Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
B cell cancers	Somatic Cell	Gene-modified, donor cell therapy	Angiocrine	Clinical Trial, Phase 3
Solid Tumors	Adult Stem Cell	Personalized cell therapy	BioEclipse Therapeutics INC.	Clinical Trial, Phase 1 or Phase 1/2
Sickle Cell Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	Boston Children's Hospital	Clinical Trial, Phase 2
Parkinson's Disease	Vital Research Opportunity	Gene Therapy, cell free	Brain Neurotherapy Bio	Clinical Trial, Phase 1 or Phase 1/2
Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Gene-modified, personalized cell therapy	BrainXell Therapeutics	Development Candidate, Proof of Concept
			BrainXell Therapeutics
Breast Cancer, Melanoma	Somatic Cell	Donor cell therapy	Calidi Biotherapeutics, Inc.	IND
Pulmonary Hypertension, Vascular Disease	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Retinitis Pigmentosa	Adult Stem Cell	Donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Heart failure	Adult Stem Cell	Nucleic acid based therapy	Cedars-Sinai	Development Candidate, Proof of Concept
Intestinal Disease	iPS Cell	Exploring disease mechanisms	Cedars-Sinai	Proof of Concept, Tool/Resources/Bottleneck
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Gene-modified, donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Intervertebral disc degeneration	iPS Cell	Donor cell therapy	Cedars-Sinai	Proof of Concept
COVID-19, Respiratory Disorders	Adult Stem Cell	Donor cell therapy	Celularity Inc.	Clinical Trial, Phase 1 or Phase 1/2
Intestinal Disease, Neurological Disorders	iPS Cell	Donor cell therapy	CHLA	Pre-IND/IDE or Equivalent
Liver Disease	iPS Cell	Gene-modified, donor cell therapy	CHLA	Development Candidate, Proof of Concept
Blood Cancer, Bone Marrow Transplant and Viral Infection	Adult Stem Cell	Donor cell therapy	CHLA	Clinical Trial, Phase 1 or Phase 1/2
Breast Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Pre-IND/IDE or Equivalent
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	IND
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Ovarian Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Pre-IND/IDE or Equivalent
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
COVID-19, Respiratory Disorders	Other, Vital Research Opportunity	Convalescent Plasma	COH	Research Insights
Prostate Cancer	iPS Cell	Gene-modified, donor cell therapy	COH	Development Candidate, Proof of Concept
Sickle Cell Disease	Adult Stem Cell	Donor cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer, Breast Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
			COH
Corneal Damage	Adult Stem Cell	Exosomes based therapy	Combangio	Clinical Trial, Phase 2
Breast Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	Cytonus Therapeutics, Inc.	Development Candidate, Proof of Concept
			Eureka Therapeutics, Inc.
HIV/AIDS		Gene Therapy, cell free	Excision BioTherapeutics	Clinical Trial, Phase 1 or Phase 1/2
Osteoarthritis	Somatic Cell	Gene Therapy, cell free	Genascence Corporation	Clinical Trial, Phase 1 or Phase 1/2
Heart failure	iPS Cell	Nucleic acid based therapy	Gladstone	Development Candidate, Proof of Concept
Dementia	iPS Cell	Donor cell therapy	Gladstone	Development Candidate, Proof of Concept
Spinal Cord Injury	Embryonic Stem Cell, iPS Cell	Donor cell therapy	Gladstone	Development Candidate, Proof of Concept
Other	iPS Cell	Model system development	Greenstone Biosciences	Tool/Resources/Bottleneck
Duchenne Muscular Dystrophy	iPS Cell	Model system development	Greenstone Biosciences	Tool/Resources/Bottleneck
Leukemia, Acute Myeloid (AML)	Cancer Stem Cell	Antibody	Immune-Onc Therapeutics	Clinical Trial, Phase 1 or Phase 1/2
IPEX Syndrome	Adult Stem Cell	Gene-modified, personalized cell therapy	ImmunoVec	Pre-IND/IDE or Equivalent
X-linked Chronic Granulomatous Disease	Adult Stem Cell	Gene-modified, personalized cell therapy	ImmunoVec	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	ImmunoVec	Pre-IND/IDE or Equivalent
Metabolic Disorders	Somatic Cell	Gene-modified, personalized cell therapy	Immusoft Corporation	Pre-IND/IDE or Equivalent
Bone or Cartilage Disease, Hearing Loss, Intellectual Disability, Metabolic Disorders, Vision Loss	Somatic Cell	Personalized cell therapy	Immusoft Corporation	Clinical Trial, Phase 1 or Phase 1/2
Other	Adult Stem Cell	Protein/peptide therapy	Intact Therapeutics, Inc.	Development Candidate, Proof of Concept
Severe Combined Immunodeficiency, X-linked (X-SCID)	Adult Stem Cell	Antibody	Jasper Therapeutics, Inc.	Clinical Trial, Phase 1 or Phase 1/2
Retinitis Pigmentosa		Therapeutic Approach	jCyte	Clinical Trial, Phase 2
Retinitis Pigmentosa	Other	Donor cell therapy	jCyte	Clinical Trial, Phase 2
Muscular Dystrophy		Protein/peptide therapy	Juvena Therapeutics Inc.	Pre-IND/IDE or Equivalent
Neurological Disorders, Sanfilippo Syndrome/MPS III	Embryonic Stem Cell	Gene-modified, donor cell therapy	Lundquist Institute	Development Candidate, Proof of Concept

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
– Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
– Tendon/Ligament/Connective Tissue Injury or Disorder
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
–– Hypertension, pulmonary arterial
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
– Sanfilippo Syndrome/MPS III
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Intellectual Disability
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscle Injury
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
– Wounds, ulcers
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Bioinformatics/Computational Tools
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering