Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
			VxBiosciences inc.
			Stanford
			USC
			BrainXell Therapeutics
Metabolic Disorders, Neurological Disorders	Somatic Cell		Stanford	IND
			UCLA
Colon Cancer			Tachyon Therapeutics, Inc	Clinical Trial, Phase 1 or Phase 1/2
			COH
			Eureka Therapeutics, Inc.
Anemia	Adult Stem Cell	Antibody	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders	Adult Stem Cell	Antibody	Stanford	Development Candidate
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Antibody	Immune-Onc Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
Pancreatic Cancer	Cancer Stem Cell	Antibody	UCSD	Development Candidate
Heart Disease	Adult Stem Cell	Antibody	UCLA	Pre-IND/IDE or Equivalent
Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Antibody	Jasper Therapeutics, Inc.	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Solid Tumors	Cancer Stem Cell	Biologic	Nammi Therapeutics, Inc.	IND
Leukemia	Cancer Stem Cell	Biologic	UCLA	Development Candidate
Tendon/Ligament/Connective Tissue Injury or Disorder	Embryonic Stem Cell	Biologic	Scripps Health	Development Candidate, Proof of Concept
Age-related macular degeneration	Embryonic Stem Cell	Biologic	USC	Pre-IND/IDE or Equivalent
Cartilage defect	Adult Stem Cell	Biologic	The Stone Research Foundation for Sports Medicine and Arthritis	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell, iPS Cell	Biologic	UCLA	Development Candidate, Proof of Concept
	Embryonic Stem Cell	Cell processing & handling	Stanford	Research Insights
COVID-19, Respiratory Disorders	Other, Vital Research Opportunity	Convalescent Plasma	COH	Research Insights
Kidney Failure	Adult Stem Cell	Device	UC Davis	Pre-IND/IDE or Equivalent
Beta Thalassemia, Sickle Cell Disease	Adult Stem Cell	Diagnostic Test	UCSF	Regulated Lab Test, Ready for Validation
Liver Disease	iPS Cell	Diagnostic Test	UCSF	Development Candidate, Proof of Concept
Pulmonary Hypertension, Vascular Disease	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Spina Bifida	Adult Stem Cell	Donor cell therapy	UC Davis	Clinical Trial, Phase 1 or Phase 1/2
Retinitis Pigmentosa	Other	Donor cell therapy	jCyte	Clinical Trial, Phase 2
Dementia	iPS Cell	Donor cell therapy	Gladstone	Development Candidate, Proof of Concept
Retinitis Pigmentosa	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Autism	iPS Cell	Donor cell therapy	UCSD	Development Candidate, Proof of Concept
Spinal Cord Injury	Adult Stem Cell	Donor cell therapy	UC Irvine	Pre-IND/IDE or Equivalent
Immune Disease	Adult Stem Cell	Donor cell therapy	Ossium Health, Inc.	IND
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Donor cell therapy	UCSD	Development Candidate, Proof of Concept
Alpha Thalassemia Major	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Age-related macular degeneration	Adult Stem Cell	Donor cell therapy	Stanford	Pre-IND/IDE or Equivalent
Parkinson's Disease	iPS Cell	Donor cell therapy	Ryne Biotechnology	IND
Type 1 diabetes	Embryonic Stem Cell	Donor cell therapy	ViaCyte	Clinical Trial, Phase 1 or Phase 1/2
Huntington's Disease	Embryonic Stem Cell	Donor cell therapy	UC Irvine	IND
Kidney Failure	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Breast Cancer, Melanoma	Somatic Cell	Donor cell therapy	Calidi Biotherapeutics, Inc.	IND
B cell cancers, Leukemia, Leukemia, Acute Myeloid (AML)	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Blood Cancer, Bone Marrow Transplant and Viral Infection	Adult Stem Cell	Donor cell therapy	CHLA	Clinical Trial, Phase 1 or Phase 1/2
Cartilage defect	Embryonic Stem Cell	Donor cell therapy	USC	IND
Stroke	Embryonic Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Intervertebral disc degeneration	iPS Cell	Donor cell therapy	Cedars-Sinai	Proof of Concept
Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Donor cell therapy	Gladstone	Development Candidate, Proof of Concept
Type 1 diabetes	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
– Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
– Tendon/Ligament/Connective Tissue Injury or Disorder
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
–– Hypertension, pulmonary arterial
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
– Sanfilippo Syndrome/MPS III
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Intellectual Disability
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscle Injury
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
– Wounds, ulcers
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Bioinformatics/Computational Tools
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering