Publications by Grantees

The following list of publications describe research carried out with CIRM funding. Click on the publication title for a brief summary of the research and for more information about the CIRM grants that contributed to the research.

Title Year Journal
Modeling brain macrophage biology and neurodegenerative diseases using human iPSC-derived neuroimmune organoids. 2023 Front Cell Neurosci
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI. 2023 Res Sq
Neonatal Cardiovascular-Progenitor-Cell-Derived Extracellular Vesicles Activate YAP1 in Adult Cardiac Progenitor Cells. 2023 Int J Mol Sci
Neurons require glucose uptake and glycolysis in vivo. 2023 Cell Rep
Ocular Surface Regeneration by Limbal Stem Cells Therapies: State of the Art, Challenges, and Perspectives. 2023 Stem Cells Transl Med
OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis. 2023 Proc Natl Acad Sci U S A
Patient-derived SLC6A1 variant S295L results in an epileptic phenotype similar to haploinsufficient mice. 2023 Epilepsia
Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2. 2023 bioRxiv
Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition. 2023 bioRxiv
Preferential FGF18/FGFR activity in pseudoglandular versus canalicular stage human lung fibroblasts. 2023 Front Cell Dev Biol
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis. 2023 Nat Genet
Present and Future Modeling of Human Psychiatric Connectopathies With Brain Organoids. 2023 Biol Psychiatry
Presentation of Human Neural Stem Cell Antigens Drives Regulatory T Cell Induction. 2023 J Immunol
Profiling of repetitive RNA sequences in the blood plasma of patients with cancer. 2023 Nat Biomed Eng
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design. 2023 iScience
Protein-encapsulated doxorubicin reduces cardiotoxicity in hiPSC-cardiomyocytes and cardiac spheroids while maintaining anticancer efficacy. 2023 Stem Cell Reports
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice. 2023 Cell Mol Gastroenterol Hepatol
PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection. 2023 JCI Insight
Purification and functional characterization of novel human skeletal stem cell lineages. 2023 Nat Protoc
Pushing the boundaries of brain organoids to study Alzheimer’s disease. 2023 Trends Mol Med
Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors. 2023 Hum Mol Genet
RNA editing: Expanding the potential of RNA therapeutics. 2023 Mol Ther
RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. 2023 Blood
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. 2023 Nat Commun
Signalling by senescent melanocytes hyperactivates hair growth. 2023 Nature
Single mRNA detection of Wnt signaling pathway in the human limbus. 2023 Exp Eye Res
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance. 2023 Sci Adv
Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. 2023 iScience
SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs. 2023 Development
Sonogenetic control of multiplexed genome regulation and base editing. 2023 Nat Commun
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus. 2023 Nat Biomed Eng
Stem Cell-Based Organoid Models of Neurodevelopmental Disorders. 2023 Biol Psychiatry
Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. 2023 Elife
Sustained postconfluent culture of human mammary epithelial cells enriches for luminal and c-Kit+ subtypes. 2023 Breast Cancer Res
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. 2023 bioRxiv
T-allo10 Infusion after αβ depleted-HSCT in Children and Young Adults with Hematologic Malignancies: Improved Immune Reconstitution in the Absence of Severe GvHD 2023 Transplantation and Cellular Therapy
Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation. 2023 Anal Chem
Targeting the ADPKD methylome using nanoparticle-mediated combination therapy. 2023 APL Bioeng
Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets. 2023 Neurobiol Dis
The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain. 2023 Cell Rep
Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD(4)-selective WNT surrogate in mice. 2023 Nat Commun
Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station. 2023 Biomolecules
Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington’s disease mice and innervate the striatum. 2023 Mol Ther
TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs. 2023 Proc Natl Acad Sci U S A
Tumor inflammation-associated neurotoxicity. 2023 Nat Med
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes. 2023 Dev Cell
Understanding Fibroblast Heterogeneity in Form and Function. 2023 Biomedicines
Wnt activation as a potential therapeutic approach to treat partial limbal stem cell deficiency. 2023 Sci Rep
A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. 2022 Nat Commun
A randomized placebo-controlled phase 3 study of mesenchymal stem cells induced to secrete high levels of neurotrophic factors in amyotrophic lateral sclerosis. 2022 Muscle Nerve