Analyses reveals intra-Hair follicle Stem Cells gene regulatory network with feed-back control between activators and inhibitors. The robust molecular circuits allows for a constant competitive balance between BMP and WNT signaling. BMP inhibition regulates ligand-receptor dependent canonical Wnt activation. The self-regulatory nature allows activation and quiescence of stem cells to occur in a cyclic way during physiological conditions, response to injury, and protection against tumorigenesis when over-activated.