Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
Heart Disease	Adult Stem Cell	Antibody	UCLA	Pre-IND/IDE or Equivalent
Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Antibody	Jasper Therapeutics, Inc.	Clinical Trial, Phase 1 or Phase 1/2
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Antibody	Immune-Onc Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Leukemia	Cancer Stem Cell	Antibody	UCSD	Clinical Trial, Phase 1 or Phase 1/2
Vascular Disease	Adult Stem Cell	Biologic	UCSD	Pre-IND/IDE or Equivalent
Age-related macular degeneration	Embryonic Stem Cell	Biologic	USC	Pre-IND/IDE or Equivalent
Amyotrophic Lateral Sclerosis, Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Cell imaging & tracking	UCSD	Research Insights
	Embryonic Stem Cell	Cell processing & handling	Stanford	Research Insights
COVID-19, Respiratory Disorders	Other, Vital Research Opportunity	Convalescent Plasma	COH	Research Insights
Liver Disease	iPS Cell	Diagnostic Test	UCSF	Development Candidate, Proof of Concept
Beta Thalassemia, Sickle Cell Disease	Adult Stem Cell	Diagnostic Test	UCSF	Regulated Lab Test, Ready for Validation
Brain Injury, hypoxic, ischemic	Adult Stem Cell	Donor cell therapy	Sanford-Burnham	Pre-IND/IDE or Equivalent
Stroke	iPS Cell	Donor cell therapy	UCLA	Development Candidate, Proof of Concept
Pulmonary Hypertension, Vascular Disease	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Heart Disease	iPS Cell	Donor cell therapy	UC Davis	Development Candidate, Proof of Concept
Leukemia, Acute Myeloid (AML)	Embryonic Stem Cell	Donor cell therapy	UCSD	Pre-IND/IDE or Equivalent
Stroke	iPS Cell	Donor cell therapy	UCLA	Pre-IND/IDE or Equivalent
COVID-19, Respiratory Disorders	Adult Stem Cell	Donor cell therapy	Celularity Inc	Clinical Trial, Phase 1 or Phase 1/2
Retinitis Pigmentosa	Other	Donor cell therapy	jCyte	Clinical Trial, Phase 2
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Kidney Failure	Adult Stem Cell	Donor cell therapy	Medeor Therapeutics	Clinical Trial, Phase 3
Retinitis Pigmentosa	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Donor cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Age-related macular degeneration	Adult Stem Cell	Donor cell therapy	Stanford	Pre-IND/IDE or Equivalent
Huntington's Disease	Embryonic Stem Cell	Donor cell therapy	UC Irvine	IND
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Alpha Thalassemia Major	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Spinal Cord Injury	Adult Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Spina Bifida	Adult Stem Cell	Donor cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Donor cell therapy	UCSD	Development Candidate, Proof of Concept
Retinitis Pigmentosa	Embryonic Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Type 1 diabetes	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Type 1 diabetes	Embryonic Stem Cell	Donor cell therapy	ViaCyte	Clinical Trial, Phase 1 or Phase 1/2
COVID-19	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 2
Inflammatory bowel disease	Adult Stem Cell	Donor cell therapy	Vitabolus, Inc.	Development Candidate, Proof of Concept
Blood Cancer, Bone Marrow Transplant and Viral Infection	Adult Stem Cell	Donor cell therapy	CHLA	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Leukemia, Leukemia, Acute Myeloid (AML)	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Donor cell therapy	ExCellThera Inc.	Clinical Trial, Phase 1 or Phase 1/2
Neurological Disorders	Embryonic Stem Cell	Donor cell therapy	UC Irvine	Development Candidate, Proof of Concept
Stroke	Embryonic Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Cartilage defect	Embryonic Stem Cell	Donor cell therapy	USC	IND
Traumatic Brain Injury	Embryonic Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Intestinal Disease, Neurological Disorders	iPS Cell	Donor cell therapy	CHLA	Pre-IND/IDE or Equivalent
Spinal Cord Injury	Embryonic Stem Cell	Donor cell therapy	UCSD	Pre-IND/IDE or Equivalent
Traumatic Brain Injury	iPS Cell	Donor cell therapy	UC Irvine	Development Candidate, Research Insights
Heart failure	Embryonic Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Dementia	iPS Cell	Donor cell therapy	Gladstone	Development Candidate, Proof of Concept
Brain Cancer, Neurological Disorders	Embryonic Stem Cell	Exosomes based therapy	UC Irvine	Development Candidate, Proof of Concept
Traumatic Brain Injury	Embryonic Stem Cell	Exosomes based therapy	UC Irvine	Development Candidate, Proof of Concept, Research Insights
Heart failure	iPS Cell	Exosomes based therapy	Stanford	Development Candidate, Proof of Concept

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering