Active Awards Portfolio Dashboard

It takes a lot of effort to develop a promising stem cell research idea into an effective treatment that can help patients. CIRM funds a pipeline of projects spanning discovery, translation and clinical stage research. Check out our portfolio of active research awards in our interactive dashboard below. For a detailed list of CIRM-funded clinical trials, visit our Clinical Trials Dashboard.

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Disease

Therapeutic or Technology

Disease	Cell Type	Therapeutic or Technology	Institution	Project Objective
			USC
	Embryonic Stem Cell	Cell processing & handling	Stanford	Research Insights
			BrainXell Therapeutics
			UCLA
			COH
	iPS Cell	Model system development	Nanotools Bioscience	Proof of Concept
			Eureka Therapeutics, Inc.
			VxBiosciences inc.
			Stanford
Age-related macular degeneration	Adult Stem Cell	Donor cell therapy	Stanford	Pre-IND/IDE or Equivalent
Age-related macular degeneration	Embryonic Stem Cell	Biologic	USC	Pre-IND/IDE or Equivalent
Age-related macular degeneration	iPS Cell	Personalized cell therapy	UCLA	IND
Alpha Thalassemia Major	Adult Stem Cell	Donor cell therapy	UCSF	Clinical Trial, Phase 1 or Phase 1/2
Alpha Thalassemia Major	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Development Candidate
Alzheimer's Disease, Parkinson's Disease	iPS Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Donor cell therapy	UCSD	Development Candidate, Proof of Concept
Amyotrophic Lateral Sclerosis	Adult Stem Cell	Gene-modified, donor cell therapy	Cedars-Sinai	Clinical Trial, Phase 1 or Phase 1/2
Anemia, Bone Marrow Transplant and Viral Infection	Adult Stem Cell	Immune tolerance/management	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Anemia	Adult Stem Cell, iPS Cell	Small molecule therapy	Stanford	Development Candidate, Proof of Concept
Anemia	Adult Stem Cell	Antibody	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Angelman Syndrome, Autism	iPS Cell	Gene Therapy, cell free	UC Davis	Development Candidate, Proof of Concept
Autism, Epilepsy, Other	iPS Cell	Nucleic acid based therapy	UCSD	Development Candidate, Proof of Concept
Autism, Intellectual Disability, Metabolic Disorders	iPS Cell	Gene Therapy, cell free	UCLA	Development Candidate, Proof of Concept
Autism	iPS Cell	Donor cell therapy	UCSD	Development Candidate, Proof of Concept
B cell cancers, Leukemia, Leukemia, Acute Myeloid (AML)	Adult Stem Cell	Donor cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers		Gene-modified, personalized cell therapy	UC Davis	Pre-IND/IDE or Equivalent
B cell cancers, Leukemia	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
B cell cancers, Solid Tumors	Cancer Stem Cell	Biologic	Nammi Therapeutics, Inc.	IND
B cell cancers	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
B cell cancers	Somatic Cell	Gene-modified, donor cell therapy	Angiocrine	Clinical Trial, Phase 3
Beta Thalassemia, Sickle Cell Disease	Adult Stem Cell	Diagnostic Test	UCSF	Regulated Lab Test, Ready for Validation
Bladder or Urinary Tract Disorder, Incontinence	iPS Cell	Personalized cell therapy	Stanford	Pre-IND/IDE or Equivalent
Bladder or Urinary Tract Disorder	Somatic Cell	Tissue engineering	Wake Forest University Health Sciences	Clinical Trial, Phase 1 or Phase 1/2
Blood Disorders	Adult Stem Cell	Small molecule therapy	Scripps	Development Candidate, Proof of Concept
Blood Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	ImmunoVec	Pre-IND/IDE or Equivalent
Blood Disorders	Adult Stem Cell	Antibody	Stanford	Development Candidate
Blood Disorders	Adult Stem Cell	Gene-modified, personalized cell therapy	UCLA	Development Candidate, Proof of Concept
Blood Cancer, Bone Marrow Transplant and Viral Infection	Adult Stem Cell	Donor cell therapy	CHLA	Clinical Trial, Phase 1 or Phase 1/2
Blood Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	UCSD	IND
Bone or Cartilage Disease, Hearing Loss, Intellectual Disability, Metabolic Disorders, Vision Loss	Somatic Cell	Personalized cell therapy	Immusoft Corporation	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, donor cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	Stanford	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer	Cancer Stem Cell	Small molecule therapy	UCLA	Development Candidate
Brain Cancer, Breast Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	Clinical Trial, Phase 1 or Phase 1/2
Brain Cancer, Neurological Disorders	Embryonic Stem Cell	Exosomes based therapy	UC Irvine	Development Candidate, Proof of Concept
Brain Cancer	Somatic Cell	Gene-modified, personalized cell therapy	UCSF	Pre-IND/IDE or Equivalent
Brain Cancer	Adult Stem Cell	Gene-modified, personalized cell therapy	COH	IND
Brain Injury, hypoxic, ischemic	Adult Stem Cell	Donor cell therapy	Sanford-Burnham	Pre-IND/IDE or Equivalent

