Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
COVID-19, Respiratory Disorders	Adult Stem Cell	Donor cell therapy	Celularity Inc	Clinical Trial, Phase 1 or Phase 1/2
Bone or Cartilage Disease	Adult Stem Cell	Donor cell therapy	UCLA	Proof of Concept
Age-related macular degeneration	iPS Cell	Exploring disease mechanisms	UCSD	Research Insights
Blood Disorders, Leukemia	Adult Stem Cell	Exploring stem cell mechanisms	UCLA	Development Candidate, Proof of Concept, Research Insights
Hemophilia A	Adult Stem Cell	Gene modification	COH	Development Candidate, Proof of Concept
Liver Disease	Directly Reprogrammed Cell	Gene modification	UCSF	Development Candidate
IPEX Syndrome, Immune Disease		Gene Therapy, cell free	Stanford	IND
Parkinson's Disease		Gene Therapy, cell free	Brain Neurotherapy Bio	Clinical Trial, Phase 1 or Phase 1/2
Liver Disease	iPS Cell	Gene-modified, donor cell therapy	CHLA	Development Candidate, Proof of Concept
Blood Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	Angiocrine	Clinical Trial, Phase 1 or Phase 1/2
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Gene-modified, donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Type 1 diabetes	Embryonic Stem Cell	Gene-modified, donor cell therapy	UCSD	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell	Gene-modified, donor cell therapy	ViaCyte	Development Candidate
Parkinson's Disease	Adult Stem Cell	Gene-modified, donor cell therapy	UCSF	IND
Solid Tumors	iPS Cell	Gene-modified, donor cell therapy	Fate Therapeutics	IND
Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	UCLA	Development Candidate, Proof of Concept
Stroke	Adult Stem Cell	Gene-modified, donor cell therapy	SanBio, Inc.	Clinical Trial, Phase 2
COVID-19	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell	Gene-modified, donor cell therapy	Salk	Development Candidate, Proof of Concept
Ovarian Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Pre-IND/IDE or Equivalent
COVID-19, Respiratory Disorders	iPS Cell	Gene-modified, donor cell therapy	USC	Development Candidate, Proof of Concept
Sarcoma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	Orchard Therapeutics	Clinical Trial, Phase 2
Leukocyte Adhesion Deficiency	Adult Stem Cell	Gene-modified, personalized cell therapy	Rocket Pharmaceuticals, Inc.	Clinical Trial, Phase 1 or Phase 1/2
Lung Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
HIV-related Lymphoma, HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Immune Disease, Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	St. Jude	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	IND
Immune Disease, X-linked Chronic Granulomatous Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Cystinosis, Kidney Failure	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Brain Cancer, Breast Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Canavan Disease	iPS Cell	Gene-modified, personalized cell therapy	COH	Pre-IND/IDE or Equivalent
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	IND
Multiple Myeloma	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Development Candidate, Proof of Concept
HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Development Candidate, Proof of Concept
Ovarian Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Development Candidate, Proof of Concept
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	CHORI	Pre-IND/IDE or Equivalent
Multiple Myeloma	Adult Stem Cell	Gene-modified, personalized cell therapy	Poseida Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
Epidermolysis Bullosa	iPS Cell	Gene-modified, personalized cell therapy	Stanford	Pre-IND/IDE or Equivalent
Heart Disease, Danon Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	Development Candidate, Proof of Concept
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Clinical Trial, Phase 1 or Phase 1/2
Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Hyper IgM Syndrome, Immune Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Pre-IND/IDE or Equivalent
Cancer	Cancer Stem Cell	Gene-modified, personalized cell therapy	UCSD	Pre-IND/IDE or Equivalent
B cell cancers, Leukemia	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
– Liver Disease
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering