Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
MitoScribe single-cell molecular recorder logs graded signaling dynamics into mitochondrial DNA. 2025 bioRxiv
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. 2025 Stem Cell Reports
Molecular Signatures in Cortical Development. 2025 Annu Rev Neurosci
Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology. 2025 bioRxiv
MYOD represses gene expression from non-E-box motifs. 2025 Genes Dev
Neuroendocrinology and the Genetics of Obesity. 2025 Endocrinology
Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics. 2025 Nat Commun
On the Feasibility of SERS-Based Monitoring of Drug Loading Efficiency in Exosomes for Targeted Delivery. 2025 Biosensors (Basel)
Opposing roles of p38alpha-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. 2025 Cell Rep
Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells. 2025 Med
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells. 2025 Nat Commun
Paracrine effect of human stem cell-derived progenitor cells on remodeling of the vagina. 2025 NPJ Regen Med
Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers. 2025 bioRxiv
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling. 2025 bioRxiv
Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1. 2025 Stem Cell Reports
Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids. 2025 RSC Adv
Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects. 2025 J Hematol Oncol
Proteome-wide profiling of S-nitrosylated proteins using the SNOTRAP probe and mass spectrometry-based detection. 2025 Nat Protoc
Protocol for the isolation and characterization of mouse alveolar bone marrow hematopoietic stem cells. 2025 STAR Protoc
Protocol for vibratome sectioning, immunofluorescence, and S-phase labeling of inner ear organoids. 2025 STAR Protoc
Protocol to study ductal progenitor-like cells from the adult human pancreas using 3D suspension and methylcellulose-based culture systems. 2025 STAR Protoc
PTPN2 Regulates Iron Handling Protein Expression in Inflammatory Bowel Disease Patients and Prevents Iron Deficiency in Mice. 2025 Int J Mol Sci
Rapamycin enhances CAR-T control of HIV replication and reservoir elimination in vivo. 2025 J Clin Invest
Regulatory roles of three-dimensional structures of chromatin domains. 2025 Genome Biol
Reversible proliferative arrest induced by rapid depletion of RNase MRP. 2025 Nat Commun
Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens. 2025 Cell
Size and Structural Control of Mechanoluminescent ZnS:Mn(2+) Nanocrystals for Optogenetic Neuromodulation. 2025 ACS Nano
Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians. 2025 bioRxiv
Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians. 2025 Elife
Spatial and Single-Cell Transcriptomics Reveal Keratinocytes as Key Players in Vulvar Lichen Sclerosus Pathogenesis. 2025 J Invest Dermatol
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling. 2025 Cell Stem Cell
Spinal Cord Injury in Real Time: Intra-Operative Ultrasound for Acute Phase Examination in Non-Human Primates. 2025 Brain Sci
Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein pocket domain. 2025 J Biol Chem
Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis. 2025 Proc Natl Acad Sci U S A
Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development. 2025 Geroscience
Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline. 2025 bioRxiv
The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition. 2025 Mol Cell
The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia. 2025 Blood
The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis. 2025 Gut Microbes
The single-molecule accessibility landscape of newly replicated mammalian chromatin. 2025 Cell
The UCSC Genome Browser database: 2025 update. 2025 Nucleic Acids Res
Therapeutic genetic restoration through allogeneic brain microglia replacement. 2025 Nature
Towards universal modeling of transcript isoform expression levels. 2025 bioRxiv
Understanding human embryogenesis by building programmable stem cell-based models. 2025 Trends Cell Biol
Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction. 2025 Nat Commun
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment. 2025 bioRxiv
Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology. 2025 Nat Commun
Wnt/beta-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis. 2025 Mucosal Immunol
Xenophagocytosis blockade enhances interspecies chimerism. 2025 bioRxiv
A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-gamma-induced CD38 expression. 2024 Blood