Clinical Trial Stage Funding Opportunities

UPDATE: In response to the large volume of clinical grant applications and resulting review and budgetary issues, CIRM will not be accepting new CLIN1 or CLIN2 applications through the June ICOC meeting, at which time circumstances will be reevaluated to determine the course of action going forward.

This action will not impact the review and approval of applications submitted on or before January 31st or the processing of any Tier 2 resubmissions, or to our previously issued or approved awards. In addition, CLIN4 applications will be accepted in April as previously scheduled. Click here to read the public memo. Click here to read FAQ’s regarding this action.


CLIN 1: Late Stage Preclinical Projects

CLIN 2: Clinical Trial Stage Projects


The mission of California Institute for Regenerative Medicine (CIRM) is to accelerate world class science to deliver transformative regenerative medicine treatments in an equitable manner to a diverse California and world. With this initiative, we intend to speed up support for clinical stage candidate stem cell treatments that demonstrate scientific excellence. Under this initiative, we will provide funding for eligible projects that are completing late stage preclinical development through any stage of clinical trial activity.

Please note that acceptance of applications for CLIN1 and CLIN2 are postponed until the end of June 2024.


CLIN 4: Late Stage Development Projects


With this initiative, we intend to speed up support late-stage clinical candidate stem cell and genetic therapy treatments to Biologics License Application (BLA) readiness.

Effective immediately, CIRM is establishing an open call for proposals and will accept applications monthly for the late-stage development CLIN4 award type described in the Program Announcement listed below.

Applications for CLIN 4 are available to access in the grants management portal. Applications are due by 2:00 pm (PDT/PST) on the last business day of each month (except October).

For previous versions of the CLIN Program Announcements, please refer to our Previous Funding Opportunities page.

To Submit an Application:

  1. Go to the Grants Management Portal ( and log in with your existing CIRM Username and Password. If you do not have a Username, Click on the “New User” link and follow the instructions to create a CIRM Username and password.
  2. After logging in, Click on the Menu tab. Select the tab labeled “Open Programs“. Under the section labeled “RFAs and Programs Open for Applications“, click on the “Start a Grant Application” link for your selected program.
  3. Complete each section of the Application by clicking on the appropriate link and following the posted instructions. Proposal templates can be located and submitted under the “Uploads” section.
  4. To submit your Application, click on the “Done with Application” button. The “Done with Application” button will be enabled when all of the mandatory sections have been completed. Please note that once this has been selected, you will no longer be able to make changes to your Application.
  5. To confirm submission of your Application, select the tab labeled “Your Applications” and check the table under the section labeled “Your Submitted Applications“. You will see your Application number and project title listed once the submission process has been completed.