, MD 626-256-4673 ext 88442 jrosenthal@coh.org	City of Hope	Sickle Cell Disease	Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Disease (PISMO)	Recruiting
UCLA	Maricela Gonzalez (310) 557-3729 mmgonzalez@mednet.ucla.edu	Calimmune	HIV/AIDS	Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-1 Infection	No longer active
UCSD	(844) 317-7836 alphastemcellclinic@ucsd.edu	Neuralstem	Spinal Cord Injury	Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI	Recruiting
City of Hope & UCLA	City of Hope: Amrita Krishnan, MD (626) 256-4673 ext 62405 AKrishnan@coh.org UCLA: Maricella Gonzalez 310-557-3729 mmgonzalez@mednet.ucla.edu	City of Hope	HIV/AIDS	Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients	No longer active
City of Hope	Karen Reckamp, MD (626) 256-4673 x89200 kreckamp@coh.org	Adaptimmune	Cancer - Lung	Screening Protocol for Tumor Antigen Expression and HLA Sub-Type in NSCLC	Recruiting
UCSD	844-317-7836 alphastemcellclinic@ucsd.edu	UCSD & CIRM	Cystinosis	Stem cell gene therapy for cystinosis	Recruiting	Stem cell gene therapy for Cystinosis
UCLA	Fabrizia Urbinati, PhD (310) 794-1884 furbinati@ucla.edu	UCLA	Sickle Cell Disease	Stem Cell Gene Therapy for Sickle Cell Disease	Recruiting
UCI	UCI Stem Cell Clinic (949) 824-3990 stemcell@uci.edu	Stratetech	Burn wounds	StrataGraft® Skin Tissue in the Promotion of Autologous Skin Regeneration of Complex Skin Defects Due to Thermal Burns That Contain Intact Dermal Elements	No longer active
City of Hope	Cara Nolan 626-256-4673 ext 32341 cnolan@coh.org	Juno Therapeutics	Cancer - Leukemia	Study Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia (B-ALL)	No longer active
City of Hope	Myo Htut, MD 626-218-2405 ext 82405 mhtut@coh.org	Juno Therapeutics	Cancer - Myeloma	Study Evaluating the Safety and Efficacy of JCARH125 in Subjects With Relapsed and/or Refractory Multiple Myeloma (EVOLVE)	Recruiting
City of Hope	Cara Nolan 626-256-4673 ext 32341 cnolan@coh.org	Juno Therapeutics	Cancer - Lymphoma	Study Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (NHL)	Recruiting
UCSD	Barbara Parker, MD 858-822-6135 baparker@ucsd.edu Rebecca Shatsky, MD 858-657-7000 rshatsky@ucsd.edu	UCSD	Cancer - Breast	Study of Cirmtuzumab and Paclitaxel for Metastatic or Locally Advanced, Unresectable Breast Cancer	Active, not recruiting
UCLA	Caroline Kuo, MD 310-794-1940 ckuo@mednet.ucla.edu	UCLA	X-linked Chronic Granulomatous Disease	Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease	Active, not recruiting
UCI	UCI Stem Cell Clinic (949) 824-3990 stemcell@uci.edu	SanBio	Stroke	Study of Modified Stem Cells in Patients With Chronic Motor Deficit From Ischemic Stroke	No longer active
UCSD	(844) 317-7836 alphastemcellclinic@ucsd.edu	Tigenix	Crohn's Disease	Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn’s Disease (CD)	Active, not recruiting	Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of C
UCSD	Teresa Rzesiewicz 844-317-7836 alphstemcellclinic@ucsd.edu	Discgenics	Degenerative Disc Disease	Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration	No longer active
City of Hope	Erminia Massarelli, MD 626-218-9200 emassarelli@coh.org	Atara Bio.	Cancer - Nasopharyngeal Carcinoma	Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)	No longer active
UCLA	Sarah Larson, MD 310-206-8477 slarson@mednet.ucla.edu	UCLA	Cancer	TCR Genetically Engineered PBMC and PBSC After Melphalan Conditioning Regimen in Treating Participants With Relapsed and Refractory Multiple Myeloma (NYSCT MM)	No longer active
UCSD	(844) 317-7836 alphastemcellclinic@ucsd.edu	Mesoblast	Heart Failure	The Purpose of This Study is to Evaluate the Efficacy and Safety of a Allogeneic Mesenchymal Precursor Cells (CEP-41750) for the Treatment of Chronic Heart Failure	No longer active
UCSD	(844) 317-7836 alphastemcellclinic@ucsd.edu	Viacyte	Diabetes - Type 1	Three Year Follow-up Safety Study in Subjects Previously Implanted With VC-01	No longer active
UCSF	Cyrus Bascon 510-428-3885 ext 6953 Cyrus.bascon@ucsf.edu	CIRM & NHLBI	Severe sickle cell disease	Transplantation of CRISPRCas9 Corrected Hematopoietic Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease	Active, not recruiting
City of Hope	Mihaela Cristea, MD 626-218-9200 mcristea@coh.org	Torque Therapeutics, Inc.	Cancer - Lymphoma	TRQ15-01 in Patients With Relapsed/Refractory Solid Tumors and Lymphomas	Recruiting
UCSD	(844) 317-7836 alphastemcellclinic@ucsd.edu	UCSD	Cancer - Leukemia	UC-961 (Cirmtuzumab) in Relapsed or Refractory Chronic Lymphocytic Leukemia	No longer active

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Clinical trials conducted at CIRM Alpha Clinics must comply with applicable federal and state laws and medical and ethical standards governing the conduct of human clinical trials. If you or a family member is interested in participating in a clinical trial, please visit clinicaltrials.gov to find a trial near you.

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