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Institution
Researcher name
Grant Type
Grant Title
Award Value
University of California, Los Angeles
Dr. Richard Joseph Pietras
Quest – Discovery Stage Research Projects
Reversal of dysregulated myelopoiesis in breast cancers and cancer stem cells to boost antitumor immunotherapy
$2,327,680
Greenstone Biosciences, Inc.
Paul D Pang
Quest – Discovery Stage Research Projects
Drug Discovery for Duchenne Muscular Dystrophy Using Patient-Derived Human iPSCs
$675,000
University of California, Berkeley
Mr. Fyodor Urnov
Quest – Discovery Stage Research Projects
A Treatment for Artemis-deficient Severe Combined Immunodeficiency using Non-Viral CRISPR-driven Safe Harbor Transgenesis in Hematopoietic Stem Cells
$1,809,372
University of California, Davis
Aijun Wang PhD
Quest – Discovery Stage Research Projects
In Utero Treatment of Duchenne Muscular Dystrophy with Non-viral Gene Editing
$2,035,544
Rubedo Life Sciences Inc.
Marco Quarta
Quest – Discovery Stage Research Projects
Pharmacological regenerative treatment of idiopathic pulmonary fibrosis targeting the senescent niche of lung progenitor cells.
$1,450,876
University of California, Los Angeles
Dr. Gerald Lipshutz
Quest – Discovery Stage Research Projects
Gene Therapy for SLC6A8 Creatine Transporter Disorder
$2,296,920
University of California, Los Angeles
Frank Pajonk
Quest – Discovery Stage Research Projects
Development of novel small molecules against cancer stem cells in solid cancers
$2,340,000
Scripps Health
Dr. Darryl D. D’Lima
Quest – Discovery Stage Research Projects
Pluripotent Stem Cells for Tendon Tissue Engineering
$2,734,163
Cedars-Sinai Medical Center
Dmitriy Sheyn
Quest – Discovery Stage Research Projects
Microgel encapsulated iPSC-derived notochordal cells to treat intervertebral disc degeneration and low back pain
$2,020,166
Lundquist Institute for Biomedical Innovation at Harbor – UCLA Medical Center
Dr. Michelina Iacovino PhD
Quest – Discovery Stage Research Projects
A Novel Therapy for Sanfilippo B
$2,297,884
University of California, Berkeley
5106433559 Kevin E. Healy
Quest – Discovery Stage Research Projects
Novel Lipid Nanoparticles for Enhancing eNOS Synthesis for Cardioprotection Post Myocardial Infarction
$2,060,248
BrainXell Therapeutics
Matthew Goodus
Quest – Discovery Stage Research Projects
Autologous stem cell-derived interneuron cell therapy for spinal cord injury (SCI)
$2,025,000
University of California, San Diego
Professor Alysson R Muotri
Quest – Discovery Stage Research Projects
A treatment for Rett syndrome using glial-restricted neural progenitor cells
$1,402,240
Gladstone Institutes, J. David
Dr. Deepak Srivastava
Quest – Discovery Stage Research Projects
Modified RNA-Based Gene Therapy for Cardiac Regeneration Through Cardiomyocyte Proliferation
$1,565,784
The Scintillon Institute
Brian Lawson
Quest – Discovery Stage Research Projects
An hematopoietic stem-cell-based approach to treat HIV employing CAR T cells and anti-HIV broadly neutralizing antibodies.
$1,143,600
University of California, Irvine
Dr. Michael Demetriou
Quest – Discovery Stage Research Projects
CAR T cells targeting abnormal N-glycans for the treatment of refractory/metastatic solid cancers
$1,414,800
University of California, Los Angeles
Dr. Lili Yang
Quest – Discovery Stage Research Projects
Combating Ovarian Cancer Using Stem Cell-Engineered Off-The-Shelf CAR-iNKT Cells
$1,404,000
Minutia, Inc.
Katy Digovich
Quest – Discovery Stage Research Projects
Bioengineering human stem cell-derived beta cell organoids to monitor cell health in real time and improve therapeutic outcomes in patients
$1,198,550
Nanotools Bioscience
Dr. Alex Savtchenko PhD
Quest – Discovery Stage Research Projects
Enabling non-genetic activity-driven maturation of iPSC-derived neurons
$675,000
University of California, Los Angeles
Dr. Xian-Jie Yang
Quest – Discovery Stage Research Projects
Developing gene therapy for dominant optic atrophy using human pluripotent stem cell-derived retinal organoid disease models
$1,345,691
University of California, San Diego
Dr. Joseph G. Gleeson
Quest – Discovery Stage Research Projects
Novel antisense therapy to treat genetic forms of neurodevelopmental disease.
$1,180,654
Scripps Research Institute
Stuart A Lipton
Quest – Discovery Stage Research Projects
Drug Development of Inhibitors of Inflammation Using Human iPSC-Derived Microglia (hiMG)
$1,658,123
University of California, Los Angeles
Dr Dinesh S Rao
Quest – Discovery Stage Research Projects
Novel methods to eliminate cancer stem cells
$1,384,347
University of California, San Diego
Dr. Michael Karin
Quest – Discovery Stage Research Projects
Targeting pancreatic cancer stem cells with DDR1 antibodies.