California's Stem Cell Agency

California Institute for Regenerative Medicine

Active Awards Portfolio Dashboard

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aa Multiple Diseases (Centers & Resoures)
Aging
– Arthritis
Blood Disorders
– Alpha Thalassemia Major
– Anemia
– Beta Thalassemia
– Bone Marrow Transplant and Viral Infection
– Hemophilia A
– Hyper IgM Syndrome
– IPEX Syndrome
– Leukocyte Adhesion Deficiency
– Severe Combined Immunodeficiency, Adenosine deaminase-deficient (ADA-SCID)
– Severe Combined Immunodeficiency, Artemis deficient (ART-SCID)
– Severe Combined Immunodeficiency, X-linked (X-SCID)
– Sickle Cell Disease
– X-linked Chronic Granulomatous Disease
Bone or Cartilage Disease
– Cartilage defect
– Intervertebral disc degeneration
– Osteoarthritis
– Osteonecrosis
– Osteoporosis, malignant infantile
– Tendon/Ligament/Connective Tissue Injury or Disorder
Cancer
– Blood Cancer
–– Acute Myeloid Leukemia
–– B cell cancers
–– HIV-related Lymphoma
–– Leukemia
–– Leukemia, Acute Myeloid (AML)
–– Multiple Myeloma
– Solid Tumors
–– Brain Cancer
–– Breast Cancer
–– Colon Cancer
–– Lung Cancer
–– Melanoma
–– Ovarian Cancer
–– Pancreatic Cancer
–– Prostate Cancer
–– Sarcoma
–– Skin cancer
Developmental Disorders
Fertility
Genetic Disorder
Hearing Loss
Heart Disease
– Heart disease associated with Duchenne muscular dystrophy
– Heart failure
– Pulmonary Hypertension
–– Hypertension, pulmonary arterial
Immune Disease
– Thymic Disorder, 22q11 Deletion/DiGeorge
Incontinence
Infectious Disease
– COVID-19
– HIV/AIDS
– Zika virus
Kidney Disease
– Kidney Failure
Metabolic Disorders
– Cystinosis
– Danon Disease
– Diabetes
–– Diabetic Wounds
–– Type 1 diabetes
– Intestinal Disease
–– Inflammatory bowel disease
– Liver Disease
– Sanfilippo Syndrome/MPS III
Multiple Indications (Alpha Clinics)
Neurological Disorders
– Alzheimer's Disease
– Amyotrophic Lateral Sclerosis
– Angelman Syndrome
– Autism
– Brain Injury, hypoxic, ischemic
– Canavan Disease
– Dementia
– Epilepsy
– Huntington's Disease
– Intellectual Disability
– Multiple Sclerosis
– Neuropathy
– Parkinson's Disease
– Rett's Syndrome
– Spina Bifida
– Spinal Cord Injury
– Spinal Muscular Atrophy
– Stroke
– Traumatic Brain Injury
Other
Pediatrics
Respiratory Disorders
– Cystic Fibrosis
– Lung Disease, Fibrosis
Skeletal/Smooth Muscle disorders
– Bladder or Urinary Tract Disorder
– Duchenne Muscular Dystrophy
– Muscle Injury
– Muscular Dystrophy
Skin Disease
– Epidermolysis Bullosa
– Wounds, ulcers
Toxicity
Trauma
Vascular Disease
Vision Loss
– Age-related macular degeneration
– Corneal Damage
– Retinitis Pigmentosa

Therapeutic Approach
– Biologic
–– Antibody
–– Convalescent Plasma
–– Exosomes based therapy
–– Gene modification
–– Nucleic acid based therapy
–– Protein/peptide therapy
–– Vaccine
– Gene Therapy (All)
–– Gene Therapy, cell free
–– Gene-modified, donor cell therapy
–– Gene-modified, personalized cell therapy
– Small molecule therapy
– Device
– Donor cell therapy
– Personalized cell therapy
– Other Components
Technology
– Assay development
– Bioinformatics/Computational Tools
– Cell Line Generation-Resource
– Diagnostic Test
– Gene editing tools
– Cell delivery or targeting
– Cell imaging & tracking
– Cell processing & handling
– Exploring disease mechanisms
– Exploring stem cell mechanisms
– Immune tolerance/management
– Model system development
– Specific Cell Type Derivation
– Therapeutic target discovery
– Tissue engineering