Institution RFA PI Name Award Value University of California, Irvine Disease Team Therapy Development - Research Henry Klassen Retinal progenitor cells for treatment of retinitis pigmentosa $17,144,825 University of California, Irvine Basic Biology II Marian Waterman TCF-3: A Wnt Pathway Effector and Nanog Regulator in Pluripotent Stem Cell Self-Renewal $1,259,879 University of California, Irvine Shared Labs Peter Donovan Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course $3,072,500 University of California, Irvine Preclinical Development Awards Leslie Thompson A hNSC Development Candidate for Huntington’s Disease $4,951,623 University of California, Irvine Early Translational II Brian Cummings Neural restricted, FAC-sorted, human neural stem cells to treat traumatic brain injury $1,517,767 University of California, Irvine Early Translational IV Magdalene Seiler Restoring vision by sheet transplants of retinal progenitors and retinal pigment epithelium (RPE) derived from human embryonic stem cells (hESCs) $3,998,948 University of California, Irvine Research Training II Peter Donovan Research Training Program II $6,315,379 University of California, Irvine Early Translational III Craig Walsh Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells $4,590,219 StemCells, Inc. Disease Team Therapy Development - Research Alexandra Capela Restoration of memory in Alzheimer’s disease: a new paradigm using neural stem cell therapy $8,901,641 University of California, Irvine Disease Team Planning Henry Klassen Stem cells for neuroprotection of photoreceptors in retinitis pigmentosa $23,537 University of California, Irvine New Faculty II Edwin Monuki Mechanisms in Choroid Plexus Epithelial Development $2,793,395 StemCells, Inc. Disease Team Therapy Development - Research Nobuko Uchida Neural stem cell transplantation for chronic cervical spinal cord injury $0 University of California, Irvine SEED Grant Kyoko Yokomori Derivation and characterization of human ES cells from FSHD embryos $607,200 University of California, Irvine Tools and Technologies I Orhan NALCIOGLU A Multimodality Molecular Imaging Systen (MRSPECT) for in Vivo Stem Cell Tracking $719,798 University of California, Irvine Disease Team Planning Leslie Thompson Huntington's Disease Team $41,953 University of California, Irvine Early Translational II Leslie Thompson A hESc-based Development Candidate for Huntington's Disease $4,045,253 University of California, Irvine Comprehensive Grant Peter Donovan Improved hES Cell Growth and Differentiation $2,381,713 University of California, Irvine SEED Grant Thomas Lane Human Embryonic Stem Cells and Remyelination in a Viral Model of Demyelination $368,081 University of California, Irvine New Faculty I Andrew Putnam A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells $395,764 University of California, Irvine Shared Labs Peter Donovan Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course $2,107,376 University of California, Irvine Early Translational II Henry Klassen Human retinal progenitor cells as candidate therapy for retinitis pigmentosa $1,803,768 University of California, Irvine Comprehensive Grant Douglas Wallace The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning $1,790,133 University of California, Irvine SEED Grant Brian Cummings The Immunological Niche: Effect of immunosuppressant drugs on stem cell proliferation, gene expression, and differentiation in a model of spinal cord injury. $595,345 University of California, Irvine Early Translational II leif Havton Repair of Conus Medullaris/Cauda Equina Injury using Human ES Cell-Derived Motor Neurons $1,538,467 University of California, Irvine Comprehensive Grant Hans Keirstead hESC-Derived Motor Neurons For the Treatment of Cervical Spinal Cord Injury $2,158,445 University of California, Irvine Basic Biology V Lisa Flanagan Molecular basis of plasma membrane characteristics reflecting stem cell fate potential $994,108 University of California, Irvine SEED Grant Charles Limoli Using human embryonic stem cells to treat radiation-induced stem cell loss: Benefits vs cancer risk $593,242 University of California, Irvine Training Grant I-1 Peter Bryant Stem Cell Research Training Grant $1,935,487 University of California, Irvine Tools and Technologies III Mathew Blurton-Jones Optimizing the differentiation and expansion of microglial progenitors from human pluripotent stem cells for the study and treatment of neurological disease. $1,147,596 University of California, Irvine New Cell Lines Leslie Thompson New Cell Lines for Huntington's Disease $1,302,526 University of California, Irvine Early Translational I Frank LaFerla Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease $3,599,997 University of California, Irvine Basic Biology V Peter Donovan Non-invasive live imaging of stem cell signature metabolic states $540,480 University of California, Irvine Basic Biology II Aileen Anderson Role of the microenvironment in human iPS and NSC fate and tumorigenesis $1,256,194 University of California, Irvine SEED Grant Frank LaFerla Development of human ES cell lines as a model system for Alzheimer disease drug discovery $473,963 University of California, Irvine SEED Grant Grant MacGregor Production of Oocytes from Human ES Cells $385,466 University of California, Irvine Major Facilities Michael Drake UC Irvine CIRM Institute $27,156,000 University of California, Irvine SEED Grant Vincent Procaccio Mitochondrial Dysfunction in Embryonic Stem Cells $245,582 University of California, Irvine SEED Grant Michelle Khine Micro Platform for Controlled Cardiac Myocyte Differentiation $156,426 University of California, Irvine Tools and Technologies I Lisa Flanagan Novel Separation of Stem Cell Subpopulations $861,122 University of California, Irvine Tools and Technologies III leif Havton Development of Relevant Pre-clinical Animal Model as a Tool to Evaluate Human Stem Cell-Derived Replacement Therapies for Motor Neuron Injuries and Degenerative Diseases $1,308,711