$1,425,600
Cedars-Sinai Medical Center
Dr. Robert Barrett
Quest – Discovery Stage Research Projects
A new precision medicine based iPSC-derived model to study personalized intestinal fibrosis treatments in pediatric patients with Crohn’s disease
$776,340
Scripps Research Institute
Dr Michael J Bollong
Quest – Discovery Stage Research Projects
Therapeutics to overcome the differentiation roadblock in Myelodysplastic Syndrome (MDS)
$1,244,160
University of California, Davis
Dr. Kyle D Fink PhD
Quest – Discovery Stage Research Projects
AAV-dCas9 Epigenetic Editing for CDKL5 Deficiency Disorder
$1,429,378
University of California, Los Angeles
Dr. Caroline Y. Kuo
Quest – Discovery Stage Research Projects
Defining the Optimal Gene Therapy Approach of Human Hematopoietic Stem Cells for the Treatment of Dedicator of Cytokinesis 8 (DOCK8) Deficiency
$1,386,232
University of California, Los Angeles
Dr. Donald B. Kohn PhD
Quest – Discovery Stage Research Projects
Hematopoietic Stem Cell Gene Therapy for Alpha Thalassemia
$1,177,739
Stanford University
Dr. Judith A Shizuru
Quest – Discovery Stage Research Projects
Targeted Immunotherapy-Based Blood Stem Cell Transplantation
$1,341,910
Tenaya Therapeutics, Inc.
Karl N Doerner
Quest – Discovery Stage Research Projects
Cardiac Reprogramming Gene Therapy for Post-Myocardial Infarction Heart Failure
$1,017,000
Intact Therapeutics, Inc.
Jeffrey Linhardt
Quest – Discovery Stage Research Projects
Modulation of oral epithelium stem cells by RSpo1 for the prevention and treatment of oral mucositis
$942,050
Cytonus Therapeutics, Inc.
Dr. Edward Filardo
Quest – Discovery Stage Research Projects
Development of a novel stem-cell based carrier for intravenous delivery of oncolytic viruses
$899,342
Salk Institute for Biological Studies
Ronald Mark Evans
Quest – Discovery Stage Research Projects
Extending Immune-Evasive Human Islet-Like Organoids (HILOs) Survival and Function as a Cure for T1D
$1,523,285
Stanford University
Ansuman Satpathy
Quest – Discovery Stage Research Projects
Preclinical development of an exhaustion-resistant CAR-T stem cell for cancer immunotherapy
$1,420,200
Stanford University
Dr. Bertha Chen
Quest – Discovery Stage Research Projects
iPSC-derived smooth muscle cell progenitor conditioned medium for treatment of pelvic organ prolapse
$1,420,200
University of California, San Francisco
Brian Feeley
Quest – Discovery Stage Research Projects
Matrix Assisted Cell Transplantation of Promyogenic Fibroadipogenic Progenitor (FAP) Stem Cells
$1,179,478
University of California, Los Angeles
Prof. Song Li
Quest – Discovery Stage Research Projects
iPSC Extracellular Vesicles for Diabetes Therapy
$1,354,928
Scripps Health
Dr. Darryl D. D’Lima
Quest – Discovery Stage Research Projects
Meniscal Repair and Regeneration
$1,361,775
The Stone Research Foundation for Sports Medicine and Arthritis
Dr. Kevin Stone
Quest – Discovery Stage Research Projects
A Novel Therapy for Articular Cartilage Autologous Cellular Repair by Paste Grafting
$1,180,309
University of California, San Diego
Gene Wei-Ming Yeo
Quest – Discovery Stage Research Projects
RNA-directed therapy for Huntington’s disease
$1,253,110
University of California, Irvine
Dr. Mathew Mark Blurton-Jones
Quest – Discovery Stage Research Projects
Transplantation of genetically corrected iPSC-microglia for the treatment of Sanfilippo Syndrome (MPSIIIA)
$1,083,379
University of California, San Francisco
Dr. Julie Deane Saba
Quest – Discovery Stage Research Projects
Providing a cure for sphingosine phosphate lyase insufficiency syndrome (SPLIS) through adeno-associated viral mediated SGPL1 gene therapy
$1,463,400
Scripps Research Institute
Luke L Lairson
Quest – Discovery Stage Research Projects
Improving the efficacy and tolerability of clinically validated remyelination-inducing molecules using developable combinations of approved drugs
$1,554,126
University of California, San Francisco
Dr Julia Carnevale
Quest – Discovery Stage Research Projects
Generating deeper and more durable BCMA CAR T cell responses in Multiple Myeloma through non-viral knockin/knockout multiplexed genome engineering
$1,463,368
Stanford University
Dr. Sarah C Heilshorn
Quest – Discovery Stage Research Projects
Injectable, autologous iPSC-based therapy for spinal cord injury
$789,000
Navega Therapeutics
Ana Maria Moreno
Quest – Discovery Stage Research Projects
Optimization of a gene therapy for inherited erythromelalgia in iPSC-derived neurons
$1,157,313
Cedars-Sinai Medical Center
Dr Eduardo Marban
Quest – Discovery Stage Research Projects
New noncoding RNA chemical entity for heart failure with preserved ejection fraction.
$1,397,412
Stanford University
Dr. Stanley Qi
Quest – Discovery Stage Research Projects
A novel hybrid CRISPR tool for gene network perturbation and hiPSC engineering
$704,661
University of California, San Diego
Ziwei Huang
Quest – Discovery Stage Research Projects
Development of a new therapeutic for directing target specific stem cell migration and treatment
$1,129,512
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