All CIRM Grants

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Institution Researcher name Grant Type Grant Title Award Value
City of Hope, Beckman Research Institute Dr Jana Portnow Clinical Trial Stage Projects A Phase I Study of Multiple doses of NSC-Based Oncolytic Virotherapy Administered Intracerebrally to Patients with Recurrent High-Grade Gliomas $11,999,984
University of California, Davis Peter C Belafsky Clinical Trial Stage Projects A Double-Blind Randomized Placebo-Controlled Investigation of Autologous Muscle Derived Progenitor Cells for the Treatment of Dysphagia $11,015,936
BioEclipse Therapeutics INC. Dr. Pamela Reilly Contag Clinical Trial Stage Projects PHASE 1, OPEN LABEL, DOSE-ESCALATION STUDY OF CRX100 IN PATIENTS WITH ADVANCED SOLID TUMORS $7,999,689
Stanford University Dr. Joseph C. Wu Clinical Trial Stage Projects A Phase I, Pilot Study of Human Embryonic Stem Cell-Derived Cardiomyocytes in PaTients with ChrOnic Ischemic Left VentRicular Dysfunction (HECTOR) $6,987,507
Stanford University Crystal Mackall Clinical Trial Stage Projects Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor T Cells for Diffuse Intrinsic Pontine Gliomas and Spinal Diffuse Midline Glioma $11,998,310
Stanford University Dr. Matthew H Porteus Clinical Trial Stage Projects Phase 1/1b study of T-allo10 infusion after HLA-partially matched abdepleted-HSCT in children and young adults with hematologic malignancies. $10,563,822
Stanford University Dr. Gary Steinberg Clinical Trial Stage Projects Safety and Tolerability Study of Neural Stem Cells (NR1) in Subjects with Chronic Ischemic Subcortical Stroke $11,998,988
Cedars-Sinai Medical Center Clive Svendsen Clinical Trial Stage Projects CNS10-NPC-GDNF delivered into the motor cortex for the treatment of ALS $11,990,372
City of Hope, Beckman Research Institute Dr. Leo D Wang Clinical Trial Stage Projects Phase I Study of IL13Rα2-Targeting CAR T Cells After Lymphodepletion for Children with Refractory or Recurrent Malignant Brain Tumors $8,401,309
Immune-Onc Therapeutics Joseph Paul Woodard Clinical Trial Stage Projects Phase 1 Clinical Development of IO-202, A First-in-Class Antibody Targeting LILRB4, for the Treatment of AML with Monocytic Differentiation and CMML $6,000,000
University of California, Davis Dr. Diana L. Farmer Clinical Trial Stage Projects The CuRe Trial: Cellular Therapy for In Utero Myelomeningocele Repair $8,946,474
Rocket Pharmaceuticals, Inc. Dr. Gayatri Rao Clinical Trial Stage Projects A Phase I Clinical Trial for a Lentiviral Gene Therapy Targeting the TCIRG1 Gene for Infantile Malignant Osteopetrosis (IMO) $1,010,000
University of California, San Francisco Steven G. Deeks Clinical Trial Stage Projects Anti-HIV duoCAR-T cell therapy for HIV infection $8,970,732
Brain Neurotherapy Bio Krystof S. Bankiewicz Clinical Trial Stage Projects A Phase 1b Safety Study for MRI guided delivery of AAV2-GDNF for the treatment of Parkinson’s disease $5,510,462
University of California, Los Angeles Dr. Sophie X Deng Clinical Trial Stage Projects Safety and Feasibility of Cultivated Autologous Limbal Stem Cells for Limbal Stem Cell Deficiency $10,301,486
Cedars-Sinai Medical Center Clive Svendsen Clinical Trial Stage Projects Clinical Study to Assess Safety and Efficacy of Subretinal Injection of Human Neural Progenitor Cells for Treatment of Retinitis Pigmentosa $10,444,063
City of Hope, Beckman Research Institute Dr Saul J Priceman Clinical Trial Stage Projects A Phase I Study of Chimeric Antigen Receptor Engineered Stem/Memory T Cells for the Treatment of HER2-Positive Brain Metastases $9,015,149
Rocket Pharmaceuticals, Inc. Dr. Kinnari Patel Clinical Trial Stage Projects LADICell $5,867,085
University of California, San Diego Dr. Stephanie Cherqui Clinical Trial Stage Projects Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. $11,999,944
jCyte, Inc Henry John Klassen Clinical Trial Stage Projects A Phase 2 Study of the Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa $5,175,000
University of California, San Francisco Peter Stock Clinical Trial Stage Projects Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM $11,083,012
Jasper Therapeutics, Inc. Wendy Pang Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $2,313,398
Stanford University Dr. Judith A Shizuru Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $1,113,487
Stanford University Dr. Everett H. Meyer Clinical Trial Stage Projects Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients $11,955,585
University of California, Los Angeles Theodore Scott Nowicki Clinical Trial Stage Projects Genetic Modification of Stem Cells and T cells to Activate the Immune System to Target Solid Tumors $4,230,000
Angiocrine Bioscience, Inc. Dr. Edward Kavalerchik Clinical Trial Stage Projects AB-205-001 Phase 1b Trial and Related Activities to Support Clinical Development of AB-205 $6,192,579
