| Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination. |
2019 |
Cell Stem Cell |
| Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility. |
2019 |
Nat Commun |
| Human induced pluripotent stem cell line with genetically encoded fluorescent voltage indicator generated via CRISPR for action potential assessment post-cardiogenesis. |
2019 |
Stem Cells |
| Human iPSC Generation from Antigen-Specific T Cells. |
2019 |
Methods Mol Biol |
| Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model. |
2019 |
Theranostics |
| Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. |
2019 |
Nat Biotechnol |
| Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. |
2019 |
Stem Cells Int |
| Identification of preexisting adaptive immunity to Cas9 proteins in humans. |
2019 |
Nat Med |
| Improved Computational Identification of Drug Response Using Optical Measurements of Human Stem Cell Derived Cardiomyocytes in Microphysiological Systems. |
2019 |
Front Pharmacol |
| In Utero Treatment of Myelomeningocele with Placental Mesenchymal Stromal Cells – Selection of an Optimal Cell Line in Preparation for Clinical Trials. |
2019 |
J Pediatr Surg |
| Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. |
2019 |
Am J Cancer Res |
| Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis. |
2019 |
Kidney Int |
| Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1. |
2019 |
N Engl J Med |
| LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. |
2019 |
Sci Rep |
| Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. |
2019 |
Nature |
| LRRK2 modifies alpha-syn pathology and spread in mouse models and human neurons. |
2019 |
Acta Neuropathol |
| Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking. |
2019 |
Sci Rep |
| Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA. |
2019 |
Stem Cells Transl Med |
| Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle. |
2019 |
Cell Rep |
| Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. |
2019 |
Cell Rep |
| Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment. |
2019 |
Cell |
| Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. |
2019 |
Cell Stem Cell |
| Modeling Snyder-Robinson Syndrome in multipotent stromal cells reveals impaired mitochondrial function as a potential cause for deficient osteogenesis. |
2019 |
Sci Rep |
| Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas. |
2019 |
Sci Rep |
| Multiscale, multispectral fluorescence lifetime imaging using a double-clad fiber. |
2019 |
Opt Lett |
| Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes. |
2019 |
FASEB J |
| Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro. |
2019 |
Sci Rep |
| Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells. |
2019 |
Semin Immunopathol |
| Online measurement of oxygen enables continuous noninvasive evaluation of human-induced pluripotent stem cell (hiPSC) culture in a perfused 3D hollow-fiber bioreactor. |
2019 |
J Tissue Eng Regen Med |
| Paramagnetic Fluorinated Nanoemulsions for in vivo F-19 MRI. |
2019 |
Mol Imaging Biol |
| Phenotypic Variation Between Stromal Cells Differentially Impacts Engineered Cardiac Tissue Function. |
2019 |
Tissue Eng Part A |
| Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells. |
2019 |
Stem Cell Res Ther |
| Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. |
2019 |
Cell Res |
| Preliminary Results of a Phase 1/2 Clinical Study of Zinc Finger Nuclease-Mediated Editing of BCL11A in Autologous Hematopoietic Stem Cells for Transfusion-Dependent Beta Thalassemia |
2019 |
Blood |
| Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation. |
2019 |
Biochem Biophys Res Commun |
| Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. |
2019 |
PLoS One |
| PTPsigma inhibitors promote hematopoietic stem cell regeneration. |
2019 |
Nat Commun |
| Receptor subtype discrimination using extensive shape complementary designed interfaces. |
2019 |
Nat Struct Mol Biol |
| Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. |
2019 |
Nat Commun |
| Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. |
2019 |
Nat Commun |
| Single-cell genomics identifies cell type-specific molecular changes in autism. |
2019 |
Science |
| Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair. |
2019 |
Cell Rep |
| Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. |
2019 |
Elife |
| Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele. |
2019 |
Fetal Diagn Ther |
| Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. |
2019 |
Nat Med |
| Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells. |
2019 |
Gene Ther |
| Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. |
2019 |
Elife |
| T cell antigen discovery via signaling and antigen-presenting bifunctional receptors. |
2019 |
Nat Methods |
| TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. |
2019 |
Cell Stem Cell |
| The application of human amniotic membrane in the surgical management of limbal stem cell deficiency. |
2019 |
Ocul Surf |
