Gladstone Institutes, J. David

Awards to the Institution

Program	Investigator	Award Title	Award Value
SEED Grant	Fen-Biao Gao	MicroRNAs in Human Stem Cell Differentiation and Mental Disorders	$748,800
Basic Biology III	Deepak Srivastava	Mechanisms of Direct Cardiac Reprogramming	$1,572,380
Early Translational IV	Steven Finkbeiner	Development of Novel Autophagy Inducers to Block the Progression of and Treat Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Diseases	$2,049,053
Conference	Deepak Srivastava	Keystone Symposia, "Stem Cells and Reprogramming"	$50,000
SEED Grant	Warner Greene	The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells	$717,363
Research Training II	Robert Mahley	Gladstone CIRM Scholars Program	$4,869,300
Basic Biology V	Sheng Ding	A novel druggable mechanism to safeguard stem cell genome	$1,294,495
Conference	Steven Finkbeiner	THE 5TH ANNUAL CALIFORNIA ALS PAC10 AND RESEARCH NETWORK MEETING	$9,529
New Faculty II	Benoit Bruneau	Induction of cardiogenesis in pluripotent cells via chromatin remodeling factors	$2,723,653
Training Grant I-2	Robert Mahley	Gladstone CIRM Scholar Program	$2,192,073
Disease Team Planning	Deepak Srivastava	Pluripotent Stem Cell–Based Therapy for Heart Disease	$13,505
Conference	Deepak Srivastava	ISSCR - Roddenberry International Symposium on Cellular reprogramming	$43,000
New Faculty II	Yadong Huang	Defining the Isoform-Specific Effects of Apolipoprotein E on the Development of iPS Cells into Functional Neurons in Vitro and in Vivo	$2,757,303
Early Translational III	Deepak Srivastava	Direct Cardiac Reprogramming for Heart Regeneration	$5,795,871
Shared Labs	Deepak Srivastava	The Gladstone CIRM Shared Human Embryonic Stem Cell Core Laboratory	$842,672
Quest - Discovery Stage Research Projects	Li Gan	Develop iPSC-derived microglia to treat progranulin-deficient Frontotemporal Dementia	$1,547,157
Research Training Grant	Bruce Conklin	CIRM Regenerative Medicine Research Training Program	$5,000,000
New Cell Lines	Bruce Conklin	Induced Pluripotent Stem Cells for Cardiovascular Diagnostics	$1,708,560
Comprehensive Grant	Deepak Srivastava	microRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells	$2,994,719
Basic Biology IV	Steven Finkbeiner	Common molecular mechanisms in neurodegenerative diseases using patient based iPSC neurons	$1,395,184
Research Leadership	Todd McDevitt	Engineering microscale tissue constructs from human pluripotent stem cells	$5,849,100
Quest - Discovery Stage Research Projects	Deepak Srivastava	Modified RNA-Based Gene Therapy for Cardiac Regeneration Through Cardiomyocyte Proliferation	$1,565,784
New Cell Lines	Robert Farese	Establishment of Frontotemporal Dementia Patient-Specific Induced Pluripotent Stem (iPS) Cell Lines with Defined Genetic Mutations	$1,696,424
Early Translational I	Warner Greene	Maximizing the Safety of Induced Pluripotent Stem Cells as an Infusion Therapy: Limiting the Mutagenic Threat of Retroelement Retrotransposition during iPSC Generation, Expansion and Differentiation	$1,280,001
Basic Biology IV	Benoit Bruneau	Epigenetic regulation of human cardiac differentiation	$1,568,148
Quest - Discovery Stage Research Projects	Deepak Srivastava	Use of Human iPSC-derived Endothelial Cells for Calcific Aortic Valve Disease Therapeutics	$2,400,048
Foundation - Discovery Stage Research Projects	Julia Kaye	Developing a Human Model of Sporadic ALS Using Machine Learning and Robotic Microscopy	$1,406,622
New Cell Lines	Sheng Ding	Derivation of New ICM-stage hESCs	$778,859
Shared Labs	Deepak Srivastava	The Gladstone CIRM Shared Human Embryonic Stem Cell Core Laboratory	$1,698,515
Basic Biology IV	Sheng Ding	A new paradigm of lineage-specific reprogramming	$1,568,395
Therapeutic Translational Research Projects	Yadong Huang	Human iPSC-derived GABAergic Progenitors for Alzheimer’s Disease Treatment	$1,900,000
Quest - Discovery Stage Research Projects	Lyandysha Zholudeva	Excitatory spinal interneurons from human pluripotent stem cells to treat spinal cord injury	$2,942,198
SEED Grant	Eric Verdin	Role of HDAC in human stem cells pluripotentiality and differentiation	$590,997
New Faculty I	Sheng Ding	Reprogramming of human somatic cells back to pluripotent embryonic stem cells	$1,320,101
Creativity Awards	Shannon Noonan	Gladstone Summer Scholars (GSS) internship program	$35,044
Quest - Discovery Stage Research Projects	Deepak Srivastava	Direct Cardiac Reprogramming for Regenerative Medicine	$2,392,157
			Total: $67,317,010.00