Grant Award Details
Programmatic objective to provide appropriate enriching environment to the trainees
Progress Reports
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Grant Application Details
- CIRM Stem Cell Biology Training Program
This is a proposal to renew funding for the host institution’s Type I Comprehensive Training Program in Stem Cell Biology. Since funding was first applied for in the summer of 2005, stem cell research at the host institution has undergone a major transformation: a center for regenerative medicine and stem cell research was established, and a world class stem cell biologist was recruited to be its director. Seven new faculty, representing a wide spectrum of stem cell-related disciplines, have been recruited as members of the Center. Groundbreaking for construction of a CIRM Stem Cell Facility took place in early [REDACTED] 2008. This initiative was launched with a multi-million dollar gift from a private foundation, and was recently matched with a Major Facilities Award from CIRM. Also with CIRM funding, the host institution has developed a Training Program in Stem Cell Biology which has thus far supported 24 individuals. Key features of this program are a flagship course in stem cell biology, co-taught with two neighboring institutions, as well as courses in stem cell ethics, developmental biology and a practical course in the culture of human ES cells. A yearly retreat was instituted and created a website created, which will soon be the principal mode of recruitment. A major benefit of our stem cell training program has been the promotion of interactions among stem cell biologists, developmental biologists and clinical scientists. The breadth of the program, in terms of the number of faculty and wide range of their expertise in stem cell biology, will provide trainees with many choices of mentor, and it will also make for training that is strongly interdisciplinary. The host institution seeks to continue and improve what is believed to be already an excellent training program in stem cell biology. Funding for 6 predoctoral fellows, 8 postdoctoral fellows, and 2 clinical fellows (a total of 16 slots) is requested. These individuals will be supported for two years, during which they will conduct research with one (or more) of 39 potential mentors. They will take courses in stem cell biology, stem cell ethics, as well as selected optional courses, including developmental biology. They will attend and present their work in the weekly combined stem cell biology/developmental biology research forum and will attend a yearly retreat. Finally, they will benefit from the extensive informal interactions among the students and faculty in stem cell biology. The host institution is also extremely pleased to partner with several nearby institutions for CIRM's "Bridges to Stem Cell Research" program. This program would enable these institutions to place trainees in stem cell labs at the host institution. We note that these collaborative efforts will broaden the influence of our training program substantially and make efficient use of state stem cell resources
This is a proposal to renew funding for the host institution’s Type I Comprehensive Training Program in Stem Cell Biology. Since funding was first applied for in the summer of 2005, stem cell research at the host institution has undergone a major transformation: a center for regenerative medicine and stem cell research was established, and groundbreaking for construction of a CIRM Stem Cell Facility took place in [REDACTED] 2008. The recent establishment of [REDACTED] an innovative agreement among 6 research institutions in [REDACTED] (including the host institution) allows members to share training programs, scientific core facilities and expertise, thus achieving highly efficient use of state funding. In mid-2006, the host institution instituted a Training Program in Stem Cell Biology (which has thus far supported 24 individuals), and seeks to continue and to improve what is believed to be already an excellent training program in stem cell biology. This program will bring great educational, scientific and economic benefit to Californians. Key features of this program are a flagship course in stem cell biology, co-taught with two neighboring institutions, as well as courses in stem cell ethics, developmental biology and a practical course in the culture of human ES cells. A major benefit of our stem cell training program has been the promotion of interactions among stem cell biologists, developmental biologists and clinical scientists. The breadth of the program, in terms of the number of faculty and wide range of their expertise in stem cell biology, will make for training that is strongly interdisciplinary. The structure of the courses, capitalizing on the rich distance learning capabilities of the host institution to produce a highly interactive, yet flexible, course accommodates the diversity of pre- and post-doctoral students as well as clinical fellows. An added benefit is this course structure will allow for enrollment by interested parties statewide and nationally. Further, the agreement between the Institutions to contribute exceptional didactic training to the program regardless of funding by this mechanism truly demonstrates the commitment of each to training in this field. The host institution is also extremely pleased to partner with several nearby institutions for CIRM's "Bridges to Stem Cell Research" program. This program would enable these institutions to place trainees in stem cell labs at the host institution. We note that these collaborative efforts will broaden the influence of our training program substantially and make efficient use of state stem cell resources.
Publications
- Cancer Discov (2019) Circulating tumor cells exhibit metastatic tropism and reveal brain metastasis drivers. (PubMed: 31601552)
- Development (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. (PubMed: 29777011)
- Sci Rep (2017) Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. (PubMed: 28566723)
- EMBO Rep (2017) A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP. (PubMed: 28615290)
- Oncogene (2017) Wnt/beta-catenin activation and macrophage induction during liver cancer development following steatosis. (PubMed: 28671671)
- Nat Genet (2017) Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. (PubMed: 28783163)
- J Assoc Res Otolaryngol (2016) Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. (PubMed: 27539716)
- PLoS One (2016) Correction: Identification of Androgen Receptor Splice Variants in the Pten Deficient Murine Prostate Cancer Model. (PubMed: 26998759)
- Nucleic Acids Res (2016) Circular RNA profile in gliomas revealed by identification tool UROBORUS. (PubMed: 26873924)
- Dev Biol (2016) Dysregulated endocardial TGFbeta signaling and mesenchymal transformation result in heart outflow tract septation failure. (PubMed: 26522286)
- Nat Commun (2016) RUNX1 prevents oestrogen-mediated AXIN1 suppression and beta-catenin activation in ER-positive breast cancer. (PubMed: 26916619)
- PLoS One (2016) Spatial Variations in Vitreous Oxygen Consumption. (PubMed: 26930281)
- Sci Rep (2016) Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9. (PubMed: 26898344)
- Cell Metab (2016) NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism. (PubMed: 26724859)
- Development (2016) Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. (PubMed: 26884396)
- PLoS Genet (2016) Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. (PubMed: 27058748)
- Gastroenterology (2016) TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. (PubMed: 26582088)
- Invest Ophthalmol Vis Sci (2016) Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. (PubMed: 27233037)
- Nat Commun (2016) Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. (PubMed: 26822151)
- Am J Pathol (2016) alphaB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. (PubMed: 26878210)
- Stem Cell Res Ther (2015) Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities. (PubMed: 26319495)
- Sci Rep (2015) Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. (PubMed: 26552368)
- Annu Rev Anim Biosci (2015) Development, regeneration, and evolution of feathers. (PubMed: 25387232)
- J Evol Biol (2015) Evolution and functional significance of derived sternal ossification patterns in ornithothoracine birds. (PubMed: 26079847)
- J Bone Miner Res (2015) Natural large-scale regeneration of rib cartilage in a mouse model. (PubMed: 25142306)