Our Grants

CIRM provides funding across five key areas: Infrastructure, Education, Discovery Research, Translational Research, and Clinical Research. By supporting projects at every stage of development, from initial discovery to clinical trials, CIRM drives progress in regenerative medicine and accelerates innovative therapies to patients.

See our complete portfolio of awards below.

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Institution Researcher name Grant Type Grant Title Award Value
Tenaya Therapeutics, Inc. Dr. Matthew Pollman Clinical Trial Stage Projects Phase 1b Study of TN-401 in Adults with PKP2 Mutation-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) $8,000,000
Tr1X Inc. Maria Grazia Roncarolo Clinical Trial Stage Projects TRX103 for prevention of GvHD in patients receiving HLA mismatched HSCT for the treatment of hematologic malignancies $8,000,000
University of California, Los Angeles Dr. Donald B. Kohn Clinical Trial Stage Projects Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS-ADA lentiviral vector encoding for human ADA gene in ADA-SCID subjects $14,325,181
Fate Therapeutics, Inc. Dr. Vaneet Sandhu Clinical Trial Stage Projects A Phase 1 Study of FT819 in Participants with Moderate to Severe Active Systemic Lupus Erythematosus $7,934,448
Nexcella, Inc. Ilya Rachman MD PhD Clinical Trial Stage Projects Autologous BCMA CAR-T Cells for the Treatment of Relapsed Refractory Light Chain Amyloidosis $7,999,467
University of California, San Francisco Dr. Hideho Okada Clinical Trial Stage Projects Phase 1 Study of Autologous E-SYNC T Cells in Adult Participants with EGFRvIII+ Glioblastoma $10,927,618
Aspen Neuroscience Dr. Edward Wirth III Clinical Trial Stage Projects Phase 1/2a Dose Escalation Study of ANPD001 in Sporadic Parkinson Disease $8,000,000
Allogene Therapeutics Zachary J. Roberts Clinical Trial Stage Projects A PHASE 1B STUDY EVALUATING THE SAFETY AND EFFICACY OF AN ALLOGENEIC CELL THERAPY IN SUBJECTS WITH CLEAR CELL RENAL CELL CARCINOMA (ccRCC) $9,238,404
University of California, San Francisco Noriyuki Kasahara Clinical Trial Stage Projects A Phase I/IIa Study to Evaluate the Efficacy of Toca 511/Toca FC with Standard of Care Therapy in Newly Diagnosed High Grade Glioma $11,807,220
Luxa Biotechnology Dr. Jeffrey H Stern Clinical Trial Stage Projects RPESC-RPE-4W Therapy for dry Age-related Macular Degeneration $4,009,675
Rocket Pharmaceuticals, Inc. Dr. Jonathan Schwartz Clinical Trial Stage Projects A Phase 2 Study Evaluating the Efficacy and Safety of IV Administered rAAV9 Vector Containing RP-A501 in Male Patients with Danon Disease $5,808,735
University of California, Davis Dr. Diana L. Farmer Clinical Trial Stage Projects The CuRe Trial: Cellular Therapy for In Utero Repair of Myelomeningocele $8,996,477
Stanford University Dr. Reena Parada Thomas Clinical Trial Stage Projects Phase I Trial of Locoregionally Delivered Autologous B7-H3 CAR T Cells (B7-H3CART) in Adults with Recurrent Glioblastoma Multiforme $11,999,991
City of Hope, Beckman Research Institute Elizabeth Budde Clinical Trial Stage Projects Phase I Study of Chimeric Antigen Receptor Engineered T Cells targeting CD33 for the Treatment of Relapsed/Refractory Acute Myeloid Leukemia $11,983,547
University of California, San Diego Prof. Olivia Kim-McManus Clinical Trial Stage Projects Personalized antisense oligonucleotide therapy for rare pediatric genetic disease: SCN2A $960,713
Stanford University Anusha Kalbasi Clinical Trial Stage Projects Stem-Derived IL13Ra2 Chimeric Antigen Receptor T cells for Patients with Melanoma and Advanced Solid Tumors $10,211,085
University of California, Los Angeles Dr. Jeffrey L Veale Clinical Trial Stage Projects The UCLA Delayed Immunological Tolerance after Kidney Transplantation Program $6,717,608
Regenerative Patch Technologies LLC Jane Stephanie Lebkowski Clinical Trial Stage Projects A Phase 2b, Randomized, Assessor-Masked Clinical Trial to Assess the Safety and Efficacy of the CPCB-RPE1 Implant in Subjects with Geographic Atrophy $12,373,748
City of Hope, Beckman Research Institute Dr. Angelo Manuel Almeida Cardoso Ph.D., MD Clinical Trial Stage Projects Evaluation of Safety and Feasibility of Cytomegalovirus-Specific, Anti-HIV Chimeric Antigen Receptor (CMV/HIV-CAR) T Cells in People with HIV $11,299,976
Immusoft of CA, Inc. Dr Robert Hayes Clinical Trial Stage Projects A Phase I Open Label Study to Evaluate the Safety and Tolerability of ISP-001 in Patients with Mucopolysaccharidosis Type 1 $8,000,000
Eureka Therapeutics, Inc. Pei Wang Clinical Trial Stage Projects Autologous ARTEMIS® T Cells to Treat Refractory/Relapsed Pediatric Liver Cancer $10,600,072
Stanford University Dr. Matthew H Porteus Clinical Trial Stage Projects Reduced intensity conditioning with JSP191 prior to TCRαβ+ T-cell/CD19+ B-cell depleted hematopoietic stem cell transplant for Fanconi Anemia patients $10,642,420
Genascence Corporation Dr. Thomas W Chalberg Jr. Clinical Trial Stage Projects A Phase 1b, Randomized, Blinded, Placebo-Controlled Dose-Ranging Study of GNSC-001 Evaluating Safety, Pharmacodynamics, and Biomarkers in Knee OA $11,637,194
City of Hope, Beckman Research Institute Ryotaro Nakamura Clinical Trial Stage Projects Treatment of Severe Aplastic Anemia by induction of mixed chimerism using CD4+ T cell depleted haploidentical donor stem cell transplant $9,054,216
Stanford University Alice Bertaina Clinical Trial Stage Projects Sequential same donor αβdepleted-HSCT from an HLA-partially matched donor allowing immunosuppression free kidney transplant $11,998,188
Neurona Therapeutics Dr. Cory R Nicholas Clinical Trial Stage Projects Phase 1/2 Study of NRTX-1001 Neural Cell Therapy in Subjects with Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy $7,999,999
Stanford University Dr. Rosa Bacchetta Clinical Trial Stage Projects Phase 1 Study of Autologous CD4LVFOXP3 in Participants with IPEX Syndrome $11,999,179
City of Hope, Beckman Research Institute Dr Jana Portnow Clinical Trial Stage Projects A Phase I Study of Multiple doses of NSC-Based Oncolytic Virotherapy Administered Intracerebrally to Patients with Recurrent High-Grade Gliomas $11,999,984
University of California, Davis Peter C Belafsky Clinical Trial Stage Projects A Double-Blind Randomized Placebo-Controlled Investigation of Autologous Muscle Derived Progenitor Cells for the Treatment of Dysphagia $11,015,936
Stanford University Dr. Joseph C. Wu Clinical Trial Stage Projects A Phase I, Pilot Study of Human Embryonic Stem Cell-Derived Cardiomyocytes in PaTients with ChrOnic Ischemic Left VentRicular Dysfunction (HECTOR) $6,987,507
Stanford University Crystal Mackall Clinical Trial Stage Projects Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor T Cells for Diffuse Intrinsic Pontine Gliomas and Spinal Diffuse Midline Glioma $11,998,310
Stanford University Dr. Matthew H Porteus Clinical Trial Stage Projects Phase 1/1b study of T-allo10 infusion after HLA-partially matched abdepleted-HSCT in children and young adults with hematologic malignancies. $10,563,822
Cedars-Sinai Medical Center Professor Clive Niels Svendsen Clinical Trial Stage Projects CNS10-NPC-GDNF delivered into the motor cortex for the treatment of ALS $7,545,804
City of Hope, Beckman Research Institute Dr. Leo D Wang Clinical Trial Stage Projects Phase I Study of IL13Rα2-Targeting CAR T Cells After Lymphodepletion for Children with Refractory or Recurrent Malignant Brain Tumors $8,401,309
University of California, San Francisco Steven G. Deeks Clinical Trial Stage Projects Anti-HIV duoCAR-T cell therapy for HIV infection $8,970,732
University of California, Los Angeles Dr. Sophie X Deng Clinical Trial Stage Projects Safety and Feasibility of Cultivated Autologous Limbal Stem Cells for Limbal Stem Cell Deficiency $10,301,486
Cedars-Sinai Medical Center Professor Clive Niels Svendsen Clinical Trial Stage Projects Clinical Study to Assess Safety and Efficacy of Subretinal Injection of Human Neural Progenitor Cells for Treatment of Retinitis Pigmentosa $6,354,477
University of California, San Diego Dr. Stephanie Cherqui Clinical Trial Stage Projects Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. $11,999,944
Stanford University Dr. Everett H. Meyer Clinical Trial Stage Projects Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients $8,920,000
Stanford University Robert Lowsky Clinical Trial Stage Projects Induction of Tolerance to Combined Kidney and Hematopoietic Progenitor Cell Transplants from HLA Haplotype Matched Living Donors $6,653,266
University of California, Los Angeles Dr. Donald B. Kohn Clinical Trial Stage Projects Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects $5,827,000
Cure Rare Disease Late Stage Preclinical Projects Advancing a novel antisense oligonucleotide for the treatment of SCA3, a devastating neurodegenerative disease $5,692,538
University of California, Davis Dr. Joseph S Anderson Late Stage Preclinical Projects Expression of Ube3a by the hematopoietic system for the treatment of Angelman syndrome $4,487,656
Amplo Biotechnology Patricio Sepulveda Late Stage Preclinical Projects Targeted DOK7 gene therapy for Congenital Myasthenic Syndromes $2,894,305
University of California, San Diego Mark H Tuszynski Late Stage Preclinical Projects Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI) $6,000,000
University of California, Los Angeles Arjun Deb Late Stage Preclinical Projects Development of a therapeutic monoclonal antibody for the treatment of myocardial infarction and heart failure $5,999,998
Children’s Hospital of Los Angeles Shahab Asgharzadeh Late Stage Preclinical Projects Chimeric TGFB Signaling Receptor (CTSR) Enabled Anti-B7H3 CAR T-cell Therapy in Children and AYA with Recurrent Solid Tumors $6,000,000
City of Hope, Beckman Research Institute Prof. Karen S Aboody M.D. Late Stage Preclinical Projects Neural stem cell delivered CRAd-S-pk7 oncolytic viro-immunotherapy for ovarian cancer $5,314,547
Mahzi Therapeutics Dr. Yael Weiss Late Stage Preclinical Projects Development of a Gene Therapy for the Treatment of WWOX related epileptic encephalopathy (WOREE) $4,000,000
University of California, Davis Mehrdad Abedi Late Stage Preclinical Projects Superior forward-oriented b-globin vector for treating Sickle Cell Disease $4,598,398
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