Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Protocol for the isolation of mouse muscle stem cells using fluorescence-activated cell sorting. 2023 STAR Protoc
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice. 2023 Cell Mol Gastroenterol Hepatol
PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection. 2023 JCI Insight
Purification and functional characterization of novel human skeletal stem cell lineages. 2023 Nat Protoc
Pushing the boundaries of brain organoids to study Alzheimer’s disease. 2023 Trends Mol Med
Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells. 2023 Nat Cell Biol
Retention of Human iPSC-Derived or Primary Cells Following Xenotransplantation into Rat Immune-Privileged Sites. 2023 Bioengineering (Basel)
Retinal pathological features and proteome signatures of Alzheimer’s disease. 2023 Acta Neuropathol
Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors. 2023 Hum Mol Genet
RNA editing: Expanding the potential of RNA therapeutics. 2023 Mol Ther
RNA Modifications in Cancer Stem Cell Biology. 2023 Cancer Treat Res
RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. 2023 Blood
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. 2023 Nat Commun
Signalling by senescent melanocytes hyperactivates hair growth. 2023 Nature
Simultaneous multi-site editing of individual genomes using retron arrays. 2023 bioRxiv
Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes. 2023 Nat Cardiovasc Res
Single mRNA detection of Wnt signaling pathway in the human limbus. 2023 Exp Eye Res
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance. 2023 Sci Adv
Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. 2023 iScience
SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs. 2023 Development
Sonogenetic control of multiplexed genome regulation and base editing. 2023 Nat Commun
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus. 2023 Nat Biomed Eng
Stem Cell-Based Organoid Models of Neurodevelopmental Disorders. 2023 Biol Psychiatry
Stereochemical Control of Splice Modulation in FD-895 Analogues. 2023 J Med Chem
Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells. 2023 Cell Rep
Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. 2023 Elife
Sustained postconfluent culture of human mammary epithelial cells enriches for luminal and c-Kit+ subtypes. 2023 Breast Cancer Res
Systemic Delivery of Extracellular Vesicles Attenuates Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction. 2023 JACC Clin Electrophysiol
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. 2023 bioRxiv
T-allo10 Infusion after αβ depleted-HSCT in Children and Young Adults with Hematologic Malignancies: Improved Immune Reconstitution in the Absence of Severe GvHD 2023 Transplantation and Cellular Therapy
Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation. 2023 Anal Chem
Targeting Endothelial HIF2alpha/ARNT Expression for Ischemic Heart Disease Therapy. 2023 Biology (Basel)
Targeting the ADPKD methylome using nanoparticle-mediated combination therapy. 2023 APL Bioeng
TDO2-augmented fibroblasts secrete EVs enriched in immunomodulatory Y-derived small RNA. 2023 J Extracell Biol
Tetracycline-Inducible and Reversible Stable Gene Expression in Human iPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain. 2023 Curr Protoc
Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets. 2023 Neurobiol Dis
The breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of Long COVID symptoms. 2023 J Med Virol
The hunt for novel AAV capsids with improved cardiac tropism. 2023 Mol Ther Methods Clin Dev
The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain. 2023 Cell Rep
The tour-de-force for reducing cardiovascular disease risk in diabetic patients. 2023 Int J Cardiol
Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD(4)-selective WNT surrogate in mice. 2023 Nat Commun
Theta Frequency Electromagnetic Stimulation Enhances Functional Recovery After Stroke. 2023 Transl Stroke Res
Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model. 2023 Mol Ther
Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station. 2023 Biomolecules
Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington’s disease mice and innervate the striatum. 2023 Mol Ther
TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs. 2023 Proc Natl Acad Sci U S A
Tumor inflammation-associated neurotoxicity. 2023 Nat Med
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes. 2023 Dev Cell
Understanding Fibroblast Heterogeneity in Form and Function. 2023 Biomedicines
Vascularized liver-on-a-chip model to investigate nicotine-induced dysfunction. 2023 Biomicrofluidics