Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Immune Disease, Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	St. Jude	Clinical Trial, Phase 1 or Phase 1/2
Intervertebral disc degeneration	iPS Cell	Donor cell therapy	Cedars-Sinai	Proof of Concept
Intestinal Disease	iPS Cell	Exploring disease mechanisms	Cedars-Sinai	Proof of Concept, Tool/Resources/Bottleneck
Intestinal Disease, Neurological Disorders	iPS Cell	Donor cell therapy	CHLA	Pre-IND/IDE or Equivalent
IPEX Syndrome	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
IPEX Syndrome	Adult Stem Cell	Gene-modified, personalized cell therapy	ImmunoVec	Pre-IND/IDE or Equivalent
Kidney Disease	Somatic Cell	Gene Therapy, cell free	UCSF	Development Candidate, Proof of Concept
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Kidney Failure	Adult Stem Cell	Donor cell therapy	Medeor Therapeutics	Clinical Trial, Phase 3
Kidney Failure	Adult Stem Cell	Device	UC Davis	Pre-IND/IDE or Equivalent
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Leukemia	Cancer Stem Cell	Biologic	UCLA	Development Candidate
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSF	IND
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Antibody	Immune-Onc Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
Liver Disease	iPS Cell	Diagnostic Test	UCSF	Development Candidate, Proof of Concept
Liver Disease	iPS Cell	Gene-modified, donor cell therapy	CHLA	Development Candidate, Proof of Concept
Lung Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Lung Disease, Fibrosis	Adult Stem Cell	Small molecule therapy	Rubedo Life Sciences Inc.	Development Candidate, Proof of Concept
Melanoma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Melanoma	Adult Stem Cell	Vaccine	UCLA	Proof of Concept
Metabolic Disorders, Neurological Disorders	Somatic Cell		Stanford	IND
Metabolic Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	Rampart Bioscience	IND
Metabolic Disorders	Somatic Cell	Gene-modified, personalized cell therapy	Immusoft Corporation	Pre-IND/IDE or Equivalent
Multiple Myeloma	Adult Stem Cell	Gene-modified, donor cell therapy	UCLA	Pre-IND/IDE or Equivalent
Multiple Myeloma	Adult Stem Cell	Personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Multiple Myeloma	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Multiple Myeloma	Adult Stem Cell	Gene-modified, personalized cell therapy	Poseida Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
Multiple Sclerosis	Adult Stem Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Skeletal/Smooth Muscle disorders	Embryonic Stem Cell, iPS Cell	Exosomes based therapy	Stanford	Development Candidate, Proof of Concept
Muscle Injury	Adult Stem Cell	Personalized cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Muscle Injury	Adult Stem Cell	Other Components	UCSF	Development Candidate, Proof of Concept
Muscular Dystrophy		Protein/peptide therapy	Juvena Therapeutics Inc	Pre-IND/IDE or Equivalent
Neurological Disorders	iPS Cell	Gene Therapy, cell free	Navega Therapeutics	Development Candidate, Proof of Concept
Neurological Disorders, Sanfilippo Syndrome/MPS III	Embryonic Stem Cell	Gene-modified, donor cell therapy	Lundquist Institute	Development Candidate, Proof of Concept
Neurological Disorders, Sanfilippo Syndrome/MPS III	iPS Cell	Gene-modified, personalized cell therapy	UC Irvine	Development Candidate, Proof of Concept
Neurological Disorders, Other	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Pre-IND/IDE or Equivalent
Neurological Disorders		Gene Therapy, cell free	Mahzi Therapeutics	Pre-IND/IDE or Equivalent
Neurological Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	UC Davis	IND
Osteoarthritis	Somatic Cell	Gene Therapy, cell free	Genascence Corporation	Clinical Trial, Phase 1 or Phase 1/2
Other	Adult Stem Cell	Protein/peptide therapy	Intact Therapeutics, Inc.	Development Candidate, Proof of Concept
Other	iPS Cell	Model system development	Greenstone Biosciences	Tool/Resources/Bottleneck
Ovarian Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Pre-IND/IDE or Equivalent
Ovarian Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	UCLA	Development Candidate
Ovarian Cancer	iPS Cell	Gene-modified, donor cell therapy	UCSD	Development Candidate, Proof of Concept
Pancreatic Cancer	Cancer Stem Cell	Antibody	UCSD	Development Candidate
Pancreatic Cancer	Cancer Stem Cell	Small molecule therapy	UCSD	Development Candidate, Proof of Concept
Parkinson's Disease	iPS Cell	Donor cell therapy	Ryne Bio	IND
Parkinson's Disease	Vital Research Opportunity	Gene Therapy, cell free	Brain Neurotherapy Bio	Clinical Trial, Phase 1 or Phase 1/2
Prostate Cancer	iPS Cell	Gene-modified, donor cell therapy	COH	Development Candidate, Proof of Concept

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
– Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
– Tendon/Ligament/Connective Tissue Injury or Disorder
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
–– Hypertension, pulmonary arterial
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
– Sanfilippo Syndrome/MPS III
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Intellectual Disability
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscle Injury
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
– Wounds, ulcers
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Bioinformatics/Computational Tools
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering