Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Lung Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Sarcoma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Development Candidate, Proof of Concept
Wounds, ulcers		Small molecule therapy	UCLA	IND
COVID-19, Respiratory Disorders	iPS Cell	Small molecule therapy	UCLA	Development Candidate, Proof of Concept
Hypertension, pulmonary arterial	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Stroke	iPS Cell	Donor cell therapy	UCLA	Pre-IND/IDE or Equivalent
Heart Disease	Adult Stem Cell	Antibody	UCLA	Pre-IND/IDE or Equivalent
Heart Disease, Danon Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Development Candidate, Proof of Concept
Spinal Cord Injury	Embryonic Stem Cell	Donor cell therapy	UCSD	Pre-IND/IDE or Equivalent
Spinal Cord Injury	Embryonic Stem Cell	Gene-modified, donor cell therapy	UCSD	Development Candidate, Research Insights
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Small molecule therapy	UCSD	Pre-IND/IDE or Equivalent
Leukemia, Acute Myeloid (AML)	Embryonic Stem Cell	Donor cell therapy	UCSD	Pre-IND/IDE or Equivalent
Ovarian Cancer	iPS Cell	Gene-modified, donor cell therapy	UCSD	Development Candidate, Proof of Concept
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Donor cell therapy	UCSD	Development Candidate, Proof of Concept
Vascular Disease	Adult Stem Cell	Biologic	UCSD	Pre-IND/IDE or Equivalent
Blood Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	IND
Cystinosis, Kidney Failure	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Leukemia	Cancer Stem Cell	Antibody	UCSD	Clinical Trial, Phase 1 or Phase 1/2
COVID-19	iPS Cell	Small molecule therapy	UCSD	Development Candidate, Proof of Concept
Pancreatic Cancer	Cancer Stem Cell	Small molecule therapy	UCSD	Development Candidate, Proof of Concept
Huntington's Disease	iPS Cell	Gene Therapy, cell free	UCSD	Development Candidate, Proof of Concept
Liver Disease	iPS Cell	Diagnostic Test	UCSF	Development Candidate, Proof of Concept
Brain Cancer	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Muscle Injury	Adult Stem Cell	Personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Beta Thalassemia, Sickle Cell Disease	Adult Stem Cell	Diagnostic Test	UCSF	Regulated Lab Test, Ready for Validation
B cell cancers	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Brain Cancer	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
HIV/AIDS, Immune Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	IND
Alpha Thalassemia Major	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Multiple Myeloma	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Type 1 diabetes	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Parkinson's Disease	Adult Stem Cell	Gene-modified, donor cell therapy	UCSF	IND
Kidney Disease	Somatic Cell	Gene Therapy, cell free	UCSF	Development Candidate, Proof of Concept
COVID-19	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 2
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Cartilage defect	Embryonic Stem Cell	Donor cell therapy	USC	IND
			USC
Age-related macular degeneration	Embryonic Stem Cell	Biologic	USC	Pre-IND/IDE or Equivalent
Type 1 diabetes	Embryonic Stem Cell	Donor cell therapy	ViaCyte	Clinical Trial, Phase 1 or Phase 1/2
Inflammatory bowel disease	Adult Stem Cell	Donor cell therapy	Vitabolus, Inc.	Development Candidate, Proof of Concept

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
–– Hypertension, pulmonary arterial
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
– Sanfilippo Syndrome/MPS III
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscle Injury
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
– Wounds, ulcers
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering