All CIRM Grants

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Institution Researcher name Grant Type Grant Title Award Value
City of Hope, Beckman Research Institute Elizabeth Budde Clinical Trial Stage Projects Phase I Study of Chimeric Antigen Receptor Engineered T Cells targeting CD33 for the Treatment of Relapsed/Refractory Acute Myeloid Leukemia $11,983,547
Stanford University Anusha Kalbasi Clinical Trial Stage Projects Stem-Derived IL13Ra2 Chimeric Antigen Receptor T cells for Patients with Melanoma and Advanced Solid Tumors $10,211,085
Regenerative Patch Technologies LLC Dr Jane S Lebkowski Clinical Trial Stage Projects A Phase 2b, Randomized, Assessor-Masked Clinical Trial to Assess the Safety and Efficacy of the CPCB-RPE1 Implant in Subjects with Geographic Atrophy $12,373,748
City of Hope, Beckman Research Institute Dr. Angelo Manuel Almeida Cardoso Ph.D., MD Clinical Trial Stage Projects Evaluation of Safety and Feasibility of Cytomegalovirus-Specific, Anti-HIV Chimeric Antigen Receptor (CMV/HIV-CAR) T Cells in People with HIV $11,299,976
Combangio, Inc. R. Kim Brazzell Clinical Trial Stage Projects Phase 2b Clinical Study of KPI-012 Topical Ophthalmic Human Mesenchymal Stem Cell Secretome for the Treatment of Persistent Corneal Epithelial Defect $15,000,000
Immusoft Corporation Dr Robert Hayes Clinical Trial Stage Projects A Phase I Open Label Study to Evaluate the Safety and Tolerability of ISP-001 in Patients with Mucopolysaccharidosis Type 1 $8,000,000
Eureka Therapeutics, Inc. Pei Wang Clinical Trial Stage Projects Autologous ARTEMIS® T Cells to Treat Refractory/Relapsed Pediatric Liver Cancer $10,600,072
Stanford University Dr. Matthew H Porteus Clinical Trial Stage Projects Reduced intensity conditioning with JSP191 prior to TCRαβ+ T-cell/CD19+ B-cell depleted hematopoietic stem cell transplant for Fanconi Anemia patients $10,642,420
Angiocrine Bioscience, Inc. Dr. Paul Finnegan Clinical Trial Stage Projects AB-205-301 Phase 3 Trial and Related Activities to Support Clinical Development of AB-205 $10,930,014
Genascence Corporation Dr. Thomas W Chalberg Jr. Clinical Trial Stage Projects A Phase 1b, Randomized, Blinded, Placebo-Controlled Dose-Ranging Study of GNSC-001 Evaluating Safety, Pharmacodynamics, and Biomarkers in Knee OA $11,637,194
City of Hope, Beckman Research Institute Ryotaro Nakamura Clinical Trial Stage Projects Treatment of Severe Aplastic Anemia by induction of mixed chimerism using CD4+ T cell depleted haploidentical donor stem cell transplant $9,054,216
Tachyon Therapeutics, Inc Ivan King Clinical Trial Stage Projects TACH101: A Potent, First-In-Class KDM4 Inhibitor for Advanced Cancers $6,862,609
Stanford University Alice Bertaina Clinical Trial Stage Projects Sequential same donor αβdepleted-HSCT from an HLA-partially matched donor allowing immunosuppression free kidney transplant $11,998,188
Neurona Therapeutics Dr. Cory R Nicholas Clinical Trial Stage Projects Phase 1/2 Study of NRTX-1001 Neural Cell Therapy in Subjects with Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy $7,999,999
Excision BioTherapeutics William Kennedy Clinical Trial Stage Projects Phase 1 Clinical research program for functional cure of HIV with EBT-101, in-vivo gene therapy $6,852,486
Wake Forest University Health Sciences James Yoo Clinical Trial Stage Projects Phase I Treatment of Urethral Strictures in Humans $3,841,593
Stanford University Dr. Rosa Bacchetta Clinical Trial Stage Projects Phase 1 Study of Autologous CD4LVFOXP3 in Participants with IPEX Syndrome $11,999,179
City of Hope, Beckman Research Institute Dr Jana Portnow Clinical Trial Stage Projects A Phase I Study of Multiple doses of NSC-Based Oncolytic Virotherapy Administered Intracerebrally to Patients with Recurrent High-Grade Gliomas $11,999,984
University of California, Davis Peter C Belafsky Clinical Trial Stage Projects A Double-Blind Randomized Placebo-Controlled Investigation of Autologous Muscle Derived Progenitor Cells for the Treatment of Dysphagia $11,015,936
BioEclipse Therapeutics INC. Dr. Pamela Reilly Contag Clinical Trial Stage Projects PHASE 1, OPEN LABEL, DOSE-ESCALATION STUDY OF CRX100 IN PATIENTS WITH ADVANCED SOLID TUMORS $7,999,689
Stanford University Dr. Joseph C. Wu Clinical Trial Stage Projects A Phase I, Pilot Study of Human Embryonic Stem Cell-Derived Cardiomyocytes in PaTients with ChrOnic Ischemic Left VentRicular Dysfunction (HECTOR) $6,987,507
Stanford University Crystal Mackall Clinical Trial Stage Projects Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor T Cells for Diffuse Intrinsic Pontine Gliomas and Spinal Diffuse Midline Glioma $11,998,310
Stanford University Dr. Matthew H Porteus Clinical Trial Stage Projects Phase 1/1b study of T-allo10 infusion after HLA-partially matched abdepleted-HSCT in children and young adults with hematologic malignancies. $10,563,822
Stanford University Dr. Gary Steinberg Clinical Trial Stage Projects Safety and Tolerability Study of Neural Stem Cells (NR1) in Subjects with Chronic Ischemic Subcortical Stroke $11,998,988
Cedars-Sinai Medical Center Clive Svendsen Clinical Trial Stage Projects CNS10-NPC-GDNF delivered into the motor cortex for the treatment of ALS $11,990,372
City of Hope, Beckman Research Institute Dr. Leo D Wang Clinical Trial Stage Projects Phase I Study of IL13Rα2-Targeting CAR T Cells After Lymphodepletion for Children with Refractory or Recurrent Malignant Brain Tumors $8,401,309
Immune-Onc Therapeutics Joseph Paul Woodard Clinical Trial Stage Projects Phase 1 Clinical Development of IO-202, A First-in-Class Antibody Targeting LILRB4, for the Treatment of AML with Monocytic Differentiation and CMML $6,000,000
University of California, Davis Dr. Diana L. Farmer Clinical Trial Stage Projects The CuRe Trial: Cellular Therapy for In Utero Myelomeningocele Repair $8,946,474
Rocket Pharmaceuticals, Inc. Dr. Gayatri Rao Clinical Trial Stage Projects A Phase I Clinical Trial for a Lentiviral Gene Therapy Targeting the TCIRG1 Gene for Infantile Malignant Osteopetrosis (IMO) $1,010,000
University of California, San Francisco Steven G. Deeks Clinical Trial Stage Projects Anti-HIV duoCAR-T cell therapy for HIV infection $8,970,732
Brain Neurotherapy Bio Krystof S. Bankiewicz Clinical Trial Stage Projects A Phase 1b Safety Study for MRI guided delivery of AAV2-GDNF for the treatment of Parkinson’s disease $5,510,462
University of California, Los Angeles Dr. Sophie X Deng Clinical Trial Stage Projects Safety and Feasibility of Cultivated Autologous Limbal Stem Cells for Limbal Stem Cell Deficiency $10,301,486
Cedars-Sinai Medical Center Clive Svendsen Clinical Trial Stage Projects Clinical Study to Assess Safety and Efficacy of Subretinal Injection of Human Neural Progenitor Cells for Treatment of Retinitis Pigmentosa $10,444,063
City of Hope, Beckman Research Institute Dr Saul J Priceman Clinical Trial Stage Projects A Phase I Study of Chimeric Antigen Receptor Engineered Stem/Memory T Cells for the Treatment of HER2-Positive Brain Metastases $9,015,149
Rocket Pharmaceuticals, Inc. Dr. Kinnari Patel Clinical Trial Stage Projects LADICell $5,867,085
University of California, San Diego Dr. Stephanie Cherqui Clinical Trial Stage Projects Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. $11,999,944
jCyte, Inc Henry John Klassen Clinical Trial Stage Projects A Phase 2 Study of the Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa $5,175,000
University of California, San Francisco Peter Stock Clinical Trial Stage Projects Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM $11,083,012
Jasper Therapeutics, Inc. Wendy Pang Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $2,313,398
Stanford University Dr. Judith A Shizuru Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $1,113,487
Stanford University Dr. Everett H. Meyer Clinical Trial Stage Projects Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients $11,955,585
University of California, Los Angeles Theodore Scott Nowicki Clinical Trial Stage Projects Genetic Modification of Stem Cells and T cells to Activate the Immune System to Target Solid Tumors $4,230,000
Angiocrine Bioscience, Inc. Dr. Edward Kavalerchik Clinical Trial Stage Projects AB-205-001 Phase 1b Trial and Related Activities to Support Clinical Development of AB-205 $6,192,579
Sangamo BioSciences, Inc. Bettina Cockroft Clinical Trial Stage Projects A Phase 1/2 Study to Assess the Safety, Tolerability, and Efficacy of ST-400 Autologous HSPC Transplant in Transfusion-dependent β-Thalassemia $5,150,000
City of Hope, Beckman Research Institute Dr. De-Fu Zeng Clinical Trial Stage Projects Treatment of sickle cell disease by induction of mixed chimerism and immune tolerance using CD4+ T-depleted haploidentical blood stem cell transplant $4,352,180
Stanford University Dr. David B. Miklos Clinical Trial Stage Projects Phase 1 Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Adults with Recurrent or Refractory B Cell Malignancies $11,034,982
University of California, San Francisco Mort Cowan Clinical Trial Stage Projects Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells $12,000,000
University of California, Los Angeles Steven M. Dubinett Clinical Trial Stage Projects A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC $10,955,315
Medeor Therapeutics, Inc. Daniel Brennan Clinical Trial Stage Projects Cellular Immunotherapy for Induction of Immune Tolerance in HLA Matched Living Donor Kidney Transplant Recipients $11,217,155
Poseida Therapeutics, Inc. Rajesh Belani MD Clinical Trial Stage Projects Clinical Study of T stem cell memory (Tscm)-based CAR-T cells in Patients with Multiple Myeloma $19,813,407