Sangamo BioSciences, Inc. Bettina Cockroft Clinical Trial Stage Projects A Phase 1/2 Study to Assess the Safety, Tolerability, and Efficacy of ST-400 Autologous HSPC Transplant in Transfusion-dependent β-Thalassemia $5,150,000
City of Hope, Beckman Research Institute Dr. De-Fu Zeng Clinical Trial Stage Projects Treatment of sickle cell disease by induction of mixed chimerism and immune tolerance using CD4+ T-depleted haploidentical blood stem cell transplant $4,352,180
Stanford University Dr. David B. Miklos Clinical Trial Stage Projects Phase 1 Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Adults with Recurrent or Refractory B Cell Malignancies $11,034,982
University of California, San Francisco Mort Cowan Clinical Trial Stage Projects Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells $12,000,000
University of California, Los Angeles Dr. Steven M. Dubinett MD Clinical Trial Stage Projects A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC $10,955,315
Medeor Acquisition Corp. Daniel Brennan Clinical Trial Stage Projects Cellular Immunotherapy for Induction of Immune Tolerance in HLA Matched Living Donor Kidney Transplant Recipients $11,217,155
Poseida Therapeutics, Inc. Rajesh Belani MD Clinical Trial Stage Projects Clinical Study of T stem cell memory (Tscm)-based CAR-T cells in Patients with Multiple Myeloma $19,813,407
Children’s Hospital of Los Angeles Michael A. Pulsipher Clinical Trial Stage Projects Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation (ACES) $4,825,587
Calibr Dr. Kristen A Johnson Clinical Trial Stage Projects Evaluation of the Safety and Tolerability of KA34 in a Phase 1, Double-Blind, Dose Escalation Trial in Patients with Knee Osteoarthritis $8,447,523
Angiocrine Bioscience, Inc. Dr. Edward Kavalerchik Clinical Trial Stage Projects AB-110-001 Phase 1b Trial and Related Activities to Support Clinical Development of AB-110 $5,000,000
SanBio, Inc. Dr. Bijan Nejadnik Clinical Trial Stage Projects A Double-Blind, Controlled Ph 2b Study of the Safety and Efficacy of Modified Stem Cells in Patients with Chronic Motor Deficit from Ischemic Stroke $18,970,000
City of Hope, Beckman Research Institute Dr. Christine E. Brown Clinical Trial Stage Projects Phase I Study of Chimeric Antigen Receptor Engineered Central Memory T cells for the Treatment of Malignant Glioma $12,753,854
University of California, San Diego Thomas J Kipps Clinical Trial Stage Projects A Phase 1b/2a Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab, and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in B-Cell Cancers $18,292,674
Forty Seven Inc. Mark Chao Clinical Trial Stage Projects Phase 1b Trial of Hu5F9-G4 Monotherapy or Hu5F9-G4 in Combination with Azacitidine in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome $0
BrainStorm Cell Therapeutics Dr. Ralph Kern Clinical Trial Stage Projects A Phase 3, Randomized, Placebo-controlled Multicenter Study to Evaluate Efficacy & Safety of Repeated Administrations of NurOwn® in Patients with ALS $15,912,390
Caladrius Biosciences Dr. William Sietsema Clinical Trial Stage Projects Phase 2 Safety and Efficacy Study of CLBS03 Autologous T-Regulatory Cells in Adolescents with Recent Onset Type 1 Diabetes Mellitus $8,175,946
jCyte, Inc Henry John Klassen Clinical Trial Stage Projects Phase 2b Clinical Study of Safety and Efficacy of Intravitreal Injection of Retinal Progenitor Cells (jCell) for Treatment of Retinitis Pigmentosa $8,295,750
Humacyte, Inc. Jeffrey Lawson Clinical Trial Stage Projects A Phase 3 Study Comparing the Utility of Human Acellular Vessels to Arteriovenous Fistula in Subjects with End-Stage Renal Disease (California Sites) $3,525,000
ViaCyte, Inc. Manasi Jaiman Clinical Trial Stage Projects Clinical trial of directly vascularized islet cell replacement therapy for high-risk type 1 diabetes $13,607,002
Forty Seven Inc. Mark Chao Clinical Trial Stage Projects A Phase 1b/2 Trial of the Anti-CD47 Antibody Hu5F9-G4 in Combination with Cetuximab in Patients with Solid Tumors and Advanced Colorectal Cancer $0
Nohla Therapeutics Inc Dr. Colleen Delaney Clinical Trial Stage Projects A Phase 2 Open-Label, Multi-Center, Randomized, Controlled, Optimal Dose-Finding Study of DCC-UCB in Adults Receiving High Dose Chemotherapy for AML $4,310,000
St. Jude Children’s Research Hospital Stephen Gottschalk Clinical Trial Stage Projects Lentiviral Gene Therapy for Infants with X-linked Severe Combined Immunodeficiency using Autologous Bone Marrow Stem Cells and Busulfan Conditioning $5,118,785
Cedars-Sinai Medical Center Dr. Michael I Lewis Clinical Trial Stage Projects Pulmonary Arterial Hypertension Treated with Cardiosphere-Derived Allogeneic Stem Cells $7,354,772
Stanford University Dr Robert Lowsky Clinical Trial Stage Projects Induction of Tolerance to Combined Kidney and Hematopoietic Progenitor Cell Transplants from HLA Haplotype Matched Living Donors $6,653,266
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