Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
			VxBiosciences inc.
			Stanford
			USC
			BrainXell Therapeutics
			UCLA
			COH
			Eureka Therapeutics, Inc.
Multiple Myeloma	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Development Candidate, Proof of Concept
Leukemia	Cancer Stem Cell	Biologic	UCLA	Development Candidate
Neurological Disorders, Sanfilippo Syndrome/MPS III	Embryonic Stem Cell	Gene-modified, donor cell therapy	Lundquist Institute	Development Candidate, Proof of Concept
Multiple Sclerosis	Adult Stem Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Alzheimer's Disease, Parkinson's Disease	iPS Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Intervertebral disc degeneration	iPS Cell	Donor cell therapy	Cedars-Sinai	Proof of Concept
COVID-19	Adult Stem Cell	Vaccine	UCLA	Development Candidate, Proof of Concept
Kidney Disease	Somatic Cell	Gene Therapy, cell free	UCSF	Development Candidate, Proof of Concept
Autism, Epilepsy, Other	iPS Cell	Nucleic acid based therapy	UCSD	Development Candidate, Proof of Concept
Tendon/Ligament/Connective Tissue Injury or Disorder	Embryonic Stem Cell	Biologic	Scripps Health	Development Candidate, Proof of Concept
Heart Disease	iPS Cell	Donor cell therapy	UC Davis	Development Candidate, Proof of Concept
Neurological Disorders, Sanfilippo Syndrome/MPS III	iPS Cell	Gene-modified, personalized cell therapy	UC Irvine	Development Candidate, Proof of Concept
Vision Loss	Embryonic Stem Cell, iPS Cell	Gene Therapy, cell free	UCLA	Development Candidate, Proof of Concept
Brain Cancer	Cancer Stem Cell	Small molecule therapy	UCLA	Development Candidate
COVID-19, Respiratory Disorders	iPS Cell	Small molecule therapy	Sanford-Burnham	Development Candidate, Proof of Concept
Pancreatic Cancer	Cancer Stem Cell	Small molecule therapy	UCSD	Development Candidate, Proof of Concept
Huntington's Disease	iPS Cell	Gene Therapy, cell free	UCSD	Development Candidate, Proof of Concept
	iPS Cell	Model system development	Nanotools Bioscience	Proof of Concept
Autism, Intellectual Disability, Metabolic Disorders	iPS Cell	Gene Therapy, cell free	UCLA	Development Candidate, Proof of Concept
Liver Disease	iPS Cell	Diagnostic Test	UCSF	Development Candidate, Proof of Concept
Cartilage defect	Adult Stem Cell	Biologic	The Stone Research Foundation for Sports Medicine and Arthritis	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell, iPS Cell	Donor cell therapy	Minutia, Inc.	Development Candidate, Proof of Concept
Lung Disease, Fibrosis	Adult Stem Cell	Small molecule therapy	Rubedo Life Sciences Inc.	Development Candidate, Proof of Concept
Traumatic Brain Injury	Embryonic Stem Cell	Exosomes based therapy	UC Irvine	Development Candidate, Proof of Concept, Research Insights
Brain Cancer, Neurological Disorders	Embryonic Stem Cell	Exosomes based therapy	UC Irvine	Development Candidate, Proof of Concept
Cartilage defect, Osteoarthritis	Embryonic Stem Cell	Donor cell therapy	Scripps Health	Development Candidate, Proof of Concept
Ovarian Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	UCLA	Development Candidate
Duchenne Muscular Dystrophy	Other, Somatic Cell	Gene Therapy, cell free	UC Davis	Proof of Concept
Anemia	Adult Stem Cell, iPS Cell	Small molecule therapy	Stanford	Development Candidate, Proof of Concept
Type 1 diabetes	Embryonic Stem Cell, iPS Cell	Biologic	UCLA	Development Candidate, Proof of Concept
Solid Tumors	Somatic Cell	Gene-modified, personalized cell therapy	UC Irvine	Development Candidate
Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)	Adult Stem Cell	Gene-modified, personalized cell therapy	UC Berkeley	Development Candidate
Heart failure	iPS Cell	Exosomes based therapy	Stanford	Development Candidate, Proof of Concept
Muscle Injury	Adult Stem Cell	Other Components	UCSF	Development Candidate, Proof of Concept
Heart failure		Gene Therapy, cell free	Tenaya Therapeutics, Inc.	Development Candidate
HIV/AIDS	Adult Stem Cell	Gene-modified, personalized cell therapy	Scintillon Inst	Development Candidate, Proof of Concept
Duchenne Muscular Dystrophy	iPS Cell	Model system development	Greenstone Biosciences	Tool/Resources/Bottleneck
Dementia	iPS Cell	Donor cell therapy	Gladstone	Development Candidate, Proof of Concept
Angelman Syndrome, Autism	iPS Cell	Gene Therapy, cell free	UC Davis	Development Candidate, Proof of Concept
Skeletal/Smooth Muscle disorders	Embryonic Stem Cell, iPS Cell	Exosomes based therapy	Stanford	Development Candidate, Proof of Concept
Blood Disorders	Adult Stem Cell	Antibody	Stanford	Development Candidate
Heart failure	iPS Cell	Nucleic acid based therapy	Gladstone	Development Candidate, Proof of Concept
Breast Cancer	Adult Stem Cell	Small molecule therapy	UCLA	Development Candidate, Proof of Concept

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
– Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
– Tendon/Ligament/Connective Tissue Injury or Disorder
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
–– Hypertension, pulmonary arterial
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
– Sanfilippo Syndrome/MPS III
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Intellectual Disability
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscle Injury
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
– Wounds, ulcers
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Bioinformatics/Computational Tools
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering