BioTime Stem Cell Lines Agreement
BioTime Human Embryonic Stem Cell Lines
Please Note: This MTA has expired. Please contact Biotime to negotiate a similar agreement. The MTA below is no longer valid but listed for archiving purposes.
BioTime has previously agreed to provide access to five research grade versions of clinical-grade human embryonic stem cell lines to California researchers and future access to the GMP versions of these lines in one year. The letter agreement between CIRM and BioTime sets forth pre-negotiated terms and a template Material Transfer Agreement in order to assist in accelerating access. Key terms of the agreement provide:
- Access to CIRM grantees and California researchers of research grade cell lines at $950 per ampoule; no other charges for research use.
- Access to GMP grade lines along with a letter of cross-reference to a Biologics Master File (BMF) containing the manufacturing and controls information and additional documentation needed to establish GMP compliance and complete DNA sequence information on the lines will be available at the supplier’s cost.
- For Commercial Use: a royalty cap of 2% of net sales reducible to 1.5% in the event additional royalties are owed in resulting product commercialization. The parties may seek to negotiate more favorable terms. Cost per ampoule to be negotiated, in good faith, and to approximate costs of BioTime and its subsidiary.
- CIRM has not obtained agreements with or commitments from other third parties. Permissions, licenses, from third parties, for instance by WARF, may be required.
To acquire the lines:
Interested parties should contact firstname.lastname@example.org
- Read the letter of agreement [pdf]
- Read the MTA [pdf]
- MTA for UC scientists [pdf]
Latest Press Releases
CIRM-funded research programs are helping turn stem cells into cures. Browse our press release archive below to find out the latest advances. For even more breaking news, visit our blog, The Stem Cellar.
Feb 27, 2023
Jan 26, 2023
Dec 15, 2022
Nov 29, 2022
CIRM holds regular scientific workshops and meetings to update the scientific staff and CIRM grantees about particular areas of stem cell and related research.
- Engineering Strategies, Opportunities, and Challenges for Tissue Repair and Regeneration: CIRM Workshop Summary and Recommendati [pdf]
- Cell Therapies for Parkinson’s Disease from Discovery to Clinic [pdf]
- Alpha Stem Cell Clinics: Delivering a New Kind of Medicine [pdf]
- Cerebral Palsy Workshop Report [pdf]